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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:substance-induced psychosis
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Accession:DOID:8646 term browser browse the term
Definition:Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Synonyms:exact_synonym: Drug Psychoses;   Toxic Psychoses;   substance-induced psychoses
 primary_id: MESH:D011605;   RDO:0006434
 xref: ICD9CM:293.89
For additional species annotation, visit the Alliance of Genome Resources.


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substance-induced psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:17196621 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
JBrowse link
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19386276 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
G GRM2 glutamate metabotropic receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr20:37,915,178...37,926,276
Ensembl chr20:37,915,665...37,924,296
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19747927 NCBI chr 2:50,005,277...50,006,548
Ensembl chr 2:50,002,740...50,006,548
JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr 2:79,022,790...79,033,975
Ensembl chr 2:79,022,775...79,033,975
JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19566775 NCBI chr15:59,580,546...59,587,753
Ensembl chr15:59,580,809...59,583,237
JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr 1:43,972,915...44,037,477
Ensembl chr 1:43,972,219...44,141,238
JBrowse link
G PHB prohibitin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18504422 NCBI chr 9:25,525,711...25,536,722
Ensembl chr 9:25,526,649...25,536,722
JBrowse link
G PICK1 protein interacting with PRKCA 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chr10:26,595,301...26,614,170
Ensembl chr10:26,595,768...26,613,756
JBrowse link
G RGS9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17318883 NCBI chr 9:14,809,977...14,905,299
Ensembl chr 9:14,809,864...14,905,197
JBrowse link
G SLC6A3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chr34:11,209,118...11,245,456
Ensembl chr34:11,210,939...11,246,742
JBrowse link
G SNCA synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542733 NCBI chr32:12,915,871...13,079,338
Ensembl chr32:12,916,215...13,060,383
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16807759 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chr26:9,319,109...9,361,021 JBrowse link
G FOXO4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chr  X:55,469,738...55,477,699
Ensembl chr  X:55,469,382...55,477,699
JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
drug psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 ISO RGD PMID:26174132 RGD:11534754 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241
JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 4:12,166,275...12,827,175
Ensembl chr 4:12,167,550...12,827,037
JBrowse link
G APOE apolipoprotein E ISO RGD PMID:15007105 RGD:12904641 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
JBrowse link
G BPIFA1 BPI fold containing family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chr24:22,475,407...22,482,666
Ensembl chr24:22,457,631...22,482,661
JBrowse link
G CAT catalase ISO CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B treatment ISO RGD PMID:22037411 PMID:23763370 RGD:13210751 RGD:13432044 NCBI chr27:32,470,889...32,883,606
Ensembl chr27:32,471,153...32,877,680
JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G NOS1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
JBrowse link
G PTEN phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 2:73,497,128...73,533,853
Ensembl chr 2:73,497,473...73,534,378
JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RHOA ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chr20:39,824,552...39,888,089
Ensembl chr20:39,824,575...39,887,215
JBrowse link
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:24814703 RGD:10047100 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238
JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:22959208 RGD:7204702 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329
JBrowse link
G IREB2 iron responsive element binding protein 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr13:38,398,445...38,441,128
Ensembl chr13:38,400,591...38,441,015
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12734
    Chemically-Induced Disorders 1059
      substance-related disorder 514
        substance-induced psychosis 35
          alcohol-induced mental disorder + 14
          alcoholic psychosis 0
          drug-induced mental disorder + 1
          subacute delirium + 4
Path 2
Term Annotations click to browse term
  disease 12734
    disease of anatomical entity 12266
      nervous system disease 10005
        central nervous system disease 8431
          brain disease 7787
            disease of mental health 5651
              cognitive disorder 1704
                psychotic disorder 997
                  substance-induced psychosis 35
                    alcohol-induced mental disorder + 14
                    alcoholic psychosis 0
                    drug-induced mental disorder + 1
                    subacute delirium + 4
paths to the root