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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:substance-induced psychosis
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Accession:DOID:8646 term browser browse the term
Definition:Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Synonyms:exact_synonym: Drug Psychoses;   Toxic Psychoses;   substance-induced psychoses
 primary_id: MESH:D011605;   RDO:0006434
 xref: ICD9CM:293.89
For additional species annotation, visit the Alliance of Genome Resources.


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substance-induced psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
JBrowse link
G Camk2b calcium/calmodulin dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17603807 NCBI chrNW_004955456:7,711,583...7,760,506
Ensembl chrNW_004955456:7,713,552...7,760,207
JBrowse link
G Esr1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19386276 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
JBrowse link
G Grm2 glutamate metabotropic receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chrNW_004955532:3,309,034...3,320,954
Ensembl chrNW_004955532:3,309,028...3,320,966
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19747927 NCBI chrNW_004955446:4,913,181...4,917,726
Ensembl chrNW_004955446:4,913,884...4,915,146
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chrNW_004955452:323,641...338,312 JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19566775 NCBI chrNW_004955403:41,681,834...41,693,094
Ensembl chrNW_004955403:41,681,728...41,694,020
JBrowse link
G Oprm1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817
JBrowse link
G Phb prohibitin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18504422 NCBI chrNW_004955451:12,110,290...12,119,870
Ensembl chrNW_004955451:12,110,290...12,120,124
JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chrNW_004955413:24,383,130...24,399,092
Ensembl chrNW_004955413:24,383,130...24,399,196
JBrowse link
G Rgs9 regulator of G protein signaling 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17318883 NCBI chrNW_004955478:4,614,730...4,683,152
Ensembl chrNW_004955478:4,614,701...4,683,167
JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chrNW_004955504:721,470...747,553
Ensembl chrNW_004955504:721,429...747,630
JBrowse link
G Snca synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542733 NCBI chrNW_004955405:854,011...962,741
Ensembl chrNW_004955405:853,946...965,403
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16807759 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chrNW_004955482:8,352,569...8,383,097 JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chrNW_004955475:10,666,024...10,673,717
Ensembl chrNW_004955475:10,665,987...10,674,110
JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583
JBrowse link
drug psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 ISO RGD PMID:26174132 RGD:11534754 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573
JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chrNW_004955425:13,522,233...13,851,286 JBrowse link
G Apoe apolipoprotein E ISO RGD PMID:15007105 RGD:12904641 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Bpifa1 BPI fold containing family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chrNW_004955422:28,063,077...28,069,939 JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B treatment ISO RGD PMID:22037411 PMID:23763370 RGD:13210751 RGD:13432044 NCBI chrNW_004955413:10,358,931...10,780,004
Ensembl chrNW_004955413:10,376,597...10,779,145
JBrowse link
G Igf1 insulin like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666
JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566
JBrowse link
G Pten phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chrNW_004955452:5,905,561...5,938,096
Ensembl chrNW_004955452:5,904,762...5,939,091
JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451
JBrowse link
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:24814703 RGD:10047100 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:22959208 RGD:7204702 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chrNW_004955450:852,554...898,908
Ensembl chrNW_004955450:852,554...900,011
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11866
    Chemically-Induced Disorders 920
      substance-related disorder 466
        substance-induced psychosis 35
          alcohol-induced mental disorder + 14
          alcoholic psychosis 0
          drug-induced mental disorder + 1
          subacute delirium + 4
Path 2
Term Annotations click to browse term
  disease 11866
    disease of anatomical entity 11425
      nervous system disease 9372
        central nervous system disease 7954
          brain disease 7365
            disease of mental health 5369
              cognitive disorder 1607
                psychotic disorder 939
                  substance-induced psychosis 35
                    alcohol-induced mental disorder + 14
                    alcoholic psychosis 0
                    drug-induced mental disorder + 1
                    subacute delirium + 4
paths to the root