RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
GViewer not supported for the selected species.
G
Ada
adenosine deaminase
ISO
protein:decreased activity:saliva:
RGD
PMID:16120121
RGD:152995281
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
susceptibility
ISO
DNA:SNP: :rs578776(human)
RGD
PMID:24505444
RGD:151347542
NCBI chrNW_004955450:1,013,897...1,030,232
Ensembl chrNW_004955450:1,013,607...1,030,282
G
Cxcl8
C-X-C motif chemokine ligand 8
ISO
mRNA:increased expression:head, neck (human)
RGD
PMID:31452775
RGD:150520018
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
G
LOC102010850
cytochrome P450 1A1
ISO
RGD
PMID:17461521
RGD:14700965
NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488
G
LOC102026028
cytochrome P450 2E1
ISO
RGD
PMID:16721740
RGD:14700978
NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193
G
Sod3
superoxide dismutase 3
ISO
RGD
PMID:23057317
RGD:14700938
NCBI chrNW_004955480:257,716...263,149
G
Il10
interleukin 10
ISO
RGD
PMID:26723902
RGD:14975265
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
G
Nuf2
NUF2 component of NDC80 kinetochore complex
disease_progression
ISO
RGD
PMID:27499128
RGD:28867233
NCBI chrNW_004955462:13,082,874...13,142,709
Ensembl chrNW_004955462:13,082,047...13,142,944
G
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
severity
ISO
DNA:mutations
RGD
PMID:16676365
RGD:126925209
NCBI chrNW_004955513:652,048...799,182
Ensembl chrNW_004955513:653,252...799,239
G
Ada
adenosine deaminase
disease_progression
ISO
RGD
PMID:27221867
RGD:152995268
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
G
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
disease_progression
ISO
RGD
PMID:26464646
RGD:11526681
NCBI chrNW_004955458:5,436,544...5,448,201
Ensembl chrNW_004955458:5,436,630...5,448,057
G
Angpt1
angiopoietin 1
ISO
protein:decreased expression:oral mucosa (human)
RGD
PMID:26044849
RGD:153323290
NCBI chrNW_004955417:30,199,508...30,386,695
Ensembl chrNW_004955417:30,198,842...30,386,266
G
Angpt2
angiopoietin 2
ISO
protein:increased expression:oral mucosa (human)
RGD
PMID:26044849
RGD:153323290
NCBI chrNW_004955403:54,139,823...54,193,740
Ensembl chrNW_004955403:54,139,823...54,195,032
G
Arid2
AT-rich interaction domain 2
disease_progression
ISO
RGD
PMID:31918270
RGD:150340710
NCBI chrNW_004955500:4,998,555...5,177,180
Ensembl chrNW_004955500:4,998,555...5,175,776
G
Arpc1b
actin related protein 2/3 complex subunit 1B
severity
ISO
protein:increased expression:oral mucosa (human)
RGD
PMID:26138391
RGD:11046268
NCBI chrNW_004955460:15,055,753...15,069,093
Ensembl chrNW_004955460:15,055,480...15,069,093
G
Atm
ATM serine/threonine kinase
disease_progression
ISO
protein:increased expression:mucosa of oral region (human)
RGD
PMID:18288488 PMID:29928356
RGD:150340604 RGD:150340709
NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
G
Atp6v1c1
ATPase H+ transporting V1 subunit C1
ISO
RGD
PMID:26984774
RGD:14700648
NCBI chrNW_004955417:27,340,916...27,376,541
Ensembl chrNW_004955417:27,356,483...27,375,747
G
Axin1
axin 1
disease_progression
ISO
protein:decreased expression:oral epithelium (human) mRNA:increased expression:oral epithelium (human)
RGD
PMID:17143481 PMID:21393552
RGD:150530474 RGD:150530486
NCBI chrNW_004955442:16,845,728...16,898,301
Ensembl chrNW_004955442:16,843,152...16,898,430
G
Axin2
axin 2
susceptibility ameliorates disease_progression
ISO
DNA:SNP:intron: C>T (rs3923087)(human)
RGD
PMID:21393552 PMID:33046030
RGD:150530486 RGD:151356656
NCBI chrNW_004955478:4,952,551...4,982,223
Ensembl chrNW_004955478:4,952,488...4,982,225
G
Azgp1
alpha-2-glycoprotein 1, zinc-binding
ISO
protein:increased expression:saliva protein:decreased expression:saliva
RGD
PMID:29199150 PMID:33564003
RGD:153350131 RGD:153350144
NCBI chrNW_004955573:902,153...910,481
Ensembl chrNW_004955573:899,798...912,272
G
Barhl2
BarH like homeobox 2
ISO
protein:decreased expression:mouth mucosa
RGD
PMID:27542258
RGD:14390167
NCBI chrNW_004955423:3,516,973...3,522,459
Ensembl chrNW_004955423:3,516,660...3,522,536
G
Bcl2l1
BCL2 like 1
ISO
mRNA, protein:increased expression:mouth (human)
RGD
PMID:34111459
RGD:153344573
NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
G
Bhlhe41
basic helix-loop-helix family member e41
treatment
ISO
Human cells in mouse model
RGD
PMID:27602964
RGD:151665310
NCBI chrNW_004955413:21,100,021...21,103,358
G
Birc2
baculoviral IAP repeat containing 2
ISO
protein:increased expression:oral cavity (human)
RGD
PMID:20967871
RGD:152999012
NCBI chrNW_004955412:5,658,322...5,685,628
Ensembl chrNW_004955412:5,659,478...5,685,114
G
Birc3
baculoviral IAP repeat containing 3
ameliorates disease_progression
ISO
protein:decreased expression:oral cavity (human) protein:increased expression:oral cavity (human) mRNA:increased expression:oral cavity (human)
RGD
PMID:20967871 PMID:21952624 PMID:23852810 PMID:29286141
RGD:152998980 RGD:152998987 RGD:152999009 RGD:152999012
NCBI chrNW_004955412:5,624,865...5,643,520
Ensembl chrNW_004955412:5,628,973...5,643,410
G
Brinp2
BMP/retinoic acid inducible neural specific 2
ISO
DNA:amplication:oral epithelium
RGD
PMID:21334929
RGD:14398483
NCBI chrNW_004955406:16,748,824...16,840,924
Ensembl chrNW_004955406:16,748,824...16,844,093
G
Btk
Bruton tyrosine kinase
treatment
ISO
mRNA:increased expression:oral epithelium (human)
RGD
PMID:33640903
RGD:151347851
NCBI chrNW_004955503:7,483,819...7,515,085
Ensembl chrNW_004955503:7,482,793...7,515,120
G
Ca12
carbonic anhydrase 12
disease_progression
ISO
RGD
PMID:22172588
RGD:153352330
NCBI chrNW_004955450:11,927,730...11,975,553
Ensembl chrNW_004955450:11,943,340...11,975,928
G
Calr
calreticulin
exacerbates
ISO
protein:increased expression:oral epithelium (human) protein:increased expression:mouth (human)
RGD
PMID:23375593 PMID:28599487
RGD:150520158 RGD:150521688
NCBI chrNW_004955415:31,985,147...31,989,372
Ensembl chrNW_004955415:31,985,147...31,989,372
G
Camk2n1
calcium/calmodulin dependent protein kinase II inhibitor 1
ISO
RGD
PMID:30205384
RGD:18337270
NCBI chrNW_004955452:1,044,696...1,046,657
Ensembl chrNW_004955452:1,043,459...1,046,669
G
Cbx2
chromobox 2
disease_progression
ISO
RGD
PMID:24885002
RGD:9586732
NCBI chrNW_004955506:3,045,395...3,053,003
Ensembl chrNW_004955506:3,046,607...3,053,001
G
Ccr2
C-C motif chemokine receptor 2
susceptibility
ISO
DNA:polymorphism,haplotype:cds:p.V64I(human)
RGD
PMID:21883707
RGD:8661694
NCBI chrNW_004955420:25,641,184...25,664,413
G
Cdc73
cell division cycle 73
ISO
mRNA:altered expression: tongue, oral cavity (human)
RGD
PMID:24257751
RGD:150537040
NCBI chrNW_004955406:30,533,919...30,665,812
Ensembl chrNW_004955406:30,533,060...30,665,812
G
Cdh1
cadherin 1
disease_progression
ISO
RGD
PMID:26464646
RGD:11526681
NCBI chrNW_004955484:7,782,409...7,861,082
Ensembl chrNW_004955484:7,782,772...7,860,967
G
Cdkn1a
cyclin dependent kinase inhibitor 1A
disease_progression susceptibility no_association
ISO
DNA:polymorphism:exon:149A>G(human) DNA:polymorphism: :98C>A(human)
RGD
PMID:10873097 PMID:15817070 PMID:18251939
RGD:8662371 RGD:8662374 RGD:8662395
NCBI chrNW_004955437:6,254,638...6,261,278
Ensembl chrNW_004955437:6,254,309...6,261,479
G
Cers1
ceramide synthase 1
exacerbates
ISO
RGD
PMID:33753723
RGD:156431057
NCBI chrNW_004955524:2,788,672...2,798,068
Ensembl chrNW_004955524:2,788,653...2,796,370
G
Chaf1b
chromatin assembly factor 1 subunit B
disease_progression
ISO
protein:increased expression:mouth mucosa:
RGD
PMID:22882088
RGD:9587477
NCBI chrNW_004955407:35,601,992...35,618,287
Ensembl chrNW_004955407:35,602,819...35,617,917
G
Clptm1l
CLPTM1 like
susceptibility
ISO
DNA:SNP: :rs402710(human)
RGD
PMID:28025427
RGD:150530487
NCBI chrNW_004955504:677,824...695,660
Ensembl chrNW_004955504:677,772...695,660
G
Ctnnd1
catenin delta 1
disease_progression
ISO
RGD
PMID:26464646
RGD:11526681
NCBI chrNW_004955511:2,658,879...2,705,992
Ensembl chrNW_004955511:2,658,858...2,703,958
G
Daxx
death domain associated protein
ameliorates
ISO
human cell line in a mouse model
RGD
PMID:26205068
RGD:152025200
NCBI chrNW_004955437:1,869,692...1,874,041
Ensembl chrNW_004955437:1,869,572...1,873,050
G
Ddr1
discoidin domain receptor tyrosine kinase 1
ISO
mRNA, protein:increased expression:mouth (human)
RGD
PMID:31253192
RGD:151347620
NCBI chrNW_004955583:820,893...838,515
Ensembl chrNW_004955583:820,931...841,654
G
Ddr2
discoidin domain receptor tyrosine kinase 2
severity
ISO
RGD
PMID:29945346
RGD:150429700
NCBI chrNW_004955462:13,578,638...13,644,834
Ensembl chrNW_004955462:13,584,724...13,642,968
G
Dnmt3b
DNA methyltransferase 3 beta
disease_progression
ISO
RGD
PMID:24625449
RGD:9589120
NCBI chrNW_004955422:28,380,595...28,427,012
Ensembl chrNW_004955422:28,380,591...28,421,301
G
Dock6
dedicator of cytokinesis 6
disease_progression
ISO
RGD
PMID:34742001
RGD:155791563
NCBI chrNW_004955495:2,174,802...2,216,424
Ensembl chrNW_004955495:2,174,966...2,216,423
G
Efnb2
ephrin B2
ISO
protein:increased expression:oral mucosa (human)
RGD
PMID:26044849
RGD:153323290
NCBI chrNW_004955404:5,000,906...5,030,068
Ensembl chrNW_004955404:5,000,906...5,030,126
G
Egfr
epidermal growth factor receptor
ISO
RGD
PMID:11673832
RGD:126781761
NCBI chrNW_004955456:321,222...456,431
G
Erbb2
erb-b2 receptor tyrosine kinase 2
ISO
RGD
PMID:11673832
RGD:126781761
NCBI chrNW_004955451:14,442,816...14,456,009
Ensembl chrNW_004955451:14,442,816...14,459,379
G
Erbb4
erb-b2 receptor tyrosine kinase 4
disease_progression
ISO
RGD
PMID:14595263
RGD:126781770
NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558
G
Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
susceptibility
ISO
associated with oral mucosa leukoplakia DNA:SNPs, haplotypes: :multiple
RGD
PMID:21697275 PMID:24122997 PMID:26807327
RGD:126779588 RGD:126779606 RGD:126781699
NCBI chrNW_004955491:4,215,353...4,292,229
Ensembl chrNW_004955491:4,215,298...4,292,235
G
Fat1
FAT atypical cadherin 1
onset
ISO
protein:increased expression:tongue (mouse) DNA:mutations:multiple
RGD
PMID:28435450 PMID:30624777
RGD:151347668 RGD:151347687
NCBI chrNW_004955403:22,502,625...22,618,513
Ensembl chrNW_004955403:22,502,625...22,619,211
G
Fgfr3
fibroblast growth factor receptor 3
ISO
associated with human papillomavirus;DNA:missense mutation:cds: p.S249C (human)
RGD
PMID:30563911
RGD:38500239
NCBI chrNW_004955514:1,030,244...1,038,590
Ensembl chrNW_004955514:1,025,600...1,038,590
G
Fgfr4
fibroblast growth factor receptor 4
severity
ISO
DNA:SNP:exon 9: p.G388R (human)
RGD
PMID:20127014
RGD:150520164
NCBI chrNW_004955408:29,370,480...29,383,531
Ensembl chrNW_004955408:29,370,468...29,383,971
G
Flt3
fms related receptor tyrosine kinase 3
ISO
mRNA:decreased expression:oral epithelium (human)
RGD
PMID:32048621
RGD:149735374
NCBI chrNW_004955497:7,357,533...7,441,215
Ensembl chrNW_004955497:7,357,212...7,461,439
G
Fosl2
FOS like 2, AP-1 transcription factor subunit
ISO
mRNA, protein:increased expression:mouth (human)
RGD
PMID:34111459
RGD:153344573
NCBI chrNW_004955469:10,297,179...10,319,180
Ensembl chrNW_004955469:10,297,179...10,319,180
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
ISO
RGD
PMID:27375172
RGD:13792673
NCBI chrNW_004955413:4,162,467...4,166,783
Ensembl chrNW_004955413:4,162,467...4,166,783
G
Gpx1
glutathione peroxidase 1
exacerbates
ISO
protein:increased expression:oral cavity (human)
RGD
PMID:28653098
RGD:152995473
NCBI chrNW_004955532:1,298,336...1,298,830
G
Gpx4
glutathione peroxidase 4
disease_progression
ISO
protein:increased expression:oral cavity (human)
RGD
PMID:28653098
RGD:152995473
NCBI chrNW_004955495:6,767,969...6,772,256
Ensembl chrNW_004955495:6,767,975...6,772,178
G
Gsk3b
glycogen synthase kinase 3 beta
susceptibility
ISO
DNA:SNP:intron: (rs9879992) (human)
RGD
PMID:21393552
RGD:150530486
NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
G
Gstp1
glutathione S-transferase pi 1
ISO
mRNA,protein:decreased expression:mucosa:
RGD
PMID:16982972
RGD:10755432
NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428
G
Hes1
hes family bHLH transcription factor 1
ISO
protein:increased expression:tongue (mouse)
RGD
PMID:30624777
RGD:151347668
NCBI chrNW_004955420:14,565,921...14,568,447
Ensembl chrNW_004955420:14,564,283...14,568,447
G
Il10
interleukin 10
susceptibility
ISO
DNA:SNP:promoter:-592A>C (human)
RGD
PMID:28157558
RGD:14975130
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
G
Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
RGD
PMID:19065664
RGD:8549498
NCBI chrNW_004955490:708,144...758,195
Ensembl chrNW_004955490:709,446...758,272
G
Il1b
interleukin 1 beta
disease_progression
ISO
associated with social isolation;protein:increased expression:tongue (rat)
RGD
PMID:33411841
RGD:152998999
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
G
Il2
interleukin 2
ISO
RGD
PMID:10389944
RGD:8662949
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
G
Il6
interleukin 6
disease_progression
ISO
RGD
PMID:24625449
RGD:9589120
NCBI chrNW_004955410:25,079,835...25,084,390
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
mRNA, protein:increased expression:mouth (human)
RGD
PMID:34111459
RGD:153344573
NCBI chrNW_004955464:1,107,598...1,110,326
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
associated with papillomavirus infectious disease;protein:increased expression:oral cavity (human)
RGD
PMID:28155253
RGD:151347666
NCBI chrNW_004955415:31,876,508...31,878,289
Ensembl chrNW_004955415:31,876,793...31,877,836
G
Kmt2d
lysine methyltransferase 2D
severity
ISO
RGD
PMID:31660637
RGD:150521713
NCBI chrNW_004955500:7,850,782...7,891,703
Ensembl chrNW_004955500:7,853,292...7,886,067
G
LOC102010850
cytochrome P450 1A1
ISO
RGD
PMID:22660220
RGD:14700952
NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488
G
LOC102013768
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
susceptibility
ISO
DNA:SNP:exon: (rs2296241) (human)
RGD
PMID:22612324
RGD:151665337
NCBI chrNW_004955445:4,874,583...4,891,723
Ensembl chrNW_004955445:4,873,942...4,891,780
G
LOC102025775
histone H2AX
disease_progression
ISO
protein:increased expression:mucosa of oral region (human)
RGD
PMID:29928356
RGD:150340604
NCBI chrNW_004955412:20,203,173...20,204,714
Ensembl chrNW_004955412:20,203,772...20,204,203
G
LOC102026028
cytochrome P450 2E1
ISO
RGD
PMID:22954124
RGD:14700880
NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193
G
Mcph1
microcephalin 1
ISO
mRNA:protein:decreased expression:oral cavity, tissue (human)
RGD
PMID:23472065
RGD:9589036
NCBI chrNW_004955403:54,143,454...54,273,201
G
Met
MET proto-oncogene, receptor tyrosine kinase
ISO
protein:increased expression, altered expression:mouth mucosa:
RGD
PMID:20662906
RGD:8548617
NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647
G
Mthfr
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:missense mutation:cds:677C>T (human)
RGD
PMID:16365753
RGD:10449416
NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240
G
Naip
NLR family apoptosis inhibitory protein
ISO
protein:increased expression:oral cavity (human)
RGD
PMID:20967871
RGD:152999012
NCBI chrNW_004955575:249,659...283,378
G
Notch1
notch receptor 1
ISO
protein:increased expression:tongue (mouse)
RGD
PMID:30624777
RGD:151347668
NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259
G
Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
protein:decreased expression:oral mucosa (human)
RGD
PMID:26044849
RGD:153323290
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
G
Plau
plasminogen activator, urokinase
severity
ISO
protein:increased expression:oral mucosa (rat)
RGD
PMID:15878520
RGD:8547730
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
G
Plcg1
phospholipase C gamma 1
disease_progression ameliorates
ISO
protein:decreased expression:oral cavity (human)
RGD
PMID:25085076 PMID:26464646
RGD:11526681 RGD:151356936
NCBI chrNW_004955445:15,787,496...15,823,859
Ensembl chrNW_004955445:15,787,496...15,823,859
G
Prdx2
peroxiredoxin 2
ISO
protein:increased expression:saliva
RGD
PMID:29199150
RGD:153350131
NCBI chrNW_004955415:31,880,801...31,884,453
Ensembl chrNW_004955415:31,880,588...31,884,778
G
Pten
phosphatase and tensin homolog
disease_progression
ISO
protein:increased expression:oral epithelium (human)
RGD
PMID:33109573
RGD:127285606
NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829
G
Ptgis
prostaglandin I2 synthase
ISO
mRNA,protein:decreased expression:mouth mucosa (human)
RGD
PMID:30532780
RGD:151347832
NCBI chrNW_004955445:8,624,228...8,663,385
Ensembl chrNW_004955445:8,623,430...8,677,658
G
Ptpn13
protein tyrosine phosphatase non-receptor type 13
treatment
ISO
RGD
PMID:21176871
RGD:152600900
NCBI chrNW_004955474:2,988,109...3,140,520
Ensembl chrNW_004955474:2,988,639...3,140,513
G
Rad21
RAD21 cohesin complex component
exacerbates
ISO
mRNA:decreased expression:oral cavity (human)
RGD
PMID:16416296
RGD:150520028
NCBI chrNW_004955417:22,941,549...22,966,395
Ensembl chrNW_004955417:22,941,479...22,966,837
G
Rela
RELA proto-oncogene, NF-kB subunit
ISO
protein:increased expression:mouth (human)
RGD
PMID:34111459
RGD:153344573
NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
G
Serpine1
serpin family E member 1
severity disease_progression
ISO
protein:increased expression:oral mucosa (rat)
RGD
PMID:15878520 PMID:24999729
RGD:13208508 RGD:8547730
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
G
Skp2
S-phase kinase associated protein 2
ISO
protein:increased expression:mucosa of oral region (human)
RGD
PMID:24743017
RGD:151665336
NCBI chrNW_004955426:20,972,663...20,999,769
Ensembl chrNW_004955426:20,972,663...20,999,769
G
Slc7a5
solute carrier family 7 member 5
severity
ISO
RGD
PMID:23801167
RGD:151361213
NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310
G
Tert
telomerase reverse transcriptase
susceptibility
ISO
DNA:SNPs: :rs2736100,rs2736098(human)
RGD
PMID:28025427
RGD:150530487
NCBI chrNW_004955504:649,248...669,796
Ensembl chrNW_004955504:651,779...670,589
G
Tet2
tet methylcytosine dioxygenase 2
ISO
protein:decreased expression:oral epithelium (human)
RGD
PMID:24122999
RGD:150429611
NCBI chrNW_004955496:3,885,684...3,963,056
Ensembl chrNW_004955496:3,885,035...3,926,106
G
Tnf
tumor necrosis factor
disease_progression
ISO
associated with social isolation;protein:increased expression:tongue (rat)
RGD
PMID:33411841
RGD:152998999
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
G
Tp53
tumor protein p53
ISO
DNA:missense mutations: :multiple protein:increased expression:mouth (human)
RGD
PMID:27283772 PMID:34111459
RGD:14995497 RGD:153344573
NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
G
Ttr
transthyretin
ISO
protein:increased expression:saliva (human)
RGD
PMID:23784731
RGD:151664609
NCBI chrNW_004955402:18,921,235...18,927,976
Ensembl chrNW_004955402:18,921,274...18,928,108
G
Vegfa
vascular endothelial growth factor A
ISO
protein:increased expression:oral mucosa (human)
RGD
PMID:26044849
RGD:153323290
NCBI chrNW_004955437:9,527,445...9,541,908
G
Wnt11
Wnt family member 11
susceptibility
ISO
DNA:SNP:exon: A>G (rs1533767) (human)
RGD
PMID:21393552
RGD:150530486
NCBI chrNW_004955414:15,674,478...15,694,758
Ensembl chrNW_004955414:15,674,940...15,694,883
G
Mtus1
microtubule associated scaffold protein 1
disease_progression
ISO
RGD
PMID:25885343
RGD:25330345
NCBI chrNW_004955552:1,867,477...2,040,659
Ensembl chrNW_004955552:1,924,922...2,040,653
G
Xrcc4
X-ray repair cross complementing 4
susceptibility
ISO
DNA:SNP:intron: (rs13180356) (human)
RGD
PMID:26035306
RGD:151361290
NCBI chrNW_004955418:27,174,510...27,426,245
Ensembl chrNW_004955418:27,173,659...27,426,264
G
Gon4l
gon-4 like
ISO
MouseDO
NCBI chrNW_004955545:1,990,202...2,054,614
G
Kdr
kinase insert domain receptor
disease_progression
ISO
RGD
PMID:26498950
RGD:126907998
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
G
Ptgs1
prostaglandin-endoperoxide synthase 1
disease_progression
ISO
RGD
PMID:26498950
RGD:126907998
NCBI chrNW_004955419:5,678,750...5,699,305
Ensembl chrNW_004955419:5,678,694...5,699,305
G
Rad52
RAD52 homolog, DNA repair protein
sexual_dimorphism
ISO
DNA:SNP:intron: (rs3748522) (human)
RGD
PMID:26035306
RGD:151361290
NCBI chrNW_004955454:6,206,195...6,227,859
Ensembl chrNW_004955454:6,215,129...6,231,726
G
Xrcc4
X-ray repair cross complementing 4
sexual_dimorphism
ISO
DNA:SNP:intron: (rs13180356) (human)
RGD
PMID:26035306
RGD:151361290
NCBI chrNW_004955418:27,174,510...27,426,245
Ensembl chrNW_004955418:27,173,659...27,426,264
G
Ddx3x
DEAD-box helicase 3 X-linked
ameliorates
ISO
RGD
PMID:25918862
RGD:151356506
NCBI chrNW_004955565:1,387,043...1,403,624
Ensembl chrNW_004955565:1,386,973...1,404,220
G
Fgfr3
fibroblast growth factor receptor 3
severity
ISO
associated with human papillomavirus;protein:decreased expression:tumor cells
RGD
PMID:30061236
RGD:36947883
NCBI chrNW_004955514:1,030,244...1,038,590
Ensembl chrNW_004955514:1,025,600...1,038,590
G
Rictor
RPTOR independent companion of MTOR complex 2
disease_progression
ISO
protein:increased expression:tongue (human)
RGD
PMID:25749387
RGD:152995520
NCBI chrNW_004955426:23,468,112...23,582,587
Ensembl chrNW_004955426:23,468,112...23,582,587
G
Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
ISO
associated with oral squamous cell carcinoma; protein:increased expression: oral mucosa squamous cell, cervical lymph node (human)
RGD
PMID:20204288
RGD:27372889
NCBI chrNW_004955416:7,105,302...7,159,121
Ensembl chrNW_004955416:7,105,261...7,160,012
G
Ada
adenosine deaminase
ISO
protein:increased activity:saliva:
RGD
PMID:20379753
RGD:152995262
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
G
Adipoq
adiponectin, C1Q and collagen domain containing
disease_progression
ISO
protein:decreased expression:serum
RGD
PMID:23181352
RGD:8694469
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
G
Bcl2
BCL2 apoptosis regulator
ISO
protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
G
Birc2
baculoviral IAP repeat containing 2
exacerbates
ISO
protein:increased expression:tongue (human)
RGD
PMID:18621506
RGD:153323319
NCBI chrNW_004955412:5,658,322...5,685,628
Ensembl chrNW_004955412:5,659,478...5,685,114
G
Brinp3
BMP/retinoic acid inducible neural specific 3
ISO
mRNA:decreased expression:tongue:
RGD
PMID:19787213
RGD:14398487
NCBI chrNW_004955406:27,870,115...28,240,328
Ensembl chrNW_004955406:27,869,456...28,238,978
G
Cav2
caveolin 2
ISO
protein:increased expression:mucosa of tongue
RGD
PMID:20558341
RGD:8661771
NCBI chrNW_004955432:22,240,041...22,242,200
G
Ccnd1
cyclin D1
ISO
protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955422:16,449,921...16,462,676
Ensembl chrNW_004955422:16,448,770...16,463,300
G
Cdkn1a
cyclin dependent kinase inhibitor 1A
disease_progression
ISO
RGD
PMID:12162767
RGD:8662376
NCBI chrNW_004955437:6,254,638...6,261,278
Ensembl chrNW_004955437:6,254,309...6,261,479
G
Cxcl8
C-X-C motif chemokine ligand 8
ISO
mRNA:increased expression:head, neck (human)
RGD
PMID:31452775
RGD:150520018
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
G
Egfr
epidermal growth factor receptor
treatment
ISO
RGD
PMID:19380367
RGD:8551769
NCBI chrNW_004955456:321,222...456,431
G
Erbb3
erb-b2 receptor tyrosine kinase 3
disease_progression
ISO
RGD
PMID:19691460
RGD:126781771
NCBI chrNW_004955458:3,683,126...3,701,752
Ensembl chrNW_004955458:3,683,126...3,702,978
G
Erbb4
erb-b2 receptor tyrosine kinase 4
severity
ISO
RGD
PMID:19691460
RGD:126781771
NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558
G
Fancb
FA complementation group B
ISO
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955519:3,337,138...3,364,963
Ensembl chrNW_004955519:3,343,446...3,363,814
G
Fancc
FA complementation group C
ISO
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955422:22,031,825...22,246,478
Ensembl chrNW_004955422:22,032,258...22,247,044
G
Fancf
FA complementation group F
ISO
mRNA:decreased expression:tongue:
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955476:3,067,491...3,069,637
Ensembl chrNW_004955476:3,067,689...3,068,728
G
Fancg
FA complementation group G
ISO
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955472:1,097,986...1,105,836
Ensembl chrNW_004955472:1,098,839...1,104,911
G
Fanci
FA complementation group I
ISO
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955416:15,788,812...15,857,933
Ensembl chrNW_004955416:15,788,922...15,853,480
G
Fancl
FA complementation group L
ISO
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955424:25,251,701...25,307,236
Ensembl chrNW_004955424:25,251,689...25,307,180
G
Fancm
FA complementation group M
ISO
RGD
PMID:17409780
RGD:11049143
NCBI chrNW_004955409:16,751,658...16,809,352
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
mRNA,protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955523:307,181...310,728
Ensembl chrNW_004955523:305,728...310,728
G
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
ISO
protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955555:2,438,864...2,445,846
Ensembl chrNW_004955555:2,438,864...2,445,846
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
ISO
protein:decreased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955422:19,425,741...19,431,801
Ensembl chrNW_004955422:19,423,591...19,433,885
G
Fosl2
FOS like 2, AP-1 transcription factor subunit
ISO
mRNA,protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955469:10,297,179...10,319,180
Ensembl chrNW_004955469:10,297,179...10,319,180
G
Fubp1
far upstream element binding protein 1
exacerbates
ISO
mRNA, protein:increased expression:tongue (human)
RGD
PMID:32339054
RGD:151361191
NCBI chrNW_004955423:15,245,645...15,278,628
Ensembl chrNW_004955423:15,245,610...15,278,628
G
Gja1
gap junction protein alpha 1
ISO
protein:decreased expression:epithelium
RGD
PMID:23568744
RGD:8662380
NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
G
Hgf
hepatocyte growth factor
ISO
protein:increased expression:tongue:
RGD
PMID:20848408
RGD:8548612
NCBI chrNW_004955410:4,114,280...4,181,953
Ensembl chrNW_004955410:4,114,778...4,182,058
G
Ifng
interferon gamma
disease_progression
ISO
protein:decreased expression:serum:
RGD
PMID:17338814
RGD:8662972
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
G
Il10
interleukin 10
disease_progression
ISO
protein:increased expression:serum:
RGD
PMID:17338814
RGD:8662972
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
G
Il1rl1
interleukin 1 receptor like 1
disease_progression
ISO
RGD
PMID:25193287
RGD:39938972
NCBI chrNW_004955470:7,779,828...7,849,157
G
Il2
interleukin 2
ISO
protein:decreased expression:serum:
RGD
PMID:17338814
RGD:8662972
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
G
Il33
interleukin 33
disease_progression
ISO
RGD
PMID:25193287
RGD:39938972
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
G
Jak3
Janus kinase 3
disease_progression
ISO
RGD
PMID:26860129
RGD:11531126
NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
mRNA,protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955464:1,107,598...1,110,326
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955415:31,876,508...31,878,289
Ensembl chrNW_004955415:31,876,793...31,877,836
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
ISO
protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955524:3,176,849...3,177,936
G
Kdr
kinase insert domain receptor
treatment
ISO
RGD
PMID:19380367
RGD:8551769
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
G
Map2k4
mitogen-activated protein kinase kinase 4
ISO
mRNA:increased expression:tongue squamous epithelium (human)
RGD
PMID:28319306
RGD:150429750
NCBI chrNW_004955467:5,188,036...5,295,570
Ensembl chrNW_004955467:5,187,356...5,307,692
G
Met
MET proto-oncogene, receptor tyrosine kinase
ISO
protein:increased expression:tongue:
RGD
PMID:20848408
RGD:8548612
NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647
G
Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression:tongue (human)
RGD
PMID:26581505
RGD:11535375
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
G
Mtus1
microtubule associated scaffold protein 1
disease_progression
ISO
RGD
PMID:22153618
RGD:25330347
NCBI chrNW_004955552:1,867,477...2,040,659
Ensembl chrNW_004955552:1,924,922...2,040,653
G
Slc1a5
solute carrier family 1 member 5
disease_progression
ISO
RGD
PMID:24762957
RGD:151361157
NCBI chrNW_004955574:798,004...806,631
G
Slc3a2
solute carrier family 3 member 2
disease_progression
ISO
RGD
PMID:24762957
RGD:151361157
NCBI chrNW_004955599:376,133...391,434
Ensembl chrNW_004955599:376,245...391,311
G
Slc7a11
solute carrier family 7 member 11
severity
ISO
RGD
PMID:24762957
RGD:151361157
NCBI chrNW_004955428:5,238,460...5,309,085
Ensembl chrNW_004955428:5,237,865...5,309,085
G
Slc7a5
solute carrier family 7 member 5
disease_progression
ISO
RGD
PMID:24762957
RGD:151361157
NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310
G
Sox2
SRY-box transcription factor 2
disease_progression
ISO
RGD
PMID:21689966
RGD:8661665
NCBI chrNW_004955420:10,671,888...10,674,080
Ensembl chrNW_004955420:10,671,978...10,672,934
G
Tp53
tumor protein p53
ISO
protein:increased expression:tongue:
RGD
PMID:20385474
RGD:8547851
NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all