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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hodgkin's lymphoma
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Accession:DOID:8567 term browser browse the term
Definition:A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell. (DO)
Synonyms:exact_synonym: CHL;   HL;   Hodgkin disease;   Hodgkin lymphoma;   Hodgkin's Disease;   Hodgkin's sarcoma;   Hodgkins Disease;   Hodgkins Lymphoma;   LYMPHOMA, HODGKIN, CLASSIC;   Lymphocyte Depletion Hodgkin's Lymphoma;   Lymphocyte Rich Classical Hodgkin's Lymphoma;   Malignant Granuloma;   Malignant Granulomas;   adult Hodgkin lymphoma;   malignant lymphogranuloma;   malignant lymphogranulomas;   nodular lymphocyte predominant Hodgkin's lymphoma;   nodular sclerosing Hodgkin's lymphoma;   stage I subdiaphragmatic Hodgkin lymphoma;   stage II subdiaphragmatic Hodgkin lymphoma
 narrow_synonym: Splenic Hodgkin Lymphoma;   classical Hodgkin's lymphoma
 primary_id: MESH:D006689
 alt_id: OMIM:236000
 xref: EFO:0000183;   EFO:0000346;   EFO:1000548;   GARD:2714;   ICD10CM:C81;   ICD9CM:201;   NCI:C9357;   ORDO:98293
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Hodgkin's lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8656679 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd68 Cd68 molecule severity ISO associated with Epstein-Barr Virus Infections;protein:increased expression:tumor(human)
protein:increased expression:tumor (human)		 RGD PMID:21071500 PMID:23045593 RGD:40925944, RGD:40925946 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659339 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:17562247 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:28492532 PMID:32934698 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:25741868 PMID:32934698 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 disease_progression ISO RGD PMID:21916526 RGD:10450802 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11406608 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 disease_progression ISO RGD PMID:21916526 RGD:10450802 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7621881 PMID:8656679 PMID:7686390 RGD:11520780 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:21466366 RGD:11049168 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 treatment ISO DNA:SNPs: :multiple RGD PMID:19573080 PMID:21466366 RGD:11049165, RGD:11049168 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:12145210 RGD:1549449 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:12145210 RGD:1549449 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Klhdc8b kelch domain containing 8B susceptibility ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD		 PMID:19706467 NCBI chr 8:109,141,594...109,146,584
Ensembl chr 8:109,141,594...109,146,918 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:16361624 PMID:16618717 PMID:18316791 PMID:19114683 PMID:19679400 More... NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7545087 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:1104268 PMID:14559814 PMID:17483355 PMID:21970370 PMID:22703879 More... NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24688052 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:25741868 PMID:32934698 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkbia NFKB inhibitor alpha ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19223558 PMID:10340377 PMID:10556199 RGD:2298893, RGD:2298894 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pramex1 PRAME like, X-linked 1 severity ISO mRNA:increased expression:lymphoid tissue (human) RGD PMID:26044287 RGD:11060455 NCBI chr  X:98,567,994...98,574,654
Ensembl chr  X:98,569,415...98,572,096 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24531327 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Pvt1 Pvt1 oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Sdc1 syndecan 1 ISO protein:altered expression:tumor (human) RGD PMID:9746758 RGD:9743928 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8701986 PMID:10908157 PMID:12358914 PMID:12453859 More... NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8656679 PMID:8701986 PMID:8896393 PMID:9058727 More... NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18768784 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of cellular proliferation 7667
      Neoplasms by Histologic Type 5258
        lymphoma 575
          Hodgkin's lymphoma 31
            Hodgkin Disease, X-Linked Pseudoautosomal 0
            Hodgkin Disease, Y-Linked Pseudoautosomal 0
            Hodgkin's granuloma 0
            Hodgkin's lymphoma, lymphocytic depletion 0
            Hodgkin's lymphoma, lymphocytic-histiocytic predominance 0
            Hodgkin's lymphoma, mixed cellularity 0
            Hodgkin's lymphoma, nodular sclerosis 0
            Hodgkin's paragranuloma 0
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      Immune & Inflammatory Diseases 5566
        immune system disease 4773
          lymphatic system disease 1666
            lymphatic system cancer 663
              lymphoma 575
                Hodgkin's lymphoma 31
                  Hodgkin Disease, X-Linked Pseudoautosomal 0
                  Hodgkin Disease, Y-Linked Pseudoautosomal 0
                  Hodgkin's granuloma 0
                  Hodgkin's lymphoma, lymphocytic depletion 0
                  Hodgkin's lymphoma, lymphocytic-histiocytic predominance 0
                  Hodgkin's lymphoma, mixed cellularity 0
                  Hodgkin's lymphoma, nodular sclerosis 0
                  Hodgkin's paragranuloma 0
paths to the root