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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hodgkin's lymphoma
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Accession:DOID:8567 term browser browse the term
Definition:A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell. (DO)
Synonyms:exact_synonym: CHL;   HL;   Hodgkin disease;   Hodgkin lymphoma;   Hodgkin's Disease;   Hodgkin's sarcoma;   Hodgkins Disease;   Hodgkins Lymphoma;   LYMPHOMA, HODGKIN, CLASSIC;   Lymphocyte Depletion Hodgkin's Lymphoma;   Lymphocyte Rich Classical Hodgkin's Lymphoma;   Malignant Granuloma;   Malignant Granulomas;   adult Hodgkin lymphoma;   malignant lymphogranuloma;   malignant lymphogranulomas;   nodular lymphocyte predominant Hodgkin's lymphoma;   nodular sclerosing Hodgkin's lymphoma;   stage I subdiaphragmatic Hodgkin lymphoma;   stage II subdiaphragmatic Hodgkin lymphoma
 narrow_synonym: Splenic Hodgkin Lymphoma;   classical Hodgkin's lymphoma
 primary_id: MESH:D006689
 alt_id: OMIM:236000
 xref: EFO:0000183;   EFO:0000346;   EFO:1000548;   GARD:2714;   ICD10CM:C81;   ICD9CM:201;   NCI:C9357;   ORDO:98293
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
Hodgkin's lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093 		JBrowse link
G Cd40lg CD40 ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8656679 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746 		JBrowse link
G Cd68 CD68 molecule severity ISO associated with Epstein-Barr Virus Infections;protein:increased expression:tumor(human)
protein:increased expression:tumor (human)		 RGD PMID:21071500 PMID:23045593 RGD:40925944 RGD:40925946 NCBI chrNW_004955467:9,340,490...9,343,912
Ensembl chrNW_004955467:9,341,364...9,343,836 		JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659339 NCBI chrNW_004955403:415,092...442,214
Ensembl chrNW_004955403:412,632...434,741 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:17562247 NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:28492532 PMID:32934698 NCBI chrNW_004955514:1,030,244...1,038,590
Ensembl chrNW_004955514:1,025,600...1,038,590 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:25741868 PMID:32934698 NCBI chrNW_004955408:29,370,480...29,383,531
Ensembl chrNW_004955408:29,370,468...29,383,971 		JBrowse link
G Gata3 GATA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chrNW_004955421:24,448,446...24,477,885
Ensembl chrNW_004955421:24,457,496...24,478,744 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11406608 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:		 CTD
RGD		 PMID:7621881 PMID:7686390 PMID:8656679 RGD:11520780 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:21466366 RGD:11049168 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il6 interleukin 6 treatment ISO DNA:SNPs: :multiple RGD PMID:19573080 PMID:21466366 RGD:11049165 RGD:11049168 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:12145210 RGD:1549449 NCBI chrNW_004955464:1,107,598...1,110,326 JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:12145210 RGD:1549449 NCBI chrNW_004955415:31,876,508...31,878,289
Ensembl chrNW_004955415:31,876,793...31,877,836 		JBrowse link
G Klhdc8b kelch domain containing 8B susceptibility ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma OMIM
ClinVar		 PMID:19706467 NCBI chrNW_004955532:1,158,888...1,162,710
Ensembl chrNW_004955532:1,158,162...1,163,305 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:16361624 PMID:16618717 PMID:18316791 PMID:19114683 PMID:19679400 More... NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7545087 NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:1104268 PMID:14559814 PMID:17483355 PMID:21970370 PMID:22703879 More... NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24688052 NCBI chrNW_004955424:11,538,344...11,550,119
Ensembl chrNW_004955424:11,539,399...11,550,220 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO ClinVar Annotator: match by term: Classic Hodgkin lymphoma ClinVar PMID:25741868 PMID:32934698 NCBI chrNW_004955461:2,714,022...2,718,872
Ensembl chrNW_004955461:2,714,022...2,718,982 		JBrowse link
G Nfkbia NFKB inhibitor alpha ISO CTD Direct Evidence: marker/mechanism
DNA:deletion:C-terminally truncated protein		 CTD
RGD		 PMID:10340377 PMID:10556199 PMID:19223558 RGD:2298893 RGD:2298894 NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520 		JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator severity ISO mRNA:increased expression:lymphoid tissue (human) RGD PMID:26044287 RGD:11060455 NCBI chrNW_004955455:6,921,420...6,930,453
Ensembl chrNW_004955455:6,921,052...6,930,537 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24531327 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:21037568 NCBI chrNW_004955424:22,909,035...22,939,651
Ensembl chrNW_004955424:22,911,541...22,939,651 		JBrowse link
G Sdc1 syndecan 1 ISO protein:altered expression:tumor (human) RGD PMID:9746758 RGD:9743928 NCBI chrNW_004955469:2,762,696...2,773,697 JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8701986 PMID:10908157 PMID:12358914 PMID:12453859 More... NCBI chrNW_004955486:1,839,642...1,910,080 JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7621881 PMID:8656679 PMID:8701986 PMID:8896393 PMID:9058727 More... NCBI chrNW_004955419:12,763,343...12,790,044
Ensembl chrNW_004955419:12,762,748...12,788,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      Neoplasms by Histologic Type 4638
        lymphoma 495
          Hodgkin's lymphoma 27
            Hodgkin Disease, X-Linked Pseudoautosomal 0
            Hodgkin Disease, Y-Linked Pseudoautosomal 0
            Hodgkin's granuloma 0
            Hodgkin's lymphoma, lymphocytic depletion 0
            Hodgkin's lymphoma, lymphocytic-histiocytic predominance 0
            Hodgkin's lymphoma, mixed cellularity 0
            Hodgkin's lymphoma, nodular sclerosis 0
            Hodgkin's paragranuloma 0
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      Immune & Inflammatory Diseases 4634
        immune system disease 4032
          lymphatic system disease 1492
            lymphatic system cancer 582
              lymphoma 495
                Hodgkin's lymphoma 27
                  Hodgkin Disease, X-Linked Pseudoautosomal 0
                  Hodgkin Disease, Y-Linked Pseudoautosomal 0
                  Hodgkin's granuloma 0
                  Hodgkin's lymphoma, lymphocytic depletion 0
                  Hodgkin's lymphoma, lymphocytic-histiocytic predominance 0
                  Hodgkin's lymphoma, mixed cellularity 0
                  Hodgkin's lymphoma, nodular sclerosis 0
                  Hodgkin's paragranuloma 0
paths to the root