chronic fatigue syndrome - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	chronic fatigue syndrome	go back to main search page
Accession:	DOID:8544	browse the term
Definition:	A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. (DO)
Synonyms:	exact_synonym:	CFS; Chronic Fatigue Disorder; Chronic Fatigue Fibromyalgia Syndrome; Chronic Fatigue Syndromes; Chronic Fatigue-Fibromyalgia Syndromes; Infectious Mononucleosis Like Syndrome, Chronic; Myalgic Encephalomyelitis; Postviral Fatigue Syndrome; chronic fatigue and immune dysfunction syndrome; chronic fatigue disorders; myalgic encephalitis; postviral fatigue syndromes; royal free disease
	primary_id:	MESH:D015673
	xref:	EFO:0004540; GARD:7121; ICD10CM:G93.32; ICD10CM:R53.82; ICD9CM:780.71; NCI:C3037
For additional species annotation, visit the Alliance of Genome Resources.

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Genes (11)

chronic fatigue syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 24

protein:increased expression:plasma:

NCBI chr 6:7,166,165...7,179,606
Ensembl chr 6:7,166,479...7,180,051

G

CD28 molecule

NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854

G

C-X3-C motif chemokine ligand 1

protein:decreased expression:plasma:

NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095

G

DISC1 scaffold protein

susceptibility

DNA:SNP:Cds:p.S704C(human)

NCBI chr 4:7,524,336...7,825,143
Ensembl chr 4:7,524,397...7,822,558

G

interleukin 16

protein:decreased expression:plasma:

NCBI chr 3:56,473,485...56,575,504
Ensembl chr 3:56,473,486...56,575,104

G

perforin 1

NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864

G

renin

associated with Postural Orthostatic Tachycardia Syndrome; protein:increased activity:plasma (human)

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

G

serpin family F member 1

protein:increased expression:cerebrospinal fluid (human)

NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765

G

solute carrier family 6 member 4

severity

DNA:repeats, haplotype:promoter:
DNA:repeats:promoter:
protein:decreased expression:rostral anterior cingulate cortex (human)

PMID:14592408 PMID:15570154 PMID:26473596

RGD:11098915 RGD:36947383 RGD:38500210

NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736

G

transient receptor potential cation channel subfamily C member 6

DNA:SNPs: :

NCBI chr 5:29,897,378...30,007,885
Ensembl chr 5:29,897,210...30,007,723

G

vascular endothelial growth factor A

protein:decreased expression:plasma:

NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965

Term paths to the root

Path 1
Term	Annotations
disease	17773
syndrome	10064
chronic fatigue syndrome	11
Path 2
Term	Annotations
disease	17773
disease of anatomical entity	15145
nervous system disease	13207
peripheral nervous system disease	4038
neuropathy	3843
neuromuscular disease	3017
muscular disease	2130
chronic fatigue syndrome	11

paths to the root