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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:chronic fatigue syndrome
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Accession:DOID:8544 term browser browse the term
Definition:A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. (DO)
Synonyms:exact_synonym: CFS;   Chronic Fatigue Disorder;   Chronic Fatigue Fibromyalgia Syndrome;   Chronic Fatigue Syndromes;   Chronic Fatigue-Fibromyalgia Syndromes;   Infectious Mononucleosis Like Syndrome, Chronic;   Myalgic Encephalomyelitis;   Postviral Fatigue Syndrome;   chronic fatigue and immune dysfunction syndrome;   chronic fatigue disorders;   myalgic encephalitis;   postviral fatigue syndromes;   royal free disease
 primary_id: MESH:D015673
 xref: EFO:0004540;   GARD:7121;   ICD10CM:G93.32;   ICD10CM:R53.82;   ICD9CM:780.71;   NCI:C3037
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
chronic fatigue syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl24 C-C motif chemokine ligand 24 ISO protein:increased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
JBrowse link
G Cd28 Cd28 molecule ISO RGD PMID:18801465 RGD:5131614 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Disc1 DISC1 scaffold protein susceptibility ISO DNA:SNP:Cds:p.S704C(human) RGD PMID:20227423 RGD:5509831 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
JBrowse link
G Il16 interleukin 16 ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Prf1 perforin 1 ISO RGD PMID:21619669 RGD:6482801 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Ren renin ISO associated with Postural Orthostatic Tachycardia Syndrome; protein:increased activity:plasma (human) RGD PMID:21906029 RGD:6892702 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:polymorphism (human)
DNA:polymorphism: :HLA-DQA1*01 (human)
RGD PMID:16049290 PMID:16049290 RGD:5147827, RGD:5147827 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16321154 RGD:28867246 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Slc6a4 solute carrier family 6 member 4 severity ISO DNA:repeats:promoter:
protein:decreased expression:rostral anterior cingulate cortex (human)
DNA:repeats, haplotype:promoter:
RGD PMID:14592408 PMID:15570154 PMID:26473596 RGD:36947383, RGD:38500210, RGD:11098915 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 ISO DNA:SNPs: : RGD PMID:27834303 RGD:40886272 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21089
    syndrome 10784
      chronic fatigue syndrome 13
Path 2
Term Annotations click to browse term
  disease 21089
    disease of anatomical entity 18156
      nervous system disease 13996
        peripheral nervous system disease 4059
          neuropathy 3838
            neuromuscular disease 3023
              muscular disease 2110
                chronic fatigue syndrome 13
paths to the root