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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:chronic fatigue syndrome
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Accession:DOID:8544 term browser browse the term
Definition:A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. (DO)
Synonyms:exact_synonym: CFS;   Chronic Fatigue Disorder;   Chronic Fatigue Fibromyalgia Syndrome;   Chronic Fatigue Syndromes;   Chronic Fatigue-Fibromyalgia Syndromes;   Infectious Mononucleosis Like Syndrome, Chronic;   Myalgic Encephalomyelitis;   Postviral Fatigue Syndrome;   chronic fatigue and immune dysfunction syndrome;   chronic fatigue disorders;   myalgic encephalitis;   postviral fatigue syndromes;   royal free disease
 primary_id: MESH:D015673
 xref: GARD:7121;   ICD10CM:R53.82;   ICD9CM:780.71;   NCI:C3037
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
chronic fatigue syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl24 C-C motif chemokine ligand 24 ISO protein:increased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
JBrowse link
G Cd28 Cd28 molecule ISO RGD PMID:18801465 RGD:5131614 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Disc1 DISC1 scaffold protein susceptibility ISO DNA:SNP:Cds:p.S704C(human) RGD PMID:20227423 RGD:5509831 NCBI chr19:57,818,838...58,069,992
Ensembl chr19:57,820,260...58,066,152
JBrowse link
G Il16 interleukin 16 ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Prf1 perforin 1 ISO RGD PMID:21619669 RGD:6482801 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Ren renin ISO associated with Postural Orthostatic Tachycardia Syndrome; protein:increased activity:plasma (human) RGD PMID:21906029 RGD:6892702 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-Ba RT1 class II, locus Ba ISO DNA:polymorphism (human) RGD PMID:16049290 RGD:5147827 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16321154 RGD:28867246 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Slc6a4 solute carrier family 6 member 4 severity ISO DNA:repeats:promoter:
protein:decreased expression:rostral anterior cingulate cortex (human)
DNA:repeats, haplotype:promoter:
RGD PMID:14592408, PMID:15570154, PMID:26473596 RGD:36947383, RGD:38500210, RGD:11098915 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:decreased expression:plasma: RGD PMID:26615570 RGD:11538286 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16035
    syndrome 7010
      chronic fatigue syndrome 12
Path 2
Term Annotations click to browse term
  disease 16035
    disease of anatomical entity 15289
      nervous system disease 10903
        peripheral nervous system disease 2500
          neuropathy 2320
            neuromuscular disease 1805
              muscular disease 1223
                chronic fatigue syndrome 12
paths to the root