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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:gastroesophageal reflux disease
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Accession:DOID:8534 term browser browse the term
Definition:Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Synonyms:exact_synonym: Esophageal Reflux;   GASTROESOPHAGEAL REFLUX, PEDIATRIC;   GER;   GERD;   GERD - gastro-esophageal reflux disease;   Gastric Acid Reflux;   Gastric Acid Reflux Disease;   Gastro Esophageal Reflux;   acid reflux;   gastresophageal reflux;   gastro-oesophageal reflux;   gastroesophageal reflux
 primary_id: MESH:D005764
 alt_id: OMIM:109350
 xref: ICD10CM:K21;   ICD10CM:K21.9;   ICD9CM:530.81;   NCI:C26781
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
gastroesophageal reflux disease term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21552517 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 ISO protein:increased expression:esophagus (human) RGD PMID:17900656 RGD:11081162 NCBI chr12:24,157,182...24,161,870
Ensembl chr12:24,158,766...24,161,869
JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO RGD PMID:19672667 RGD:6482726 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21451212 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ryr1 ryanodine receptor 1 ISO ClinVar Annotator: match by term: Acid reflux ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20616304 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:decreased expression:sputum, macrophage RGD PMID:21426732 RGD:7240539 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tp63 tumor protein p63 ISS OMIM:109350 MouseDO NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Zfp469 zinc finger protein 469 ISO ClinVar Annotator: match by term: Acid reflux ClinVar PMID:25741868 NCBI chr19:54,843,864...55,083,935 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17129
    disease of anatomical entity 16476
      gastrointestinal system disease 6054
        esophageal disease 362
          dyskinesia of esophagus 21
            gastroesophageal reflux disease 9
              Esophageal Ulcer 0
              Laryngopharyngeal Reflux + 0
              Sandifer Syndrome 0
              hereditary sensory neuropathy type 1B 0
Path 2
Term Annotations click to browse term
  disease 17129
    disease of anatomical entity 16476
      nervous system disease 12074
        sensory system disease 5584
          Otorhinolaryngologic Diseases 1322
            Pharyngeal Diseases 173
              Deglutition Disorders 30
                dyskinesia of esophagus 21
                  gastroesophageal reflux disease 9
                    Esophageal Ulcer 0
                    Laryngopharyngeal Reflux + 0
                    Sandifer Syndrome 0
                    hereditary sensory neuropathy type 1B 0
paths to the root