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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:extrinsic allergic alveolitis
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Accession:DOID:841 term browser browse the term
Definition:An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss. (DO)
Synonyms:exact_synonym: extrinsic allergic alveolitides;   hypersensitivity pneumonitides;   hypersensitivity pneumonitis
 primary_id: MESH:D000542
 xref: GARD:12;   ICD10CM:J67.9;   ICD9CM:495;   NCI:C34369
For additional species annotation, visit the Alliance of Genome Resources.

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extrinsic allergic alveolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO protein:increased expression:plasma RGD PMID:19218674 RGD:4140920 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung, secretion (mouse)
mRNA:increased expression:lung:bronchoalveolar lavage cell (human)		 RGD PMID:16387809, PMID:10384061 RGD:4891434, RGD:4891436 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO RGD PMID:20027288 RGD:5130978 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO RGD PMID:19842835 RGD:4145620 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997 		JBrowse link
G Cd86 CD86 molecule ISO associated with Paramyxoviridae Infections; protein:increased expression:lung (mouse) RGD PMID:19282343 RGD:4892294 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO mRNA:increased expression:alveolar macrophage RGD PMID:14991597, PMID:15725351 RGD:5135448, RGD:5135490 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO RGD PMID:14991597 RGD:5135448 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO mRNA:increased expression:alveolar macrophage RGD PMID:14991597, PMID:15725351 RGD:5135448, RGD:5135490 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:14991597, PMID:19842835 RGD:5135448, RGD:4145620 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO mRNA:decreased expression:leukocyte RGD PMID:20514434 RGD:4892076 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Il13 interleukin 13 IMP
ISO		 mRNA:increased expression:lung RGD PMID:9916735, PMID:20861649 RGD:4145650, RGD:5128548 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il17a interleukin 17A ISO associated with Silicosis RGD PMID:20421647, PMID:19151189 RGD:4888525, RGD:4889106 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Il17ra interleukin 17 receptor A ISO RGD PMID:19414809 RGD:5144217 NCBI chr 4:152,995,865...153,018,394
Ensembl chr 4:152,995,865...153,018,394 		JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:10882225 RGD:4142832 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta disease_progression ISO
IMP		 protein:increased expression:serum (human) RGD PMID:19556641, PMID:1519663 RGD:4142842, RGD:7401229 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il5 interleukin 5 ISO protein:increased expression:lung,respiratory system fluid/secretion RGD PMID:19151189 RGD:4889106 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:lung RGD PMID:11789718 RGD:4891449 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Sftpa1 surfactant protein A1 ISO protein:decreased expression:lung RGD PMID:10543276 RGD:4143437 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10673208 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member susceptibility ISO DNA:polymorphisms:cds:P. D637G, P661P (human) RGD PMID:18342853 RGD:5147840 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669 		JBrowse link
G Tlr6 toll-like receptor 6 ISO RGD PMID:20070409 RGD:4889532 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446 		JBrowse link
G Tnc tenascin C ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:9780295 RGD:4889595 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:10882225, PMID:15653992 RGD:4142832, RGD:4143466 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:alveolar macrophage (human) RGD PMID:15929959 RGD:5131148 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:alveolar macrophage (human) RGD PMID:15929959 RGD:5131148 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:15764076 RGD:5684419 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
bird fancier's lung term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Muc1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:15881280 RGD:5131172 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874 		JBrowse link
farmer's lung term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12b interleukin 12B ISO RGD PMID:12084045 RGD:4145430 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased secretion:macrophage
DNA:polymorphism:promoter		 RGD PMID:8466130, PMID:11179110 RGD:4143375, RGD:4143374 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
sick building syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpla6 patatin-like phospholipase domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23418070 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16123
    disease of anatomical entity 15370
      respiratory system disease 2708
        respiratory allergy 372
          extrinsic allergic alveolitis 29
            Familial Hypersensitivity Pneumonitis 0
            Silo filler's disease 0
            bagassosis 0
            bird fancier's lung 1
            cork-handlers' disease 0
            farmer's lung 2
            malt worker's lung 0
            mushroom workers' lung 0
            sick building syndrome 1
            trichosporonosis 0
            ventilation pneumonitis 0
Path 2
Term Annotations click to browse term
  disease 16123
    disease of anatomical entity 15370
      Immune & Inflammatory Diseases 3585
        immune system disease 2954
          allergic disease 569
            Immediate Hypersensitivity 439
              respiratory allergy 372
                extrinsic allergic alveolitis 29
                  Familial Hypersensitivity Pneumonitis 0
                  Silo filler's disease 0
                  bagassosis 0
                  bird fancier's lung 1
                  cork-handlers' disease 0
                  farmer's lung 2
                  malt worker's lung 0
                  mushroom workers' lung 0
                  sick building syndrome 1
                  trichosporonosis 0
                  ventilation pneumonitis 0
paths to the root