RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: extrinsic allergic alveolitis
Accession: DOID:841
browse the term
Definition: An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss. (DO)
Synonyms: exact_synonym: extrinsic allergic alveolitides; hypersensitivity pneumonitides; hypersensitivity pneumonitis
primary_id: MESH:D000542
xref: GARD:12 ; ICD10CM:J67.9 ; ICD9CM:495 ; NCI:C34369
For additional species annotation, visit the
Alliance of Genome Resources .
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Ace
angiotensin I converting enzyme
ISO
protein:increased expression:plasma
RGD
PMID:19218674
RGD:4140920
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung, secretion (mouse) mRNA:increased expression:lung:bronchoalveolar lavage cell (human)
RGD
PMID:16387809 , PMID:10384061
RGD:4891434 , RGD:4891436
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Ccl7
C-C motif chemokine ligand 7
ISO
RGD
PMID:20027288
RGD:5130978
NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
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Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:19842835
RGD:4145620
NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
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Cd86
CD86 molecule
ISO
associated with Paramyxoviridae Infections; protein:increased expression:lung (mouse)
RGD
PMID:19282343
RGD:4892294
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
mRNA:increased expression:alveolar macrophage
RGD
PMID:14991597 , PMID:15725351
RGD:5135448 , RGD:5135490
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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Cxcl11
C-X-C motif chemokine ligand 11
ISO
RGD
PMID:14991597
RGD:5135448
NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
mRNA:increased expression:alveolar macrophage
RGD
PMID:14991597 , PMID:15725351
RGD:5135448 , RGD:5135490
NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:14991597 , PMID:19842835
RGD:5135448 , RGD:4145620
NCBI chr X:71,614,346...71,616,997
Ensembl chr X:71,614,346...71,616,997
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO
mRNA:decreased expression:leukocyte
RGD
PMID:20514434
RGD:4892076
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Il13
interleukin 13
IMP ISO
mRNA:increased expression:lung
RGD
PMID:9916735 , PMID:20861649
RGD:4145650 , RGD:5128548
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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Il17a
interleukin 17A
ISO
associated with Silicosis
RGD
PMID:20421647 , PMID:19151189
RGD:4888525 , RGD:4889106
NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
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Il17ra
interleukin 17 receptor A
ISO
RGD
PMID:19414809
RGD:5144217
NCBI chr 4:152,995,865...153,018,394
Ensembl chr 4:152,995,865...153,018,394
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Il1a
interleukin 1 alpha
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:10882225
RGD:4142832
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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Il1b
interleukin 1 beta
disease_progression
ISO IMP
protein:increased expression:serum (human)
RGD
PMID:19556641 , PMID:1519663
RGD:4142842 , RGD:7401229
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il5
interleukin 5
ISO
protein:increased expression:lung,respiratory system fluid/secretion
RGD
PMID:19151189
RGD:4889106
NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
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Nos2
nitric oxide synthase 2
ISO
protein:increased expression:lung
RGD
PMID:11789718
RGD:4891449
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Sftpa1
surfactant protein A1
ISO
protein:decreased expression:lung
RGD
PMID:10543276
RGD:4143437
NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10673208
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Tap1
transporter 1, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:polymorphisms:cds:P. D637G, P661P (human)
RGD
PMID:18342853
RGD:5147840
NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
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Tlr6
toll-like receptor 6
ISO
RGD
PMID:20070409
RGD:4889532
NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
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Tnc
tenascin C
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:9780295
RGD:4889595
NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
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Tnf
tumor necrosis factor
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:10882225 , PMID:15653992
RGD:4142832 , RGD:4143466
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
protein:increased expression:alveolar macrophage (human)
RGD
PMID:15929959
RGD:5131148
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
protein:increased expression:alveolar macrophage (human)
RGD
PMID:15929959
RGD:5131148
NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
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Vegfa
vascular endothelial growth factor A
ISO
RGD
PMID:15764076
RGD:5684419
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Muc1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:15881280
RGD:5131172
NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
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Il12b
interleukin 12B
ISO
RGD
PMID:12084045
RGD:4145430
NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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Tnf
tumor necrosis factor
ISO
protein:increased secretion:macrophage DNA:polymorphism:promoter
RGD
PMID:8466130 , PMID:11179110
RGD:4143375 , RGD:4143374
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Pnpla6
patatin-like phospholipase domain containing 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23418070
NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
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