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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:osteoarthritis
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Accession:DOID:8398 term browser browse the term
Definition:An arthritis that has_material_basis_in worn out cartilage located_in joint. (DO)
Synonyms:exact_synonym: DIPOA;   Degenerative Arthritis;   GOA1;   OA;   OADIP;   OSTEOARTHRITIS OF DISTAL INTERPHALANGEAL JOINTS;   OSTEOARTHRITIS OF KNEE/HIP;   OSTEOARTHRITIS, GENERALIZED, WITHOUT DYSPLASIA;   Osteoarthroses;   Osteoarthrosis;   degenerative arthritides;   degenerative joint disease;   hypertrophic arthritis;   osteoarthritides;   osteoarthrosis and allied disorder;   osteoarthrosis deformans
 narrow_synonym: HAND OSTEOARTHRITIS;   HOA HEBERDEN NODES;   osteoarthritis, toe
 related_synonym: OS1;   OS2;   OS3;   OS4;   OS5;   OS6;   osteoarthritis susceptibility 1;   osteoarthritis susceptibility 2;   osteoarthritis susceptibility 3;   osteoarthritis susceptibility 4;   osteoarthritis susceptibility 5;   osteoarthritis susceptibility 6
 primary_id: MESH:D010003
 alt_id: OMIM:140600;   OMIM:165720;   OMIM:607850;   OMIM:610839;   OMIM:612400;   OMIM:612401
 xref: EFO:0002506;   EFO:1000788;   ICD9CM:715.3;   MONDO:0005178;   NCI:C3293
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

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osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955402:34,857,317...34,885,169
Ensembl chrNW_004955402:34,857,317...34,885,169 		JBrowse link
G Acan aggrecan treatment ISO RGD PMID:21853458 PMID:22833446 RGD:11570535 RGD:11570544 NCBI chrNW_004955416:16,125,536...16,186,046 JBrowse link
G Aco1 aconitase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955472:3,141,473...3,170,959
Ensembl chrNW_004955472:3,141,257...3,170,959 		JBrowse link
G Actb actin beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955460:10,358,100...10,361,585
Ensembl chrNW_004955460:10,356,699...10,361,585 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955477:3,917,637...4,263,529
Ensembl chrNW_004955477:3,922,644...4,263,296 		JBrowse link
G Adam15 ADAM metallopeptidase domain 15 ISO RGD PMID:15818704 RGD:1559176 NCBI chrNW_004955545:1,545,532...1,555,826
Ensembl chrNW_004955545:1,545,635...1,555,614 		JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif 14 ISO DNA:missense mutation:cds: (rs4747096) (human) RGD PMID:18790654 RGD:6771189 NCBI chrNW_004955437:20,592,278...20,664,075
Ensembl chrNW_004955437:20,593,739...20,664,075 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 treatment ISO associated with Bone Diseases, Metabolic RGD PMID:22432033 RGD:10043110 NCBI chrNW_004955468:12,950,333...12,958,599
Ensembl chrNW_004955468:12,951,155...12,958,212 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 treatment
no_association
disease_progression		 ISO DNA:missense mutations:exon: (rs226794, rs2830585) (human)
DNA:missense mutation:exon:p.R614H (human)
protein:alternative form:synovium
mRNA:increased expression:cartilage
associated with Bone Diseases, Metabolic		 RGD PMID:11801682 PMID:17530714 PMID:18240210 PMID:22084394 PMID:22432033 More... RGD:10003165 RGD:10043101 RGD:10043102 RGD:10043103 RGD:10043105 RGD:10043106 RGD:10043107 RGD:10043110 RGD:2300093 NCBI chrNW_004955407:26,597,165...26,643,972
Ensembl chrNW_004955407:26,603,479...26,643,103 		JBrowse link
G Adgrg2 adhesion G protein-coupled receptor G2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004955586:359,573...477,277
Ensembl chrNW_004955586:359,567...479,325 		JBrowse link
G Ager advanced glycosylation end-product specific receptor treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16948116 PMID:23894457 RGD:8695985 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479 		JBrowse link
G Ak4 adenylate kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955423:25,395,086...25,402,324
Ensembl chrNW_004955423:25,395,836...25,427,474 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family member A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24728293 NCBI chrNW_004955450:16,406,578...16,453,048
Ensembl chrNW_004955450:16,406,436...16,453,180 		JBrowse link
G Aspn asporin no_association ISO DNA:repeats:exon: RGD
OMIM		 PMID:16542493 RGD:9684966 NCBI chrNW_004955515:5,322,074...5,345,715
Ensembl chrNW_004955515:5,321,943...5,345,894 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955555:869,508...892,510
Ensembl chrNW_004955555:869,325...893,542 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955403:43,860,811...43,886,398
Ensembl chrNW_004955403:43,860,728...43,886,732 		JBrowse link
G Atp7a ATPase copper transporting alpha ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:612400 MouseDO NCBI chrNW_004955557:1,355,471...1,515,725
Ensembl chrNW_004955557:1,355,397...1,515,393 		JBrowse link
G Bad BCL2 associated agonist of cell death ISO RGD PMID:19217321 RGD:10053643 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
G Bag6 BAG cochaperone 6 susceptibility ISO DNA:SNP: :rs3117582(human) RGD PMID:25231575 RGD:14390133 NCBI chrNW_004955437:176,848...188,243
Ensembl chrNW_004955437:176,797...188,003 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO protein:increased expression:chondrocyte RGD PMID:16864079 PMID:19217321 RGD:10053643 RGD:10054095 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO protein:increased expression:chondrocyte RGD PMID:16864079 PMID:19217321 RGD:10053643 RGD:10054095 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G Becn1 beclin 1 ISO protein:decreased expression:cartilage RGD PMID:20187128 RGD:6483317 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein disease_progression ISO RGD PMID:20157712 RGD:6483599 NCBI chrNW_004955545:2,381,091...2,382,114
Ensembl chrNW_004955545:2,381,156...2,381,978 		JBrowse link
G Bmp2 bone morphogenetic protein 2 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955415:17,048,374...17,058,172
Ensembl chrNW_004955415:17,048,030...17,060,181 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377 		JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955445:2,154,057...2,235,594
Ensembl chrNW_004955445:2,153,170...2,235,795 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29138829 RGD:13782343 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:29138829 RGD:13782343 NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738 		JBrowse link
G Cav1 caveolin 1 ISO RGD PMID:16508959 RGD:10043354 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO protein:increased expression:plasma: RGD PMID:19942450 RGD:10054497 NCBI chrNW_004955433:15,002,001...15,007,324
Ensembl chrNW_004955433:15,001,930...15,008,032 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 ISO protein:increased expression:synovial membrane: RGD PMID:19942450 RGD:10054497 NCBI chrNW_004955421:205,297...210,944
Ensembl chrNW_004955421:205,297...210,944 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313 		JBrowse link
G Cebpb CCAAT enhancer binding protein beta susceptibility ISO RGD PMID:22095691 RGD:10401214 NCBI chrNW_004955445:8,060,432...8,061,289 JBrowse link
G Chi3l1 chitinase 3 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955406:39,195,101...39,201,808
Ensembl chrNW_004955406:39,191,073...39,202,020 		JBrowse link
G Cilp cartilage intermediate layer protein disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955450:10,231,082...10,244,632
Ensembl chrNW_004955450:10,232,641...10,245,945 		JBrowse link
G Clec3b C-type lectin domain family 3 member B disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955420:26,665,472...26,669,474 JBrowse link
G Clic1 chloride intracellular channel 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955437:269,276...275,949
Ensembl chrNW_004955437:269,276...275,949 		JBrowse link
G Clic4 chloride intracellular channel 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955452:4,479,783...4,534,115
Ensembl chrNW_004955452:4,479,783...4,534,115 		JBrowse link
G Clu clusterin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 PMID:18784066 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955435:7,352,617...7,545,235
Ensembl chrNW_004955435:7,352,617...7,545,235 		JBrowse link
G Col1a1 collagen type I alpha 1 chain no_association ISO DNA:SNP:intron:IVS1 RGD PMID:10743824 RGD:5688331 NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073 		JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955432:11,127,961...11,164,145
Ensembl chrNW_004955432:11,128,112...11,163,302 		JBrowse link
G Col2a1 collagen type II alpha 1 chain onset
treatment		 ISO DNA:missense mutation:exon:p.R75C (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9061443 PMID:16189708 PMID:16755660 PMID:19216861 RGD:8657384 RGD:8661226 NCBI chrNW_004955500:6,860,771...6,885,466
Ensembl chrNW_004955500:6,860,771...6,885,473 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955407:42,575,677...42,600,967
Ensembl chrNW_004955407:42,575,170...42,600,495 		JBrowse link
G Col9a1 collagen type IX alpha 1 chain ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955488:5,296,895...5,384,940
Ensembl chrNW_004955488:5,296,895...5,384,940 		JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955422:13,576,315...13,584,267
Ensembl chrNW_004955422:13,576,202...13,584,298 		JBrowse link
G Ctsk cathepsin K ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955588:149,036...158,093
Ensembl chrNW_004955588:148,748...158,093 		JBrowse link
G Dapp1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955496:7,813,540...7,855,754
Ensembl chrNW_004955496:7,813,540...7,855,539 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 disease_progression ISO RGD PMID:24938620 RGD:150429973 NCBI chrNW_004955462:13,578,638...13,644,834
Ensembl chrNW_004955462:13,584,724...13,642,968 		JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955565:1,387,043...1,403,624
Ensembl chrNW_004955565:1,386,973...1,404,220 		JBrowse link
G Dpep1 dipeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955541:3,204,421...3,215,514
Ensembl chrNW_004955541:3,204,055...3,215,565 		JBrowse link
G Dpysl2 dihydropyrimidinase like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955403:49,188,259...49,306,916
Ensembl chrNW_004955403:49,188,205...49,307,810 		JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955418:26,391,309...26,680,553
Ensembl chrNW_004955418:26,391,299...26,680,553 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955495:4,800,103...4,807,714
Ensembl chrNW_004955495:4,799,922...4,807,252 		JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 ISO mRNA:increased expression:articular cartilage of joint (rat) RGD PMID:31396630 RGD:42722015 NCBI chrNW_004955422:19,463,090...19,470,605
Ensembl chrNW_004955422:19,463,987...19,470,605 		JBrowse link
G Egr1 early growth response 1 ISO mRNA, protein: decreased expression RGD PMID:10806043 RGD:1626498 NCBI chrNW_004955418:2,001,509...2,005,269
Ensembl chrNW_004955418:2,002,699...2,005,007 		JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955486:4,275,371...4,287,152
Ensembl chrNW_004955486:4,274,238...4,289,809 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955436:12,416,147...12,477,214
Ensembl chrNW_004955436:12,415,737...12,480,359 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO mRNA:increased expression:cartilage
protein:increased expression:layer of synovial tissue, stromal cell		 RGD PMID:12823854 PMID:20495569 PMID:21869830 RGD:10395364 RGD:10395365 RGD:10395366 NCBI chrNW_004955441:13,244,626...13,328,220
Ensembl chrNW_004955441:13,244,626...13,328,369 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO mRNA:decreased expression:knee, articular cartilage of joint RGD PMID:24964749 RGD:10045611 NCBI chrNW_004955555:2,393,510...2,430,180
Ensembl chrNW_004955555:2,393,278...2,406,582 		JBrowse link
G Erg ETS transcription factor ERG ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955407:37,372,471...37,613,674
Ensembl chrNW_004955407:37,369,641...37,542,751 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401 MouseDO NCBI chrNW_004955486:4,941,143...4,955,693
Ensembl chrNW_004955486:4,941,143...4,955,693 		JBrowse link
G Esd esterase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955431:524,491...551,871
Ensembl chrNW_004955431:525,795...547,922 		JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:SNPs:introns: (rs2234693, rs9340799) (human)
DNA:SNP:intron: (rs2234693) (human)		 RGD PMID:19884274 PMID:20417295 RGD:10045662 RGD:10045830 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Esr2 estrogen receptor 2 ISO DNA:SNP:intron: (rs1256031) (human) RGD PMID:19884274 RGD:10045830 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946 		JBrowse link
G Etfa electron transfer flavoprotein subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955450:1,392,526...1,451,591
Ensembl chrNW_004955450:1,392,479...1,451,591 		JBrowse link
G Ezr ezrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955439:3,701,722...3,740,345
Ensembl chrNW_004955439:3,703,013...3,740,345 		JBrowse link
G Fgf18 fibroblast growth factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955408:24,225,459...24,260,057
Ensembl chrNW_004955408:24,225,459...24,260,092 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:22393163 RGD:10402075 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO mRNA:increased expression:trabecular bone: RGD PMID:15781004 RGD:10402109 NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472 		JBrowse link
G Fn1 fibronectin 1 ISO protein:increased expression:cartilage: RGD PMID:8646429 RGD:10402156 NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975 		JBrowse link
G Frzb frizzled related protein susceptibility ISO ClinVar Annotator: match by term: Osteoarthritis OMIM
ClinVar		 PMID:15210948 PMID:25741868 NCBI chrNW_004955403:14,598,765...14,627,997
Ensembl chrNW_004955403:14,598,765...14,631,154 		JBrowse link
G Ftl ferritin light chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955559:1,691,722...1,693,381 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955413:4,162,467...4,166,783
Ensembl chrNW_004955413:4,162,467...4,166,783 		JBrowse link
G Gdf5 growth differentiation factor 5 ISO OMIM NCBI chrNW_004955422:25,992,081...25,997,122
Ensembl chrNW_004955422:25,992,081...25,997,122 		JBrowse link
G Ghr growth hormone receptor ISO DNA:deletion:exon: RGD PMID:23740230 RGD:10003113 NCBI chrNW_004955426:26,553,509...26,873,619
Ensembl chrNW_004955426:26,689,581...26,871,684 		JBrowse link
G Gls glutaminase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955403:8,195,241...8,261,402
Ensembl chrNW_004955403:8,195,255...8,261,402 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955494:383,107...387,483
Ensembl chrNW_004955494:383,341...387,630 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955469:8,183,945...8,233,869
Ensembl chrNW_004955469:8,183,945...8,233,869 		JBrowse link
G Hbp1 HMG-box transcription factor 1 ISO RGD PMID:22586168 RGD:10402054 NCBI chrNW_004955410:11,626,743...11,652,343
Ensembl chrNW_004955410:11,626,743...11,652,343 		JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30651232 RGD:14746965 NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143 		JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955403:8,752,339...8,796,693
Ensembl chrNW_004955403:8,752,309...8,792,927 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:layer of synovial tissue, stromal cell RGD PMID:12823854 PMID:18789153 RGD:10395366 RGD:10402406 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:22330250 RGD:10401949 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955416:15,197,611...15,212,919
Ensembl chrNW_004955416:15,197,366...15,223,363 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955450:685,905...703,593
Ensembl chrNW_004955450:685,905...703,586 		JBrowse link
G Igf1 insulin like growth factor 1 ISO protein:decreased expression:blood: RGD PMID:2290165 RGD:10045857 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Igf1r insulin like growth factor 1 receptor severity ISO mRNA:increased expression:articular cartilage of joint: RGD PMID:8609369 RGD:10045889 NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666 		JBrowse link
G Igf2 insulin like growth factor 2 ISO mRNA:increased expression:cartilage RGD PMID:22527881 RGD:10402552 NCBI chrNW_004955422:13,880,525...13,907,963
Ensembl chrNW_004955422:13,880,471...13,888,566 		JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:18775662 RGD:10402575 NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845 		JBrowse link
G Ihh Indian hedgehog signaling molecule ISO protein:increased expression:cartilage RGD PMID:24786088 RGD:12910979 NCBI chrNW_004955453:14,376,665...14,382,536
Ensembl chrNW_004955453:14,376,718...14,381,747 		JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:chonodrocyte: RGD PMID:9497936 RGD:10047053 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466 		JBrowse link
G Il1b interleukin 1 beta treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:21954917 PMID:22890185 RGD:7207218 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il4r interleukin 4 receptor ISO protein:increased expression:serum RGD PMID:16647277 RGD:10402785 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Il5 interleukin 5 ISO RGD PMID:22035391 RGD:5687147 NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358 		JBrowse link
G Immt inner membrane mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955424:1,438,158...1,476,552
Ensembl chrNW_004955424:1,438,158...1,476,552 		JBrowse link
G Ins insulin ISO protein:increased expression:blood: RGD PMID:2290165 RGD:10045857 NCBI chrNW_004955422:13,909,408...13,910,419
Ensembl chrNW_004955422:13,909,407...13,910,419 		JBrowse link
G Isoc2 isochorismatase domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955567:829,799...835,322
Ensembl chrNW_004955567:829,300...835,505 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO RGD PMID:18354251 RGD:6482239 NCBI chrNW_004955415:20,490,414...20,526,068
Ensembl chrNW_004955415:20,490,414...20,527,917 		JBrowse link
G Lep leptin severity ISO protein:increased expression:tibia, cartilage, chondrocyte (human) RGD PMID:14613274 RGD:10053634 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472 		JBrowse link
G Lgals3 galectin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34894372 NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438 		JBrowse link
G LOC102021597 alpha-1-antiproteinase S-like ISO RGD PMID:20434574 RGD:2324964 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11790802 PMID:12379497 NCBI chrNW_004955422:19,714,161...19,730,344
Ensembl chrNW_004955422:19,714,627...19,729,855 		JBrowse link
G Matn3 matrilin 3 susceptibility ISO ClinVar Annotator: match by term: Osteoarthritis susceptibility 2 ClinVar
OMIM		 PMID:12736871 PMID:14729835 PMID:25741868 PMID:28492532 NCBI chrNW_004955469:2,548,443...2,568,497
Ensembl chrNW_004955469:2,548,443...2,568,497 		JBrowse link
G Mmp13 matrix metallopeptidase 13 treatment ISO mRNA, protein:increased expression:cartilage RGD PMID:11134178 PMID:16128596 PMID:17530714 PMID:22890185 PMID:23982761 RGD:10043101 RGD:10043117 RGD:2300093 RGD:7207089 RGD:7207218 NCBI chrNW_004955412:6,106,994...6,118,760
Ensembl chrNW_004955412:6,106,994...6,118,760 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:synovial fluid (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775 		JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004955412:5,928,997...5,939,012
Ensembl chrNW_004955412:5,928,997...5,939,012 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:synovial fluid, serum (human) RGD PMID:15194590 RGD:7207131 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Msn moesin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955475:5,301,856...5,370,378
Ensembl chrNW_004955475:5,301,910...5,370,691 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:22084394 PMID:24651621 RGD:10003163 RGD:10003165 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Mvp major vault protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955493:7,113,194...7,141,944
Ensembl chrNW_004955493:7,113,319...7,143,582 		JBrowse link
G Myh13 myosin heavy chain 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955467:6,816,393...6,872,754
Ensembl chrNW_004955467:6,816,393...6,872,754 		JBrowse link
G Myl3 myosin light chain 3 ISO MouseDO NCBI chrNW_004955420:25,308,513...25,311,959
Ensembl chrNW_004955420:25,305,759...25,312,271 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D ISO protein:increased expression:spinal cord RGD PMID:20722027 RGD:10412653 NCBI chrNW_004955410:8,217,684...8,233,302
Ensembl chrNW_004955410:8,220,400...8,247,486 		JBrowse link
G Ncor2 nuclear receptor corepressor 2 susceptibility ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955482:4,927,482...5,031,848
Ensembl chrNW_004955482:4,942,221...5,031,904 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955422:17,781,374...17,785,395
Ensembl chrNW_004955422:17,781,204...17,784,404 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955422:17,876,496...17,881,773
Ensembl chrNW_004955422:17,873,872...17,881,773 		JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 treatment ISO RGD PMID:34738623 RGD:329328930 NCBI chrNW_004955402:62,558,392...62,674,347
Ensembl chrNW_004955402:62,558,286...62,674,457 		JBrowse link
G Ngf nerve growth factor treatment ISO RGD PMID:25677108 PMID:33806315 RGD:402463969 RGD:402463970 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081 		JBrowse link
G P3h3 prolyl 3-hydroxylase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955413:4,429,558...4,440,602
Ensembl chrNW_004955413:4,429,633...4,440,256 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955421:1,034,843...1,109,637
Ensembl chrNW_004955421:1,034,843...1,110,438 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955586:98,492...114,927
Ensembl chrNW_004955586:97,172...114,928 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO mRNA:increased expression:tibia (rat) RGD PMID:21864409 RGD:6771362 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO mRNA:increased expression:cartilage tissue (human) RGD PMID:31472145 RGD:152177908 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Plcd1 phospholipase C delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955421:4,856,366...4,880,309
Ensembl chrNW_004955421:4,856,366...4,880,309 		JBrowse link
G Plod2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955474:11,392,163...11,473,918
Ensembl chrNW_004955474:11,392,163...11,475,508 		JBrowse link
G Pls3 plastin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955490:125,913...221,152
Ensembl chrNW_004955490:122,328...221,388 		JBrowse link
G Pomc proopiomelanocortin ISO RGD PMID:21378032 RGD:5508809 NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit Aalpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955558:381,794...410,485
Ensembl chrNW_004955558:381,794...410,485 		JBrowse link
G Psmb1 proteasome 20S subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955411:3,285,610...3,304,210
Ensembl chrNW_004955411:3,286,835...3,304,931 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 susceptibility ISO DNA:SNP (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:15334463 PMID:32004530 RGD:1625347 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
G Ran RAN, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955482:1,222,944...1,223,891
Ensembl chrNW_004955482:1,220,876...1,224,395 		JBrowse link
G Rcn3 reticulocalbin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955559:1,309,621...1,319,925
Ensembl chrNW_004955559:1,309,621...1,319,925 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20008919 NCBI chrNW_004955437:10,598,145...10,885,858
Ensembl chrNW_004955437:10,598,145...10,800,560 		JBrowse link
G S100a4 S100 calcium binding protein A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16948116 NCBI chrNW_004955545:192,236...194,468
Ensembl chrNW_004955545:192,116...195,394 		JBrowse link
G Scrn1 secernin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955410:31,231,418...31,299,772
Ensembl chrNW_004955410:31,231,119...31,298,152 		JBrowse link
G Sdcbp syndecan binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955454:17,093,930...17,113,491
Ensembl chrNW_004955454:17,089,232...17,113,484 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955504:36,939...66,507
Ensembl chrNW_004955504:36,911...70,494 		JBrowse link
G Sec23a SEC23 homolog A, COPII coat complex component ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955409:22,192,549...22,243,090
Ensembl chrNW_004955409:22,189,181...22,247,467 		JBrowse link
G Sgcg sarcoglycan gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004955497:3,592,041...3,702,780
Ensembl chrNW_004955497:3,615,003...3,701,300 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18973239 NCBI chrNW_004955537:2,408,042...2,438,788
Ensembl chrNW_004955537:2,408,042...2,439,511 		JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism
OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:610839 | OMIM:612400 | OMIM:612401		 CTD
MouseDO		 PMID:21217753 PMID:22772368 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 PMID:18784066 PMID:22108257 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Tent5a terminal nucleotidyltransferase 5A susceptibility ISO DNA:repeats: : RGD PMID:25231575 RGD:14390133 NCBI chrNW_004955411:9,695,149...9,701,463
Ensembl chrNW_004955411:9,699,011...9,701,507 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15292528 NCBI chrNW_004955432:10,635,626...10,641,345
Ensembl chrNW_004955432:10,631,843...10,641,538 		JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO OMIM:140600 | OMIM:165720 | OMIM:607850 | OMIM:612400 MouseDO NCBI chrNW_004955419:26,490,899...26,546,349
Ensembl chrNW_004955419:26,490,899...26,547,017 		JBrowse link
G Tgm2 transglutaminase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955445:18,544,192...18,576,576
Ensembl chrNW_004955445:18,544,183...18,576,570 		JBrowse link
G Tlr8 toll like receptor 8 ISO ClinVar Annotator: match by term: Osteoarthritis ClinVar NCBI chrNW_004955544:302,027...317,110
Ensembl chrNW_004955544:303,319...306,426 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b disease_progression ISO RGD PMID:15334463 RGD:1625347 NCBI chrNW_004955417:24,804,708...24,831,338
Ensembl chrNW_004955417:24,804,664...24,831,894 		JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO RGD PMID:14872496 RGD:2290500 NCBI chrNW_004955420:2,550,392...2,566,448
Ensembl chrNW_004955420:2,549,142...2,566,564 		JBrowse link
G Tnfsf15 TNF superfamily member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955419:12,863,617...12,884,498
Ensembl chrNW_004955419:12,863,615...12,879,517 		JBrowse link
G Trap1 TNF receptor associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955442:13,697,471...13,733,161
Ensembl chrNW_004955442:13,696,810...13,733,161 		JBrowse link
G Trim2 tripartite motif containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17568789 NCBI chrNW_004955471:7,523,895...7,698,436
Ensembl chrNW_004955471:7,594,966...7,698,436 		JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21964574 NCBI chrNW_004955455:8,744,865...8,781,644
Ensembl chrNW_004955455:8,744,176...8,783,741 		JBrowse link
G Txnrd1 thioredoxin reductase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955405:38,863,762...38,928,615
Ensembl chrNW_004955405:38,903,918...38,927,410 		JBrowse link
G Vdac2 voltage dependent anion channel 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955437:16,857,715...16,871,717
Ensembl chrNW_004955437:16,853,433...16,872,345 		JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16876394 PMID:18784066 NCBI chrNW_004955429:10,708,852...10,716,743
Ensembl chrNW_004955429:10,707,719...10,717,554 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18784066 NCBI chrNW_004955487:5,229,485...5,263,749
Ensembl chrNW_004955487:5,230,506...5,263,752 		JBrowse link
Beukes hip dysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfap96 cilia and flagella associated protein 96 ISO ClinVar Annotator: match by term: Hip dysplasia, Beukes type | ClinVar Annotator: match by term: Osteoarthropathy, premature degenerative, of hip ClinVar PMID:25741868 PMID:25741905 PMID:28492532 PMID:33473208 NCBI chrNW_004955403:23,617,764...23,634,689
Ensembl chrNW_004955403:23,619,399...23,634,731 		JBrowse link
G Ufsp2 UFM1 specific peptidase 2 ISO ClinVar Annotator: match by term: Hip dysplasia, Beukes type | ClinVar Annotator: match by term: Osteoarthropathy, premature degenerative, of hip OMIM
ClinVar		 PMID:2389793 PMID:21228277 PMID:25741868 PMID:25741905 PMID:26428751 More... NCBI chrNW_004955403:23,634,967...23,655,429
Ensembl chrNW_004955403:23,634,924...23,655,429 		JBrowse link
Digital Arthropathy-Brachydactyly, Familial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO ClinVar Annotator: match by term: Familial digital arthropathy-brachydactyly OMIM
ClinVar		 PMID:4056805 PMID:8179305 PMID:11891693 PMID:20037586 PMID:20037587 More... NCBI chrNW_004955455:8,744,865...8,781,644
Ensembl chrNW_004955455:8,744,176...8,783,741 		JBrowse link
Hand Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 no_association ISO DNA:SNPs:exons: (rs2077647, rs1801132) (human) RGD PMID:19884274 RGD:10045830 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Esr2 estrogen receptor 2 no_association ISO DNA:SNPs:introns: (rs1256034, rs1256059, rs944460) (human) RGD PMID:19884274 RGD:10045830 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946 		JBrowse link
G Il4 interleukin 4 no_association ISO DNA:SNPs:promoter, 5' utr, intron:multiple RGD PMID:20219689 RGD:10402786 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il4r interleukin 4 receptor no_association ISO DNA:SNPs:promoter, exons:multiple RGD PMID:20219689 RGD:10402786 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
Knee Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 disease_progression ISO protein:increased expression:chondrocyte: RGD PMID:10903884 RGD:10053727 NCBI chrNW_004955450:14,545,586...14,574,161
Ensembl chrNW_004955450:14,512,381...14,574,696 		JBrowse link
G Anxa5 annexin A5 disease_progression ISO protein:increased expression:chondrocyte: RGD PMID:10903884 RGD:10053727 NCBI chrNW_004955428:18,873,782...18,907,955
Ensembl chrNW_004955428:18,873,782...18,907,955 		JBrowse link
G Ar androgen receptor ISO DNA:repeat:exon:c.172(CAG)8-34 (human) RGD PMID:16098017 RGD:10043199 NCBI chrNW_004955475:7,013,960...7,192,473
Ensembl chrNW_004955475:7,013,960...7,186,069 		JBrowse link
G Aspn asporin severity ISO DNA:repeats:exon:
mRNA:increased expression:cartilage:		 RGD PMID:15640800 RGD:9684965 NCBI chrNW_004955515:5,322,074...5,345,715
Ensembl chrNW_004955515:5,321,943...5,345,894 		JBrowse link
G B2m beta-2-microglobulin ISO protein:increased expression:serum RGD PMID:18795399 RGD:6482710 NCBI chrNW_004955416:11,205,503...11,211,325
Ensembl chrNW_004955416:11,204,849...11,215,568 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:20131282 RGD:6907382 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:20131282 RGD:6907382 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO RGD PMID:21387139 PMID:22294259 RGD:6483563 RGD:6483595 NCBI chrNW_004955545:2,381,091...2,382,114
Ensembl chrNW_004955545:2,381,156...2,381,978 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA,protein:increased expression:dorsal root ganglion: RGD PMID:23185004 RGD:8661785 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Cd36 CD36 molecule (CD36 blood group) disease_progression ISO RGD PMID:19342682 PMID:21765106 RGD:6893494 RGD:6893565 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313 		JBrowse link
G Ctnnb1 catenin beta 1 ISO protein:increased expression:cartilage: RGD PMID:22702043 RGD:10395278 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 ameliorates ISO RGD PMID:31258642 RGD:150519887 NCBI chrNW_004955462:13,578,638...13,644,834
Ensembl chrNW_004955462:13,584,724...13,642,968 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 severity ISO mRNA,protein:increased expression:fat pad: RGD PMID:21765106 RGD:6893494 NCBI chrNW_004955414:16,059,781...16,089,727
Ensembl chrNW_004955414:16,059,781...16,089,727 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO RGD PMID:20131282 RGD:6907382 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:25435813 RGD:13506963 NCBI chrNW_004955493:8,661,317...8,663,190 JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 ISO protein:increased expression:serum: RGD PMID:22275171 RGD:10401792 NCBI chrNW_004955424:27,181,717...27,240,067
Ensembl chrNW_004955424:27,181,099...27,240,446 		JBrowse link
G Epas1 endothelial PAS domain protein 1 no_association ISO DNA:SNP:5' utr: (rs17039192) (human) RGD PMID:20495570 PMID:22247019 RGD:10395367 RGD:10395368 NCBI chrNW_004955441:13,244,626...13,328,220
Ensembl chrNW_004955441:13,244,626...13,328,369 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:25422652 RGD:10400892 NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355 		JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:repeat:promoter:-1174(TA)9-25 (human)
DNA:SNP:cds:c.1782G>A (rs2228480) (human)
DNA:SNPs:intron: (rs2234693, rs9340799) (human)
DNA:polymorphisms, haplotype:intron, exon		 RGD PMID:15380041 PMID:16098017 PMID:20128071 PMID:24772413 RGD:10043199 RGD:10045829 RGD:10045835 RGD:10045840 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Esr2 estrogen receptor 2 ISO DNA:repeat:intron:c.1092+3607(CA)13-27 (human) RGD PMID:16098017 RGD:10043199 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:21041276 RGD:5147774 NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 treatment ISO RGD PMID:27159076 RGD:11568056 NCBI chrNW_004955514:1,030,244...1,038,590
Ensembl chrNW_004955514:1,025,600...1,038,590 		JBrowse link
G Gdf5 growth differentiation factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955422:25,992,081...25,997,122
Ensembl chrNW_004955422:25,992,081...25,997,122 		JBrowse link
G Gsr glutathione-disulfide reductase ISO protein:increased expression:synovial fluid RGD PMID:16289733 RGD:10401830 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583 		JBrowse link
G Hmgb1 high mobility group box 1 severity ISO mRNA:decreased expression:articular cartilage
protein:increased expression:synovial fluid		 RGD PMID:19139395 PMID:21968272 RGD:10402061 RGD:10402184 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339 		JBrowse link
G Hmgb2 high mobility group box 2 severity ISO mRNA:decreased expression:articular cartilage RGD PMID:19139395 RGD:10402184 NCBI chrNW_004955403:33,656,314...33,659,115
Ensembl chrNW_004955403:33,656,300...33,659,428 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO mRNA:increased expression:tibial plateaux (mouse)
mRNA:decreased expression:blood (human)		 RGD PMID:9497939 PMID:16139532 RGD:10412655 RGD:10429075 NCBI chrNW_004955538:1,469,544...1,475,010
Ensembl chrNW_004955538:1,469,544...1,475,019 		JBrowse link
G Igf1 insulin like growth factor 1 severity
disease_progression		 ISO protein:decreased expression:plasma (rat)
mRNA:increased expression:meniscus:		 RGD PMID:8461919 PMID:9497937 PMID:17133593 PMID:20633672 RGD:10003130 RGD:10045862 RGD:10045868 RGD:10046057 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO RGD PMID:8948288 RGD:10045874 NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666 		JBrowse link
G Il1a interleukin 1 alpha ISO protein:increased expression:cartilage cell: RGD PMID:9034998 PMID:9497937 PMID:24534736 RGD:10045944 RGD:10045946 RGD:10046057 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466 		JBrowse link
G Il2 interleukin 2 severity ISO protein:increased expression:synovial fluid: RGD PMID:22035391 RGD:5687147 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il4 interleukin 4 susceptibility ISO DNA:repeat:intron: (rs8179190) (human) RGD PMID:18182309 PMID:24406619 RGD:10402787 RGD:2317291 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Kl klotho susceptibility ISO DNA:SNPs:promoter,exon:395G>A,2998C>T(human) RGD PMID:18465812 RGD:10403041 NCBI chrNW_004955431:12,782,913...12,833,215
Ensembl chrNW_004955431:12,782,846...12,833,215 		JBrowse link
G Lep leptin ISO protein:decreased expression:serum: RGD PMID:23575542 RGD:10411887 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472 		JBrowse link
G Lepr leptin receptor susceptibility ISO DNA:SNP:CDS:668A>G (human)
protein:increased expression:serum		 RGD PMID:23575542 RGD:10411887 NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407 		JBrowse link
G LOC102023780 aromatase ISO DNA:SNP:intron, 5' utr: (rs1062033) (human) RGD PMID:20417295 RGD:10045662 NCBI chrNW_004955409:3,198,622...3,313,072
Ensembl chrNW_004955409:3,266,233...3,313,142 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 susceptibility ISO DNA:snp:promoter:g.-2820G>A (rs10980705) (human) RGD PMID:18325907 RGD:10054291 NCBI chrNW_004955419:16,190,109...16,324,702
Ensembl chrNW_004955419:16,191,244...16,325,602 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955441:1,405,340...1,626,668
Ensembl chrNW_004955441:1,232,041...1,627,470 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ameliorates ISO RGD PMID:31258642 RGD:150519887 NCBI chrNW_004955412:6,106,994...6,118,760
Ensembl chrNW_004955412:6,106,994...6,118,760 		JBrowse link
G Penk proenkephalin treatment ISO RGD PMID:21928671 RGD:10003115 NCBI chrNW_004955454:15,425,712...15,426,685
Ensembl chrNW_004955454:15,426,017...15,426,685 		JBrowse link
G Ptges prostaglandin E synthase ISO RGD PMID:17530714 RGD:2300093 NCBI chrNW_004955445:10,053,745...10,056,981 JBrowse link
G Sbno1 strawberry notch homolog 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955482:5,519,165...5,571,416
Ensembl chrNW_004955482:5,528,652...5,576,234 		JBrowse link
G Slc26a2 solute carrier family 26 member 2 susceptibility ISO DNA:deletion:promoter:-716_-713del4A(human) RGD PMID:11558903 RGD:13208866 NCBI chrNW_004955415:4,540,302...4,556,360
Ensembl chrNW_004955415:4,540,302...4,556,360 		JBrowse link
G Tgfa transforming growth factor alpha ISO protein:increased expression:cartilage
mRNA:increased expression:cartilage		 RGD PMID:17968906 RGD:2317486 NCBI chrNW_004955424:14,616,390...14,709,723
Ensembl chrNW_004955424:14,616,259...14,710,183 		JBrowse link
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955484:6,853,820...6,967,261
Ensembl chrNW_004955484:6,851,307...6,967,261 		JBrowse link
Osteoarthritis with Mild Chondrodysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain ISO ClinVar Annotator: match by term: Namaqualand hip dysplasia | ClinVar Annotator: match by term: Osteoarthritis with mild chondrodysplasia OMIM
ClinVar		 PMID:1905723 PMID:1975693 PMID:1985108 PMID:7695699 PMID:7757086 More... NCBI chrNW_004955500:6,860,771...6,885,466
Ensembl chrNW_004955500:6,860,771...6,885,473 		JBrowse link
Osteoarthritis, Experimental term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19404941 RGD:9068434 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp6 caspase 6 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004955496:575,839...584,287
Ensembl chrNW_004955496:577,832...584,287 		JBrowse link
G Casp7 caspase 7 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:29621761 RGD:13782275 NCBI chrNW_004955403:322,082...348,591
Ensembl chrNW_004955403:322,555...347,053 		JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment ISO RGD PMID:25128628 RGD:11041187 NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 treatment ISO RGD PMID:25975052 RGD:150429975 NCBI chrNW_004955462:13,578,638...13,644,834
Ensembl chrNW_004955462:13,584,724...13,642,968 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:22833219 RGD:10402072 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO RGD PMID:23041435 RGD:10402106 NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO mRNA:decreased expression:knee RGD PMID:24754147 RGD:10412054 NCBI chrNW_004955514:2,195,228...2,208,258
Ensembl chrNW_004955514:2,195,228...2,208,688 		JBrowse link
G Map1lc3a microtubule associated protein 1 light chain 3 alpha treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chrNW_004955422:26,774,466...26,776,024
Ensembl chrNW_004955422:26,774,922...26,775,884 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO RGD PMID:29364174 RGD:13800565 NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO protein:decreased expression:skeletal joint RGD PMID:31742919 RGD:40924673 NCBI chrNW_004955412:14,630,109...14,923,847
Ensembl chrNW_004955412:14,630,443...14,923,926 		JBrowse link
G Serpinf1 serpin family F member 1 severity ISO RGD PMID:28122611 RGD:27226703 NCBI chrNW_004955481:1,414,930...1,426,436
Ensembl chrNW_004955481:1,414,930...1,426,241 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 treatment ISO RGD PMID:23589102 RGD:11561955 NCBI chrNW_004955482:760,200...777,133
Ensembl chrNW_004955482:761,811...777,133 		JBrowse link
Osteoarthritis, Hip term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO mRNA:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chrNW_004955407:26,597,165...26,643,972
Ensembl chrNW_004955407:26,603,479...26,643,103 		JBrowse link
G Aspn asporin ISO DNA:repeats:exon: RGD PMID:15640800 RGD:9684965 NCBI chrNW_004955515:5,322,074...5,345,715
Ensembl chrNW_004955515:5,321,943...5,345,894 		JBrowse link
G Astn2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955419:10,486,200...11,387,553
Ensembl chrNW_004955419:10,486,118...11,390,085 		JBrowse link
G Chadl chondroadherin like ISO CTD Direct Evidence: marker/mechanism CTD PMID:28319091 PMID:30374069 NCBI chrNW_004955413:26,846,714...26,862,082
Ensembl chrNW_004955413:26,851,420...26,862,081 		JBrowse link
G Col10a1 collagen type X alpha 1 chain ISO mRNA, protein:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chrNW_004955526:641,577...679,295 JBrowse link
G Col11a1 collagen type XI alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955435:7,352,617...7,545,235
Ensembl chrNW_004955435:7,352,617...7,545,235 		JBrowse link
G Col1a1 collagen type I alpha 1 chain susceptibility
no_association		 ISO DNA:SNP:intron:g.2046G>T (human) RGD PMID:9811048 PMID:15880349 PMID:17187661 RGD:5688305 RGD:5688306 RGD:5688330 NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955478:10,380,185...10,390,838
Ensembl chrNW_004955478:10,379,287...10,404,825 		JBrowse link
G Diablo diablo IAP-binding mitochondrial protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955482:6,354,502...6,364,424
Ensembl chrNW_004955482:6,354,146...6,365,344 		JBrowse link
G Esr1 estrogen receptor 1 ISO DNA:SNP:intron:g.-397T>C (human) RGD PMID:17419075 RGD:10045661 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Filip1 filamin A interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955502:3,806,016...3,976,013
Ensembl chrNW_004955502:3,823,872...3,903,481 		JBrowse link
G Gdf5 growth differentiation factor 5 ISO ClinVar Annotator: match by term: Osteoarthritis, hip ClinVar PMID:17384641 PMID:28492532 NCBI chrNW_004955422:25,992,081...25,997,122
Ensembl chrNW_004955422:25,992,081...25,997,122 		JBrowse link
G Ghr growth hormone receptor ISO associated with Acromegaly;DNA:deletion:exon: RGD PMID:19864451 RGD:10003142 NCBI chrNW_004955426:26,553,509...26,873,619
Ensembl chrNW_004955426:26,689,581...26,871,684 		JBrowse link
G Hdac9 histone deacetylase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955410:21,046,312...21,932,029
Ensembl chrNW_004955410:21,245,562...21,932,023 		JBrowse link
G Hfe homeostatic iron regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 PMID:30664745 NCBI chrNW_004955567:868,272...883,563
Ensembl chrNW_004955567:871,489...883,563 		JBrowse link
G Il4r interleukin 4 receptor no_association
susceptibility		 ISO DNA:missense mutations:cds:p.S411L, p.S727A (rs1805013, rs1805016) (human)
DNA:SNPs:multiple		 RGD PMID:14745651 PMID:19036616 RGD:10402782 RGD:10402784 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Itih1 inter-alpha-trypsin inhibitor heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955430:2,738,128...2,751,007
Ensembl chrNW_004955430:2,737,859...2,751,379 		JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955419:1,782,566...1,857,375
Ensembl chrNW_004955419:1,782,566...1,857,375 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955422:19,714,161...19,730,344
Ensembl chrNW_004955422:19,714,627...19,729,855 		JBrowse link
G Mapt microtubule associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:30664745 NCBI chrNW_004955478:10,222,439...10,271,439
Ensembl chrNW_004955478:10,225,823...10,271,442 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO mRNA, protein:increased expression:cartilage RGD PMID:22670655 RGD:10043109 NCBI chrNW_004955412:6,106,994...6,118,760
Ensembl chrNW_004955412:6,106,994...6,118,760 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955437:10,598,145...10,885,858
Ensembl chrNW_004955437:10,598,145...10,800,560 		JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136 		JBrowse link
G Smo smoothened, frizzled class receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955479:9,963,377...9,991,670
Ensembl chrNW_004955479:9,964,170...9,993,165 		JBrowse link
G Tnc tenascin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:30374069 NCBI chrNW_004955419:12,569,620...12,662,897
Ensembl chrNW_004955419:12,569,547...12,662,958 		JBrowse link
SHORT STATURE AND ADVANCED BONE AGE, WITH OR WITHOUT EARLY-ONSET OSTEOARTHRITIS AND/OR OSTEOCHONDRITIS DISSECANS term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan ISO ClinVar Annotator: match by term: Short stature and advanced bone age | ClinVar Annotator: match by term: Short stature and advanced bone age, with early-onset osteoarthritis | ClinVar Annotator: match by term: Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans | ClinVar Annotator: match by term: Short stature-advanced bone age-early-onset osteoarthritis syndrome OMIM
ClinVar		 PMID:14216462 PMID:16080123 PMID:19110214 PMID:20137779 PMID:24762113 More... NCBI chrNW_004955416:16,125,536...16,186,046 JBrowse link
Spine Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34697729 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34697729 NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34697729 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Lrp5 LDL receptor related protein 5 susceptibility ISO DNA:polymorphism:cds:p.Q89R(human) RGD PMID:17202888 RGD:12792278 NCBI chrNW_004955422:17,394,371...17,475,244
Ensembl chrNW_004955422:17,394,371...17,505,763 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34697729 NCBI chrNW_004955426:20,972,663...20,999,769
Ensembl chrNW_004955426:20,972,663...20,999,769 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:34697729 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
Temporomandibular Joint Osteoarthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543 		JBrowse link
G Becn1 beclin 1 ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 disease_progression ISO RGD PMID:28147322 RGD:155791443 NCBI chrNW_004955416:7,807,049...7,816,346
Ensembl chrNW_004955416:7,807,049...7,817,420 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:mandibular condyle, cartilage (rat) RGD PMID:23934157 RGD:8663479 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO mRNA,protein:increased expression:chondrocyte RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131 		JBrowse link
G Map1lc3b microtubule associated protein 1 light chain 3 beta ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955541:1,852,388...1,868,194 JBrowse link
G Rps6 ribosomal protein S6 ISO RGD PMID:31007149 RGD:34888237 NCBI chrNW_004955434:21,744,045...21,745,646
Ensembl chrNW_004955434:21,744,082...21,746,626 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    Diseases of the Aged 1159
      osteoarthritis 231
        Beukes hip dysplasia 2
        Brachydactylous Dwarfism Mseleni Type 0
        Chondrocalcinosis 1 0
        Digital Arthropathy-Brachydactyly, Familial 1
        Hand Osteoarthritis 4
        Knee Osteoarthritis 45
        Osteoarthritis with Mild Chondrodysplasia 1
        Osteoarthritis, Experimental 16
        Osteoarthritis, Hip 26
        SHORT STATURE AND ADVANCED BONE AGE, WITH OR WITHOUT EARLY-ONSET OSTEOARTHRITIS AND/OR OSTEOCHONDRITIS DISSECANS 1
        Spine Osteoarthritis 6
        Temporomandibular Joint Osteoarthritis 10
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      musculoskeletal system disease 7251
        connective tissue disease 4916
          bone disease 3596
            bone inflammation disease 1195
              arthropathy 1176
                arthritis 782
                  osteoarthritis 231
                    Beukes hip dysplasia 2
                    Brachydactylous Dwarfism Mseleni Type 0
                    Chondrocalcinosis 1 0
                    Digital Arthropathy-Brachydactyly, Familial 1
                    Hand Osteoarthritis 4
                    Knee Osteoarthritis 45
                    Osteoarthritis with Mild Chondrodysplasia 1
                    Osteoarthritis, Experimental 16
                    Osteoarthritis, Hip 26
                    SHORT STATURE AND ADVANCED BONE AGE, WITH OR WITHOUT EARLY-ONSET OSTEOARTHRITIS AND/OR OSTEOCHONDRITIS DISSECANS 1
                    Spine Osteoarthritis 6
                    Temporomandibular Joint Osteoarthritis 10
paths to the root