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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cocaine abuse
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Accession:DOID:809 term browser browse the term
Definition:A substance abuse that involves the recurring use of cocaine despite negative consequences. (DO)
Synonyms:exact_synonym: cocaine use disorder
 xref: ICD10CM:F14.1;   ICD9CM:305.6
For additional species annotation, visit the Alliance of Genome Resources.


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cocaine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase severity ISO RGD PMID:21540357 RGD:401960084 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462 		JBrowse link
G BDNF brain derived neurotrophic factor ISO mRNA:increased expression:nucleus accumbens RGD PMID:31280332 RGD:596948400 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 ISO mRNA:decreased expression:caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,647...13,388,048 		JBrowse link
G CARTPT CART prepropeptide IEP mRNA:increased expression:nucleus accumbens RGD PMID:15009677 RGD:597805894 NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 severity IEP RGD PMID:21806491 RGD:401794583 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CD40LG CD40 ligand severity IEP RGD PMID:21806491 RGD:401794583 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit onset IAGP DNA:SNP:exon:rs16969968(human) RGD PMID:32841724 RGD:150530292 NCBI chr15:78,565,520...78,595,269
Ensembl chr15:78,565,520...78,595,269 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit susceptibility IAGP DNA:SNP::rs892413(human) RGD PMID:24675634 RGD:405849277 NCBI chr 8:42,752,620...42,768,786
Ensembl chr 8:42,752,620...42,796,392 		JBrowse link
G CHRNB4 cholinergic receptor nicotinic beta 4 subunit onset IAGP DNA:SNP::rs950776(human) RGD PMID:32841724 RGD:150530292 NCBI chr15:78,624,111...78,661,641
Ensembl chr15:78,624,111...78,727,754 		JBrowse link
G CLOCK clock circadian regulator ISO mRNA:increased expression:caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,547,491 		JBrowse link
G CNR2 cannabinoid receptor 2 treatment ISO RGD PMID:31437433 RGD:598130084 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO protein:increased expression, increased phosphorylation:prefrontal cortex RGD PMID:24205196 PMID:18001273 RGD:401940185, RGD:401959587 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CRHBP corticotropin releasing hormone binding protein ameliorates IAGP associated with opioid abuse;DNA:SNP:3' utr:rs1500 RGD PMID:30844877 RGD:617302492 NCBI chr 5:76,953,045...76,981,159
Ensembl chr 5:76,953,044...76,981,158 		JBrowse link
G CRY1 cryptochrome circadian regulator 1 ISO mRNA:decreased expression:caudate-putamen (mouse) RGD PMID:15994025 RGD:405866347 NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,855 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO mRNA:increased expression:nucleus accumbens (rat) RGD PMID:27114539 RGD:405855871 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 sexual_dimorphism ISO mRNA:increased expression:brain (rat) RGD PMID:31029877 RGD:401976486 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,572,945...35,728,622 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:28366798 RGD:405100962 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO associated with alcohol dependence;protein:increased expression: caudate-putamen (rat) RGD PMID:17572394 PMID:9294222 RGD:401900302, RGD:407446380 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 sexual_dimorphism ISO protein:increased expression:prefrontal cortex (mouse)
protein:increased expression:nucleus accumbens (rat)
protein:decreased expression:nucleus accumbens (mouse) 		RGD PMID:33497752 PMID:11801363 PMID:22197517 RGD:401976469, RGD:405650201, RGD:405650197 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G HCRT hypocretin neuropeptide precursor treatment ISO RGD PMID:29454841 RGD:401960065 NCBI chr17:42,184,060...42,185,452
Ensembl chr17:42,184,060...42,185,452 		JBrowse link
G HOMER2 homer scaffold protein 2 ISO RGD PMID:29234834 RGD:617212664 NCBI chr15:82,834,661...82,986,157
Ensembl chr15:82,834,664...82,986,153 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A treatment ISO protein:decreased expression:dentate gyrus, hypothalamus RGD PMID:9723786 PMID:31437433 RGD:401900605, RGD:598130084 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A treatment ISO mRNA:increased expression:orbitofrontal cortex RGD PMID:27733540 PMID:20814782 PMID:11259563 RGD:401900753, RGD:401901179, RGD:401900755 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C treatment ISO RGD PMID:20814782 RGD:401901179 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,755,537...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO protein:increased phosphorylation:nucleus accumbens RGD PMID:25522720 RGD:401851063 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MB myoglobin IEP protein:increased expression:umbilical cord blood RGD PMID:8989474 RGD:458925290 NCBI chr22:35,606,764...35,623,354
Ensembl chr22:35,606,764...35,637,951 		JBrowse link
G NPAS2 neuronal PAS domain protein 2 ISO mRNA:decreased expression:hippocampal formation,caudate-putamen (mouse) RGD PMID:15994025 RGD:405866347 NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,091...100,996,829 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 susceptibility IAGP DNA:SNP:intron: (rs4518200) (human) RGD PMID:33242852 RGD:402463938 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,852 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 treatment ISO
IEP 		mRNA:decreased expression:blood RGD PMID:12805318 PMID:29761890 PMID:9765324 RGD:401976288, RGD:407987269, RGD:401976376 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 treatment ISO mRNA:increased expression:nucleus accumbens RGD PMID:27576164 PMID:31280332 RGD:596948399, RGD:596948400 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:23219985 RGD:617148291 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,079,967...64,100,649 		JBrowse link
G PDYN prodynorphin ISO mRNA:increased expression:caudate putamen
mRNA:increased expression:central amygdaloid nucleus, dentate gyrus of hippocampal formation 		RGD PMID:7694032 PMID:12523490 RGD:401850578, RGD:401850585 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285 		JBrowse link
G PER1 period circadian regulator 1 ISO mRNA:increased expression:hippocampal formation, caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr17:8,140,472...8,152,404
Ensembl chr17:8,140,467...8,156,506 		JBrowse link
G PER2 period circadian regulator 2 ISO mRNA:increased expression, decreased expression:hippocampal formation, caudate-putamen (mouse) RGD PMID:15994025 RGD:405866348 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G PNOC prepronociceptin ISO RGD PMID:23219985 RGD:617148291 NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355 		JBrowse link
G PRL prolactin treatment IEP RGD PMID:17391744 RGD:401960113 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G TLR2 toll like receptor 2 ISO protein:increased expression:striatum, microglial cell RGD PMID:26860188 RGD:597538483 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,708,537 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 treatment ISO RGD PMID:31437433 RGD:598130084 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 138869
    Chemically-Induced Disorders 3678
      substance-related disorder 2662
        substance abuse 966
          cocaine abuse 39
Path 2
Term Annotations click to browse term
  disease 138869
    disease of anatomical entity 126275
      nervous system disease 59946
        central nervous system disease 38636
          brain disease 37040
            disease of mental health 28654
              substance-related disorder 2662
                Cocaine-Related Disorders 231
                  cocaine abuse 39
paths to the root