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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:chronic kidney disease
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Accession:DOID:784 term browser browse the term
Definition:A kidney failure that is characterized by the gradual loss of kidney function. (DO)
Synonyms:exact_synonym: CKD;   CRF;   chronic kidney diseases;   chronic kidney insufficiencies;   chronic kidney insufficiency;   chronic renal disease;   chronic renal diseases;   chronic renal failure;   chronic renal failure syndrome;   chronic renal insufficiencies;   chronic renal insufficiency
 narrow_synonym: congenital chronic kidney disease
 primary_id: MESH:D051436
 xref: EFO:0003884;   EFO:0021433;   ICD10CM:N18.9;   NCI:C80078;   NCI:C9438
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
chronic kidney disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN4 actinin alpha 4 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr 6:33,290,639...33,373,059
Ensembl chr 6:33,290,622...33,374,693 		JBrowse link
G AGER advanced glycosylation end-product specific receptor susceptibility
disease_progression
severity		 ISO associated with Diabetes Mellitus, Type 2; DNA:polymorphism:promoter:g.-429T>C (human)
DNA:polymorphism:promoter:g.-374T>A (human)
DNA:polymorphisms:promoter, intron:g.-429T>C, g.2184A>G (human)
protein:increased expression:serum (human)		 RGD PMID:20185929 PMID:20353610 PMID:21432860 PMID:21822023 PMID:23593165 RGD:7242570 RGD:7243185 RGD:7243867 RGD:7243958 RGD:7244142 NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127 		JBrowse link
G AGTR1 angiotensin II receptor type 1 disease_progression ISO DNA:polymorphism:3' utr:1166A>C (human) RGD PMID:12089373 PMID:12832734 RGD:6903863 RGD:8548869 NCBI chr15:41,957,826...42,002,776 JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:12089373 RGD:6903863
G AHR aryl hydrocarbon receptor ISO mRNA, protein:increased expression:heart (mouse) RGD PMID:31746392 RGD:401793746 NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 susceptibility ISO DNA:polymorphism: :rs756009(human) RGD PMID:19724895 RGD:14349027 NCBI chr13:78,691,588...78,812,333
Ensembl chr13:78,691,816...78,812,834 		JBrowse link
G ANLN anillin actin binding protein ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr21:22,034,213...22,099,207
Ensembl chr21:22,034,259...22,099,158 		JBrowse link
G AOC3 amine oxidase copper containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23154672 NCBI chr16:63,435,494...63,442,790
Ensembl chr16:63,437,067...63,442,256 		JBrowse link
G APOA1 apolipoprotein A1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609 		JBrowse link
G APOA4 apolipoprotein A4 disease_progression ISO protein:increased expression:blood plasma (human) RGD PMID:21569504 RGD:5685637 NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698 		JBrowse link
G APOC3 apolipoprotein C3 ISO protein:increased expression:plasma RGD PMID:21297177 PMID:21829457 RGD:7207207 RGD:7207209 NCBI chr 1:108,196,283...108,199,274
Ensembl chr 1:108,196,939...108,199,342 		JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr16:73,741,402...73,745,079
Ensembl chr16:73,740,944...73,745,062 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr10:101,128,583...101,166,668 JBrowse link
G AXDND1 axonemal dynein light chain domain containing 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:8589695 PMID:10742096 PMID:11805166 PMID:15253708 PMID:15327385 More... NCBI chr25:49,807,102...49,988,152 JBrowse link
G AZGP1 alpha-2-glycoprotein 1, zinc-binding ISO protein:increased expression:white adipose tissue:
protein:increased expression:plasma,white adipose tissue:		 RGD PMID:23423258 RGD:153352319 NCBI chr28:13,104,262...13,120,329
Ensembl chr28:13,104,323...13,120,363 		JBrowse link
G B2M beta-2-microglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:37921072 NCBI chr26:38,331,818...38,338,785
Ensembl chr26:38,331,442...38,338,809 		JBrowse link
G CFH complement factor H ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr25:32,557,697...32,744,763 JBrowse link
G CFHR5 complement factor H related 5 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:17000000 PMID:22503529 PMID:22527104 PMID:24033266 PMID:25260719 More... NCBI chr25:32,411,268...32,440,499
Ensembl chr25:32,410,158...32,439,961 		JBrowse link
G CFI complement factor I ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:17084897 PMID:20301541 PMID:25741868 PMID:28492532 NCBI chr 7:57,641,363...57,713,209
Ensembl chr 7:57,640,141...57,700,805 		JBrowse link
G CLU clusterin ISO associated with Obesity;protein:increased expression:urine RGD PMID:24325231 RGD:9068427 NCBI chr 8:25,704,441...25,721,789
Ensembl chr 8:25,703,257...25,721,789 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 3:88,410,800...88,564,191
Ensembl chr 3:88,412,168...88,564,057 		JBrowse link
G COL4A3 collagen type IV alpha 3 chain ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:14871398 PMID:17216251 PMID:24033266 PMID:24854265 PMID:25741868 More... NCBI chr10:113,183,843...113,338,230
Ensembl chr10:113,257,483...113,335,312 		JBrowse link
G COL4A4 collagen type IV alpha 4 chain ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:12028435 PMID:12325029 PMID:12631110 PMID:16467446 PMID:17942953 More... NCBI chr10:113,028,552...113,183,240
Ensembl chr10:113,028,552...113,165,958 		JBrowse link
G COL6A3 collagen type VI alpha 3 chain ISO DNA:SNP:CDS:E1386K (rs146092501) (human) RGD PMID:30226566 RGD:401851058 NCBI chr10:123,326,337...123,418,836
Ensembl chr10:123,327,102...123,400,114 		JBrowse link
G CPB2 carboxypeptidase B2 ISO DNA:polymorphism:cds :p.A147T(rs3742264)(human) RGD PMID:19056482 RGD:7243119 NCBI chr 3:24,108,854...24,161,669
Ensembl chr 3:24,109,416...24,161,408 		JBrowse link
G CST3 cystatin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:32450046 NCBI chr 2:52,834,497...52,838,785
Ensembl chr 2:52,832,181...52,838,865 		JBrowse link
G CUBN cubilin ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:15024727 PMID:22929189 PMID:24033266 PMID:25349199 PMID:25741868 More... NCBI chr 9:16,774,644...17,079,776
Ensembl chr 9:16,774,757...17,079,681 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 ISO mRNA, protein:increased expression:heart (mouse) RGD PMID:31746392 RGD:401793746 NCBI chr14:69,318,713...69,327,277
Ensembl chr14:69,319,495...69,324,157 		JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 ISO protein:decreased expression:liver: RGD PMID:23045433 RGD:10400847 NCBI chr 8:138,531,113...138,541,721
Ensembl chr 8:138,531,384...138,541,637 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 ISO protein:decreased expression:liver: RGD PMID:23045433 RGD:10400847 NCBI chr 1:66,985,413...67,018,058
Ensembl chr 1:66,985,466...67,021,182 		JBrowse link
G DNM1L dynamin 1 like treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr11:32,114,642...32,178,330
Ensembl chr11:32,114,675...32,177,661 		JBrowse link
G DSTYK dual serine/threonine and tyrosine protein kinase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr25:24,128,889...24,200,115
Ensembl chr25:24,128,899...24,195,085 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr15:4,164,795...4,228,593
Ensembl chr15:4,164,838...4,228,651 		JBrowse link
G ETFB electron transfer flavoprotein subunit beta ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:24215330 PMID:25741868 PMID:28492532 NCBI chr 6:44,269,123...44,286,039
Ensembl chr 6:44,267,702...44,286,065 		JBrowse link
G FGF21 fibroblast growth factor 21 ISO protein:increased expression:serum: RGD PMID:22494291 RGD:10401925 NCBI chr 6:42,006,125...42,008,749
Ensembl chr 6:42,006,064...42,008,736 		JBrowse link
G FGF23 fibroblast growth factor 23 ISO protein:increased expression:serum: RGD PMID:20016468 RGD:10044210 NCBI chr11:4,398,318...4,408,415
Ensembl chr11:4,398,675...4,407,209 		JBrowse link
G FIS1 fission, mitochondrial 1 treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr28:11,934,848...11,940,230
Ensembl chr28:11,934,821...11,941,901 		JBrowse link
G FN1 fibronectin 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr10:101,177,867...101,254,613
Ensembl chr10:101,176,789...101,254,633 		JBrowse link
G FREM1 FRAS1 related extracellular matrix 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr12:64,681,181...64,849,266 JBrowse link
G GANAB glucosidase II alpha subunit ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:11,257,867...11,279,534
Ensembl chr 1:11,257,935...11,281,111 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32045570 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha exacerbates ISO RGD PMID:11314805 RGD:42722629 NCBI chr16:4,412,693...4,415,841 JBrowse link
G GPX1 glutathione peroxidase 1 treatment ISO DNA:SNP: :rs17080528 (human) RGD PMID:15954914 PMID:31924810 RGD:11352759 RGD:401827826 NCBI chr22:10,754,976...10,756,617 JBrowse link
G GRP gastrin releasing peptide ISO mRNA, protein:increased expression:aorta, plasma (human) RGD PMID:32192106 RGD:329961569 NCBI chr18:20,496,201...20,508,551
Ensembl chr18:20,496,516...20,507,153 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO RGD PMID:22269876 RGD:7245952 NCBI chr23:59,422,769...59,454,183
Ensembl chr23:59,423,334...59,453,531 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO mRNA, protein:increased expression:liver RGD PMID:12841361 RGD:1300058 NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686 		JBrowse link
G IL19 interleukin 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24714768 NCBI chr25:22,514,199...22,523,680
Ensembl chr25:22,514,559...22,520,499 		JBrowse link
G IL1B interleukin 1 beta ISO protein:decreased expression:serum (human)
mRNA:increased expression:kidney (mouse)
associated with Periodontitis; DNA:SNP:intron:g.3954C>T (human)		 RGD PMID:21975861 PMID:22398717 PMID:22613545 PMID:22728154 PMID:22795294 RGD:6906881 RGD:7175095 RGD:7175169 RGD:7175171 RGD:7175304 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*1 (human)
protein:increased expression:plasma (human)		 RGD PMID:22795294 PMID:23024164 RGD:6906880 RGD:6906881 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G INF2 inverted formin 2 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr24:82,628,339...82,658,879
Ensembl chr24:82,629,090...82,660,118 		JBrowse link
G INSR insulin receptor ISO protein:decreased phosphorylation:aorta RGD PMID:22942179 RGD:7207055 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592 		JBrowse link
G KL klotho treatment
disease_progression		 ISO mRNA,protein:decreased expression:renal tubule, epithelial cell:
protein:decreased expression:urine:		 RGD PMID:11967236 PMID:21115613 RGD:10403077 RGD:70544 NCBI chr 3:11,755,015...11,799,537
Ensembl chr 3:11,755,016...11,797,596 		JBrowse link
G KLK1 kallikrein 1 susceptibility ISO associated with Vesico-Ureteral Reflux RGD PMID:15086490 RGD:1581752 NCBI chr 6:43,867,629...43,873,364
Ensembl chr 6:43,867,596...43,872,178 		JBrowse link
G LCN2 lipocalin 2 disease_progression ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20921623 PMID:24714768 RGD:126781837 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
G LEPR leptin receptor ISO RGD PMID:27465994 PMID:32390513 RGD:12911217 RGD:34888223 NCBI chr20:67,454,205...67,567,524
Ensembl chr20:67,454,334...67,524,229 		JBrowse link
G LOC103216393 paired box protein Pax-2 treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr 9:93,763,975...93,847,180 JBrowse link
G LOC103243271 leucine-rich repeat-containing protein 37A3 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:34145744 NCBI chr16:59,592,891...59,634,813 JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO protein:increased expression:aorta (rat) RGD PMID:32581266 RGD:155804294 NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor treatment ISO RGD PMID:24614509 RGD:401793742 NCBI chr13:87,520,860...87,523,523
Ensembl chr13:87,521,947...87,523,098 		JBrowse link
G MFN1 mitofusin 1 treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr15:10,050,616...10,093,118
Ensembl chr15:10,047,599...10,093,126 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO DNA:polymorphism:cds:g.677C>T (human) RGD PMID:23595572 RGD:7244284 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MYH9 myosin heavy chain 9 no_association ISO RGD PMID:22956460 RGD:12798515 NCBI chr19:18,985,709...19,093,304
Ensembl chr19:18,986,598...19,052,671 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:23174956 RGD:10412711 NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339 		JBrowse link
G NGF nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:24244623 NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833 		JBrowse link
G NHERF1 NHERF family PDZ scaffold protein 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:18784102 PMID:25741868 PMID:28492532 NCBI chr16:46,889,454...46,910,776
Ensembl chr16:46,888,942...46,910,842 		JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility
treatment		 ISO mRNA:decreased expression:cortex of kidney (rat) RGD PMID:29018182 PMID:29247650 RGD:13450920 RGD:13504713 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin severity
treatment		 ISO mRNA:increased expression:urine (human)
human cells in rat model		 RGD PMID:30133147 PMID:33298161 RGD:155631310 RGD:38549368 NCBI chr 6:30,736,869...30,763,054
Ensembl chr 6:30,736,966...30,762,929 		JBrowse link
G NPHS2 NPHS2 stomatin family member, podocin ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:8589695 PMID:10742096 PMID:11729243 PMID:11805166 PMID:11854170 More... NCBI chr25:49,786,126...49,804,917 JBrowse link
G NPPA natriuretic peptide A disease_progression ISO protein:increased expression:plasma RGD PMID:19052536 RGD:7247723 NCBI chr20:119,942,412...119,946,211
Ensembl chr20:119,944,532...119,945,917 		JBrowse link
G NPPB natriuretic peptide B disease_progression ISO RGD PMID:23725445 RGD:7246908 NCBI chr20:119,930,931...119,933,391
Ensembl chr20:119,932,021...119,933,197 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:22227174 RGD:10769366 NCBI chr 5:57,676,547...57,695,434
Ensembl chr 5:57,675,981...57,716,599 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 disease_progression ISO RGD PMID:24722447 RGD:12910103 NCBI chr11:48,208,354...48,232,857
Ensembl chr11:48,208,587...48,233,063 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr15:87,679,656...87,778,767
Ensembl chr15:87,679,077...87,779,102 		JBrowse link
G PASK PAS domain containing serine/threonine kinase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr10:127,156,577...127,206,745
Ensembl chr10:127,156,558...127,199,845 		JBrowse link
G PCSK2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:18039782 RGD:6483556 NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr 5:1,985,165...2,031,518
Ensembl chr 5:1,983,632...2,015,551 		JBrowse link
G POSTN periostin ISO protein:increased secretion:urine:
protein:increased expression:kidney:		 RGD PMID:22167593 PMID:22403621 RGD:10040972 RGD:10041032 NCBI chr 3:16,060,013...16,095,867
Ensembl chr 3:16,059,965...16,095,791 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:22648295 RGD:7242023 NCBI chr27:25,882,385...26,563,530
Ensembl chr27:26,465,499...26,564,582 		JBrowse link
G PTH parathyroid hormone treatment
severity		 ISO protein:decreased expression:plasma (rat)
associated with Diabetes Mellitus, Type 2; protein:increased expression:serum (human)		 RGD PMID:21826734 PMID:22517117 PMID:23345625 PMID:23467111 PMID:23528898 RGD:7242412 RGD:7242418 RGD:7242572 RGD:7242935 RGD:7242949 NCBI chr 1:51,327,555...51,330,810 JBrowse link
G RBP4 retinol binding protein 4 onset ISO associated with type 2 diabetes mellitus; protein:increased expression:blood serum (human) RGD PMID:21817822 RGD:329853323 NCBI chr 9:86,831,042...86,840,668
Ensembl chr 9:86,830,957...86,840,250 		JBrowse link
G RETN resistin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22421264 NCBI chr 6:7,154,771...7,156,459
Ensembl chr 6:7,155,337...7,156,505 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO protein, activity:decreased expression:plasma, heart, kidney: RGD PMID:18299506 RGD:7327164 NCBI chr 9:81,725,115...82,029,361 JBrowse link
G RTN3 reticulon 3 ISO MouseDO NCBI chr 1:10,485,943...10,559,725 JBrowse link
G SALL1 spalt like transcription factor 1 treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr 5:36,928,711...36,944,158
Ensembl chr 5:36,927,990...36,943,630 		JBrowse link
G SERPINA3 serpin family A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35635602 NCBI chr24:72,388,948...72,415,746
Ensembl chr24:72,402,560...72,415,507 		JBrowse link
G SHH sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395 		JBrowse link
G SIX2 SIX homeobox 2 treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr14:62,212,920...62,219,976
Ensembl chr14:62,213,115...62,220,069 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO mRNA:decreased expression:multiple (rat) RGD PMID:21149507 RGD:7327184 NCBI chr 2:89,188,171...89,232,081
Ensembl chr 2:89,188,733...89,209,281 		JBrowse link
G SLC19A2 solute carrier family 19 member 2 ISO mRNA:decreased expression:liver, heart (rat) RGD PMID:21149507 RGD:7327184 NCBI chr25:59,568,801...59,587,398
Ensembl chr25:59,568,893...59,585,094 		JBrowse link
G SLC34A1 solute carrier family 34 member 1 ISO mRNA:decreased expression:kidney (rat)
DNA:snp:intron:IVS9+122A>G rs6420094 (human)		 RGD PMID:20383146 PMID:21826734 RGD:7242935 RGD:7243100 NCBI chr23:79,395,923...79,410,835
Ensembl chr23:79,396,250...79,411,695 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO mRNA:decreased expression:liver, heart, jejunum (rat) RGD PMID:21149507 RGD:7327184 NCBI chr16:22,164,661...22,173,376
Ensembl chr16:22,166,318...22,173,240 		JBrowse link
G SYNPO synaptopodin treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr23:53,189,617...53,261,808
Ensembl chr23:53,220,796...53,262,103 		JBrowse link
G TBX18 T-box transcription factor 18 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr13:9,407,384...9,441,157
Ensembl chr13:9,411,004...9,439,642 		JBrowse link
G TERT telomerase reverse transcriptase treatment ISO RGD PMID:23013219 RGD:11038770 NCBI chr 4:1,082,894...1,119,373
Ensembl chr 4:1,083,384...1,117,468 		JBrowse link
G TFCP2L1 transcription factor CP2 like 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:33097957 NCBI chr10:9,010,583...9,079,869
Ensembl chr10:9,011,036...9,072,084 		JBrowse link
G TTC21B tetratricopeptide repeat domain 21B ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr10:51,365,156...51,449,207
Ensembl chr10:51,364,889...51,449,183 		JBrowse link
G UMOD uromodulin ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr 5:18,620,927...18,641,312
Ensembl chr 5:18,619,895...18,638,719 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO protein:increased expression:serum:
protein:increased expression:kidney		 RGD PMID:20820841 PMID:21111939 RGD:4145364 RGD:7241036 NCBI chr20:32,616,425...32,635,903
Ensembl chr20:32,615,333...32,635,862 		JBrowse link
G WNT9B Wnt family member 9B ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:34145744 NCBI chr16:60,560,132...60,596,782
Ensembl chr16:60,581,258...60,586,596 		JBrowse link
G WT1 WT1 transcription factor treatment ISO ClinVar Annotator: match by term: Chronic kidney disease
human cells in rat model		 ClinVar
RGD		 PMID:25741868 PMID:33298161 RGD:155631310 NCBI chr 1:32,750,300...32,801,832 JBrowse link
G XDH xanthine dehydrogenase treatment ISO associated with Hypertension;DNA:SNP: :66292C>G (human) RGD PMID:18712049 PMID:22622455 RGD:7247640 RGD:7247654 NCBI chr14:76,084,693...76,162,840
Ensembl chr14:76,085,368...76,163,936 		JBrowse link
G ZNF423 zinc finger protein 423 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 PMID:32723786 NCBI chr 5:35,281,679...35,657,045
Ensembl chr 5:35,278,652...35,621,956 		JBrowse link
end stage renal disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr12:34,587,123...34,734,936
Ensembl chr12:34,587,118...34,731,642 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:17135344 RGD:2301067 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO RGD PMID:17135344 RGD:2301067 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO protein:decreased expression:intestine RGD PMID:17135344 RGD:2301067 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney (rat)		 CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr 2:86,098,818...86,176,101
Ensembl chr 2:86,099,414...86,179,949 		JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney (rat)		 CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr 1:99,552,760...99,580,079
Ensembl chr 1:99,552,838...99,579,914 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum, urine
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19539174 PMID:24028144 RGD:8695941 NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391 		JBrowse link
G ADIPOR1 adiponectin receptor 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19539174 PMID:24028144 RGD:8695941 NCBI chr25:26,445,993...26,462,346
Ensembl chr25:26,453,242...26,462,549 		JBrowse link
G ADIPOR2 adiponectin receptor 2 ISO RGD PMID:24028144 RGD:8695941 NCBI chr11:1,802,694...1,836,703
Ensembl chr11:1,738,026...1,837,060 		JBrowse link
G ADRB2 adrenoceptor beta 2 ISO RGD PMID:9730702 RGD:7175286 NCBI chr23:51,445,920...51,447,942
Ensembl chr23:51,446,154...51,447,401 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO protein:increased expression:serum (human) RGD PMID:21822023 RGD:7243867 NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO associated with Vesico-Ureteral Reflux;DNA:SNP: :-1332A>G (human) RGD PMID:19212419 PMID:20149750 RGD:6903283 RGD:6903843
G ALB albumin disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11849406 PMID:11938814 RGD:11036089 NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407 		JBrowse link
G ALMS1 ALMS1 centrosome and basal body associated protein ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:17594715 PMID:24462884 PMID:25296579 PMID:25741868 PMID:26066530 More... NCBI chr14:33,571,894...33,795,404
Ensembl chr14:33,573,296...33,789,549 		JBrowse link
G APOA1 apolipoprotein A1 treatment ISO protein:increased expression, increased glycation:plasma
associated with Hyperlipidemias
protein:decreased expression:blood		 RGD PMID:18079481 PMID:20488818 PMID:22515595 RGD:7241208 RGD:7241571 RGD:7241576 NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609 		JBrowse link
G APOC2 apolipoprotein C2 ISO associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:8139482 RGD:2313968 NCBI chr 6:38,406,829...38,411,239
Ensembl chr 6:38,409,641...38,410,927 		JBrowse link
G APOC3 apolipoprotein C3 ISO protein:increased expression: :
associated with Diabetes Mellitus, Insulin-Dependent		 RGD PMID:8139482 PMID:10822722 RGD:2313968 RGD:7207212 NCBI chr 1:108,196,283...108,199,274
Ensembl chr 1:108,196,939...108,199,342 		JBrowse link
G APOE apolipoprotein E ISO protein:increased expression:serum (human) RGD PMID:21332332 PMID:21705678 RGD:6903287 RGD:6904217 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G ARG2 arginase 2 ISO protein:decreased activity:kidney (rat) RGD PMID:16809898 RGD:4110828 NCBI chr24:44,851,139...44,884,118
Ensembl chr24:44,851,175...44,883,853 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:20424483 RGD:11522730 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BDKRB1 bradykinin receptor B1 resistance
no_association		 ISO DNA: SNP: G-699-->C
DNA: SNP: G(-699)C		 RGD PMID:9555662 PMID:10604543 PMID:10809796 RGD:7241560 RGD:7241561 RGD:7241582 NCBI chr24:74,136,464...74,146,668
Ensembl chr24:74,145,531...74,146,592 		JBrowse link
G BECN1 beclin 1 ISO protein:increased expression:kidney RGD PMID:24090408 RGD:11561926 NCBI chr16:63,469,187...63,482,627
Ensembl chr16:63,469,192...63,485,322 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:17365904 PMID:20845051 RGD:7207235 RGD:7207409 NCBI chr20:7,623,716...7,626,353
Ensembl chr20:7,623,883...7,624,812 		JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO protein:increased expression:kidney RGD PMID:24090408 RGD:11561926 NCBI chr 9:124,570,958...124,586,002
Ensembl chr 9:124,568,695...124,585,980 		JBrowse link
G C6 complement C6 severity ISO RGD PMID:11912252 RGD:1600675 NCBI chr 4:39,912,385...40,033,338
Ensembl chr 4:39,912,155...39,983,634 		JBrowse link
G CASR calcium sensing receptor ISO protein:decreased expression:epigastric artery (human) RGD PMID:17537980 RGD:7205455 NCBI chr22:58,579,640...58,612,142
Ensembl chr22:58,578,396...58,604,756 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism
protein: decreased expression :kidney		 CTD
RGD		 PMID:16518626 PMID:19420110 PMID:20007347 RGD:6892947 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment
susceptibility		 ISO protein:increased expression:renal proximal tubule (rat)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-2518A>G (human)		 RGD
CTD		 PMID:12080327 PMID:17982227 PMID:18797164 PMID:19420110 PMID:19539174 RGD:2306990 RGD:2307007 RGD:8549739 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:kidney cortex (rat) RGD PMID:19535570 RGD:4889989 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO associated with Candidiasis, Invasive; RGD PMID:22916017 RGD:7241817 NCBI chr22:7,634,205...7,641,380 JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:kidney cortex (rat) RGD PMID:19535570 RGD:4889989 NCBI chr22:7,803,794...7,818,112 JBrowse link
G CD2AP CD2 associated protein ISO MouseDO NCBI chr17:24,664,245...24,815,786
Ensembl chr17:24,663,872...24,815,829 		JBrowse link
G CD40 CD40 molecule severity
treatment		 ISO protein:increased expression:plasma RGD PMID:12941150 PMID:20846521 RGD:7248709 RGD:7248723 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:plasma RGD PMID:19019166 RGD:7248427 NCBI chr  X:111,655,301...111,667,602
Ensembl chr  X:111,655,397...111,666,639 		JBrowse link
G CD68 CD68 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19539174 NCBI chr16:6,956,633...6,959,645
Ensembl chr16:6,957,212...6,959,042 		JBrowse link
G CFB complement factor B severity ISO RGD PMID:1837062 PMID:17522263 RGD:7242704 RGD:7242753 Ensembl chr17:40,069,909...40,094,207 JBrowse link
G CHGA chromogranin A ISO protein:increased expression:serum
associated with Hypertension;DNA:polymorphisms, haplotypes:promoter, 3' utr:multiple 		RGD PMID:18235090 PMID:20730520 RGD:6906898 RGD:6906903 NCBI chr24:70,663,040...70,675,827
Ensembl chr24:70,663,298...70,677,116 		JBrowse link
G COL1A1 collagen type I alpha 1 chain ISO RGD PMID:25782334 RGD:11041185 NCBI chr16:43,134,648...43,152,313
Ensembl chr16:43,134,779...43,150,930 		JBrowse link
G COL3A1 collagen type III alpha 1 chain ISO DNA:polymorphism: :p.I1205V (human) RGD PMID:19424605 RGD:7257553 NCBI chr10:74,455,133...74,493,392 JBrowse link
G COL4A3 collagen type IV alpha 3 chain ISO RGD PMID:19357112 RGD:7242047 NCBI chr10:113,183,843...113,338,230
Ensembl chr10:113,257,483...113,335,312 		JBrowse link
G COL4A4 collagen type IV alpha 4 chain ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr10:113,028,552...113,183,240
Ensembl chr10:113,028,552...113,165,958 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:kidney (rat)		 CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr 1:5,704,275...5,784,077
Ensembl chr 1:5,730,853...5,784,337 		JBrowse link
G CRP C-reactive protein disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma		 CTD
RGD		 PMID:19539174 PMID:22865783 RGD:6906886 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
G CSF1 colony stimulating factor 1 ISO protein:increased expression:plasma RGD PMID:11340249 RGD:7257586 NCBI chr20:23,615,107...23,635,399 JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO associated with Wegener Granulomatosis;DNA:polymorphisms:promoter,exon::-318C>T, (AT)repeats (human) RGD PMID:15708894 RGD:7204725 NCBI chr10:89,637,176...89,644,436
Ensembl chr10:89,638,314...89,642,344 		JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 ISO RGD PMID:20649681 RGD:7207863 NCBI chr10:104,052,709...104,056,388
Ensembl chr10:104,053,544...104,054,620 		JBrowse link
G CYBB cytochrome b-245 heavy chain ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:15550752 PMID:19420110 RGD:1599682
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA, protein:decreased expression:intestine
DNA:polymorphisms:exon, 3' utr:3801T>C (rs4646903), p.I462V (rs1048943) (human)		 RGD PMID:12039987 PMID:23619522 RGD:7257728 RGD:7296923 NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15248218 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15248218 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO DNA:polymorphisms: : RGD PMID:18769365 RGD:7243146 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO RGD PMID:8531418 PMID:11158222 RGD:6903939 RGD:6903940 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G DDC dopa decarboxylase ISO protein:altered activity:renal cortex (rat) RGD PMID:19167406 RGD:5128880 NCBI chr21:8,235,396...8,343,086
Ensembl chr21:8,235,343...8,343,361 		JBrowse link
G DRD1 dopamine receptor D1 treatment ISO RGD PMID:18402547 RGD:7248448 NCBI chr23:77,587,340...77,591,434 JBrowse link
G DRD2 dopamine receptor D2 ISO associated with Diabetes Mellitus, Non-Insulin Dependent; DNA:polymorphisms:5'utr, intron: -141delC, G>A (human) RGD PMID:18366720 RGD:2311602 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G EDN1 endothelin 1 ISO mRNA:increased expression:kidney (rat) RGD PMID:8441230 RGD:4144849 NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO Associated with Type 2 diabetes RGD PMID:18184924 RGD:6906927 NCBI chr13:41,670,416...41,755,549 JBrowse link
G EPHX2 epoxide hydrolase 2 disease_progression ISO RGD PMID:20694143 RGD:5688726 NCBI chr 8:25,603,668...25,659,232
Ensembl chr 8:25,603,735...25,659,345 		JBrowse link
G EPO erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:16707910 NCBI chr28:12,487,222...12,491,986
Ensembl chr28:12,489,766...12,491,908 		JBrowse link
G EPOR erythropoietin receptor ISO protein:decreased expression:heart RGD PMID:27468524 RGD:11532749 NCBI chr 6:10,313,382...10,320,196
Ensembl chr 6:10,313,775...10,320,066 		JBrowse link
G F5 coagulation factor V ISO DNA:mutation: :1691G>A(human) RGD PMID:19520684 RGD:6893522 NCBI chr25:59,465,610...59,539,022
Ensembl chr25:59,466,378...59,538,872 		JBrowse link
G FABP1 fatty acid binding protein 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr14:18,660,058...18,666,730
Ensembl chr14:18,659,836...18,667,127 		JBrowse link
G FABP2 fatty acid binding protein 2 ISO DNA:polymorphism:CDS:amino acid A54T, associated with Diabetes Mellitus, Type 2 (MeSH:D003924) RGD PMID:16249461 RGD:1578457 NCBI chr 7:66,797,832...66,803,459
Ensembl chr 7:66,798,990...66,802,738 		JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 NCBI chr16:73,988,410...74,008,374
Ensembl chr16:73,982,899...74,006,551 		JBrowse link
G FGB fibrinogen beta chain treatment ISO associated with hypertension;DNA:polymorphism: :-455G>A (human) RGD PMID:19352213 RGD:7175505 NCBI chr 7:101,106,468...101,114,566
Ensembl chr 7:101,106,483...101,114,662 		JBrowse link
G FN1 fibronectin 1 ISO protein:decreased expression:plasma RGD PMID:6665521 RGD:7205701 NCBI chr10:101,177,867...101,254,613
Ensembl chr10:101,176,789...101,254,633 		JBrowse link
G GATA3 GATA binding protein 3 ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064 		JBrowse link
G GCKR glucokinase regulator ISO DNA: snp: rs1260326 RGD PMID:21980298 RGD:7242279 NCBI chr14:80,069,662...80,124,038
Ensembl chr14:80,100,436...80,123,686 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:18809976 RGD:7242553 NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962 		JBrowse link
G GLO1 glyoxalase I severity ISO DNA:SNP: :419C>A (human) RGD PMID:20185929 RGD:7242570 NCBI chr17:33,446,134...33,472,240
Ensembl chr17:33,446,145...33,473,699 		JBrowse link
G GSR glutathione-disulfide reductase ISO protein:increased activity:lymphocyte:
protein:increased activity:blood:		 RGD PMID:6463365 PMID:20181004 RGD:7257547 RGD:7257560 NCBI chr 8:28,778,713...28,851,907 JBrowse link
G GTPBP4 GTP binding protein 4 ISO RGD PMID:11316846 RGD:632611 NCBI chr 9:953,062...981,213
Ensembl chr 9:952,663...981,353 		JBrowse link
G GUCA2B guanylate cyclase activator 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15780094 NCBI chr20:90,767,183...90,770,403
Ensembl chr20:90,767,609...90,770,198 		JBrowse link
G HAMP hepcidin antimicrobial peptide ISO mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma		 RGD
CTD		 PMID:16929540 PMID:19212416 PMID:20631677 RGD:11041611 RGD:11041622 NCBI chr 6:30,214,820...30,218,100
Ensembl chr 6:30,215,563...30,217,996 		JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21937979 NCBI chr23:42,981,640...42,995,116
Ensembl chr23:42,981,640...42,994,995 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:kidney (rat)
associated with Hypertension		 CTD
RGD		 PMID:19878707 PMID:21119529 RGD:2326081 RGD:5508686 NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686 		JBrowse link
G HMOX1 heme oxygenase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22622455 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:kidney (rat) RGD PMID:20820841 RGD:4145364 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:10198369 NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308 		JBrowse link
G IL1A interleukin 1 alpha no_association ISO DNA:SNPs, deletion, haplotypes:3' utr:multiple (human)
DNA:SNP, insertion/deletion:intron, 3' utr:rs1516792-3, rs16347-2 (human) 		RGD PMID:12631337 PMID:12837270 PMID:20551628 RGD:6907070 RGD:6907105 RGD:6907106 NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611 		JBrowse link
G IL1B interleukin 1 beta no_association ISO DNA:SNP
protein:increased expression:plasma (rat)		 RGD PMID:20199183 PMID:20551628 PMID:22031851 RGD:6907070 RGD:7175302 RGD:7175346 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility
disease_progression		 ISO DNA:polymorphism:exon:g.14709C>T rs315952 (human)
protein:increased expression:serum (human)
DNA:polymorphism:intron:IVS6+327A>G rs452204 (human)
DNA:repeats:intron:IVS2+914_1000dup IL1RN*1 (human)
DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)		 RGD PMID:12837270 PMID:16556139 PMID:16766392 PMID:17224277 PMID:20551628 RGD:6907070 RGD:6907105 RGD:6907131 RGD:6907368 RGD:6907370 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G IL20 interleukin 20 ISO protein:increased expression:multiple organs
protein:increased expression:serum		 RGD PMID:18639518 RGD:5147394 NCBI chr25:22,486,860...22,494,210
Ensembl chr25:22,488,338...22,491,129 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19539174 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G INSIG2 insulin induced gene 2 ISO protein:decreased expression:kidney (rat) RGD PMID:19878707 RGD:2326081 NCBI chr10:12,198,390...12,219,002
Ensembl chr10:12,196,990...12,219,023 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO protein:decreased tyrosine phosphorylation:aorta RGD PMID:22942179 RGD:7207055 NCBI chr10:112,748,283...112,812,368 JBrowse link
G ITGA8 integrin subunit alpha 8 ISO associated with Polycystic Kidney, Autosomal Dominant;DNA:polymorphism: :-414T>C(human) RGD PMID:18277079 RGD:7257723 NCBI chr 9:15,482,746...15,684,161
Ensembl chr 9:15,482,750...15,683,481 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO associated with Hypertension;DNA:polymorphism RGD PMID:19368146 RGD:6907396 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 ISO protein:increased expression:renal cortex, cytosol (rat) RGD PMID:20007347 RGD:6892947 NCBI chr 6:9,515,789...9,526,699
Ensembl chr 6:9,515,416...9,522,797 		JBrowse link
G KL klotho ISO mRNA,protein:decreased expression:kidney:
mRNA:decreased expression:kidney:		 RGD PMID:9731228 PMID:11162628 RGD:10403042 RGD:10403067 NCBI chr 3:11,755,015...11,799,537
Ensembl chr 3:11,755,016...11,797,596 		JBrowse link
G KLK1 kallikrein 1 ISO RGD PMID:11849458 RGD:1581753 NCBI chr 6:43,867,629...43,873,364
Ensembl chr 6:43,867,596...43,872,178 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase ISO RGD PMID:15280162 RGD:1581769 NCBI chr 5:59,495,936...59,500,530
Ensembl chr 5:59,497,115...59,500,448 		JBrowse link
G LCN2 lipocalin 2 onset ISO protein:increased expression:urine: RGD PMID:22542304 RGD:7245503 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
G LEP leptin ISO protein:increased expression:serum (human) RGD PMID:9294834 RGD:10053636 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LIPC lipase C, hepatic type ISO protein, mRNA:decreased expression:hepatocytes, liver (rat) RGD PMID:8636395 RGD:2308788 NCBI chr26:24,946,843...25,109,338
Ensembl chr26:24,946,673...25,087,921 		JBrowse link
G LIPJ lipase family member J ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 9:82,032,074...82,052,232
Ensembl chr 9:82,035,967...82,052,166 		JBrowse link
G LOC103216393 paired box protein Pax-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16631587 NCBI chr 9:93,763,975...93,847,180 JBrowse link
G LOC103217855 C-X-C chemokine receptor type 2 ISO DNA:polymorphism: :1208C>T (human) RGD PMID:23615182 RGD:7257672 NCBI chr10:104,012,906...104,025,599
Ensembl chr10:104,022,811...104,023,893 		JBrowse link
G LOC103218526 carbonyl reductase [NADPH] 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26282591 NCBI chr 2:80,096,743...80,099,982 JBrowse link
G LOC103223672 low affinity immunoglobulin gamma Fc region receptor II-b ISO RGD PMID:15266033 RGD:7240530 NCBI chr20:2,398,425...2,413,328 JBrowse link
G LOC103224275 glutathione S-transferase Mu 1 ISO RGD PMID:24339523 RGD:14700960 NCBI chr20:23,854,969...23,861,634 JBrowse link
G LOC103233451 cytochrome b-245 light chain ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19420110 RGD:2306994 NCBI chr 5:74,023,134...74,030,793
Ensembl chr 5:74,023,082...74,030,750 		JBrowse link
G LOC103242767 C-C motif chemokine 3 ISO RGD PMID:22613545 RGD:7175169 NCBI chr16:29,887,799...29,897,664
Ensembl chr16:29,887,883...29,897,544 		JBrowse link
G LOC103246766 cytochrome P450 3A8 ISO mRNA, protein:decreased expression:intestine RGD PMID:12039987 RGD:7296923 NCBI chr28:13,297,566...13,330,023 JBrowse link
G LPIN1 lipin 1 ISO mRNA:increased expression:skeletal muscle RGD PMID:14718385 RGD:1641826 NCBI chr14:95,777,976...95,926,420
Ensembl chr14:95,780,478...95,926,419 		JBrowse link
G LPL lipoprotein lipase ISO RGD PMID:22009636 RGD:6909179 NCBI chr 8:18,009,049...18,038,315
Ensembl chr 8:18,009,093...18,038,598 		JBrowse link
G LRP2 LDL receptor related protein 2 ISO mRNA:decreased expression:kidney RGD PMID:15266031 RGD:1641836 NCBI chr10:54,672,876...54,889,374
Ensembl chr10:54,711,517...54,889,208 		JBrowse link
G MBL2 mannose binding lectin 2 ISO associated with Lupus Erythematosus, Systemic;DNA:polymorphisms RGD PMID:16801331 RGD:6903261 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G MLXIPL MLX interacting protein like ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr28:9,442,520...9,465,772 JBrowse link
G MMP1 matrix metallopeptidase 1 severity
no_association		 ISO DNA:insertion, haplotype:promoter:g.-1607insG (human)
DNA:insertion:promoter:g.-1607insG (human)		 RGD PMID:19221176 PMID:22401717 RGD:7206856 RGD:7207064 NCBI chr 1:94,167,507...94,177,357
Ensembl chr 1:94,167,219...94,176,767 		JBrowse link
G MMP10 matrix metallopeptidase 10 ISO associated with Hypertension; protein:increased expression:plasma (human) RGD PMID:19886850 RGD:7207051 NCBI chr 1:94,147,995...94,158,315
Ensembl chr 1:94,148,087...94,158,097 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO associated with Hypertension; protein:increased expression:plasma (human) RGD PMID:19886850 RGD:7207051 NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004 		JBrowse link
G MMP3 matrix metallopeptidase 3 severity ISO DNA:insertion, haplotype:promoter:g.-1613insA (human) RGD PMID:19221176 RGD:7207064 NCBI chr 1:94,216,156...94,224,437
Ensembl chr 1:94,216,173...94,224,264 		JBrowse link
G MPO myeloperoxidase disease_progression ISO RGD PMID:20638167 RGD:6909184 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G MSC musculin susceptibility ISO associated with type 1 diabetes mellitus;DNA:SNP:5'UTR:rs9298190(human) RGD PMID:19929986 RGD:596936222 NCBI chr 8:67,521,052...67,523,952
Ensembl chr 8:67,520,970...67,523,833 		JBrowse link
G MSR1 macrophage scavenger receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 NCBI chr 8:14,221,389...14,305,059
Ensembl chr 8:14,220,529...14,304,946 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase no_association
severity
susceptibility		 ISO DNA:transition:cds:g.677C>T (human)
associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human)
DNA:SNP: :677C>T(human)
DNA:transition, transversion:cds:g.677C>T, g.1298A>C (human)
DNA:transitions, transversion, haplotype:cds:g.677C>T, g.1298A>C, g.1793G>A (human)		 RGD PMID:14737040 PMID:17899317 PMID:19520069 PMID:19520684 PMID:25664255 RGD:14696732 RGD:6893522 RGD:6893523 RGD:6893524 RGD:6893579 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO RGD PMID:22427849 RGD:10040968 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020 		JBrowse link
G MYH9 myosin heavy chain 9 ISO associated with hypertension;DNA:polymorphisms:multiple:
associated with diabetes mellitus,type 2;DNA:SNPs: :
associated with hypertension, glomerulosclerosis, focal segmental;DNA:SNPs: :rs4821480, rs2032487, rs4821481(human)
CTD Direct Evidence: marker/mechanism
associated with diabetes mellitus, type 2;DNA:SNPs: :
DNA:SNPs:multiple:		 RGD
CTD		 PMID:18794854 PMID:18794856 PMID:19177153 PMID:19567477 PMID:20144966 More... RGD:6903237 RGD:6903238 RGD:6903239 RGD:6903243 RGD:6903256 NCBI chr19:18,985,709...19,093,304
Ensembl chr19:18,986,598...19,052,671 		JBrowse link
G NAT2 N-acetyltransferase 2 ISO mRNA,protein:decreased expression:liver: RGD PMID:20007296 RGD:11533637 NCBI chr 8:16,451,144...16,494,961
Ensembl chr 8:16,493,749...16,494,621 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr28:8,334,172...8,349,828
Ensembl chr28:8,332,772...8,349,804 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr 7:50,589,494...50,711,472
Ensembl chr 7:50,589,856...50,711,498 		JBrowse link
G NGF nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19169037 PMID:24244623 RGD:7242783 NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833 		JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO protein:decreased expression:kidney cortex RGD PMID:17200156 PMID:23185775 RGD:1642147 RGD:7257669 NCBI chr11:112,642,374...112,673,882 JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility ISO DNA:duplication, snp:intron, cds:g.IVS4?-?+27, p.E298D (human)
protein:decreased expression:glomerulus		 RGD PMID:12701818 PMID:18089446 RGD:2292109 RGD:7777097 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NOX4 NADPH oxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr 1:80,470,418...80,642,513
Ensembl chr 1:80,470,826...80,642,722 		JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin disease_progression ISO mRNA;increased expression:urine (rat) RGD PMID:19389856 RGD:38599006 NCBI chr 6:30,736,869...30,763,054
Ensembl chr 6:30,736,966...30,762,929 		JBrowse link
G NPPB natriuretic peptide B ISO protein:increased expression:plasma: RGD PMID:7606877 RGD:7246912 NCBI chr20:119,930,931...119,933,391
Ensembl chr20:119,932,021...119,933,197 		JBrowse link
G NPPC natriuretic peptide C ISO protein:increased expression:plasma
protein:increased expression:plasma (human)		 RGD PMID:8117275 PMID:8743538 RGD:1580770 RGD:1642297 NCBI chr10:117,919,889...117,924,306
Ensembl chr10:117,919,760...117,924,273 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:18591458 RGD:7174716 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:12661921 RGD:1580992 NCBI chr11:10,033,708...10,048,332
Ensembl chr11:10,033,635...10,048,256 		JBrowse link
G PGF placental growth factor ISO RGD PMID:16543713 RGD:1642390 NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 NCBI chr 5:1,985,165...2,031,518
Ensembl chr 5:1,983,632...2,015,551 		JBrowse link
G PLA2G7 phospholipase A2 group VII ISO plasma:increased expression:plasma RGD PMID:16421163 RGD:7248787 NCBI chr17:25,538,645...25,571,230
Ensembl chr17:25,538,438...25,574,269 		JBrowse link
G PLAU plasminogen activator, urokinase severity
treatment		 ISO protein:increased expression:plasma (human)
protein:increased expression, increased activity:kidney (rat)		 RGD PMID:15506291 PMID:17869326 PMID:19926968 PMID:22683425 RGD:6483806 RGD:7241081 RGD:7241218 RGD:7241279 NCBI chr 9:57,452,904...57,459,345
Ensembl chr 9:57,452,761...57,459,286 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:19926968 RGD:6483806 NCBI chr 6:37,161,957...37,191,867 JBrowse link
G POSTN periostin ISO mRNA,protein:increased expression,increased secretion:kidney,urine: RGD PMID:22167593 RGD:10040972 NCBI chr 3:16,060,013...16,095,867
Ensembl chr 3:16,059,965...16,095,791 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707
G PPARG peroxisome proliferator activated receptor gamma disease_progression ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:SNP: :p.P12A (human) RGD PMID:18467141 RGD:2301857 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G PTGER4 prostaglandin E receptor 4 treatment ISO RGD PMID:16871242 RGD:10003092 NCBI chr 4:39,440,697...39,453,983
Ensembl chr 4:39,440,276...39,454,004 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G PTH parathyroid hormone severity ISO protein:increased expression:serum (rat)
protein:increased expression:serum (human)		 RGD PMID:23243213 PMID:23548814 RGD:7242564 RGD:7242692 NCBI chr 1:51,327,555...51,330,810 JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney		 CTD
RGD		 PMID:18077597 PMID:19420110 RGD:2298859 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516 		JBrowse link
G RETN resistin severity ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum		 CTD
RGD		 PMID:19539174 PMID:22421264 RGD:7207074 NCBI chr 6:7,154,771...7,156,459
Ensembl chr 6:7,155,337...7,156,505 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 9:81,725,115...82,029,361 JBrowse link
G SCAF1 SR-related CTD associated factor 1 ISO protein:increased expression:kidney (rat) RGD PMID:19878707 RGD:2326081 NCBI chr 6:42,815,865...42,834,353
Ensembl chr 6:42,820,350...42,834,111 		JBrowse link
G SCAP SREBF chaperone multiple interactions ISO RGD PMID:19878707 RGD:2326081 NCBI chr22:8,821,809...8,887,538
Ensembl chr22:8,818,980...8,850,202 		JBrowse link
G SCARB1 scavenger receptor class B member 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr11:120,134,485...120,223,512
Ensembl chr11:120,134,874...120,216,904 		JBrowse link
G SELL selectin L no_association ISO RGD PMID:22119815 RGD:7175303 NCBI chr25:59,345,080...59,365,684
Ensembl chr25:59,345,069...59,366,946 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19420110 PMID:26903149 RGD:11073683 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO protein:decreased expression:kidney, plasma membrane RGD PMID:12110012 PMID:23280877 RGD:7243177 RGD:7243883 NCBI chr13:87,835,077...87,881,410
Ensembl chr13:87,833,430...87,881,081 		JBrowse link
G SLC34A1 solute carrier family 34 member 1 ISO mRNA:decreased expression:renal cortex (rat) RGD PMID:15452708 RGD:7242930 NCBI chr23:79,395,923...79,410,835
Ensembl chr23:79,396,250...79,411,695 		JBrowse link
G SLC9A5 solute carrier family 9 member A5 resistance ISO DNA:polymorphism RGD PMID:10642288 RGD:1643221 NCBI chr 5:60,181,229...60,207,913
Ensembl chr 5:60,182,190...60,206,523 		JBrowse link
G SOAT2 sterol O-acyltransferase 2 ISO RGD PMID:12217884 RGD:625687 NCBI chr11:49,214,295...49,228,268
Ensembl chr11:49,215,034...49,228,244 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 ISO mRNA, protein:increased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16814791 PMID:19878707 RGD:2308825 NCBI chr19:24,364,725...24,439,851
Ensembl chr19:24,364,911...24,440,014 		JBrowse link
G TBX21 T-box transcription factor 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26970513 NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:kidney		 CTD
RGD		 PMID:10919844 PMID:19420110 RGD:7394838 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G THBD thrombomodulin ISO protein:increased expression:plasma RGD PMID:21873362 PMID:22129968 RGD:5684979 RGD:5684981 NCBI chr 2:52,041,950...52,045,946
Ensembl chr 2:52,043,746...52,045,626 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:20729266 RGD:7240546 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:20729266 RGD:7240546 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TNF tumor necrosis factor ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19539174 PMID:22266663 RGD:7245510
G TNFRSF11B TNF receptor superfamily member 11b severity ISO RGD PMID:21479768 RGD:7205485 NCBI chr 8:113,520,711...113,549,370
Ensembl chr 8:113,520,596...113,548,936 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:22266663 RGD:7245510 NCBI chr11:6,364,544...6,378,880
Ensembl chr11:6,364,330...6,378,902 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:22266663 RGD:7245510 NCBI chr20:119,590,621...119,633,562
Ensembl chr20:119,590,325...119,633,497 		JBrowse link
G UCP2 uncoupling protein 2 susceptibility ISO DNA:polymorphism: :-866G>A (human)
DNA:deletion		 RGD PMID:18242170 PMID:19406964 RGD:7175298 RGD:7175299 NCBI chr 1:65,238,311...65,246,841
Ensembl chr 1:65,235,775...65,246,450 		JBrowse link
G VWF von Willebrand factor disease_progression
treatment		 ISO protein:increased oxidation:plasma RGD PMID:21378155 PMID:22091998 PMID:22189209 RGD:7205641 RGD:7205646 RGD:7205649 NCBI chr11:5,994,499...6,176,949
Ensembl chr11:5,994,039...6,162,260 		JBrowse link
G ZMIZ1 zinc finger MIZ-type containing 1 susceptibility ISO associated with type 1 diabetes mellitus;DNA:SNP:5'UTR:rs1749824(human) RGD PMID:19929986 RGD:596936222 NCBI chr 9:52,150,810...52,414,793
Ensembl chr 9:52,148,075...52,259,728 		JBrowse link
Frasier syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WT1 WT1 transcription factor ISO ClinVar Annotator: match by term: Frasier syndrome OMIM
ClinVar		 PMID:1302008 PMID:1327525 PMID:1338906 PMID:1655284 PMID:1658787 More... NCBI chr 1:32,750,300...32,801,832 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15416
    disease of anatomical entity 15079
      Urogenital Diseases 4823
        urinary system disease 2365
          kidney disease 2130
            kidney failure 500
              chronic kidney disease 245
                end stage renal disease + 170
paths to the root