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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:chronic kidney disease
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Accession:DOID:784 term browser browse the term
Definition:A kidney failure that is characterized by the gradual loss of kidney function. (DO)
Synonyms:exact_synonym: CKD;   CRF;   chronic kidney diseases;   chronic kidney insufficiencies;   chronic kidney insufficiency;   chronic renal disease;   chronic renal diseases;   chronic renal failure;   chronic renal failure syndrome;   chronic renal insufficiencies;   chronic renal insufficiency
 narrow_synonym: congenital chronic kidney disease
 primary_id: MESH:D051436
 xref: EFO:0003884;   EFO:0021433;   ICD10CM:N18.9;   NCI:C80078;   NCI:C9438
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
chronic kidney disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN4 actinin alpha 4 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr19:35,742,758...35,825,321
Ensembl chr19:44,313,569...44,395,508 		JBrowse link
G AGER advanced glycosylation end-product specific receptor disease_progression
severity
susceptibility		 ISO DNA:polymorphism:promoter:g.-374T>A (human)
DNA:polymorphisms:promoter, intron:g.-429T>C, g.2184A>G (human)
associated with Diabetes Mellitus, Type 2; DNA:polymorphism:promoter:g.-429T>C (human)
protein:increased expression:serum (human)		 RGD PMID:20185929 PMID:20353610 PMID:21432860 PMID:21822023 PMID:23593165 RGD:7242570 RGD:7243185 RGD:7243867 RGD:7243958 RGD:7244142 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AGTR1 angiotensin II receptor type 1 disease_progression ISO DNA:polymorphism:3' utr:1166A>C (human) RGD PMID:12089373 PMID:12832734 RGD:6903863 RGD:8548869 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:12089373 RGD:6903863 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685 		JBrowse link
G AHR aryl hydrocarbon receptor ISO mRNA, protein:increased expression:heart (mouse) RGD PMID:31746392 RGD:401793746 NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 susceptibility ISO DNA:polymorphism: :rs756009(human) RGD PMID:19724895 RGD:14349027 NCBI chr 6:149,058,350...149,176,710
Ensembl chr 6:153,757,081...153,873,925 		JBrowse link
G ANLN anillin, actin binding protein ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 7:37,011,518...37,075,349
Ensembl chr 7:37,243,917...37,304,137 		JBrowse link
G APOA1 apolipoprotein A1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G APOA4 apolipoprotein A4 disease_progression ISO protein:increased expression:blood plasma (human) RGD PMID:21569504 RGD:5685637 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382 		JBrowse link
G APOC3 apolipoprotein C3 ISO protein:increased expression:plasma RGD PMID:21297177 PMID:21829457 RGD:7207207 RGD:7207209 NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460 		JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr17:76,273,196...76,276,942
Ensembl chr17:81,975,340...81,978,447 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr2B:102,574,700...102,612,492
Ensembl chr2B:221,159,439...221,197,360 		JBrowse link
G AXDND1 axonemal dynein light chain domain containing 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:8589695 PMID:10742096 PMID:11805166 PMID:15253708 PMID:15327385 More... NCBI chr 1:154,847,978...155,043,339
Ensembl chr 1:158,536,967...158,724,251 		JBrowse link
G B2M beta-2-microglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:37921072 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991 		JBrowse link
G CFH complement factor H ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521 		JBrowse link
G CFHR5 complement factor H related 5 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:17000000 PMID:22503529 PMID:22527104 PMID:24033266 PMID:25260719 More... NCBI chr 1:172,541,948...172,574,591
Ensembl chr 1:176,876,635...176,908,723 		JBrowse link
G CFI complement factor I ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:17084897 PMID:20301541 PMID:25741868 PMID:28492532 NCBI chr 4:102,236,868...102,311,359
Ensembl chr 4:112,804,645...112,865,581 		JBrowse link
G CLU clusterin ISO associated with Obesity;protein:increased expression:urine RGD PMID:24325231 RGD:9068427 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529 		JBrowse link
G COL4A3 collagen type IV alpha 3 chain ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:14871398 PMID:17216251 PMID:24033266 PMID:24854265 PMID:25741868 More... NCBI chr2B:114,410,703...114,559,336
Ensembl chr2B:233,294,783...233,371,021 		JBrowse link
G COL4A4 collagen type IV alpha 4 chain ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:12028435 PMID:12325029 PMID:12631110 PMID:16467446 PMID:17942953 More... NCBI chr2B:114,227,135...114,410,564
Ensembl chr2B:233,065,678...233,205,892 		JBrowse link
G COL6A3 collagen type VI alpha 3 chain ISO DNA:SNP:CDS:E1386K (rs146092501) (human) RGD PMID:30226566 RGD:401851058 NCBI chr2B:124,554,478...124,644,482 JBrowse link
G CPB2 carboxypeptidase B2 ISO DNA:polymorphism:cds :p.A147T(rs3742264)(human) RGD PMID:19056482 RGD:7243119 NCBI chr13:26,926,788...26,979,767 JBrowse link
G CST3 cystatin C ISO CTD Direct Evidence: marker/mechanism CTD PMID:32450046 NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425 		JBrowse link
G CUBN cubilin ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:15024727 PMID:22929189 PMID:24033266 PMID:25349199 PMID:25741868 More... NCBI chr10:17,141,464...17,446,867
Ensembl chr10:17,415,551...17,719,129 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 ISO mRNA, protein:increased expression:heart (mouse) RGD PMID:31746392 RGD:401793746 NCBI chr2A:38,087,863...38,096,529
Ensembl chr2A:38,851,000...38,859,824 		JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 ISO protein:decreased expression:liver: RGD PMID:23045433 RGD:10400847 NCBI chr 8:141,079,948...141,090,619
Ensembl chr 8:144,064,587...144,080,155 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 ISO protein:decreased expression:liver: RGD PMID:23045433 RGD:10400847 NCBI chr11:70,824,791...70,857,530
Ensembl chr11:74,126,169...74,158,854 		JBrowse link
G DNM1L dynamin 1 like treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr12:53,476,553...53,541,421
Ensembl chr12:56,077,504...56,142,376 		JBrowse link
G DSTYK dual serine/threonine and tyrosine protein kinase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:180,750,987...180,820,096
Ensembl chr 1:185,041,994...185,107,041 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 3:182,228,520...182,319,339
Ensembl chr 3:190,704,695...190,796,075 		JBrowse link
G ETFB electron transfer flavoprotein subunit beta ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:24215330 PMID:25741868 PMID:28492532 NCBI chr19:48,281,101...48,301,527
Ensembl chr19:57,166,829...57,175,582 		JBrowse link
G FGF21 fibroblast growth factor 21 ISO protein:increased expression:serum: RGD PMID:22494291 RGD:10401925 NCBI chr19:45,755,466...45,758,472 JBrowse link
G FGF23 fibroblast growth factor 23 ISO protein:increased expression:serum: RGD PMID:20016468 RGD:10044210 NCBI chr12:4,479,116...4,488,797
Ensembl chr12:4,400,802...4,412,000 		JBrowse link
G FIS1 fission, mitochondrial 1 treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683 		JBrowse link
G FN1 fibronectin 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003 		JBrowse link
G FREM1 FRAS1 related extracellular matrix 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 9:14,567,781...14,748,474
Ensembl chr 9:15,081,208...15,253,399 		JBrowse link
G GANAB glucosidase II alpha subunit ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr11:57,982,393...58,003,871
Ensembl chr11:61,336,487...61,357,908 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32045570 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha exacerbates ISO RGD PMID:11314805 RGD:42722629 NCBI chr17:4,980,083...4,983,219 JBrowse link
G GPX1 glutathione peroxidase 1 treatment ISO DNA:SNP: :rs17080528 (human) RGD PMID:15954914 PMID:31924810 RGD:11352759 RGD:401827826 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826 		JBrowse link
G GRP gastrin releasing peptide ISO mRNA, protein:increased expression:aorta, plasma (human) RGD PMID:32192106 RGD:329961569 NCBI chr18:52,614,169...52,626,427
Ensembl chr18:55,942,263...55,953,188 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO RGD PMID:22269876 RGD:7245952 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO mRNA, protein:increased expression:liver RGD PMID:12841361 RGD:1300058 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G IL19 interleukin 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24714768 NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748 		JBrowse link
G IL1B interleukin 1 beta ISO protein:decreased expression:serum (human)
mRNA:increased expression:kidney (mouse)
associated with Periodontitis; DNA:SNP:intron:g.3954C>T (human)		 RGD PMID:21975861 PMID:22398717 PMID:22613545 PMID:22728154 PMID:22795294 RGD:6906881 RGD:7175095 RGD:7175169 RGD:7175171 RGD:7175304 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility ISO protein:increased expression:plasma (human)
DNA:repeats:intron:IVS2+914_1000dup IL1RN*1 (human)		 RGD PMID:22795294 PMID:23024164 RGD:6906880 RGD:6906881 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G INF2 inverted formin 2 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr14:85,339,478...85,366,336
Ensembl chr14:105,145,779...105,163,154 		JBrowse link
G INSR insulin receptor ISO protein:decreased phosphorylation:aorta RGD PMID:22942179 RGD:7207055 NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889 		JBrowse link
G KL klotho disease_progression
treatment		 ISO protein:decreased expression:urine:
mRNA,protein:decreased expression:renal tubule, epithelial cell:		 RGD PMID:11967236 PMID:21115613 RGD:10403077 RGD:70544 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458 		JBrowse link
G KLK1 kallikrein 1 susceptibility ISO associated with Vesico-Ureteral Reflux RGD PMID:15086490 RGD:1581752 NCBI chr19:47,784,368...47,789,004
Ensembl chr19:56,677,579...56,682,216 		JBrowse link
G LCN2 lipocalin 2 disease_progression ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20921623 PMID:24714768 RGD:126781837 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G LEPR leptin receptor ISO RGD PMID:27465994 PMID:32390513 RGD:12911217 RGD:34888223 NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768 		JBrowse link
G LOC100980965 zinc-alpha-2-glycoprotein ISO protein:increased expression:plasma,white adipose tissue:
protein:increased expression:white adipose tissue:		 RGD PMID:23423258 RGD:153352319 NCBI chr 7:91,999,717...92,009,066
Ensembl chr 7:105,432,782...105,442,219 		JBrowse link
G LOC100986475 metallothionein-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27122239 NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO protein:increased expression:aorta (rat) RGD PMID:32581266 RGD:155804294 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor treatment ISO RGD PMID:24614509 RGD:401793742 NCBI chr 6:157,774,098...157,799,983
Ensembl chr 6:162,801,416...162,802,393 		JBrowse link
G MFN1 mitofusin 1 treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO DNA:polymorphism:cds:g.677C>T (human) RGD PMID:23595572 RGD:7244284 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MYH9 myosin heavy chain 9 no_association ISO RGD PMID:22956460 RGD:12798515 NCBI chr22:17,200,623...17,305,826
Ensembl chr22:35,039,101...35,121,618 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:23174956 RGD:10412711 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NGF nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:24244623 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NHERF1 NHERF family PDZ scaffold protein 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:18784102 PMID:25741868 PMID:28492532 NCBI chr17:68,694,468...68,715,157
Ensembl chr17:74,250,406...74,271,234 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment
susceptibility		 ISO mRNA:decreased expression:cortex of kidney (rat) RGD PMID:29018182 PMID:29247650 RGD:13450920 RGD:13504713 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin severity
treatment		 ISO mRNA:increased expression:urine (human)
human cells in rat model		 RGD PMID:30133147 PMID:33298161 RGD:155631310 RGD:38549368 NCBI chr19:32,742,802...32,770,600
Ensembl chr19:41,492,444...41,518,471 		JBrowse link
G NPHS2 NPHS2 stomatin family member, podocin ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:8589695 PMID:10742096 PMID:11729243 PMID:11805166 PMID:11854170 More... NCBI chr 1:155,038,753...155,064,332 JBrowse link
G NPPA natriuretic peptide A disease_progression ISO protein:increased expression:plasma RGD PMID:19052536 RGD:7247723 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NPPB natriuretic peptide B disease_progression ISO RGD PMID:23725445 RGD:7246908 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:22227174 RGD:10769366 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 disease_progression ISO RGD PMID:24722447 RGD:12910103 NCBI chr12:36,703,903...36,740,211
Ensembl chr12:37,480,300...37,501,188 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase treatment ISO RGD PMID:27801955 RGD:12738369 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358 		JBrowse link
G PASK PAS domain containing serine/threonine kinase ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr2B:128,364,745...128,418,837
Ensembl chr2B:247,162,011...247,214,803 		JBrowse link
G PAX2 paired box 2 treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr10:97,344,978...97,429,086
Ensembl chr10:100,822,676...100,904,028 		JBrowse link
G PCSK2 proprotein convertase subtilisin/kexin type 2 ISO RGD PMID:18039782 RGD:6483556 NCBI chr20:17,184,878...17,443,355
Ensembl chr20:17,163,675...17,421,157 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr16:604,366...605,560 JBrowse link
G POSTN periostin ISO protein:increased expression:kidney:
protein:increased secretion:urine:		 RGD PMID:22167593 PMID:22403621 RGD:10040972 RGD:10041032 NCBI chr13:18,779,297...18,815,207
Ensembl chr13:37,368,030...37,407,212 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:22648295 RGD:7242023 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212 		JBrowse link
G PTH parathyroid hormone treatment
severity		 ISO associated with Diabetes Mellitus, Type 2; protein:increased expression:serum (human)
protein:decreased expression:plasma (rat)		 RGD PMID:21826734 PMID:22517117 PMID:23345625 PMID:23467111 PMID:23528898 RGD:7242412 RGD:7242418 RGD:7242572 RGD:7242935 RGD:7242949 NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802 		JBrowse link
G RBP4 retinol binding protein 4 onset ISO associated with type 2 diabetes mellitus; protein:increased expression:blood serum (human) RGD PMID:21817822 RGD:329853323 NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887 		JBrowse link
G RETN resistin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22421264 NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO protein, activity:decreased expression:plasma, heart, kidney: RGD PMID:18299506 RGD:7327164 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
G RTN3 reticulon 3 ISO MouseDO NCBI chr11:59,039,313...59,117,572
Ensembl chr11:62,391,284...62,468,595 		JBrowse link
G SALL1 spalt like transcription factor 1 treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr16:31,396,399...31,412,753
Ensembl chr16:50,274,090...50,284,819 		JBrowse link
G SERPINA3 serpin family A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35635602 NCBI chr14:75,220,252...75,247,996
Ensembl chr14:94,551,934...94,579,515 		JBrowse link
G SHH sonic hedgehog signaling molecule ISO mRNA, protein:increased expression:kidney RGD PMID:24744439 RGD:12859042 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
G SIX2 SIX homeobox 2 treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr2A:45,109,414...45,113,887
Ensembl chr2A:46,039,582...46,044,035 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO mRNA:decreased expression:multiple (rat) RGD PMID:21149507 RGD:7327184 NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752 		JBrowse link
G SLC19A2 solute carrier family 19 member 2 ISO mRNA:decreased expression:liver, heart (rat) RGD PMID:21149507 RGD:7327184 NCBI chr 1:144,946,248...144,968,736
Ensembl chr 1:148,668,687...148,690,713 		JBrowse link
G SLC19A3 solute carrier family 19 member 3 ISO mRNA:decreased expression:liver, heart, jejunum (rat) RGD PMID:21149507 RGD:7327184 NCBI chr2B:114,925,990...114,957,841
Ensembl chr2B:233,736,050...233,764,514 		JBrowse link
G SLC34A1 solute carrier family 34 member 1 ISO DNA:snp:intron:IVS9+122A>G rs6420094 (human)
mRNA:decreased expression:kidney (rat)		 RGD PMID:20383146 PMID:21826734 RGD:7242935 RGD:7243100 NCBI chr 5:172,685,862...172,700,440
Ensembl chr 5:179,748,492...179,762,975 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO mRNA:decreased expression:liver, heart, jejunum (rat) RGD PMID:21149507 RGD:7327184 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
G SYNPO synaptopodin treatment ISO human cells in rat model RGD PMID:33298161 RGD:155631310 NCBI chr 5:146,048,956...146,083,490
Ensembl chr 5:152,046,207...152,085,595 		JBrowse link
G TBX18 T-box transcription factor 18 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr 6:82,621,987...82,654,137
Ensembl chr 6:85,862,810...85,938,799 		JBrowse link
G TERT telomerase reverse transcriptase treatment ISO RGD PMID:23013219 RGD:11038770 Ensembl chr 5:1,300,960...1,338,872 JBrowse link
G TFCP2L1 transcription factor CP2 like 1 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:33097957 NCBI chr2B:8,155,839...8,219,017
Ensembl chr2B:121,729,061...121,792,281 		JBrowse link
G TTC21B tetratricopeptide repeat domain 21B ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr2B:53,140,199...53,220,535
Ensembl chr2B:170,616,444...170,699,471 		JBrowse link
G UMOD uromodulin ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 NCBI chr16:17,960,456...17,980,338
Ensembl chr16:20,430,085...20,449,121 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO protein:increased expression:serum:
protein:increased expression:kidney		 RGD PMID:20820841 PMID:21111939 RGD:4145364 RGD:7241036 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732 		JBrowse link
G WNT9B Wnt family member 9B ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:34145744 NCBI chr17:10,616,957...10,651,954 JBrowse link
G WT1 WT1 transcription factor treatment ISO ClinVar Annotator: match by term: Chronic kidney disease
human cells in rat model		 ClinVar
RGD		 PMID:25741868 PMID:33298161 RGD:155631310 NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249 		JBrowse link
G XDH xanthine dehydrogenase treatment ISO associated with Hypertension;DNA:SNP: :66292C>G (human) RGD PMID:18712049 PMID:22622455 RGD:7247640 RGD:7247654 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
G ZNF423 zinc finger protein 423 ISO ClinVar Annotator: match by term: Chronic kidney disease ClinVar PMID:25741868 PMID:28492532 PMID:32723786 NCBI chr16:29,748,405...30,118,999
Ensembl chr16:48,639,118...48,969,727 		JBrowse link
end stage renal disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr 9:75,948,831...76,096,136
Ensembl chr 9:104,076,516...104,224,188 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:17135344 RGD:2301067 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO RGD PMID:17135344 RGD:2301067 NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO protein:decreased expression:intestine RGD PMID:17135344 RGD:2301067 Ensembl chr17:49,603,268...49,659,318 JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney (rat)		 CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr21:28,534,697...28,619,590
Ensembl chr21:41,839,115...41,933,050 		JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 ISO protein:increased expression:kidney (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19878707 RGD:2326081 NCBI chr11:103,008,564...103,034,697
Ensembl chr11:106,483,563...106,509,787 		JBrowse link
G ACE angiotensin I converting enzyme treatment
susceptibility		 ISO associated with Vesico-Ureteral Reflux;DNA:deletion
associated with Diabetes Mellitus, Type 2;DNA:deletion:intron:IVS16+1464-1751del (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:7593601 PMID:10099885 PMID:14586729 PMID:16385653 PMID:20149750 RGD:12879398 RGD:6903283 RGD:8142355 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum, urine		 CTD
RGD		 PMID:19539174 PMID:24028144 RGD:8695941 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G ADIPOR1 adiponectin receptor 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19539174 PMID:24028144 RGD:8695941 NCBI chr 1:178,542,496...178,560,055
Ensembl chr 1:182,837,589...182,854,782 		JBrowse link
G ADIPOR2 adiponectin receptor 2 ISO RGD PMID:24028144 RGD:8695941 NCBI chr12:1,772,426...1,902,070
Ensembl chr12:1,817,620...1,852,251 		JBrowse link
G ADRB2 adrenoceptor beta 2 ISO RGD PMID:9730702 RGD:7175286 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO protein:increased expression:serum (human) RGD PMID:21822023 RGD:7243867 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO associated with Vesico-Ureteral Reflux;DNA:SNP: :-1332A>G (human) RGD PMID:19212419 PMID:20149750 RGD:6903283 RGD:6903843 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685 		JBrowse link
G ALB albumin disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11849406 PMID:11938814 RGD:11036089 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALMS1 ALMS1 centrosome and basal body associated protein ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:17594715 PMID:24462884 PMID:25296579 PMID:25741868 PMID:26066530 More... NCBI chr2A:73,438,657...73,671,313
Ensembl chr2A:74,926,650...75,152,139 		JBrowse link
G APOA1 apolipoprotein A1 treatment ISO associated with Hyperlipidemias
protein:decreased expression:blood
protein:increased expression, increased glycation:plasma		 RGD PMID:18079481 PMID:20488818 PMID:22515595 RGD:7241208 RGD:7241571 RGD:7241576 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G APOC2 apolipoprotein C2 ISO associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:8139482 RGD:2313968 NCBI chr19:41,892,954...41,896,461 JBrowse link
G APOC3 apolipoprotein C3 ISO protein:increased expression: :
associated with Diabetes Mellitus, Insulin-Dependent		 RGD PMID:8139482 PMID:10822722 RGD:2313968 RGD:7207212 NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460 		JBrowse link
G APOE apolipoprotein E ISO protein:increased expression:serum (human) RGD PMID:21332332 PMID:21705678 RGD:6903287 RGD:6904217 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G ARG2 arginase 2 ISO protein:decreased activity:kidney (rat) RGD PMID:16809898 RGD:4110828 NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:20424483 RGD:11522730 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BDKRB1 bradykinin receptor B1 resistance
no_association		 ISO DNA: SNP: G-699-->C
DNA: SNP: G(-699)C		 RGD PMID:9555662 PMID:10604543 PMID:10809796 RGD:7241560 RGD:7241561 RGD:7241582 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BECN1 beclin 1 ISO protein:increased expression:kidney RGD PMID:24090408 RGD:11561926 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein ISO protein:increased expression:serum RGD PMID:17365904 PMID:20845051 RGD:7207235 RGD:7207409 NCBI chr 1:131,583,789...131,586,459
Ensembl chr 1:135,413,871...135,416,432 		JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO protein:increased expression:kidney RGD PMID:24090408 RGD:11561926 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634 		JBrowse link
G C6 complement C6 severity ISO RGD PMID:11912252 RGD:1600675 NCBI chr 5:69,174,411...69,245,801
Ensembl chr 5:74,216,244...74,288,588 		JBrowse link
G CASR calcium sensing receptor ISO protein:decreased expression:epigastric artery (human) RGD PMID:17537980 RGD:7205455 NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism
protein: decreased expression :kidney		 CTD
RGD		 PMID:16518626 PMID:19420110 PMID:20007347 RGD:6892947 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CBR1 carbonyl reductase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26282591 NCBI chr21:22,440,726...22,443,950
Ensembl chr21:35,800,177...35,803,458 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment
susceptibility		 ISO protein:increased expression:renal proximal tubule (rat)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-2518A>G (human)		 RGD
CTD		 PMID:12080327 PMID:17982227 PMID:18797164 PMID:19420110 PMID:19539174 RGD:2306990 RGD:2307007 RGD:8549739 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:kidney cortex (rat) RGD PMID:19535570 RGD:4889989 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO associated with Candidiasis, Invasive; RGD PMID:22916017 RGD:7241817 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:kidney cortex (rat) RGD PMID:19535570 RGD:4889989 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CD2AP CD2 associated protein ISO MouseDO NCBI chr 6:47,065,284...47,210,746
Ensembl chr 6:48,328,863...48,474,163 		JBrowse link
G CD40 CD40 molecule severity
treatment		 ISO protein:increased expression:plasma RGD PMID:12941150 PMID:20846521 RGD:7248709 RGD:7248723 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:plasma RGD PMID:19019166 RGD:7248427 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CD68 CD68 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19539174 NCBI chr17:7,610,725...7,613,696
Ensembl chr17:7,596,947...7,599,981 		JBrowse link
G CFB complement factor B severity ISO RGD PMID:1837062 PMID:17522263 RGD:7242704 RGD:7242753 NCBI chr 6:31,606,716...31,612,782 JBrowse link
G CHGA chromogranin A ISO associated with Hypertension;DNA:polymorphisms, haplotypes:promoter, 3' utr:multiple
protein:increased expression:serum		 RGD PMID:18235090 PMID:20730520 RGD:6906898 RGD:6906903 NCBI chr14:73,555,834...73,568,547
Ensembl chr14:92,895,450...92,908,159 		JBrowse link
G COL1A1 collagen type I alpha 1 chain ISO RGD PMID:25782334 RGD:11041185 NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677 		JBrowse link
G COL3A1 collagen type III alpha 1 chain ISO DNA:polymorphism: :p.I1205V (human) RGD PMID:19424605 RGD:7257553 NCBI chr2B:76,285,115...76,322,703
Ensembl chr2B:194,204,613...194,242,956 		JBrowse link
G COL4A3 collagen type IV alpha 3 chain ISO RGD PMID:19357112 RGD:7242047 NCBI chr2B:114,410,703...114,559,336
Ensembl chr2B:233,294,783...233,371,021 		JBrowse link
G COL4A4 collagen type IV alpha 4 chain ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr2B:114,227,135...114,410,564
Ensembl chr2B:233,065,678...233,205,892 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:kidney (rat)		 CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr11:63,841,028...63,928,242
Ensembl chr11:67,144,736...67,205,481 		JBrowse link
G CRP C-reactive protein disease_progression ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19539174 PMID:22865783 RGD:6906886 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CSF1 colony stimulating factor 1 ISO protein:increased expression:plasma RGD PMID:11340249 RGD:7257586 NCBI chr 1:112,555,755...112,575,894
Ensembl chr 1:127,764,916...127,781,943 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO associated with Wegener Granulomatosis;DNA:polymorphisms:promoter,exon::-318C>T, (AT)repeats (human) RGD PMID:15708894 RGD:7204725 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 ISO RGD PMID:20649681 RGD:7207863 NCBI chr2B:105,429,576...105,433,243
Ensembl chr2B:224,028,838...224,029,890 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO DNA:polymorphism: :1208C>T (human) RGD PMID:23615182 RGD:7257672 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA, protein:decreased expression:intestine
DNA:polymorphisms:exon, 3' utr:3801T>C (rs4646903), p.I462V (rs1048943) (human)		 RGD PMID:12039987 PMID:23619522 RGD:7257728 RGD:7296923 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15248218 NCBI chr19:38,003,083...38,028,980
Ensembl chr19:46,509,370...46,534,672 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15248218 NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO DNA:polymorphisms: : RGD PMID:18769365 RGD:7243146 NCBI chr10:91,646,387...91,679,998
Ensembl chr10:95,157,661...95,186,620 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO mRNA, protein:decreased expression:intestine RGD PMID:12039987 RGD:7296923 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
G DDC dopa decarboxylase ISO protein:altered activity:renal cortex (rat) RGD PMID:19167406 RGD:5128880 NCBI chr 7:51,101,169...51,206,031
Ensembl chr 7:51,345,228...51,449,710 		JBrowse link
G DRD1 dopamine receptor D1 treatment ISO RGD PMID:18402547 RGD:7248448 NCBI chr 5:170,787,115...170,792,383
Ensembl chr 5:177,688,917...177,690,257 		JBrowse link
G DRD2 dopamine receptor D2 ISO associated with Diabetes Mellitus, Non-Insulin Dependent; DNA:polymorphisms:5'utr, intron: -141delC, G>A (human) RGD PMID:18366720 RGD:2311602 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G EDN1 endothelin 1 ISO mRNA:increased expression:kidney (rat) RGD PMID:8441230 RGD:4144849 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO Associated with Type 2 diabetes RGD PMID:18184924 RGD:6906927 NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644 		JBrowse link
G EPHX2 epoxide hydrolase 2 disease_progression ISO RGD PMID:20694143 RGD:5688726 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G EPO erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:16707910 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G EPOR erythropoietin receptor ISO protein:decreased expression:heart RGD PMID:27468524 RGD:11532749 NCBI chr19:10,925,148...10,931,955
Ensembl chr19:11,635,248...11,642,383 		JBrowse link
G F2 coagulation factor II, thrombin treatment ISO RGD PMID:22473220 RGD:7387323 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G F5 coagulation factor V ISO DNA:mutation: :1691G>A(human) RGD PMID:19520684 RGD:6893522 NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915 		JBrowse link
G FABP1 fatty acid binding protein 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr2A:87,256,032...87,303,505
Ensembl chr2A:89,165,315...89,170,448 		JBrowse link
G FABP2 fatty acid binding protein 2 ISO DNA:polymorphism:CDS:amino acid A54T, associated with Diabetes Mellitus, Type 2 (MeSH:D003924) RGD PMID:16249461 RGD:1578457 NCBI chr 4:111,505,269...111,510,197
Ensembl chr 4:122,055,544...122,060,461 		JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 NCBI chr17:76,483,108...76,503,148
Ensembl chr17:82,187,516...82,205,647 		JBrowse link
G FCGR2B Fc gamma receptor IIb ISO RGD PMID:15266033 RGD:7240530 NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637 		JBrowse link
G FGB fibrinogen beta chain treatment ISO associated with hypertension;DNA:polymorphism: :-455G>A (human) RGD PMID:19352213 RGD:7175505 NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766 		JBrowse link
G FN1 fibronectin 1 ISO protein:decreased expression:plasma RGD PMID:6665521 RGD:7205701 NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003 		JBrowse link
G GATA3 GATA binding protein 3 ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272 		JBrowse link
G GCKR glucokinase regulator ISO DNA: snp: rs1260326 RGD PMID:21980298 RGD:7242279 NCBI chr2A:27,497,938...27,530,650
Ensembl chr2A:27,587,077...27,613,927 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:18809976 RGD:7242553 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723 		JBrowse link
G GLO1 glyoxalase I severity ISO DNA:SNP: :419C>A (human) RGD PMID:20185929 RGD:7242570 NCBI chr 6:38,247,881...38,275,098
Ensembl chr 6:39,434,746...39,461,971 		JBrowse link
G GSR glutathione-disulfide reductase ISO protein:increased activity:lymphocyte:
protein:increased activity:blood:		 RGD PMID:6463365 PMID:20181004 RGD:7257547 RGD:7257560 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO RGD PMID:24339523 RGD:14700960 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G GTPBP4 GTP binding protein 4 ISO RGD PMID:11316846 RGD:632611 NCBI chr10:1,023,295...1,055,818
Ensembl chr10:1,071,809...1,103,521 		JBrowse link
G GUCA2B guanylate cyclase activator 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15780094 NCBI chr 1:41,452,722...41,455,192
Ensembl chr 1:42,832,196...42,835,425 		JBrowse link
G HAMP hepcidin antimicrobial peptide ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
mRNA:increased expression:liver		 CTD
RGD		 PMID:16929540 PMID:19212416 PMID:20631677 RGD:11041611 RGD:11041622 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861 		JBrowse link
G HBEGF heparin binding EGF like growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21937979 NCBI chr 5:135,699,553...135,713,366
Ensembl chr 5:141,816,402...141,830,531 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:kidney (rat)
associated with Hypertension		 CTD
RGD		 PMID:19878707 PMID:21119529 RGD:2326081 RGD:5508686 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G HMOX1 heme oxygenase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22622455 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:kidney (rat) RGD PMID:20820841 RGD:4145364 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:10198369 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IL1A interleukin 1 alpha no_association ISO DNA:SNP
DNA:SNP, insertion/deletion:intron, 3' utr:rs1516792-3, rs16347-2 (human)
DNA:SNPs, deletion, haplotypes:3' utr:multiple (human)		 RGD PMID:12631337 PMID:12837270 PMID:20551628 RGD:6907070 RGD:6907105 RGD:6907106 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1B interleukin 1 beta no_association ISO DNA:SNP
protein:increased expression:plasma (rat)		 RGD PMID:20199183 PMID:20551628 PMID:22031851 RGD:6907070 RGD:7175302 RGD:7175346 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1RN interleukin 1 receptor antagonist disease_progression
susceptibility		 ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
DNA:polymorphism:exon:g.14709C>T rs315952 (human)
DNA:polymorphism:intron:IVS6+327A>G rs452204 (human)
DNA:repeats:intron:IVS2+914_1000dup IL1RN*1 (human)
protein:increased expression:serum (human)		 RGD PMID:12837270 PMID:16556139 PMID:16766392 PMID:17224277 PMID:20551628 RGD:6907070 RGD:6907105 RGD:6907131 RGD:6907368 RGD:6907370 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL20 interleukin 20 ISO protein:increased expression:multiple organs
protein:increased expression:serum		 RGD PMID:18639518 RGD:5147394 NCBI chr 1:182,468,571...182,472,440
Ensembl chr 1:186,747,086...186,750,952 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19539174 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G INSIG2 insulin induced gene 2 ISO protein:decreased expression:kidney (rat) RGD PMID:19878707 RGD:2326081 NCBI chr2B:5,046,971...5,068,757
Ensembl chr2B:118,632,402...118,652,647 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO protein:decreased tyrosine phosphorylation:aorta RGD PMID:22942179 RGD:7207055 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967 		JBrowse link
G ITGA8 integrin subunit alpha 8 ISO associated with Polycystic Kidney, Autosomal Dominant;DNA:polymorphism: :-414T>C(human) RGD PMID:18277079 RGD:7257723 NCBI chr10:15,838,320...16,045,206
Ensembl chr10:16,114,999...16,321,360 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO associated with Hypertension;DNA:polymorphism RGD PMID:19368146 RGD:6907396 NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 ISO protein:increased expression:renal cortex, cytosol (rat) RGD PMID:20007347 RGD:6892947 NCBI chr19:10,037,544...10,055,091
Ensembl chr19:10,701,303...10,717,604 		JBrowse link
G KL klotho ISO mRNA:decreased expression:kidney:
mRNA,protein:decreased expression:kidney:		 RGD PMID:9731228 PMID:11162628 RGD:10403042 RGD:10403067 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458 		JBrowse link
G KLK1 kallikrein 1 ISO RGD PMID:11849458 RGD:1581753 NCBI chr19:47,784,368...47,789,004
Ensembl chr19:56,677,579...56,682,216 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase ISO RGD PMID:15280162 RGD:1581769 NCBI chr16:48,278,137...48,285,305
Ensembl chr16:67,668,646...67,673,127 		JBrowse link
G LCN2 lipocalin 2 onset ISO protein:increased expression:urine: RGD PMID:22542304 RGD:7245503 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G LEP leptin ISO protein:increased expression:serum (human) RGD PMID:9294834 RGD:10053636 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G LIPC lipase C, hepatic type ISO protein, mRNA:decreased expression:hepatocytes, liver (rat) RGD PMID:8636395 RGD:2308788 NCBI chr15:37,363,507...37,537,723
Ensembl chr15:55,814,017...55,847,005 		JBrowse link
G LIPJ lipase family member J ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr10:85,307,536...85,330,911
Ensembl chr10:88,816,492...88,832,860 		JBrowse link
G LOC100982531 cytochrome b-245 heavy chain ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:15550752 PMID:19420110 RGD:1599682 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183 		JBrowse link
G LOC100986914 cytochrome b-245 light chain ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19420110 RGD:2306994 NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719 		JBrowse link
G LPIN1 lipin 1 ISO mRNA:increased expression:skeletal muscle RGD PMID:14718385 RGD:1641826 NCBI chr2A:11,664,727...11,815,497
Ensembl chr2A:11,857,961...11,961,551 		JBrowse link
G LPL lipoprotein lipase ISO RGD PMID:22009636 RGD:6909179 NCBI chr 8:19,164,541...19,193,100
Ensembl chr 8:16,113,415...16,142,966 		JBrowse link
G LRP2 LDL receptor related protein 2 ISO mRNA:decreased expression:kidney RGD PMID:15266031 RGD:1641836 NCBI chr2B:56,407,871...56,640,471
Ensembl chr2B:173,873,767...174,103,697 		JBrowse link
G MBL2 mannose binding lectin 2 ISO associated with Lupus Erythematosus, Systemic;DNA:polymorphisms RGD PMID:16801331 RGD:6903261 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G MLXIPL MLX interacting protein like ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 Ensembl chr 7:80,745,765...80,776,153 JBrowse link
G MMP1 matrix metallopeptidase 1 severity
no_association		 ISO DNA:insertion, haplotype:promoter:g.-1607insG (human)
DNA:insertion:promoter:g.-1607insG (human)		 RGD PMID:19221176 PMID:22401717 RGD:7206856 RGD:7207064 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104 		JBrowse link
G MMP10 matrix metallopeptidase 10 ISO associated with Hypertension; protein:increased expression:plasma (human) RGD PMID:19886850 RGD:7207051 NCBI chr11:97,710,819...97,721,263
Ensembl chr11:101,201,665...101,212,103 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO associated with Hypertension; protein:increased expression:plasma (human) RGD PMID:19886850 RGD:7207051 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP3 matrix metallopeptidase 3 severity ISO DNA:insertion, haplotype:promoter:g.-1613insA (human) RGD PMID:19221176 RGD:7207064 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354 		JBrowse link
G MPO myeloperoxidase disease_progression ISO RGD PMID:20638167 RGD:6909184 NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111 		JBrowse link
G MSC musculin susceptibility ISO associated with type 1 diabetes mellitus;DNA:SNP:5'UTR:rs9298190(human) RGD PMID:19929986 RGD:596936222 NCBI chr 8:68,365,708...68,368,628 JBrowse link
G MSR1 macrophage scavenger receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 NCBI chr 8:15,335,795...15,421,472
Ensembl chr 8:12,088,873...12,175,927 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility
severity
no_association		 ISO DNA:transition, transversion:cds:g.677C>T, g.1298A>C (human)
DNA:SNP: :677C>T(human)
associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human)
DNA:transitions, transversion, haplotype:cds:g.677C>T, g.1298A>C, g.1793G>A (human)		 RGD PMID:14737040 PMID:17899317 PMID:19520069 PMID:19520684 PMID:25664255 RGD:14696732 RGD:6893522 RGD:6893523 RGD:6893524 RGD:6893579 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO RGD PMID:22427849 RGD:10040968 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G MYH9 myosin heavy chain 9 ISO associated with diabetes mellitus,type 2;DNA:SNPs: :
associated with hypertension;DNA:polymorphisms:multiple:
CTD Direct Evidence: marker/mechanism
associated with diabetes mellitus, type 2;DNA:SNPs: :
associated with hypertension, glomerulosclerosis, focal segmental;DNA:SNPs: :rs4821480, rs2032487, rs4821481(human)
DNA:SNPs:multiple:		 RGD
CTD		 PMID:18794854 PMID:18794856 PMID:19177153 PMID:19567477 PMID:20144966 More... RGD:6903237 RGD:6903238 RGD:6903239 RGD:6903243 RGD:6903256 NCBI chr22:17,200,623...17,305,826
Ensembl chr22:35,039,101...35,121,618 		JBrowse link
G NAT2 N-acetyltransferase 2 ISO mRNA,protein:decreased expression:liver: RGD PMID:20007296 RGD:11533637 NCBI chr 8:17,606,445...17,623,397
Ensembl chr 8:14,575,455...14,576,327 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G NGF nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19169037 PMID:24244623 RGD:7242783 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO protein:decreased expression:kidney cortex RGD PMID:17200156 PMID:23185775 RGD:1642147 RGD:7257669 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NOS3 nitric oxide synthase 3 susceptibility ISO DNA:duplication, snp:intron, cds:g.IVS4?-?+27, p.E298D (human)
protein:decreased expression:glomerulus		 RGD PMID:12701818 PMID:18089446 RGD:2292109 RGD:7777097 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NOX4 NADPH oxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr11:84,330,362...84,496,755 JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin disease_progression ISO mRNA;increased expression:urine (rat) RGD PMID:19389856 RGD:38599006 NCBI chr19:32,742,802...32,770,600
Ensembl chr19:41,492,444...41,518,471 		JBrowse link
G NPPB natriuretic peptide B ISO protein:increased expression:plasma: RGD PMID:7606877 RGD:7246912 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995 		JBrowse link
G NPPC natriuretic peptide C ISO protein:increased expression:plasma
protein:increased expression:plasma (human)		 RGD PMID:8117275 PMID:8743538 RGD:1580770 RGD:1642297 NCBI chr2B:119,148,774...119,153,381
Ensembl chr2B:237,936,939...237,941,244 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:18591458 RGD:7174716 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:12661921 RGD:1580992 NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071 		JBrowse link
G PAX2 paired box 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16631587 NCBI chr10:97,344,978...97,429,086
Ensembl chr10:100,822,676...100,904,028 		JBrowse link
G PGF placental growth factor ISO RGD PMID:16543713 RGD:1642390 NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964 		JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 NCBI chr16:604,366...605,560 JBrowse link
G PLA2G7 phospholipase A2 group VII ISO plasma:increased expression:plasma RGD PMID:16421163 RGD:7248787 NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212 		JBrowse link
G PLAU plasminogen activator, urokinase treatment
severity		 ISO protein:increased expression, increased activity:kidney (rat)
protein:increased expression:plasma (human)		 RGD PMID:15506291 PMID:17869326 PMID:19926968 PMID:22683425 RGD:6483806 RGD:7241081 RGD:7241218 RGD:7241279 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:19926968 RGD:6483806 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561 		JBrowse link
G POSTN periostin ISO mRNA,protein:increased expression,increased secretion:kidney,urine: RGD PMID:22167593 RGD:10040972 NCBI chr13:18,779,297...18,815,207
Ensembl chr13:37,368,030...37,407,212 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G PPARG peroxisome proliferator activated receptor gamma disease_progression ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:SNP: :p.P12A (human) RGD PMID:18467141 RGD:2301857 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G PTGER4 prostaglandin E receptor 4 treatment ISO RGD PMID:16871242 RGD:10003092 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19420110 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G PTH parathyroid hormone severity ISO protein:increased expression:serum (human)
protein:increased expression:serum (rat)		 RGD PMID:23243213 PMID:23548814 RGD:7242564 RGD:7242692 NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18077597 PMID:19420110 RGD:2298859 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G RETN resistin severity ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum		 CTD
RGD		 PMID:19539174 PMID:22421264 RGD:7207074 NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO ClinVar Annotator: match by term: Stage 5 chronic kidney disease ClinVar PMID:25741868 PMID:28492532 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
G SCAF1 SR-related CTD associated factor 1 ISO protein:increased expression:kidney (rat) RGD PMID:19878707 RGD:2326081 NCBI chr19:46,656,715...46,673,264
Ensembl chr19:55,578,644...55,592,455 		JBrowse link
G SCAP SREBF chaperone multiple interactions ISO RGD PMID:19878707 RGD:2326081 NCBI chr 3:47,314,535...47,379,455
Ensembl chr 3:48,414,012...48,479,845 		JBrowse link
G SCARB1 scavenger receptor class B member 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19878707 RGD:2326081 NCBI chr12:122,293,803...122,455,314
Ensembl chr12:126,659,532...126,694,767 		JBrowse link
G SELL selectin L no_association ISO RGD PMID:22119815 RGD:7175303 NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19420110 PMID:26903149 RGD:11073683 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO protein:decreased expression:kidney, plasma membrane RGD PMID:12110012 PMID:23280877 RGD:7243177 RGD:7243883 NCBI chr 6:158,058,226...158,150,917
Ensembl chr 6:163,065,317...163,158,931 		JBrowse link
G SLC34A1 solute carrier family 34 member 1 ISO mRNA:decreased expression:renal cortex (rat) RGD PMID:15452708 RGD:7242930 NCBI chr 5:172,685,862...172,700,440
Ensembl chr 5:179,748,492...179,762,975 		JBrowse link
G SLC9A5 solute carrier family 9 member A5 resistance ISO DNA:polymorphism RGD PMID:10642288 RGD:1643221 NCBI chr16:47,582,950...47,617,710
Ensembl chr16:66,983,611...67,005,957 		JBrowse link
G SOAT2 sterol O-acyltransferase 2 ISO RGD PMID:12217884 RGD:625687 NCBI chr12:35,632,018...35,653,227
Ensembl chr12:36,413,954...36,434,074 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19878707 NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 ISO mRNA, protein:increased expression:liver
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16814791 PMID:19878707 RGD:2308825 NCBI chr22:22,725,790...22,799,749
Ensembl chr22:40,811,459...40,884,947 		JBrowse link
G TBX21 T-box transcription factor 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26970513 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA, protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:10919844 PMID:19420110 RGD:7394838 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G THBD thrombomodulin ISO protein:increased expression:plasma RGD PMID:21873362 PMID:22129968 RGD:5684979 RGD:5684981 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:20729266 RGD:7240546 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:20729266 RGD:7240546 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19539174 PMID:22266663 RGD:7245510 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b severity ISO RGD PMID:21479768 RGD:7205485 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:22266663 RGD:7245510 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:22266663 RGD:7245510 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G UCP2 uncoupling protein 2 susceptibility ISO DNA:deletion
DNA:polymorphism: :-866G>A (human)		 RGD PMID:18242170 PMID:19406964 RGD:7175298 RGD:7175299 NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185 		JBrowse link
G VWF von Willebrand factor treatment
disease_progression		 ISO protein:increased oxidation:plasma RGD PMID:21378155 PMID:22091998 PMID:22189209 RGD:7205641 RGD:7205646 RGD:7205649 NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153 		JBrowse link
G ZMIZ1 zinc finger MIZ-type containing 1 susceptibility ISO associated with type 1 diabetes mellitus;DNA:SNP:5'UTR:rs1749824(human) RGD PMID:19929986 RGD:596936222 NCBI chr10:75,581,794...75,829,748
Ensembl chr10:78,294,867...78,492,475 		JBrowse link
Frasier syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WT1 WT1 transcription factor ISO ClinVar Annotator: match by term: Frasier syndrome OMIM
ClinVar		 PMID:1302008 PMID:1327525 PMID:1338906 PMID:1655284 PMID:1658787 More... NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15833
    disease of anatomical entity 15489
      Urogenital Diseases 4909
        urinary system disease 2407
          kidney disease 2170
            kidney failure 512
              chronic kidney disease 245
                end stage renal disease + 170
paths to the root