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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:ACTH-secreting pituitary adenoma
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Accession:DOID:7004 term browser browse the term
Definition:A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome. (DO)
Synonyms:exact_synonym: ACTH Producing Pituitary Adenoma;   ACTH-Secreting Pituitary Adenomas;   ACTH-producing pituitary adenomas;   CUSHING DISEASE, PITUITARY;   Corticotroph Adenoma;   Corticotroph Adenomas;   PITA4;   PITUITARY ADENOMA 4, ACTH-SECRETING;   PITUITARY ADENOMA, ACTH-SECRETING, SOMATIC;   Pituitary Corticotropin Secreting Adenoma;   corticotropinoma;   pituitary corticotropin-secreting adenomas
 primary_id: MESH:D049913
 alt_id: OMIM:219090
 xref: EFO:1000066;   GARD:12867;   NCI:C7462
For additional species annotation, visit the Alliance of Genome Resources.


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ACTH-secreting pituitary adenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pituitary adenoma, acth-secreting, somatic		 CTD
ClinVar		 PMID:17360484 PMID:18381572 PMID:19366855 PMID:20506337 PMID:20530095 More... NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:23884782 RGD:14700670 NCBI chr 1:131,526,908...131,539,740
Ensembl chr 1:131,526,977...131,539,738 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16195406 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO CTD Direct Evidence: marker/mechanism CTD
OMIM		 PMID:25485838 NCBI chr 2:126,549,280...126,601,234
Ensembl chr 2:126,549,248...126,601,217 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18301
    disease of cellular proliferation 7493
      benign neoplasm 2217
        cell type benign neoplasm 1956
          adenoma 717
            pituitary adenoma 25
              functioning pituitary adenoma 19
                ACTH-secreting pituitary adenoma 4
                  Nelson syndrome 0
Path 2
Term Annotations click to browse term
  disease 18301
    disease of anatomical entity 15631
      nervous system disease 13500
        Nervous System Neoplasms 1588
          Central Nervous System Neoplasms 1398
            central nervous system cancer 747
              brain cancer 731
                supratentorial cancer 457
                  diencephalic neoplasm 40
                    hypothalamic neoplasm 40
                      Pituitary Neoplasms 38
                        pituitary gland benign neoplasm 25
                          pituitary adenoma 25
                            functioning pituitary adenoma 19
                              ACTH-secreting pituitary adenoma 4
                                Nelson syndrome 0
paths to the root