hepatocellular carcinoma - Ontology Report

NCBI chrNW_004624769:1,586,036...1,611,092
Ensembl chrNW_004624769:1,581,727...1,610,793

Abca1

ATP binding cassette subfamily A member 1

severity

ISO

mRNA:decreased expression:liver (human)

PMID:16941710 PMID:30580964

RGD:1598532 RGD:24922199

NCBI chrNW_004624758:6,449,583...6,590,244
Ensembl chrNW_004624758:6,449,629...6,588,664

Abcc3

ATP binding cassette subfamily C member 3

ISO

mRNA:increased expression:liver

PMID:25842354

RGD:11535155

NCBI chrNW_004624795:6,516,384...6,558,332
Ensembl chrNW_004624795:6,516,224...6,557,892

Abce1

ATP binding cassette subfamily E member 1

ISO

mRNA:increased expression:liver (human)

PMID:21932399

RGD:11041873

NCBI chrNW_004624853:4,059,271...4,087,313
Ensembl chrNW_004624853:4,065,206...4,085,777

Abl1

ABL proto-oncogene 1, non-receptor tyrosine kinase

ISO

PMID:32171747

RGD:126907997

NCBI chrNW_004624760:4,878,811...5,032,719
Ensembl chrNW_004624760:4,878,556...5,031,491

Acaca

acetyl-CoA carboxylase alpha

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624871:4,103,014...4,364,690
Ensembl chrNW_004624871:4,105,067...4,412,325

Ace

angiotensin I converting enzyme

susceptibility

ISO

CTD Direct Evidence: therapeutic
DNA:insertion/deletion:intron 16:

PMID:16328049 PMID:25208933

RGD:11343535

NCBI chrNW_004624849:998,262...1,019,305
Ensembl chrNW_004624849:998,277...1,019,521

Acer3

alkaline ceramidase 3

disease_progression

ISO

PMID:30097213

RGD:35673325

NCBI chrNW_004624863:37,148...96,550
Ensembl chrNW_004624863:37,148...95,211

Acly

ATP citrate lyase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:1,872,413...1,910,495
Ensembl chrNW_004624795:1,872,454...1,911,004

Aco2

aconitase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:7,074,148...7,113,773
Ensembl chrNW_004624752:7,074,153...7,113,773

Acox1

acyl-CoA oxidase 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:12771043 PMID:15565109

NCBI chrNW_004624801:5,844,824...5,867,439
Ensembl chrNW_004624801:5,846,729...5,867,427

Acsl4

acyl-CoA synthetase long chain family member 4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624803:6,272,954...6,372,815
Ensembl chrNW_004624803:6,336,964...6,372,815

Actb

actin beta

ISO

CTD Direct Evidence: marker/mechanism

PMID:19363144 PMID:21472284

NCBI chrNW_004624740:28,087,051...28,090,359
Ensembl chrNW_004624740:28,087,736...28,090,512

Adamts1

ADAM metallopeptidase with thrombospondin type 1 motif 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:19514085

NCBI chrNW_004624745:14,802,703...14,811,568
Ensembl chrNW_004624745:14,802,371...14,811,203

Adamts13

ADAM metallopeptidase with thrombospondin type 1 motif 13

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:1,865,474...1,889,394
Ensembl chrNW_004624760:1,865,376...1,889,203

Add1

adducin 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:24,854,742...24,927,912
Ensembl chrNW_004624755:24,854,742...24,928,006

Adgrg7

adhesion G protein-coupled receptor G7

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624789:14,189,844...14,299,742
Ensembl chrNW_004624789:14,189,844...14,299,742

Adipoq

adiponectin, C1Q and collagen domain containing

susceptibility

ISO

DNA:SNP:intron:+276T>G (rs1501299) (human)

PMID:23740135

RGD:14401720

NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012

Adra1a

adrenoceptor alpha 1A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:21,557,161...21,665,432
Ensembl chrNW_004624758:21,569,908...21,665,244

Adra2b

adrenoceptor alpha 2B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:2,226,809...2,230,413
Ensembl chrNW_004624749:2,226,738...2,230,381

Afp

alpha fetoprotein

disease_progression
treatment
severity

ISO

protein:increased expression:serum (human)
associated with hepatitis B
CTD Direct Evidence: marker/mechanism

RGD:125097525 RGD:126790579 RGD:126790583 RGD:14401581 RGD:152177911

PMID:9029167 PMID:15276417 PMID:22147961 PMID:22392353 PMID:24012840 More...

NCBI chrNW_004624735:34,072,257...34,092,540
Ensembl chrNW_004624735:34,072,192...34,092,604

Aicda

activation induced cytidine deaminase

ISO

PMID:18997814

RGD:127285629

NCBI chrNW_004624860:4,912,938...4,927,846
Ensembl chrNW_004624860:4,912,656...4,926,634

Ak3

adenylate kinase 3

ISO

protein:decreased expression:liver

PMID:17203974

RGD:13842477

NCBI chrNW_004624736:9,428,736...9,494,645

Akr1a1

aldo-keto reductase family 1 member A1

ISO

CTD Direct Evidence: marker/mechanism

PMID:32805337

NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214

Akt1

AKT serine/threonine kinase 1

treatment
exacerbates

ISO

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver

PMID:25999787 PMID:31801250 PMID:32045588 PMID:37460115

RGD:151893509 RGD:152177911 RGD:408364960

NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295

Akt2

AKT serine/threonine kinase 2

ISO

protein:increased phosphorylation:liver (mouse)
protein:increased phosphorylation:liver cancer cell (rat)

PMID:19309364 PMID:28100771

RGD:127285675 RGD:2313299

NCBI chrNW_004624925:262,590...322,440
Ensembl chrNW_004624925:273,881...326,984

Alb

albumin

susceptibility

ISO

associated with hepatitis C;protein:decreased expression:serum
protein:decreased expression:serum (human)

PMID:22392353 PMID:23892757 PMID:29040987

RGD:11035269 RGD:125097525 RGD:14694841

NCBI chrNW_004624735:34,105,237...34,123,479
Ensembl chrNW_004624735:34,104,537...34,123,624

Aldh2

aldehyde dehydrogenase 2 family member

susceptibility
no_association
severity

ISO

associated with hepatitis B;DNA;missense mutation, haplotype:cds: (rs671) (human)
DNA:missense mutation:cds: (rs671) (human)
DNA:missense mutation:cds, exon 12:p.E487K (human)
DNA:missense mutation:exon 12: (human)
mRNA, protein:decreased expression:liver (human)
associated with alcoholic liver cirrhosis;DNA:missense mutation:cds:p.E487K (human)
associated with alcohol use disorder;DNA:missense mutation:cds: (human)
protein:decreased expression: liver (human)
associated with hepatitis C:DNA:SNP:exon 12 (human)

RGD:11054822 RGD:14696699 RGD:14696778 RGD:14696779 RGD:14700899 RGD:15036809 RGD:15042857 RGD:15042859 RGD:15042862

PMID:1916152 PMID:10737710 PMID:12940444 PMID:18439068 PMID:25778454 More...

NCBI chrNW_004624747:20,407,190...20,438,605
Ensembl chrNW_004624747:20,403,717...20,438,690

Aldh7a1

aldehyde dehydrogenase 7 family member A1

severity

ISO

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624774:15,048,825...15,099,443
Ensembl chrNW_004624774:15,048,627...15,101,856

Aldoc

aldolase, fructose-bisphosphate C

ISO

mRNA:increased expression:liver

PMID:3830170

RGD:2301136

NCBI chrNW_004624786:1,158,270...1,162,801
Ensembl chrNW_004624786:1,158,248...1,162,916

Alx4

ALX homeobox 4

ameliorates

ISO

mRNA, protein:decreased expression:liver

PMID:28081728 PMID:31132711

RGD:153323329 RGD:153323330

NCBI chrNW_004624767:3,770,755...3,808,511
Ensembl chrNW_004624767:3,770,762...3,805,323

Angptl6

angiopoietin like 6

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:2,291,682...2,301,165
Ensembl chrNW_004624828:2,290,511...2,296,341

Ank3

ankyrin 3

ISO

protein:decreased expression:liver

PMID:26652480

RGD:153344559

NCBI chrNW_004624791:3,299,287...3,633,631

Anln

anillin actin binding protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:24,756,633...24,831,168
Ensembl chrNW_004624740:24,756,234...24,830,978

Antxr1

ANTXR cell adhesion molecule 1

treatment

ISO

PMID:20650339

RGD:9684932

NCBI chrNW_004624762:4,051,479...4,377,237
Ensembl chrNW_004624762:4,128,127...4,377,278

Anxa10

annexin A10

disease_progression

ISO

mRNA:decreased expression:liver (human)

NCBI chrNW_004624932:1,268,193...1,335,246
Ensembl chrNW_004624932:1,268,330...1,333,965

Anxa2

annexin A2

ISO

mRNA, protein:increased expression:liver (human)

PMID:33675609

RGD:152999436

NCBI chrNW_004624781:11,781,893...11,820,440
Ensembl chrNW_004624781:11,781,886...11,821,816

Anxa4

annexin A4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:3,562,656...3,641,465
Ensembl chrNW_004624762:3,562,446...3,641,770

Anxa6

annexin A6

disease_progression

ISO

associated with tumor vascularization; protein:decreased expression:liver tumor (human)

NCBI chrNW_004624733:41,024,503...41,071,390
Ensembl chrNW_004624733:41,024,514...41,071,353

Apc

APC regulator of WNT signaling pathway

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

OMIM
ClinVar

PMID:1316610 PMID:8381579 PMID:8381580 PMID:8395941 PMID:9101302 More...

NCBI chrNW_004624743:30,517,034...30,635,740
Ensembl chrNW_004624743:30,546,323...30,635,737

Apcs

amyloid P component, serum

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,689,619...1,690,700
Ensembl chrNW_004624794:1,689,774...1,691,362

Apex1

apurinic/apyrimidinic endodeoxyribonuclease 1

treatment

ISO

CTD Direct Evidence: marker/mechanism

PMID:25109342 PMID:33841550

NCBI chrNW_004624825:4,711,921...4,714,926
Ensembl chrNW_004624825:4,708,093...4,714,921

Apln

apelin

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624797:8,857,490...8,866,157
Ensembl chrNW_004624797:8,857,070...8,866,329

Apoa1

apolipoprotein A1

disease_progression

ISO

protein:decreased expression:plasma (human)
associated with hepatitis B;
CTD Direct Evidence: marker/mechanism

PMID:21472284 PMID:23935864 PMID:31211449

RGD:153350082 RGD:25671438

NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136

Apoa2

apolipoprotein A2

ISO

associated with hepatitis B; mRNA:increased expression:liver

NCBI chrNW_004624794:164,351...165,676
Ensembl chrNW_004624794:164,370...166,248

Apoa4

apolipoprotein A4

disease_progression

ISO

associated with hepatitis B;

NCBI chrNW_004624784:12,237,329...12,240,013
Ensembl chrNW_004624784:12,233,593...12,239,763

Apoc1

apolipoprotein C1

disease_progression

ISO

associated with hepatitis B;

NCBI chrNW_004624907:1,758,671...1,760,611
Ensembl chrNW_004624907:1,758,696...1,760,611

Apoc2

apolipoprotein C2

ISO

associated with hepatitis B; mRNA:increased expression:liver

NCBI chrNW_004624907:1,765,467...1,769,786
Ensembl chrNW_004624907:1,765,481...1,769,781

Apoc3

apolipoprotein C3

susceptibility
disease_progression

ISO

associated with Chronic Hepatitis B;DNA:SNP: :rs2854116(human)
associated with hepatitis B;

PMID:27547913 PMID:31211449

RGD:153344620 RGD:153350082

NCBI chrNW_004624784:12,244,565...12,246,790
Ensembl chrNW_004624784:12,244,646...12,246,790

Apoe

apolipoprotein E

ISO

protein:increased expression:liver, serum (mouse)

PMID:21644509

RGD:6903288

NCBI chrNW_004624907:1,752,322...1,755,308

Apof

apolipoprotein F

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:11,640,942...11,645,030

Aprt

adenine phosphoribosyltransferase

ISO

protein:increased activity:hepatoma (rat)

PMID:6327016

RGD:5135035

NCBI chrNW_004624746:805,742...807,963
Ensembl chrNW_004624746:805,758...807,963

androgen receptor

ISO

CTD Direct Evidence: therapeutic

PMID:18639551

NCBI chrNW_004624891:3,135,824...3,330,487
Ensembl chrNW_004624891:3,138,848...3,329,459

Arg1

arginase 1

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

PMID:17210712 PMID:30901224

RGD:152995286 RGD:4140476

NCBI chrNW_004624753:5,737,720...5,749,313
Ensembl chrNW_004624753:5,737,237...5,752,966

Arhgap11a

Rho GTPase activating protein 11A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:1,713,261...1,735,357

Arhgap44

Rho GTPase activating protein 44

exacerbates

ISO

protein:decreased expression:liver (human)

PMID:31136984

RGD:401901276

NCBI chrNW_004624877:662,595...851,762
Ensembl chrNW_004624877:661,998...850,431

Arhgef39

Rho guanine nucleotide exchange factor 39

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624868:5,126,041...5,130,696
Ensembl chrNW_004624868:5,126,781...5,130,320

Arid1a

AT-rich interaction domain 1A

treatment
exacerbates

ISO

mRNA, protein:decreased expression:liver (human)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver (human)
human gene in mouse model
associated with non-alcoholic steatohepatitis

RGD:11344640 RGD:125097485 RGD:125097495 RGD:125097519 RGD:126790634

PMID:22561517 PMID:22634756 PMID:22922871 PMID:25975202 PMID:26569409 More...

NCBI chrNW_004624764:10,672,673...10,759,634
Ensembl chrNW_004624764:10,672,735...10,759,634

Arid1b

AT-rich interaction domain 1B

ISO

CTD Direct Evidence: marker/mechanism

PMID:22634756

NCBI chrNW_004624785:970,169...1,417,847
Ensembl chrNW_004624785:973,003...1,417,853

Arid2

AT-rich interaction domain 2

disease_progression
exacerbates

ISO

CTD Direct Evidence: marker/mechanism
associated with hepatitis B;protein:decreased expression:liver

RGD:150340708 RGD:150340711 RGD:150340712 RGD:150429631

PMID:21822264 PMID:22634756 PMID:25701229 PMID:27351279 PMID:28498550 More...

NCBI chrNW_004624816:6,329,888...6,521,535
Ensembl chrNW_004624816:6,332,612...6,521,535

Arid3a

AT-rich interaction domain 3A

ISO

CTD Direct Evidence: marker/mechanism

PMID:35179300

NCBI chrNW_004624828:7,636,211...7,666,868
Ensembl chrNW_004624828:7,635,383...7,666,416

Arrb2

arrestin beta 2

treatment

ISO

PMID:33841550

NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914

Asf1b

anti-silencing function 1B histone chaperone

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624901:1,342,855...1,354,196
Ensembl chrNW_004624901:1,342,765...1,354,165

Asl

argininosuccinate lyase

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624740:8,414,664...8,423,797
Ensembl chrNW_004624740:8,414,733...8,423,777

Asns

asparagine synthetase (glutamine-hydrolyzing)

ISO

protein:increased activity:serum (rat)

PMID:10081

RGD:2316006

NCBI chrNW_004624813:4,642,420...4,661,362
Ensembl chrNW_004624813:4,641,372...4,661,778

Aspg

asparaginase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:932,877...950,509
Ensembl chrNW_004624734:931,946...950,553

Aspm

assembly factor for spindle microtubules

disease_progression

ISO

CTD Direct Evidence: marker/mechanism

PMID:18676753 PMID:28284560

RGD:13439743

NCBI chrNW_004624798:3,164,145...3,223,810
Ensembl chrNW_004624798:3,165,393...3,225,181

Ass1

argininosuccinate synthase 1

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

PMID:12359751 PMID:30901224

RGD:152995286 RGD:4140479

NCBI chrNW_004624760:5,180,095...5,221,677
Ensembl chrNW_004624760:5,180,095...5,221,732

Atg101

autophagy related 101

disease_progression

ISO

PMID:35592424

RGD:153350091

NCBI chrNW_004624816:255,443...261,636
Ensembl chrNW_004624816:255,432...262,151

Atg7

autophagy related 7

ISO

CTD Direct Evidence: marker/mechanism

PMID:29191453

NCBI chrNW_004624943:231,978...480,933
Ensembl chrNW_004624943:232,618...481,290

Atm

ATM serine/threonine kinase

exacerbates

ISO

protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:12866955 PMID:19919837

RGD:126781750

NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216

Atp5pb

ATP synthase peripheral stalk-membrane subunit b

ISO

associated with hepatitis C

PMID:18932288

RGD:14696822

NCBI chrNW_004624772:7,167,074...7,178,756
Ensembl chrNW_004624772:7,167,147...7,179,273

Atp5pd

ATP synthase peripheral stalk subunit d

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:4,857,689...4,863,249
Ensembl chrNW_004624801:4,857,692...4,861,430

Aurka

aurora kinase A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624790:143,818...162,065
Ensembl chrNW_004624790:147,149...161,344

Aurkb

aurora kinase B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624786:10,769,797...10,775,142
Ensembl chrNW_004624786:10,765,610...10,775,112

Axin1

axin 1

disease_progression

ISO

ClinVar Annotator: match by term: AXIN1-related condition | ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
protein:decreased expression:liver (human)
associated with Hepatitis B, Chronic,DNA:SNP, haplotype:exon:(rs1805105) T>C (human)

RGD:14402039 RGD:150530482

PMID:10700176 PMID:25741868 PMID:26968103 PMID:28492532 PMID:31514071 More...

NCBI chrNW_004624913:1,139,165...1,195,477
Ensembl chrNW_004624913:1,139,165...1,195,230

Axin2

axin 2

ISO

protein:increased expression:liver:

PMID:11809809

RGD:151356508

NCBI chrNW_004624870:2,803,743...2,832,489
Ensembl chrNW_004624870:2,800,873...2,832,626

Azgp1

alpha-2-glycoprotein 1, zinc-binding

disease_progression

ISO

mRNA:decreased expression:liver
associated with hepatitis B;mRNA:decreased expression:liver

PMID:22625427 PMID:26902423 PMID:27993894

RGD:153350130 RGD:153350132 RGD:153350133

NCBI chrNW_004624740:17,054,221...17,062,420
Ensembl chrNW_004624740:17,054,221...17,063,226

Azin1

antizyme inhibitor 1

disease_progression

ISO

RNA:increased editing:liver

PMID:23291631

RGD:14700705

NCBI chrNW_004624763:19,643,980...19,667,125
Ensembl chrNW_004624763:19,643,980...19,667,125

Banf1

barrier to autointegration nuclear assembly factor 1

treatment

ISO

mRNA, protein:increased expression:liver (rat)
mRNA, protein:increased expression:liver (human)

PMID:29059470

RGD:155791679

NCBI chrNW_004624767:20,435,143...20,436,830
Ensembl chrNW_004624767:20,434,955...20,436,640

Bax

BCL2 associated X, apoptosis regulator

treatment

ISO

PMID:33841550

NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506

Bcl2

BCL2 apoptosis regulator

treatment

ISO

mRNA:increased expression:liver (mouse)

PMID:28100771 PMID:33841550

RGD:127285675 RGD:152998960

NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344

Bcl2l1

BCL2 like 1

treatment

ISO

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (mouse)

PMID:10629087 PMID:11509945 PMID:28100771 PMID:33841550

RGD:127285675 RGD:152998960

NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507

Bco2

beta-carotene oxygenase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:7,324,312...7,353,733
Ensembl chrNW_004624784:7,334,472...7,353,802

Bcorl1

BCL6 corepressor like 1

disease_progression

ISO

PMID:26879601 PMID:29679906

RGD:11556159 RGD:150340705

NCBI chrNW_004624797:9,211,625...9,283,435
Ensembl chrNW_004624797:9,240,209...9,282,020

Bhmt

betaine--homocysteine S-methyltransferase

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624869:3,618,895...3,639,621
Ensembl chrNW_004624869:3,617,948...3,642,860

Bhmt2

betaine--homocysteine S-methyltransferase 2

severity

ISO

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624869:3,571,154...3,596,389
Ensembl chrNW_004624869:3,576,369...3,599,275

Bid

BH3 interacting domain death agonist

ISO

CTD Direct Evidence: marker/mechanism

PMID:15289866

NCBI chrNW_004624735:9,557,732...9,590,862
Ensembl chrNW_004624735:9,579,979...9,589,260

Birc3

baculoviral IAP repeat containing 3

ameliorates
treatment
exacerbates

ISO

human cell line in a mouse model
mRNA, protein:increased expression:liver (human)
associated with hepatitis B;mRNA, protein:increased expression:liver (human)

PMID:22682366 PMID:22820591 PMID:30210622 PMID:30368883 PMID:33310033

RGD:152998937 RGD:152998984 RGD:152998986 RGD:152998988 RGD:152999010

NCBI chrNW_004624878:516,750...541,475
Ensembl chrNW_004624878:523,300...536,062

Birc5

baculoviral IAP repeat containing 5

disease_progression

ISO

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (human)

PMID:16086872 PMID:20514400 PMID:31964418

RGD:153344516

NCBI chrNW_004624801:7,727,084...7,735,946
Ensembl chrNW_004624801:7,727,093...7,735,940

Birc7

baculoviral IAP repeat containing 7

exacerbates

ISO

mRNA:increased expression:liver (human)

PMID:31964418

RGD:153344516

NCBI chrNW_004624741:28,937,836...28,944,000

Blzf1

basic leucine zipper nuclear factor 1

disease_progression

ISO

PMID:26342799

RGD:14398326

NCBI chrNW_004624826:7,300,216...7,327,081

Bmi1

BMI1 proto-oncogene, polycomb ring finger

treatment

ISO

PMID:26919246

RGD:14928318

NCBI chrNW_004624796:6,277,201...6,282,830
Ensembl chrNW_004624796:6,274,561...6,282,984

Bmper

BMP binding endothelial regulator

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624776:19,159,906...19,462,607
Ensembl chrNW_004624776:19,160,501...19,459,227

Braf

B-Raf proto-oncogene, serine/threonine kinase

ISO

CTD Direct Evidence: marker/mechanism

PMID:27222248

NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736

Bsg

basigin (Ok blood group)

ISO

CTD Direct Evidence: marker/mechanism

PMID:36574092

NCBI chrNW_004624828:7,913,297...7,920,891
Ensembl chrNW_004624828:7,913,099...7,920,804

Btg2

BTG anti-proliferation factor 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:18393292

NCBI chrNW_004624807:7,541,335...7,545,412
Ensembl chrNW_004624807:7,540,602...7,545,521

Bub1

BUB1 mitotic checkpoint serine/threonine kinase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:1,584,289...1,639,334
Ensembl chrNW_004624749:1,584,186...1,639,770

Bub1b

BUB1 mitotic checkpoint serine/threonine kinase B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:7,477,046...7,533,322
Ensembl chrNW_004624804:7,492,799...7,533,408

complement C3

ISO

PMID:23245919

RGD:11040806

NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946

complement C9

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:15,534,743...15,623,767
Ensembl chrNW_004624759:15,534,660...15,624,381

Ca12

carbonic anhydrase 12

disease_progression
ameliorates

ISO

mRNA:altered expression:liver

PMID:29900055 PMID:31934040 PMID:35362480

RGD:153352325 RGD:153352328 RGD:155226869

NCBI chrNW_004624781:9,140,753...9,195,651
Ensembl chrNW_004624781:9,140,837...9,196,400

Ca2

carbonic anhydrase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:6,168,030...6,183,407
Ensembl chrNW_004624744:6,167,606...6,183,538

Ca9

carbonic anhydrase 9

ISO

mRNA:altered expression:liver

PMID:29900055

RGD:155226869

NCBI chrNW_004624868:5,110,602...5,131,167
Ensembl chrNW_004624868:5,109,846...5,116,949

Cab39

calcium binding protein 39

disease_progression

ISO

PMID:28605041

RGD:14398832

NCBI chrNW_004624843:4,129,755...4,217,406
Ensembl chrNW_004624843:4,130,052...4,217,540

Cad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

ISO

mRNA:increased expression:liver
DNA:amplification:cds (rat)

PMID:2888462 PMID:2914957 PMID:7053379

RGD:10755426 RGD:2303530 RGD:5132587

NCBI chrNW_004624738:9,318,213...9,340,765
Ensembl chrNW_004624738:9,318,232...9,340,925

Cadm1

cell adhesion molecule 1

ISO

DNA, mRNA, protein:hypermethylation, decreased expression:promoter:liver

PMID:17428255

RGD:2289095

NCBI chrNW_004624784:10,595,876...10,933,024
Ensembl chrNW_004624784:10,591,824...10,932,981

Cadm2

cell adhesion molecule 2

disease_progression

ISO

mRNA, protein:decreased expression:liver

PMID:24240726

RGD:15092075

NCBI chrNW_004624789:1,245,224...2,316,519
Ensembl chrNW_004624789:1,245,304...2,314,562

Calml3

calmodulin like 3

severity

ISO

protein:decreased expression:liver (human)

PMID:29445139

RGD:151665319

NCBI chrNW_004624775:335,860...338,267
Ensembl chrNW_004624775:337,054...337,503

Calr

calreticulin

treatment
exacerbates

ISO

human cells and recombinant gene in a mouse model
protein:increased expression:liver (human)

PMID:12096119 PMID:24997628 PMID:27055635

RGD:150521681 RGD:150521690 RGD:150521691

NCBI chrNW_004624901:511,295...515,208
Ensembl chrNW_004624901:511,052...516,757

Camk2n1

calcium/calmodulin dependent protein kinase II inhibitor 1

ISO

PMID:23651211

RGD:18337283

NCBI chrNW_004624764:5,544,589...5,547,811
Ensembl chrNW_004624764:5,544,484...5,547,683

Cap2

cyclase associated actin cytoskeleton regulatory protein 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624756:8,990,151...9,174,208
Ensembl chrNW_004624756:8,989,203...9,174,283

Capn3

calpain 3

ISO

mRNA:decreased expression:skeletal muscle

PMID:10806331

RGD:1600777

NCBI chrNW_004624804:9,473,075...9,512,643
Ensembl chrNW_004624804:9,473,117...9,512,353

Carm1

coactivator associated arginine methyltransferase 1

ISO

mRNA,protein:increased expression:liver:

PMID:28643196 PMID:29133031

PMID:23912631

RGD:9586718

NCBI chrNW_004624828:2,833,011...2,872,281
Ensembl chrNW_004624828:2,832,769...2,871,167

Casp8

caspase 8

treatment
severity

ISO

associated with hepatitis B;DNA:insertion/deletion:promoter: (rs3834129) (human)

OMIM
RGD

RGD:13782296 RGD:14695027

NCBI chrNW_004624899:427,064...450,931
Ensembl chrNW_004624899:424,363...451,087

Casp9

caspase 9

treatment

ISO

PMID:29133031

RGD:13782296

NCBI chrNW_004624764:1,769,270...1,789,399
Ensembl chrNW_004624764:1,773,455...1,789,423

Cat

catalase

disease_progression

ISO

associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-262T>C (human)
CTD Direct Evidence: marker/mechanism

PMID:21907168 PMID:33010264

RGD:27095879

NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739

Cbfb

core-binding factor subunit beta

ISO

mRNA:decreased expression:liver

PMID:17094378

RGD:126775147

NCBI chrNW_004624746:19,204,415...19,264,217
Ensembl chrNW_004624746:19,204,392...19,264,194

Cbl

Cbl proto-oncogene

disease_progression

ISO

PMID:26474280

RGD:11536137

NCBI chrNW_004624784:14,577,582...14,671,816
Ensembl chrNW_004624784:14,577,515...14,667,575

Cbx2

chromobox 2

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624801:8,951,659...8,961,280
Ensembl chrNW_004624801:8,951,723...8,958,352

Cbx4

chromobox 4

disease_progression

ISO

protein:increased expression:cytoplasm:

PMID:23943028 PMID:24838576

RGD:9586738 RGD:9586739

NCBI chrNW_004624801:9,002,290...9,008,305
Ensembl chrNW_004624801:9,003,059...9,008,203

Cbx7

chromobox 7

ISO

mRNA:decreased expression:liver

PMID:22041561

RGD:9587355

NCBI chrNW_004624752:9,133,587...9,151,216
Ensembl chrNW_004624752:9,133,569...9,151,934

Ccbe1

collagen and calcium binding EGF domains 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624792:4,863,978...5,146,907
Ensembl chrNW_004624792:4,867,858...5,146,839

Ccl1

C-C motif chemokine ligand 1

ISO

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624875:2,224,784...2,229,465

Ccl14

C-C motif chemokine ligand 14

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624875:3,372,982...3,376,663

Ccl5

C-C motif chemokine ligand 5

susceptibility
treatment

ISO

associated with alcoholic liver cirrhosis;DNA:SNP:promoter:-403G>A(human)
DNA:polymorphisms:promoter:-403G>A,-28C>G (human)

PMID:21610221 PMID:22374185 PMID:28011329

RGD:14995306 RGD:14995333 RGD:14995338

NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614

Ccn1

cellular communication network factor 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:17699798

NCBI chrNW_004624742:11,882,815...11,885,686
Ensembl chrNW_004624742:11,882,907...11,885,667

Ccna1

cyclin A1

ISO

CTD Direct Evidence: marker/mechanism

PMID:12029619

NCBI chrNW_004624776:941,107...951,256
Ensembl chrNW_004624776:939,823...950,833

Ccnb2

cyclin B2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:12,875,215...12,905,878
Ensembl chrNW_004624781:12,874,020...12,905,932

Ccnd1

cyclin D1

susceptibility

ISO

associated with Hepatitis B, Chronic;DNA:SNP:splice-site mutation:870G>A (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (mouse)

RGD:127285675 RGD:14401586

PMID:12029619 PMID:19919837 PMID:22649188 PMID:25822088 PMID:25851350 More...

NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191

Ccnd2

cyclin D2

disease_progression
susceptibility
severity

ISO

associated with hepatitis B
associated with Chronic Hepatitis C;DNA:SNP: :rs1049606(human)
DNA:hypermethylation:CpG site

PMID:22004425 PMID:31059558 PMID:33320844

RGD:151664743 RGD:151665109 RGD:151665169

NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107

Ccne1

cyclin E1

ameliorates

ISO

CTD Direct Evidence: marker/mechanism

PMID:12029619 PMID:17196522 PMID:22634754 PMID:28100771 PMID:29551768

RGD:127285675 RGD:153297807 RGD:2289277

NCBI chrNW_004624794:4,957,156...4,967,058
Ensembl chrNW_004624794:4,957,178...4,967,140

Ccnf

cyclin F

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:181,696...204,045
Ensembl chrNW_004624824:181,735...204,029

Ccng1

cyclin G1

severity
disease_progression
treatment

ISO

protein:decreased expression:liver (human)
protein:increased expression:liver (human)
human cells in mouse model

RGD:151356922 RGD:151356932 RGD:151356933 RGD:151356967 RGD:151356970 RGD:151356981 RGD:151361198 RGD:151361200

PMID:19584283 PMID:22835824 PMID:23804702 PMID:24034575 PMID:25431954 More...

NCBI chrNW_004624733:26,366,448...26,378,062
Ensembl chrNW_004624733:26,367,200...26,376,664

Ccng2

cyclin G2

ISO

PMID:27982046

RGD:151361200

NCBI chrNW_004624757:13,828,768...13,837,994
Ensembl chrNW_004624757:13,828,338...13,837,407

Cd163

CD163 molecule

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624860:3,976,746...4,000,349
Ensembl chrNW_004624860:3,975,747...4,000,349

Cd274

CD274 molecule

disease_progression

ISO

associated with hepatitis B
associated with hepatitis B
CTD Direct Evidence: marker/mechanism

PMID:21912640 PMID:22396772 PMID:30267213

RGD:40818240 RGD:41410800

NCBI chrNW_004624736:9,991,851...10,017,047
Ensembl chrNW_004624736:9,996,156...10,013,814

Cd276

CD276 molecule

ISO

CTD Direct Evidence: therapeutic

PMID:16217749

NCBI chrNW_004624781:691,348...703,202

Cd34

CD34 molecule

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:3,936,043...3,958,274
Ensembl chrNW_004624807:3,936,028...3,957,249

Cd40lg

CD40 ligand

ISO

PMID:19016771

RGD:2313413

NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338

Cd5l

CD5 molecule like

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:3,060,436...3,071,570
Ensembl chrNW_004624794:3,060,365...3,072,801

Cd68

CD68 molecule

severity

ISO

protein:increased expression:liver (human)

PMID:28656201

RGD:40924686

NCBI chrNW_004624786:10,195,337...10,197,963

Cdc20

cell division cycle 20

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624892:2,675,980...2,679,709
Ensembl chrNW_004624892:2,675,754...2,679,793

Cdc25c

cell division cycle 25C

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:31,099,320...31,123,808
Ensembl chrNW_004624743:31,099,268...31,124,262

Cdc27

cell division cycle 27

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624849:2,026,433...2,105,626
Ensembl chrNW_004624849:2,026,425...2,092,857

Cdc45

cell division cycle 45

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:132,731...161,590
Ensembl chrNW_004624747:132,835...161,553

Cdc6

cell division cycle 6

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:2,980,334...2,992,579
Ensembl chrNW_004624795:2,980,185...2,992,330

Cdca2

cell division cycle associated 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:20,490,902...20,537,171
Ensembl chrNW_004624758:20,491,118...20,538,653

Cdca3

cell division cycle associated 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624860:3,516,244...3,519,107
Ensembl chrNW_004624860:3,515,411...3,518,828

Cdca5

cell division cycle associated 5

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:21,321,286...21,327,780

Cdca8

cell division cycle associated 8

disease_progression

ISO

mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:28284560 PMID:35693827

NCBI chrNW_004624764:20,418,342...20,433,763
Ensembl chrNW_004624764:20,418,585...20,434,026

Cdh1

cadherin 1

severity

ISO

mRNA:increased expression:liver
protein:decreased expression:liver
DNA:hypermethylation

PMID:17295234 PMID:18837082 PMID:24840851 PMID:30697077

RGD:14402045 RGD:14402046 RGD:14402047 RGD:2289638

NCBI chrNW_004624746:17,480,472...17,557,722
Ensembl chrNW_004624746:17,483,469...17,557,581

Cdh13

cadherin 13

ISO

CTD Direct Evidence: marker/mechanism

PMID:18425332 PMID:18553387 PMID:28284560

NCBI chrNW_004624746:3,696,608...4,759,693
Ensembl chrNW_004624746:3,698,196...4,759,442

Cdk1

cyclin dependent kinase 1

ISO

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)

PMID:19136513 PMID:28284560

RGD:2316317

NCBI chrNW_004624791:2,891,239...2,915,001

Cdk12

cyclin dependent kinase 12

exacerbates

ISO

mRNA, protein:increased expression:liver (human)

PMID:31519701

RGD:151361172

NCBI chrNW_004624795:3,490,081...3,564,144
Ensembl chrNW_004624795:3,512,429...3,562,515

Cdk13

cyclin dependent kinase 13

onset

ISO

DNA:amplification: :

PMID:22912832

RGD:155641228

NCBI chrNW_004624740:21,100,780...21,202,147
Ensembl chrNW_004624740:21,105,212...21,202,111

Cdk14

cyclin dependent kinase 14

ISO

CTD Direct Evidence: marker/mechanism

PMID:22922871

NCBI chrNW_004624809:2,067,985...2,688,847
Ensembl chrNW_004624809:2,155,554...2,688,759

Cdk4

cyclin dependent kinase 4

treatment

ISO

CTD Direct Evidence: marker/mechanism

PMID:26189965 PMID:33841550

NCBI chrNW_004624802:10,191,679...10,194,585
Ensembl chrNW_004624802:10,191,014...10,194,275

Cdkn1a

cyclin dependent kinase inhibitor 1A

ISO

OMIM:114550

NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885

Cdkn1b

cyclin dependent kinase inhibitor 1B

ISO

CTD Direct Evidence: marker/mechanism

PMID:20698225

NCBI chrNW_004624752:25,202,474...25,207,107
Ensembl chrNW_004624752:25,203,474...25,207,114

Cdkn1c

cyclin dependent kinase inhibitor 1C

severity

ISO

protein:decreased expression:liver (human)

PMID:26606000

RGD:11354707

NCBI chrNW_004624767:15,642,991...15,645,648
Ensembl chrNW_004624767:15,642,012...15,645,664

Cdkn2b

cyclin dependent kinase inhibitor 2B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:25,929,314...25,933,318
Ensembl chrNW_004624736:25,926,668...25,933,440

Cdkn2c

cyclin dependent kinase inhibitor 2C

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624859:2,092,622...2,097,628
Ensembl chrNW_004624859:2,091,734...2,097,659

Cdkn3

cyclin dependent kinase inhibitor 3

severity
treatment

ISO

protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism
associated with alcoholism; protein:increased expression:liver
mRNA:increased expression:liver

PMID:22390936 PMID:23292002 PMID:27314282 PMID:28284560

RGD:15090800 RGD:15090801 RGD:15090802

NCBI chrNW_004624731:14,838,555...14,853,588
Ensembl chrNW_004624731:14,838,561...14,852,554

Cdt1

chromatin licensing and DNA replication factor 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:808,463...813,464
Ensembl chrNW_004624746:809,252...812,993

Cebpa

CCAAT enhancer binding protein alpha

ISO

CTD Direct Evidence: marker/mechanism

PMID:16288022 PMID:21785164

NCBI chrNW_004624794:9,809,007...9,813,418

Cebpb

CCAAT enhancer binding protein beta

ISO

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)

PMID:14563831 PMID:30659195

RGD:40903042

NCBI chrNW_004624790:5,367,808...5,369,686
Ensembl chrNW_004624790:5,368,349...5,369,377

Cebpd

CCAAT enhancer binding protein delta

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:7,721,564...7,722,823
Ensembl chrNW_004624735:7,721,633...7,722,445

Celsr3

cadherin EGF LAG seven-pass G-type receptor 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:2,650,096...2,675,930
Ensembl chrNW_004624730:2,651,756...2,675,923

Cenpa

centromere protein A

ISO

protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:21956590 PMID:28284560

RGD:36947377

NCBI chrNW_004624738:8,899,260...8,906,379
Ensembl chrNW_004624738:8,899,362...8,906,373

Cenpe

centromere protein E

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624830:4,930,533...4,986,437
Ensembl chrNW_004624830:4,930,555...4,986,076

Cenpf

centromere protein F

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:19,657,489...19,702,506
Ensembl chrNW_004624771:19,656,981...19,702,625

Cenpm

centromere protein M

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:6,781,504...6,790,520
Ensembl chrNW_004624752:6,781,529...6,790,518

Cenpu

centromere protein U

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:15,450,423...15,491,393

Cenpw

centromere protein W

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624753:888,495...896,617
Ensembl chrNW_004624753:887,689...896,931

Cep131

centrosomal protein 131

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:10,212,489...10,251,015
Ensembl chrNW_004624801:10,226,629...10,248,829

Cep164

centrosomal protein 164

susceptibility

ISO

associated with Chronic Hepatitis C;DNA:SNP: :rs573455 (human)

PMID:22004425

RGD:151665169

NCBI chrNW_004624784:12,754,685...12,837,440
Ensembl chrNW_004624784:12,773,870...12,836,107

Cep55

centrosomal protein 55

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:4,718,904...4,741,317
Ensembl chrNW_004624737:4,718,883...4,740,489

Cetp

cholesteryl ester transfer protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:29,035,282...29,053,867

Cfp

complement factor properdin

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624978:180,352...194,467
Ensembl chrNW_004624978:184,286...190,970

Chaf1b

chromatin assembly factor 1 subunit B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:27,094,302...27,117,957
Ensembl chrNW_004624745:27,095,361...27,117,669

Chd4

chromodomain helicase DNA binding protein 4

exacerbates

ISO

mRNA:increased expression:liver (human)
protein:increased expression:liver (human)

PMID:26095183 PMID:28486105 PMID:32070428

RGD:11571740 RGD:153323299 RGD:153323308

NCBI chrNW_004624860:3,285,086...3,318,939
Ensembl chrNW_004624860:3,283,837...3,318,985

Chd5

chromodomain helicase DNA binding protein 5

ISO

mRNA:decreased expression:liver

PMID:26517514

RGD:11537550

NCBI chrNW_004624818:5,203,200...5,251,057
Ensembl chrNW_004624818:5,203,304...5,249,033

Ckap2l

cytoskeleton associated protein 2 like

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:12,755,752...12,786,425
Ensembl chrNW_004624749:12,756,817...12,786,361

Ckap4

cytoskeleton associated protein 4

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:increased expression:liver tumor (human)

NCBI chrNW_004624750:3,067,167...3,079,095

Cldn1

claudin 1

severity

ISO

associated with liver cirrhosis;protein:increased expression:liver (human)
protein:decreased expression:liver (human)

PMID:17270214 PMID:24696415 PMID:24815833

RGD:26884345 RGD:26884348 RGD:26884352

NCBI chrNW_004624730:66,885,674...66,902,345
Ensembl chrNW_004624730:66,885,319...66,903,079

Clec4g

C-type lectin domain family 4 member G

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:775,114...778,526
Ensembl chrNW_004624828:773,569...778,615

Clptm1l

CLPTM1 like

susceptibility
disease_progression

ISO

DNA:SNPs::rs401681(human)
DNA:SNP: :rs401681(human)

PMID:25339005 PMID:29042796

RGD:150530496 RGD:150537100

NCBI chrNW_004624751:652,857...669,400
Ensembl chrNW_004624751:652,767...669,587

Cltrn

collectrin, amino acid transport regulator

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624829:412,797...447,076
Ensembl chrNW_004624829:412,532...446,938

Cndp1

carnosine dipeptidase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624806:6,113,052...6,169,943
Ensembl chrNW_004624806:6,113,227...6,169,745

Cntnap4

contactin associated protein family member 4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:10,376,304...10,649,868
Ensembl chrNW_004624746:10,378,704...10,650,691

Col15a1

collagen type XV alpha 1 chain

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624825:1,939,685...2,041,575

Col18a1

collagen type XVIII alpha 1 chain

severity

ISO

Protein:increased expression

PMID:15739185

RGD:1600906

NCBI chrNW_004624745:30,754,654...30,792,352
Ensembl chrNW_004624745:30,754,820...30,791,426

Colec10

collectin subfamily member 10

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624763:17,302,075...17,350,682
Ensembl chrNW_004624763:17,301,993...17,352,559

Comt

catechol-O-methyltransferase

ISO

CTD Direct Evidence: marker/mechanism

PMID:15341023

NCBI chrNW_004624747:569,127...588,479
Ensembl chrNW_004624747:581,832...588,333

Cops5

COP9 signalosome subunit 5

severity

ISO

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)

PMID:20698225 PMID:26606000

RGD:11354707

NCBI chrNW_004624744:24,287,278...24,308,171
Ensembl chrNW_004624744:24,287,443...24,308,024

ceruloplasmin

ISO

CTD Direct Evidence: marker/mechanism

PMID:19229483

NCBI chrNW_004624730:26,458,554...26,510,796
Ensembl chrNW_004624730:26,462,550...26,511,078

Cpeb3

cytoplasmic polyadenylation element binding protein 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:3,352,064...3,570,317
Ensembl chrNW_004624737:3,355,360...3,542,731

Cps1

carbamoyl-phosphate synthase 1

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624765:5,527,029...5,652,343
Ensembl chrNW_004624765:5,528,112...5,651,415

Crebbp

CREB binding protein

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chrNW_004624824:1,516,481...1,655,364
Ensembl chrNW_004624824:1,517,966...1,655,329

Crhbp

corticotropin releasing hormone binding protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624869:1,412,541...1,423,891
Ensembl chrNW_004624869:1,412,499...1,423,932

Crp

C-reactive protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804

Csf1r

colony stimulating factor 1 receptor

exacerbates
severity

ISO

DNA:hypomethylation
mRNA:increased expression:liver (human)
DNA:hypomethylation:promoter (human)
protein:increased expression: liver (human)
protein:increased expression:liver (human)

PMID:11412385 PMID:14969845 PMID:20551429 PMID:32724427 PMID:32760707

RGD:150524279 RGD:150524282 RGD:150524286 RGD:150524301 RGD:150524302

NCBI chrNW_004624774:9,363,156...9,391,939
Ensembl chrNW_004624774:9,363,908...9,391,986

Csf2

colony stimulating factor 2

treatment

ISO

PMID:12731087

RGD:10450243

NCBI chrNW_004624733:40,039,127...40,041,294
Ensembl chrNW_004624733:40,039,414...40,041,294

Csk

C-terminal Src kinase

ISO

protein:decreased expression:liver

PMID:9918913

RGD:5134372

NCBI chrNW_004624894:12,621...29,400
Ensembl chrNW_004624894:24,203...29,668

Csmd1

CUB and Sushi multiple domains 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624861:1,731,662...3,244,884
Ensembl chrNW_004624861:1,733,220...3,244,830

Cspg4

chondroitin sulfate proteoglycan 4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624894:564,252...595,048
Ensembl chrNW_004624894:561,683...594,878

Csrnp1

cysteine and serine rich nuclear protein 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:1,829,158...1,841,216
Ensembl chrNW_004624731:1,829,105...1,841,216

Ctla4

cytotoxic T-lymphocyte associated protein 4

susceptibility

ISO

protein:increased expression:CD4+ and CD8+ T cells:
DNA:SNPs: :rs231775,rs231725(human)

PMID:23432218 PMID:28648905

RGD:14398741 RGD:14398742

NCBI chrNW_004624765:12,449,205...12,454,324
Ensembl chrNW_004624765:12,449,205...12,454,324

Ctnnb1

catenin beta 1

severity
susceptibility
exacerbates

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
ClinVar Annotator: match by term: AXIN1-related condition | ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA
DNA:Mutations:exon:
associated with hepatitis B;DNA:SNPs: :rs3864004,rs11564475(human)
associated with Hepatitis B, Chronic,DNA:SNP, haplotype: :rs3864004 (human)
DNA:missense mutations:exon 3:multiple (human)

RGD:14402039 RGD:14402040 RGD:14402052 RGD:150429592

PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 More...

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

Ctsb

cathepsin B

ISO

PMID:15641152

RGD:2315605

NCBI chrNW_004624758:25,366,120...25,384,554
Ensembl chrNW_004624758:25,366,840...25,373,954

Ctsd

cathepsin D

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:14,661,058...14,671,116
Ensembl chrNW_004624767:14,660,936...14,671,671

CUNH14orf180

chromosome unknown C14orf180 homolog

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:636,582...643,656

Cux1

cut like homeobox 1

ISO

mRNA:increased expression:liver (human)

PMID:30561038

RGD:152985541

NCBI chrNW_004624740:15,289,616...15,664,090
Ensembl chrNW_004624740:15,287,421...15,664,077

Cxcl10

C-X-C motif chemokine ligand 10

disease_progression
treatment

ISO

PMID:27245433 PMID:28592115 PMID:28638480

RGD:27095889 RGD:27095898 RGD:27095899

NCBI chrNW_004624757:14,989,241...14,991,650
Ensembl chrNW_004624757:14,989,084...14,991,910

Cxcl11

C-X-C motif chemokine ligand 11

ISO

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624757:14,952,966...14,954,343
Ensembl chrNW_004624757:14,952,851...14,954,905

Cxcl12

C-X-C motif chemokine ligand 12

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624922:1,261,228...1,273,755
Ensembl chrNW_004624922:1,261,228...1,273,758

Cxcl14

C-X-C motif chemokine ligand 14

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:11,455,166...11,463,086
Ensembl chrNW_004624733:11,455,047...11,463,176

Cxcl8

C-X-C motif chemokine ligand 8

disease_progression
susceptibility

ISO

protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (human)
DNA:SNPs, haplotype:multiple

PMID:12432545 PMID:24381110 PMID:26078356 PMID:30523154 PMID:35776891

RGD:11526468 RGD:26884364 RGD:26884366

NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293

Cxcr4

C-X-C motif chemokine receptor 4

treatment
severity

ISO

human cells in mouse model
protein:increased expression:liver (human)

PMID:30034941 PMID:33574707

RGD:151665327 RGD:151665331

NCBI chrNW_004624732:35,473,740...35,477,482
Ensembl chrNW_004624732:35,472,760...35,477,528

Cyld

CYLD lysine 63 deubiquitinase

ISO

CTD Direct Evidence: marker/mechanism

PMID:21109933

NCBI chrNW_004624757:5,895,912...5,953,485

Dab2ip

DAB2 interacting protein

severity

ISO

mRNA:decreased expression:liver (human)
protein:decreased expression:liver (human)

PMID:22168621 PMID:31176165

RGD:151665110 RGD:151665148

NCBI chrNW_004624760:13,472,500...13,658,070
Ensembl chrNW_004624760:13,472,672...13,657,930

Dbh

dopamine beta-hydroxylase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:2,016,066...2,030,240
Ensembl chrNW_004624760:2,015,474...2,029,939

Dcn

decorin

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:15,466,938...15,517,475
Ensembl chrNW_004624750:15,470,968...15,516,365

Ddr1

discoidin domain receptor tyrosine kinase 1

severity

ISO

mRNA:increased expression:liver (human)

PMID:33173221

RGD:151347691

NCBI chrNW_004624754:24,881,439...24,905,633
Ensembl chrNW_004624754:24,880,496...24,896,995

Ddr2

discoidin domain receptor tyrosine kinase 2

treatment
disease_progression

ISO

PMID:26362312 PMID:33969575

RGD:11086753 RGD:150429748

NCBI chrNW_004624826:1,225,217...1,255,889
Ensembl chrNW_004624826:1,173,621...1,249,692

Ddx3x

DEAD-box helicase 3 X-linked

sexual_dimorphism
exacerbates

ISO

associated with hepatitis B; mRNA,protein:decreased expression:liver (human)

PMID:16301996 PMID:30297359

RGD:151356499 RGD:151356660

NCBI chrNW_004624762:14,290,267...14,305,437
Ensembl chrNW_004624762:14,290,267...14,305,633

Depdc1

DEP domain containing 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624742:27,240,906...27,288,872
Ensembl chrNW_004624742:27,240,342...27,258,681

Depdc1b

DEP domain containing 1B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624815:9,289,221...9,372,580
Ensembl chrNW_004624815:9,289,292...9,371,716

Depdc5

DEP domain containing 5, GATOR1 subcomplex subunit

ISO

CTD Direct Evidence: marker/mechanism

PMID:21725309

NCBI chrNW_004624747:8,169,035...8,310,945
Ensembl chrNW_004624747:8,168,321...8,310,457

Dhfr

dihydrofolate reductase

ISO

ClinVar Annotator: match by term: Hepatocellular cancer

PMID:28492532

NCBI chrNW_004624743:1,446,643...1,462,319
Ensembl chrNW_004624743:1,446,643...1,461,863

Dicer1

dicer 1, ribonuclease III

susceptibility

ISO

associated with hepatitis B; DNA:SNP: :rs1057035 T>C (human)

PMID:23868705

RGD:149735346

NCBI chrNW_004624734:7,604,049...7,681,481
Ensembl chrNW_004624734:7,608,273...7,651,819

Dipk2b

divergent protein kinase domain 2B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624887:1,321,247...1,361,036
Ensembl chrNW_004624887:1,326,336...1,361,124

Dlgap5

DLG associated protein 5

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:14,264,378...14,298,170
Ensembl chrNW_004624731:14,264,298...14,299,646

Dlk1

delta like non-canonical Notch ligand 1

ISO

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624734:3,363,084...3,372,790
Ensembl chrNW_004624734:3,363,001...3,372,694

Dmgdh

dimethylglycine dehydrogenase

disease_progression

ISO

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624869:3,498,851...3,576,341
Ensembl chrNW_004624869:3,500,293...3,576,245

Dnajc6

DnaJ heat shock protein family (Hsp40) member C6

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624742:29,397,811...29,525,886
Ensembl chrNW_004624742:29,398,544...29,485,165

Dnase1l3

deoxyribonuclease 1L3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624821:845,631...871,156
Ensembl chrNW_004624821:849,434...871,609

Dnmt1

DNA methyltransferase 1

ISO

mRNA, protein:increased expression:liver

PMID:11844796

RGD:2289670

NCBI chrNW_004624828:2,316,042...2,358,866
Ensembl chrNW_004624828:2,315,251...2,358,711

Dnmt3a

DNA methyltransferase 3 alpha

ISO

protein:increased expression:liver:
mRNA, protein:increased expression:liver

PMID:11844796 PMID:15885882

RGD:2289670 RGD:9588598

NCBI chrNW_004624738:7,481,084...7,581,332
Ensembl chrNW_004624738:7,485,842...7,581,056

Dnmt3b

DNA methyltransferase 3 beta

ISO

mRNA:increased expression:liver:
mRNA, protein:increased expression:liver

PMID:11844796 PMID:15885882

RGD:2289670 RGD:9588598

NCBI chrNW_004624842:6,450,972...6,505,929
Ensembl chrNW_004624842:6,450,852...6,475,785

Dsn1

DSN1 component of MIS12 kinetochore complex

disease_progression

ISO

PMID:30136646

RGD:27372884

NCBI chrNW_004624842:2,738,739...2,762,968
Ensembl chrNW_004624842:2,738,734...2,760,783

Dtl

denticleless E3 ubiquitin protein ligase homolog

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:17,612,264...17,660,772
Ensembl chrNW_004624771:17,612,284...17,662,405

Dynlrb1

dynein light chain roadblock-type 1

ISO

PMID:11750132

RGD:13208527

NCBI chrNW_004624842:4,817,469...4,837,843
Ensembl chrNW_004624842:4,817,469...4,837,824

Dynlrb2

dynein light chain roadblock-type 2

ISO

PMID:11750132

RGD:13208527

NCBI chrNW_004624746:6,805,245...6,814,227
Ensembl chrNW_004624746:6,804,890...6,814,724

E2f1

E2F transcription factor 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:12029619 PMID:15565109 PMID:28284560

NCBI chrNW_004624842:5,602,432...5,612,951
Ensembl chrNW_004624842:5,602,432...5,612,951

E2f8

E2F transcription factor 8

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:10,652,749...10,670,886
Ensembl chrNW_004624766:10,652,745...10,669,909

Eaf2

ELL associated factor 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:20564326

NCBI chrNW_004624912:112,793...168,553
Ensembl chrNW_004624912:112,843...168,553

Ecm1

extracellular matrix protein 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:18,234,537...18,239,896
Ensembl chrNW_004624772:18,233,727...18,240,601

Ect2

epithelial cell transforming 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:50,773,465...50,841,427
Ensembl chrNW_004624730:50,773,566...50,840,510

Eef2

eukaryotic translation elongation factor 2

exacerbates

ISO

protein:increased expression, increased phosphorylation:liver (human)

PMID:28060762

RGD:153298915

NCBI chrNW_004624828:5,601,906...5,609,978
Ensembl chrNW_004624828:5,601,444...5,611,405

Efemp1

EGF containing fibulin extracellular matrix protein 1

disease_progression

ISO

protein:decreased expression:liver:

PMID:23936443

RGD:10401793

NCBI chrNW_004624833:5,654,805...5,722,185
Ensembl chrNW_004624833:5,654,016...5,723,519

Eftud2

elongation factor Tu GTP binding domain containing 2

ameliorates
severity

ISO

PMID:34282556

RGD:155791664

NCBI chrNW_004624795:407,228...435,578
Ensembl chrNW_004624795:407,598...438,734

Egfr

epidermal growth factor receptor

disease_progression

ISO

CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:11355950

RGD:126781769

NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271

Egr1

early growth response 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:31,247,855...31,251,675
Ensembl chrNW_004624743:31,247,516...31,252,205

Egr2

early growth response 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624791:953,009...959,656
Ensembl chrNW_004624791:955,161...959,791

Ehd3

EH domain containing 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624738:13,033,491...13,062,795
Ensembl chrNW_004624738:13,032,604...13,062,795

Eif3h

eukaryotic translation initiation factor 3 subunit H

ISO

CTD Direct Evidence: marker/mechanism

PMID:14578863

NCBI chrNW_004624763:14,938,624...15,027,001
Ensembl chrNW_004624763:14,935,271...15,027,010

Enah

ENAH actin regulator

disease_progression

ISO

mRNA:increased expression:liver (human)

PMID:35030977

RGD:155791678

NCBI chrNW_004624835:6,292,808...6,442,349

Eng

endoglin

ISO

protein:increased expression:liver (rat)

PMID:20368095

RGD:7257538

NCBI chrNW_004624760:7,703,979...7,735,636
Ensembl chrNW_004624760:7,703,820...7,734,457

Eno1

enolase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:3,223,384...3,235,128
Ensembl chrNW_004624818:3,223,308...3,238,419

Epas1

endothelial PAS domain protein 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:26735578

NCBI chrNW_004624738:27,747,770...27,831,213
Ensembl chrNW_004624738:27,747,696...27,834,054

Epcam

epithelial cell adhesion molecule

severity

ISO

protein:increased expression:liver

PMID:24616575

RGD:14695007

NCBI chrNW_004624738:28,755,039...28,770,160
Ensembl chrNW_004624738:28,754,602...28,770,758

Ephb1

EPH receptor B1

ISO

protein:increased phosphorylation:liver (mouse)

PMID:28100771

RGD:127285675

NCBI chrNW_004624730:11,120,018...11,564,972
Ensembl chrNW_004624730:11,119,909...11,565,293

Ephx1

epoxide hydrolase 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:7892276

NCBI chrNW_004624835:6,161,930...6,181,016
Ensembl chrNW_004624835:6,162,111...6,168,714

Eps8l3

EPS8 signaling adaptor L3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:5,502,020...5,515,704

Erbb3

erb-b2 receptor tyrosine kinase 3

disease_progression

ISO

PMID:11355950

RGD:126781769

NCBI chrNW_004624802:11,906,279...11,925,530
Ensembl chrNW_004624802:11,905,271...11,925,707

Erbb4

erb-b2 receptor tyrosine kinase 4

ISO

DNA:insertion/deletion:3'UTR:rs6147150 (human)

PMID:22294845

RGD:126781763

NCBI chrNW_004624765:3,612,781...4,742,219
Ensembl chrNW_004624765:3,613,379...4,734,585

Ercc1

ERCC excision repair 1, endonuclease non-catalytic subunit

ISO

mRNA, protein:increased expression:liver (human)

PMID:15922480

RGD:155598683

NCBI chrNW_004624907:2,288,380...2,298,909
Ensembl chrNW_004624907:2,288,423...2,298,373

Ercc2

ERCC excision repair 2, TFIIH core complex helicase subunit

susceptibility
disease_progression

ISO

DNA:SNPs:exon 23: p.K751Q (human)
DNA:SNP:cd: 312A>G (human)
DNA:SNPs:exon 23: p.K751Q (human)
DNA:SNPs:exon 23: p.K751Q (rs13181) (human)

PMID:19919686 PMID:25531380 PMID:28598207 PMID:28927037

RGD:150530503 RGD:25671459 RGD:25671460 RGD:25671461

NCBI chrNW_004624907:2,249,323...2,263,999
Ensembl chrNW_004624907:2,250,133...2,263,947

Ereg

epiregulin

ISO

CTD Direct Evidence: marker/mechanism

PMID:35776891

NCBI chrNW_004624730:1,339,017...1,353,869
Ensembl chrNW_004624730:1,339,518...1,353,429

Ern1

endoplasmic reticulum to nucleus signaling 1

ISO

DNA:hypomethylation: CpG islands:

PMID:20165882

RGD:14694974

NCBI chrNW_004624849:1,521,996...1,625,878
Ensembl chrNW_004624849:1,525,235...1,625,893

Erp29

endoplasmic reticulum protein 29

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:20,167,197...20,174,914
Ensembl chrNW_004624747:20,166,371...20,175,012

Esm1

endothelial cell specific molecule 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:4,334,532...4,343,078
Ensembl chrNW_004624759:4,334,206...4,359,232

Esr1

estrogen receptor 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326

Etfa

electron transfer flavoprotein subunit alpha

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624894:1,874,859...1,935,587
Ensembl chrNW_004624894:1,874,695...1,936,120

Exo1

exonuclease 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:12,215,957...12,230,908

Ezh2

enhancer of zeste 2 polycomb repressive complex 2 subunit

susceptibility

ISO

CTD Direct Evidence: marker/mechanism
DNA:SNPs: :multiple
mRNA:increased expression:liver
mRNA:increased expression:liver (human)

RGD:10755339 RGD:11537550 RGD:126779595 RGD:126779608

PMID:24040354 PMID:24211739 PMID:25226601 PMID:26517514 PMID:28284560 More...

NCBI chrNW_004624800:6,781,848...6,874,221
Ensembl chrNW_004624800:6,802,901...6,874,196

coagulation factor II, thrombin

severity

ISO

CTD Direct Evidence: marker/mechanism
associated with liver cirrhosis;protein:altered expression, altered processing:liver (human)

PMID:2821104 PMID:7620113

RGD:14975114

NCBI chrNW_004624767:1,876,974...1,887,720
Ensembl chrNW_004624767:1,877,024...1,887,958

Fabp5

fatty acid binding protein 5

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:10,129,515...10,133,700

Fam180a

family with sequence similarity 180 member A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624765:16,007,155...16,019,066
Ensembl chrNW_004624765:16,006,739...16,018,976

Fam83d

family with sequence similarity 83 member D

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624842:757,708...782,524
Ensembl chrNW_004624842:758,273...782,524

Fancd2

FA complementation group D2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:4,577,663...4,671,086
Ensembl chrNW_004624731:4,611,963...4,671,765

Fanci

FA complementation group I

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:16,427,060...16,493,850

Fas

Fas cell surface death receptor

treatment

ISO

protein:increased expression:liver:

PMID:11274632 PMID:29634416 PMID:30737368

RGD:13792608 RGD:14700677 RGD:14700700

NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848

Faslg

Fas ligand

ISO

protein:increased expression:liver:

PMID:11274632

RGD:14700677

NCBI chrNW_004624771:9,031,978...9,038,760
Ensembl chrNW_004624771:9,032,016...9,038,825

Fasn

fatty acid synthase

ISO

CTD Direct Evidence: marker/mechanism

PMID:14563831 PMID:15543204 PMID:21147110

NCBI chrNW_004624801:10,910,022...10,926,505
Ensembl chrNW_004624801:10,909,647...10,927,547

Fat1

FAT atypical cadherin 1

disease_progression

ISO

mRNA,protein:increased expression:liver (human)

PMID:24590895

RGD:151347630

NCBI chrNW_004624769:17,801,796...17,924,685
Ensembl chrNW_004624769:17,801,894...17,925,191

Fate1

fetal and adult testis expressed 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:15580283

NCBI chrNW_004624883:3,030,776...3,033,912

Fbp1

fructose-bisphosphatase 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:22039417

NCBI chrNW_004624753:16,019,546...16,048,096
Ensembl chrNW_004624753:16,016,022...16,048,104

Fbxl18

F-box and leucine rich repeat protein 18

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:28,098,394...28,126,181
Ensembl chrNW_004624740:28,098,310...28,126,454

Fbxo11

F-box protein 11

exacerbates
ameliorates

ISO

protein:increased expression:liver (human)
mRNA:increased expression:liver (human)

PMID:29518611 PMID:29603830 PMID:32657545

RGD:152025259 RGD:152025263 RGD:152025266

NCBI chrNW_004624738:29,108,759...29,190,725
Ensembl chrNW_004624738:29,108,809...29,191,368

Fcn3

ficolin 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:11,265,740...11,269,588
Ensembl chrNW_004624764:11,265,505...11,269,650

Fdft1

farnesyl-diphosphate farnesyltransferase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:25,340,142...25,363,669
Ensembl chrNW_004624758:25,340,074...25,366,299

Fes

FES proto-oncogene, tyrosine kinase

exacerbates

ISO

DNA:hypermethylation:promoter (human)

PMID:31038805

RGD:153323297

NCBI chrNW_004624768:17,360,602...17,372,563
Ensembl chrNW_004624768:17,359,196...17,372,712

Fgf19

fibroblast growth factor 19

ISO

CTD Direct Evidence: marker/mechanism

PMID:25822088

NCBI chrNW_004624767:17,434,501...17,439,351
Ensembl chrNW_004624767:17,432,358...17,438,173

Fgf3

fibroblast growth factor 3

ISO

CTD Direct Evidence: marker/mechanism

PMID:25822088

NCBI chrNW_004624767:17,353,989...17,360,857
Ensembl chrNW_004624767:17,353,989...17,360,705

Fgf4

fibroblast growth factor 4

ISO

CTD Direct Evidence: marker/mechanism

PMID:25822088

NCBI chrNW_004624767:17,381,387...17,385,698
Ensembl chrNW_004624767:17,381,791...17,383,468

Fgfr1

fibroblast growth factor receptor 1

treatment

ISO

CTD Direct Evidence: marker/mechanism

PMID:16452204 PMID:20155451 PMID:21573021 PMID:36029209

RGD:25330358 RGD:25440476 RGD:25440478

NCBI chrNW_004624780:5,161,245...5,212,641
Ensembl chrNW_004624780:5,161,073...5,213,870

Fgfr2

fibroblast growth factor receptor 2

severity

ISO

associated with hepatitis B;DNA:SNPs: promoter, intron:rs308379, rs1219648 (human)

PMID:30952770

RGD:38501096

NCBI chrNW_004624737:25,052,698...25,158,346
Ensembl chrNW_004624737:25,052,606...25,158,529

Fgfr4

fibroblast growth factor receptor 4

treatment

ISO

PMID:32677805

RGD:150520166

NCBI chrNW_004624733:12,964,893...12,979,198
Ensembl chrNW_004624733:12,964,746...12,976,732

fumarate hydratase

ISO

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:10896297 PMID:15221078 PMID:16876016 PMID:17182618 PMID:18313410 More...

NCBI chrNW_004624771:11,861,537...11,886,154
Ensembl chrNW_004624771:11,856,884...11,887,066

Fhit

fragile histidine triad diadenosine triphosphatase

ISO

PMID:12112319

RGD:632723

NCBI chrNW_004624822:6,621,609...8,069,590
Ensembl chrNW_004624822:6,621,909...7,380,047

Flt3

fms related receptor tyrosine kinase 3

ameliorates

ISO

human cells in mouse model

PMID:27511526

RGD:149735514

NCBI chrNW_004624776:10,407,083...10,516,350
Ensembl chrNW_004624776:10,435,850...10,517,066

Flvcr1

FLVCR choline and heme transporter 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:18,239,437...18,270,408

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

ISO

CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:28284560

NCBI chrNW_004624734:26,424,053...26,427,431
Ensembl chrNW_004624734:26,423,079...26,427,732

Fosb

FosB proto-oncogene, AP-1 transcription factor subunit

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624907:2,332,746...2,338,825
Ensembl chrNW_004624907:2,328,691...2,339,099

Fosl2

FOS like 2, AP-1 transcription factor subunit

ISO

mRNA:increased expression:liver (human)

PMID:30086463 PMID:32048611

RGD:153344517 RGD:153344521

NCBI chrNW_004624738:10,370,479...10,391,623
Ensembl chrNW_004624738:10,370,103...10,391,623

Foxa1

forkhead box A1

susceptibility
sexual_dimorphism
disease_progression

ISO

DNA:VNTR, SNPs, haplotypes:multiple:
protein:decreased expression:liver

PMID:25965836 PMID:29208003 PMID:31400761

RGD:11054501 RGD:151665752 RGD:151665820

NCBI chrNW_004624955:234,289...239,541
Ensembl chrNW_004624955:231,506...239,508

Foxm1

forkhead box M1

ISO

CTD Direct Evidence: marker/mechanism
OMIM:114550

CTD
MouseDO

PMID:15082532 PMID:17173139 PMID:28284560

NCBI chrNW_004624860:206,367...222,035
Ensembl chrNW_004624860:207,242...219,959

Foxo1

forkhead box O1

ISO

mRNA:decreased expression:liver

PMID:28972178

RGD:14401599

NCBI chrNW_004624748:1,413,754...1,529,646
Ensembl chrNW_004624748:1,413,983...1,529,992

Foxp1

forkhead box P1

treatment

ISO

PMID:25156538

RGD:9587823

NCBI chrNW_004624773:5,543,529...6,076,522
Ensembl chrNW_004624773:5,543,536...5,883,131

Foxp3

forkhead box P3

ISO

protein:increased expression:liver

PMID:21086571

RGD:38548919

NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679

Fst

follistatin

ISO

CTD Direct Evidence: marker/mechanism

PMID:12203361 PMID:19363144

NCBI chrNW_004624759:5,799,127...5,804,802
Ensembl chrNW_004624759:5,798,067...5,805,254

Fth1

ferritin heavy chain 1

ISO

mRNA:increased expression:liver (rat)

PMID:9054589

RGD:632698

NCBI chrNW_004624926:469,870...471,142

Fubp1

far upstream element binding protein 1

ameliorates
exacerbates

ISO

human cell line in a mouse model
mRNA:increased expression:liver (human)
associated with Chronic Hepatitis C;mRNA:increased expression:liver (human)

PMID:19637194 PMID:25995247 PMID:31587040

RGD:151361188 RGD:151361194 RGD:151361196

NCBI chrNW_004624742:19,279,544...19,313,139

G6pc1

glucose-6-phosphatase catalytic subunit 1

treatment

ISO

associated with Glycogen Storage Disease IA, human gene in a mouse model

PMID:28096054

RGD:14695537

NCBI chrNW_004624795:1,331,592...1,339,575
Ensembl chrNW_004624795:1,331,601...1,339,580

G6pd

glucose-6-phosphate dehydrogenase

disease_progression

ISO

mRNA:increased expression:liver (human)

PMID:25473368 PMID:35693827

RGD:10449118 RGD:153344586

NCBI chrNW_004624946:989,376...1,001,787
Ensembl chrNW_004624946:986,107...1,001,955

Gabrd

gamma-aminobutyric acid type A receptor subunit delta

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:7,856,797...7,864,552
Ensembl chrNW_004624818:7,856,797...7,864,540

Gapdh

glyceraldehyde-3-phosphate dehydrogenase

ISO

CTD Direct Evidence: marker/mechanism

PMID:16767786 PMID:21472284

NCBI chrNW_004624860:3,257,805...3,261,736
Ensembl chrNW_004624860:3,257,853...3,261,735

GC vitamin D binding protein

susceptibility

ISO

associated with Hepatitis B, Chronic;DNA:SNP: :rs7041(human)
protein:increased expression:liver

PMID:21683810 PMID:25541958

RGD:14402025 RGD:5509919

NCBI chrNW_004624890:3,274,239...3,318,281
Ensembl chrNW_004624890:3,226,900...3,318,316

Gdf15

growth differentiation factor 15

ISO

CTD Direct Evidence: marker/mechanism

PMID:20512989

NCBI chrNW_004624908:1,633,927...1,636,242
Ensembl chrNW_004624908:1,634,174...1,636,242

Ggt1

gamma-glutamyltransferase 1

disease_progression

ISO

RNA,protein:increased expression, activity:liver:
HBV associated

PMID:10572675 PMID:11940314 PMID:27793641

RGD:14701040 RGD:14701041 RGD:14701048

NCBI chrNW_004624747:10,030,034...10,048,554

Ghr

growth hormone receptor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:12,282,295...12,570,106
Ensembl chrNW_004624759:12,285,594...12,570,906

Gins1

GINS complex subunit 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624939:177,496...212,804
Ensembl chrNW_004624939:176,929...205,642

Gjb1

gap junction protein beta 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:17978847

NCBI chrNW_004624903:1,511,347...1,519,265
Ensembl chrNW_004624903:1,517,324...1,519,265

Gjb2

gap junction protein beta 2

ISO

DNA, mRNA:promoter hypermethylation, decreased expression:liver

PMID:17295234

RGD:2289638

NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936

Gli1

GLI family zinc finger 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:26189965

NCBI chrNW_004624802:10,483,279...10,494,539
Ensembl chrNW_004624802:10,483,219...10,498,609

Glul

glutamate-ammonia ligase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:2,608,779...2,618,130

Gmnn

geminin DNA replication inhibitor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624756:2,268,304...2,335,021
Ensembl chrNW_004624756:2,268,304...2,278,129

Gmps

guanine monophosphate synthase

ISO

protein:increased activity:hepatoma (rat)

PMID:6861338

RGD:5135537

NCBI chrNW_004624730:33,459,059...33,535,593
Ensembl chrNW_004624730:33,460,566...33,535,593

Gnao1

G protein subunit alpha o1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:178,616...346,443

Gnas

GNAS complex locus

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 More...

NCBI chrNW_004624741:25,138,678...25,197,194
Ensembl chrNW_004624741:25,183,329...25,196,880

Gnaz

G protein subunit alpha z

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:9,425,720...9,479,571
Ensembl chrNW_004624747:9,425,775...9,480,162

Golm1

golgi membrane protein 1

severity

ISO

protein:increased expression:serum
mRNA, protein:increased expression:liver

PMID:21140449 PMID:21443671

RGD:401827118 RGD:401827119

NCBI chrNW_004624809:9,485,832...9,555,889
Ensembl chrNW_004624809:9,486,724...9,534,333

Gpc1

glypican 1

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624847:4,832,610...4,853,849
Ensembl chrNW_004624847:4,832,488...4,853,851

Gpc3

glypican 3

severity
disease_progression
exacerbates
treatment

ISO

protein:increased expression:liver
protein:increased expression:blood serum (human)
mRNA,protein:increased expression:peripheral blood mononuclear cell,blood serum, liver (human)
mRNA:increased expression:Peripheral Blood (human)
protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

RGD:14695019 RGD:14695020 RGD:243065125 RGD:243065131 RGD:243065134 RGD:243065135 RGD:243065139

PMID:16698587 PMID:19496787 PMID:21438004 PMID:22883669 PMID:23558072 More...

NCBI chrNW_004624797:13,234,741...13,678,542
Ensembl chrNW_004624797:13,230,932...13,678,742

Gpm6a

glycoprotein M6A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:6,763,158...7,082,764
Ensembl chrNW_004624769:6,762,743...6,904,757

Gpr158

G protein-coupled receptor 158

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624796:3,299,535...3,806,346
Ensembl chrNW_004624796:3,302,496...3,806,219

Gpr182

G protein-coupled receptor 182

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:10,936,114...10,939,614
Ensembl chrNW_004624802:10,936,619...10,939,603

Gpx1

glutathione peroxidase 1

severity
no_association
susceptibility

ISO

associated with hepatitis C;DNA:missense mutation:CDS:p.P198L (rs1050450) (human)
DNA:missense mutation:CDS:p.P198L (human)
associated with alcoholic liver cirrhosis;DNA:missense mutation:CDS:p.P198L (human)

PMID:16510607 PMID:19929244 PMID:25894370 PMID:26990426

RGD:11533013 RGD:151708729 RGD:152995483 RGD:152998906

NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626

Gpx3

glutathione peroxidase 3

severity
disease_progression

ISO

mRNA,protein:decreased expression:liver, blood plasma (human)
DNA:hypermethylation

PMID:25333265 PMID:25445749 PMID:27570561

RGD:151665355 RGD:151665509 RGD:401827855

NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993

Grb7

growth factor receptor bound protein 7

exacerbates

ISO

protein:increased expression:liver (human)

PMID:17634422

RGD:151347655

NCBI chrNW_004624795:3,359,119...3,366,802
Ensembl chrNW_004624795:3,357,469...3,365,425

Gtse1

G2 and S-phase expressed 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:3,554,960...3,580,180
Ensembl chrNW_004624752:3,555,283...3,572,409

Gys2

glycogen synthase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:17,090,741...17,145,823
Ensembl chrNW_004624752:17,090,563...17,143,493

Hamp

hepcidin antimicrobial peptide

ISO

DNA:hypermethylation,hypomethylation:promoter
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:liver (human)

PMID:28284560 PMID:29235098

RGD:15042879

NCBI chrNW_004624794:8,257,760...8,259,243
Ensembl chrNW_004624794:8,257,760...8,259,264

Hao2

hydroxyacid oxidase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:14,981,777...15,022,699
Ensembl chrNW_004624772:14,981,666...15,023,173

Havcr1

hepatitis A virus cellular receptor 1

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624733:32,284,793...32,310,980

Havcr2

hepatitis A virus cellular receptor 2

disease_progression

ISO

associated with hepatitis B;DNA:SNP: : ��1516 G>T (human)

PMID:27034168

RGD:40818257

NCBI chrNW_004624733:32,521,318...32,527,499

Hdac2

histone deacetylase 2

disease_progression

ISO

mRNA:increased expression:liver:

PMID:24448241

RGD:9590206

NCBI chrNW_004624856:4,834,197...4,861,546
Ensembl chrNW_004624856:4,834,217...4,861,592

Hdac4

histone deacetylase 4

ISO

mRNA:increased expression:liver:

PMID:21837748

RGD:9681451

NCBI chrNW_004624847:3,846,196...4,101,537
Ensembl chrNW_004624847:3,845,858...4,101,487

Herc5

HECT and RLD domain containing E3 ubiquitin protein ligase 5

ISO

CTD Direct Evidence: marker/mechanism

PMID:28919514

NCBI chrNW_004624757:16,108,509...16,151,654
Ensembl chrNW_004624757:16,028,668...16,152,628

Hfe

homeostatic iron regulator

disease_progression

ISO

associated with Liver Cirrhosis;DNA:missense mutation:cds:p.C282Y (human)

PMID:20019189 PMID:29642405

RGD:14746967 RGD:2317357

NCBI chrNW_004624756:821,738...831,482
Ensembl chrNW_004624756:823,947...831,376

Hgf

hepatocyte growth factor

ISO

CTD Direct Evidence: marker/mechanism

PMID:9932610 PMID:11896611

NCBI chrNW_004624739:30,233,589...30,307,508
Ensembl chrNW_004624739:30,236,146...30,307,356

Hgfac

HGF activator

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:24,483,358...24,488,505
Ensembl chrNW_004624755:24,483,431...24,488,450

Hhip

hedgehog interacting protein

ISO

CTD Direct Evidence: marker/mechanism

PMID:18559595

NCBI chrNW_004624853:3,649,974...3,739,344
Ensembl chrNW_004624853:3,649,967...3,735,834

Hif1a

hypoxia inducible factor 1 subunit alpha

treatment
disease_progression

ISO

protein:increased expression:liver (human)

PMID:19335982 PMID:26078356 PMID:31321740

RGD:11526468 RGD:155882550 RGD:9068886

NCBI chrNW_004624734:39,414,458...39,471,705
Ensembl chrNW_004624734:39,411,824...39,471,705

Hilpda

hypoxia inducible lipid droplet associated

disease_progression

ISO

mRNA:increased expression:liver (human)
human cells in mouse model
mRNA, protein:increased expression:liver (human)

PMID:30205391 PMID:31142329 PMID:35693827

RGD:153344574 RGD:153344577 RGD:153344586

NCBI chrNW_004624783:7,536,257...7,538,380
Ensembl chrNW_004624783:7,536,167...7,538,418

Hjurp

Holliday junction recognition protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624847:166,511...179,881

Hmgb2

high mobility group box 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:20851854

NCBI chrNW_004624769:4,834,998...4,837,111

Hmgcr

3-hydroxy-3-methylglutaryl-CoA reductase

ISO

CTD Direct Evidence: marker/mechanism

PMID:9207284 PMID:21147110

NCBI chrNW_004624951:681,559...711,476
Ensembl chrNW_004624951:682,178...711,474

Hmgcs2

3-hydroxy-3-methylglutaryl-CoA synthase 2

disease_progression

ISO

PMID:28867541

RGD:14975299

NCBI chrNW_004624772:15,432,612...15,464,343
Ensembl chrNW_004624772:15,432,198...15,467,797

Hmmr

hyaluronan mediated motility receptor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:26,319,635...26,351,576
Ensembl chrNW_004624733:26,319,678...26,351,234

Hnf1a

HNF1 homeobox A

treatment

ISO

human cell line in mouse model

PMID:29466992

RGD:14700664

NCBI chrNW_004624747:12,717,713...12,746,040
Ensembl chrNW_004624747:12,717,707...12,746,724

Hnf4a

hepatocyte nuclear factor 4 alpha

ISO

protein:decreased expression:liver:

PMID:20876809

RGD:12904747

NCBI chrNW_004624790:10,039,344...10,065,167
Ensembl chrNW_004624790:10,038,999...10,100,649

Hnrnpa1

heterogeneous nuclear ribonucleoprotein A1

ISO

protein:increased expression:liver (human)

PMID:23633480

RGD:9685423

NCBI chrNW_004624904:2,314,197...2,320,900
Ensembl chrNW_004624904:2,314,249...2,318,791

Hnrnpa2b1

heterogeneous nuclear ribonucleoprotein A2/B1

ISO

mRNA:increased expression:liver (rat)
protein:increased expression:liver (human)

PMID:20604928 PMID:23633480

RGD:9685422 RGD:9685423

NCBI chrNW_004624739:4,343,164...4,353,123
Ensembl chrNW_004624739:4,343,246...4,352,066

Hnrnpab

heterogeneous nuclear ribonucleoprotein A/B

severity

ISO

mRNA:increased expression:liver (human)

PMID:24638979

RGD:10059322

NCBI chrNW_004624733:41,387,068...41,403,701
Ensembl chrNW_004624733:41,398,123...41,403,617

Hnrnpd

heterogeneous nuclear ribonucleoprotein D

ISO

protein:increased expression:liver (rat)
protein:increased expression:liver (human)

PMID:20102719 PMID:22318685

RGD:10042969 RGD:10042977

NCBI chrNW_004624757:8,532,373...8,549,840
Ensembl chrNW_004624757:8,531,601...8,549,835

Hnrnph1

heterogeneous nuclear ribonucleoprotein H1

ISO

protein:increased expression:liver (human)

PMID:23633480

RGD:9685423

NCBI chrNW_004624733:42,538,286...42,547,911
Ensembl chrNW_004624733:42,538,159...42,548,249

Hnrnpl

heterogeneous nuclear ribonucleoprotein L

ISO

associated with Hepatitis B

PMID:24125732

RGD:9999429

NCBI chrNW_004624794:12,206,278...12,220,679
Ensembl chrNW_004624794:12,206,252...12,218,173

Hoxa10

homeobox A10

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:3,425,468...3,435,218
Ensembl chrNW_004624739:3,425,468...3,433,967

Hoxa13

homeobox A13

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:3,405,860...3,410,426
Ensembl chrNW_004624739:3,406,436...3,410,851

Hoxd9

homeobox D9

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624787:13,263,020...13,265,538
Ensembl chrNW_004624787:13,249,946...13,265,627

Hprt1

hypoxanthine phosphoribosyltransferase 1

ISO

protein:increased activity:hepatoma (rat)

PMID:6327016

RGD:5135035

NCBI chrNW_004624797:14,148,580...14,184,471

Hras

HRas proto-oncogene, GTPase

treatment

ISO

human cells in a mouse model
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:10791191 PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 More...

RGD:14688055

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

Hspa5

heat shock protein family A (Hsp70) member 5

ISO

CTD Direct Evidence: marker/mechanism

PMID:21472284 PMID:29698666

NCBI chrNW_004624760:9,986,529...9,991,261
Ensembl chrNW_004624760:9,986,656...9,995,252

Hspa9

heat shock protein family A (Hsp70) member 9

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:31,324,085...31,345,681
Ensembl chrNW_004624743:31,324,085...31,345,695

Hspb1

heat shock protein family B (small) member 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:14,940,161...14,941,561
Ensembl chrNW_004624740:14,939,445...14,941,819

Htatip2

HIV-1 Tat interactive protein 2

ISO

CTD Direct Evidence: therapeutic

PMID:16799960

NCBI chrNW_004624766:11,650,643...11,667,338
Ensembl chrNW_004624766:11,649,834...11,669,418

Htra1

HtrA serine peptidase 1

exacerbates
disease_progression

ISO

protein:decreased expression:liver (human)
mRNA:decreased expression:liver (human)

PMID:20943460 PMID:26403966

RGD:152985524 RGD:152985529

NCBI chrNW_004624737:24,217,260...24,267,836
Ensembl chrNW_004624737:24,216,525...24,267,827

Icam1

intercellular adhesion molecule 1

severity

ISO

protein:increased expression:serum

PMID:26109813

RGD:11056752

NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071

Idh1

isocitrate dehydrogenase (NADP(+)) 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624765:7,806,560...7,825,520

Idh2

isocitrate dehydrogenase (NADP(+)) 2

disease_progression

ISO

PMID:24716838

RGD:14985249

NCBI chrNW_004624768:17,094,649...17,111,333
Ensembl chrNW_004624768:17,094,655...17,111,397

Ier2

immediate early response 2

ISO

human cells in mouse model

PMID:32009420

RGD:153323326

NCBI chrNW_004624901:684,313...686,488
Ensembl chrNW_004624901:684,966...685,652

Ifng

interferon gamma

ISO

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534

Igbp1

immunoglobulin binding protein 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:21339737

NCBI chrNW_004624903:71,212...94,470

Igf1

insulin like growth factor 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:5,881,065...5,954,799
Ensembl chrNW_004624750:5,881,091...5,952,300

Igf1r

insulin like growth factor 1 receptor

susceptibility

ISO

DNA:SNPs, haplotype: :
CTD Direct Evidence: marker/mechanism

PMID:17441810 PMID:23958494 PMID:24758241

RGD:14985227

NCBI chrNW_004624768:5,396,027...5,688,435
Ensembl chrNW_004624768:5,396,156...5,681,809

Igf2

insulin like growth factor 2

susceptibility

ISO

CTD Direct Evidence: marker/mechanism
associated with hepatitis B;DNA:SNPs:intron, 3'utr:+2482A>C, +820A>G (human)

PMID:12532445 PMID:16092956 PMID:16750516 PMID:17554210

RGD:14401723 RGD:2311523

NCBI chrNW_004624767:14,969,977...14,997,577
Ensembl chrNW_004624767:14,969,866...14,979,026

Igf2bp1

insulin like growth factor 2 mRNA binding protein 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:5,352,932...5,391,617
Ensembl chrNW_004624795:5,353,005...5,385,521

Igf2bp3

insulin like growth factor 2 mRNA binding protein 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:7,154,893...7,319,724
Ensembl chrNW_004624739:7,158,020...7,319,720

Igf2r

insulin like growth factor 2 receptor

disease_progression
treatment
no_association

ISO

ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:loss of heterozygosity:liver
DNA:loss of heterozygosity,mutations:liver:

PMID:9722161 PMID:10347113 PMID:18322954 PMID:25741868 PMID:30720132

RGD:14985219 RGD:14985220 RGD:14985221

NCBI chrNW_004624855:2,752,676...2,887,327
Ensembl chrNW_004624855:2,753,994...2,887,151

Igfals

insulin like growth factor binding protein acid labile subunit

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624913:460,862...464,457
Ensembl chrNW_004624913:458,844...465,193

Ikbkg

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

treatment

ISO

protein:decreased expression:liver (human)

RGD:11079569 RGD:153297807 RGD:153297813 RGD:153305943 RGD:153305945 RGD:153305947

PMID:17292824 PMID:22176836 PMID:22922425 PMID:24971483 PMID:25173965 More...

NCBI chrNW_004624946:997,571...1,015,748
Ensembl chrNW_004624946:996,814...1,013,379

Ikzf1

IKAROS family zinc finger 1

ameliorates

ISO

protein:increased expression:liver (human)

PMID:25301737

RGD:150540326

NCBI chrNW_004624740:3,785,342...3,875,892
Ensembl chrNW_004624740:3,785,209...3,875,841

Il10

interleukin 10

treatment

ISO

PMID:23822114 PMID:26890368

RGD:14975171 RGD:7365006

NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732

Il12a

interleukin 12A

susceptibility

ISO

associated with hepatitis C;DNA:SNP:3'UTR: rs568408( G>A)(human)
associated with hepatitis B; DNA:SNP, haplotype:3′UTR :rs568408(human)

PMID:20521253 PMID:26631030 PMID:27819525

RGD:25440490 RGD:25440491 RGD:25440501

NCBI chrNW_004624730:37,787,772...37,794,871
Ensembl chrNW_004624730:37,787,909...37,794,940

Il15ra

interleukin 15 receptor subunit alpha

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624775:846,063...877,894
Ensembl chrNW_004624775:847,677...877,604

Il18

interleukin 18

susceptibility
severity
disease_progression

ISO

DNA:SNP:promoter:-137G>C(rs187238)(human)
associated with hepatitis C;DNA:SNPs, haplotype:promoter:-607C>A, -137G>C(human)
associated with hepatitis B, chronic;DNA:SNP:promoter:-607C>A(human)

PMID:26893476 PMID:27429592 PMID:27470888 PMID:29341496

RGD:11538094 RGD:14695526 RGD:14695540 RGD:14696663

NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687

Il18r1

interleukin 18 receptor 1

ISO

mRNA:decreased expression:liver

PMID:26893476

RGD:11538094

NCBI chrNW_004624749:6,875,934...6,909,702
Ensembl chrNW_004624749:6,875,750...6,909,734

Il1b

interleukin 1 beta

susceptibility

ISO

DNA:polymorphism:promoter:-31T>C (human)

PMID:21653279

RGD:7401222

NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760

Il1rap

interleukin 1 receptor accessory protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:66,491,230...66,625,642

Il1rn

interleukin 1 receptor antagonist

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:13,210,365...13,224,471
Ensembl chrNW_004624749:13,210,476...13,225,890

Il2

interleukin 2

treatment

ISO

PMID:9449371 PMID:10933975

RGD:14747035 RGD:8693323

NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453

Il21

interleukin 21

ISO

associated with hepatitis B;DNA:SNPS, haplotype:(rs13143866, rs2221903, rs907715) (human)

PMID:25892873

RGD:127285359

NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304

Il6

interleukin 6

treatment
disease_progression

ISO

DNA:SNP: :rs2069852 (human)
CTD Direct Evidence: marker/mechanism
mRNA,protein:increased expression:liver, blood serum (mouse)

RGD:11344640 RGD:127285672 RGD:14975289

PMID:17615358 PMID:20818158 PMID:26297436 PMID:26569409 PMID:27022031 More...

NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318

Il6st

interleukin 6 cytokine family signal transducer

ISO

PMID:15780071

RGD:1626706

NCBI chrNW_004624759:3,258,324...3,315,265
Ensembl chrNW_004624759:3,276,741...3,312,601

Ing3

inhibitor of growth family member 3

treatment

ISO

PMID:25156538

RGD:9587823

NCBI chrNW_004624783:15,094,631...15,126,699
Ensembl chrNW_004624783:15,094,764...15,126,693

Inmt

indolethylamine N-methyltransferase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624783:17,712...22,867
Ensembl chrNW_004624783:17,084...20,921

Inpp4b

inositol polyphosphate-4-phosphatase type II B

ISO

CTD Direct Evidence: marker/mechanism

PMID:29415082

NCBI chrNW_004624853:1,350,577...2,147,616
Ensembl chrNW_004624853:1,355,384...1,868,812

Ins

insulin

ISO

associated with Chronic Hepatitis C;mRNA:decreased expression:liver (human)

PMID:33132693

RGD:150340613

NCBI chrNW_004624767:14,999,088...15,000,035
Ensembl chrNW_004624767:14,999,088...15,000,035

Insr

insulin receptor

ISO

human cells in a mouse model
mRNA, protein:increased expression:liver (human, rat)

PMID:23633480 PMID:29610518

RGD:14700930 RGD:9685423

NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184

Iqgap1

IQ motif containing GTPase activating protein 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:20977743

NCBI chrNW_004624768:17,703,113...17,797,922
Ensembl chrNW_004624768:17,702,728...17,799,022

Iqgap2

IQ motif containing GTPase activating protein 2

ISO

CTD Direct Evidence: marker/mechanism
OMIM:114550

CTD
MouseDO

PMID:20977743

NCBI chrNW_004624869:888,868...1,172,747
Ensembl chrNW_004624869:889,091...1,171,983

Iqgap3

IQ motif containing GTPase activating protein 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624885:1,730,079...1,765,250
Ensembl chrNW_004624885:1,730,771...1,765,180

Irf2

interferon regulatory factor 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:22561517

NCBI chrNW_004624769:15,167,228...15,251,689
Ensembl chrNW_004624769:15,164,744...15,251,745

Irs1

insulin receptor substrate 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:1311924 PMID:23958494

NCBI chrNW_004624843:1,113,075...1,178,859
Ensembl chrNW_004624843:1,120,974...1,178,859

Irs2

insulin receptor substrate 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:16127164

NCBI chrNW_004624793:2,615,092...2,636,835
Ensembl chrNW_004624793:2,614,589...2,636,947

Isg15

ISG15 ubiquitin like modifier

ISO

CTD Direct Evidence: marker/mechanism

PMID:28919514

NCBI chrNW_004624818:8,510,657...8,511,749

Itih3

inter-alpha-trypsin inhibitor heavy chain 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624822:4,415,962...4,429,660
Ensembl chrNW_004624822:4,416,074...4,429,623

Itih4

inter-alpha-trypsin inhibitor heavy chain 4

disease_progression

ISO

associated with hepatitis B;protein:decreased expression:serum

PMID:24836184

RGD:40903002

NCBI chrNW_004624822:4,397,704...4,411,562
Ensembl chrNW_004624822:4,397,744...4,411,406

Jag1

jagged canonical Notch ligand 1

ISO

protein:increased expression:liver

PMID:30660174

RGD:14694832

NCBI chrNW_004624741:11,647,723...11,683,137
Ensembl chrNW_004624741:11,647,463...11,683,488

Jak1

Janus kinase 1

ISO

PMID:23788652

RGD:150524353

NCBI chrNW_004624742:29,631,391...29,723,981
Ensembl chrNW_004624742:29,689,965...29,723,981

Jak2

Janus kinase 2

exacerbates
severity
ameliorates
treatment

ISO

protein:increased phosphorylation:liver (human)
mRNA:decreased expression:liver (human)
protein:increased phosphorylation:liver (mouse)
L-JAK2 KO
associated with Diseases of the Aged and non-alcoholic fatty liver disease

RGD:125097525 RGD:127285621 RGD:127285655 RGD:127285672 RGD:127285675 RGD:18182928

PMID:22392353 PMID:22821478 PMID:25420511 PMID:28100771 PMID:29486150 More...

NCBI chrNW_004624736:9,724,876...9,827,364
Ensembl chrNW_004624736:9,724,369...9,830,365

Jdp2

Jun dimerization protein 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:20214788

NCBI chrNW_004624734:26,228,147...26,276,485
Ensembl chrNW_004624734:26,224,961...26,276,612

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

ISO

CTD Direct Evidence: marker/mechanism

PMID:20214788

NCBI chrNW_004624862:1,537,886...1,540,633
Ensembl chrNW_004624862:1,538,455...1,539,426

Jund

JunD proto-oncogene, AP-1 transcription factor subunit

ISO

associated with HBV;protein:increased expression:liver (human)

PMID:15927205

RGD:153297768

NCBI chrNW_004624908:1,572,628...1,574,205
Ensembl chrNW_004624908:1,573,174...1,574,113

Kat2b

lysine acetyltransferase 2B

severity

ISO

protein:decreased expression:liver (human)

PMID:23643089

RGD:9590314

NCBI chrNW_004624821:5,387,212...5,489,013

Kbtbd11

kelch repeat and BTB domain containing 11

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624861:1,085,143...1,111,528
Ensembl chrNW_004624861:1,101,415...1,103,340

Kcnh1

potassium voltage-gated channel subfamily H member 1

ISO

protein:increased expression:liver (human)

PMID:17022810

RGD:9693723

NCBI chrNW_004624807:1,019,347...1,392,433
Ensembl chrNW_004624807:1,056,313...1,388,491

Kcnn2

potassium calcium-activated channel subfamily N member 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:7,429,681...7,931,192
Ensembl chrNW_004624733:7,429,681...7,578,596

Kdm1a

lysine demethylase 1A

severity

ISO

mRNA, protein:increased expression:liver (human)

PMID:23236241

RGD:9681002

NCBI chrNW_004624764:7,664,550...7,742,494

Kdm3a

lysine demethylase 3A

ISO

mRNA:increased expression:liver (human)

PMID:21607773

RGD:9590222

NCBI chrNW_004624749:16,784,538...16,829,784
Ensembl chrNW_004624749:16,784,538...16,829,365

Kdm5c

lysine demethylase 5C

exacerbates

ISO

protein:increased expression:liver (human)

PMID:26503415

RGD:11530160

NCBI chrNW_004624909:421,033...455,201
Ensembl chrNW_004624909:420,077...455,309

Kdm6a

lysine demethylase 6A

ameliorates

ISO

human cells in a mouse model

PMID:32765772

RGD:150429729

NCBI chrNW_004624887:1,065,173...1,279,660
Ensembl chrNW_004624887:1,065,883...1,279,186

Kdm8

lysine demethylase 8

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624782:11,884,847...11,903,944
Ensembl chrNW_004624782:11,884,631...11,903,947

Kdr

kinase insert domain receptor

disease_progression
treatment

ISO

associated with alcoholic liver cirrhosis;DNA:SNP: :1416A>T (human)
protein:decreased expression:liver
protein:increased expression:liver
DNA:SNPs: :rs1870377, rs2071559, rs2305948 (human)

PMID:19177438 PMID:23660204 PMID:24445728 PMID:25182707 PMID:25333267

RGD:126848806 RGD:126848810 RGD:126848812 RGD:126848813 RGD:126848814

NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051

Kif11

kinesin family member 11

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:3,835,788...3,874,360

Kif14

kinesin family member 14

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:10,093,518...10,144,484
Ensembl chrNW_004624807:10,092,934...10,143,399

Kif15

kinesin family member 15

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:75,644,242...75,707,159
Ensembl chrNW_004624730:75,644,163...75,707,043

Kif18a

kinesin family member 18A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:17,565,072...17,622,342
Ensembl chrNW_004624766:17,564,560...17,622,932

Kif18b

kinesin family member 18B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:376,659...394,750
Ensembl chrNW_004624795:377,001...391,934

Kif1b

kinesin family member 1B

susceptibility
severity

ISO

DNA:snp:intron:c.2537+518A>G (rs17401966) (human)
mRNA, protein:decreased expression:liver (human)

PMID:26217094 PMID:27122668

RGD:11052488 RGD:12738461

NCBI chrNW_004624818:2,282,999...2,428,586
Ensembl chrNW_004624818:2,282,999...2,428,563

Kif20a

kinesin family member 20A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:30,994,664...31,003,858
Ensembl chrNW_004624743:30,995,526...31,011,396

Kif23

kinesin family member 23

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:4,048,997...4,074,836
Ensembl chrNW_004624781:4,048,902...4,073,257

Kif2c

kinesin family member 2C

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:633,635...660,149
Ensembl chrNW_004624906:633,754...660,254

Kif4a

kinesin family member 4A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624903:261,084...386,670

Kifc1

kinesin family member C1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:23,405,951...23,421,696
Ensembl chrNW_004624754:23,410,007...23,413,902

Klf4

KLF transcription factor 4

disease_progression
treatment

ISO

PMID:22677193

RGD:14402023

NCBI chrNW_004624758:4,047,217...4,052,257
Ensembl chrNW_004624758:4,047,219...4,051,983

Kmt2a

lysine methyltransferase 2A

ISO

CTD Direct Evidence: marker/mechanism

PMID:22634756

NCBI chrNW_004624784:13,824,507...13,912,672
Ensembl chrNW_004624784:13,824,541...13,908,077

Kmt2b

lysine methyltransferase 2B

ISO

DNA:insertions, translocations:intron:IVS3, multiple (human)
CTD Direct Evidence: marker/mechanism

PMID:18320596 PMID:22634754

RGD:9588597

NCBI chrNW_004624794:10,023,229...10,046,128
Ensembl chrNW_004624794:10,023,492...10,045,820

Kmt2c

lysine methyltransferase 2C

ISO

CTD Direct Evidence: marker/mechanism

PMID:22634756

NCBI chrNW_004624800:4,510,669...4,785,909
Ensembl chrNW_004624800:4,511,549...4,784,053

Kras

KRAS proto-oncogene, GTPase

induced

ISO

aflatoxin B1 induced:DNA:transversion,transition mutations:cds:
mRNA,protein:increased expression:liver
CTD Direct Evidence: marker/mechanism

PMID:8446626 PMID:11286481 PMID:11563603 PMID:29275358

RGD:11568697 RGD:14398750

NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166

Krt18

keratin 18

ISO

OMIM:114550

NCBI chrNW_004624904:1,011,675...1,015,319
Ensembl chrNW_004624904:1,011,755...1,015,416

Lcat

lecithin-cholesterol acyltransferase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:18,438,308...18,441,650
Ensembl chrNW_004624746:18,437,429...18,441,806

Lect2

leukocyte cell derived chemotaxin 2

ameliorates

ISO

human cells in mouse model
protein:increased expression:blood serum (mouse)
protein:increased expression:blood serum (human)

PMID:21394108 PMID:24892551

RGD:153323333 RGD:153323335

NCBI chrNW_004624733:11,158,202...11,169,912
Ensembl chrNW_004624733:11,157,690...11,169,912

Lep

leptin

severity
susceptibility

ISO

protein:increased expression:liver (human)
DNA:SNP:enhancer:-2548G>A (rs7799039) (human)

PMID:18573568 PMID:28452232

RGD:15039399 RGD:25330348

NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727

Lepr

leptin receptor

susceptibility

ISO

associated with Hepatitis B, Chronic;DNA:missense mutations:cds:p.Q223R, p.K109R (human)

PMID:23090836

RGD:21079466

NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049

Letm1

leucine zipper and EF-hand containing transmembrane protein 1

ISO

CTD Direct Evidence: therapeutic

PMID:23392203

NCBI chrNW_004624755:25,604,636...25,631,974
Ensembl chrNW_004624755:25,604,454...25,631,716

Lifr

LIF receptor subunit alpha

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:16,368,390...16,478,486
Ensembl chrNW_004624759:16,410,687...16,472,014

LOC101698463

HLA class II histocompatibility antigen, DP alpha 1 chain

ISO

DNA:hypomethylation: CpG islands:

PMID:20165882

RGD:14694974

NCBI chrNW_004624754:23,674,935...23,683,044
Ensembl chrNW_004624754:23,674,448...23,683,662

LOC101703821

HLA class II histocompatibility antigen, DQ beta 1 chain

treatment

ISO

associated with hepatitis C;DNA:SNPs,haplotypes
associated with hepatitis B

PMID:27288300 PMID:28921602

RGD:14928325 RGD:14974233

NCBI chrNW_004624754:23,895,509...23,902,487
Ensembl chrNW_004624754:23,895,607...23,906,713

LOC101707509

cytochrome P450 1A1

ISO

CTD Direct Evidence: marker/mechanism

PMID:15341023

NCBI chrNW_004627988:7...1,323

LOC101714280

cytochrome P450 26B1

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624762:1,455,828...1,474,201
Ensembl chrNW_004624762:1,456,440...1,472,381

LOC101717854

24-hydroxycholesterol 7-alpha-hydroxylase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:13,980,180...14,033,591
Ensembl chrNW_004624754:13,980,354...14,034,098

LOC101719726

cytochrome c oxidase subunit 7B, mitochondrial

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624761:20,336,164...20,336,517

LOC101722366

cytochrome P450 2E1

ISO

associated with alcohol dependence
DNA, mRNA:SNP, Decreased expression:liver: rs2031920 (human)
CTD Direct Evidence: marker/mechanism

PMID:15162526 PMID:20364586 PMID:29765251

RGD:14700882 RGD:14700899

NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514

LOC101724812

C-C chemokine receptor type 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:16284949

NCBI chrNW_004624730:74,822,848...74,828,614
Ensembl chrNW_004624730:74,826,659...74,827,726

LOC101726496

steroid 17-alpha-hydroxylase/17,20 lyase

ISO

CTD Direct Evidence: marker/mechanism

PMID:15341023

NCBI chrNW_004624831:2,155,851...2,166,621
Ensembl chrNW_004624831:2,157,048...2,166,539

Loxl3

lysyl oxidase like 3

ISO

CTD Direct Evidence: marker/mechanism

PMID:35841383

NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428

Lpar1

lysophosphatidic acid receptor 1

ISO

PMID:19000703

RGD:2317680

NCBI chrNW_004624758:518,070...668,915
Ensembl chrNW_004624758:519,249...669,471

Lrat

lecithin retinol acyltransferase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624853:2,936,426...2,941,993
Ensembl chrNW_004624853:2,936,109...2,945,101

Lrp1b

LDL receptor related protein 1B

exacerbates

ISO

protein:increased expression:liver (human)
DNA:mutations:multiple: (human)

PMID:33324588 PMID:33391418

RGD:150429776 RGD:150429785

NCBI chrNW_004624732:39,993,972...41,903,552
Ensembl chrNW_004624732:39,993,907...41,902,824

Lrrc1

leucine rich repeat containing 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624850:1,105,844...1,232,595
Ensembl chrNW_004624850:1,105,926...1,234,504

Lrrc56

leucine rich repeat containing 56

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 More...

NCBI chrNW_004624766:21,895,967...21,910,727
Ensembl chrNW_004624766:21,896,933...21,907,911

Lrrc59

leucine rich repeat containing 59

ISO

CTD Direct Evidence: marker/mechanism

PMID:30705370

NCBI chrNW_004624795:6,317,677...6,328,554
Ensembl chrNW_004624795:6,316,472...6,329,166

Lyve1

lymphatic vessel endothelial hyaluronan receptor 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:2,634,355...2,648,354
Ensembl chrNW_004624766:2,633,120...2,648,413

Lztr1

leucine zipper like post translational regulator 1

ISO

DNA:missense mutation:cds, liver (human)

PMID:28622513

RGD:151893487

NCBI chrNW_004624945:691,063...709,599
Ensembl chrNW_004624945:691,059...709,564

Map2k2

mitogen-activated protein kinase kinase 2

exacerbates

ISO

protein:increased expression:liver, cytosol (rat)
mRNA:increased expression:liver (human)

PMID:9397988 PMID:33553243

RGD:150530475 RGD:150530477

NCBI chrNW_004624828:5,489,085...5,511,166
Ensembl chrNW_004624828:5,488,814...5,511,445

Map2k4

mitogen-activated protein kinase kinase 4

ISO

protein:decreased expression:liver (human)

PMID:32850377

RGD:150429765

NCBI chrNW_004624786:14,457,382...14,597,027
Ensembl chrNW_004624786:14,457,452...14,597,027

Map3k1

mitogen-activated protein kinase kinase kinase 1

exacerbates

ISO

mRNA:decreased expression:liver (human)

PMID:31310010

RGD:150573714

NCBI chrNW_004624759:2,360,655...2,429,189
Ensembl chrNW_004624759:2,363,076...2,428,273

Map3k8

mitogen-activated protein kinase kinase kinase 8

ameliorates

ISO

PMID:26560698

RGD:11342977

NCBI chrNW_004624805:2,611,297...2,633,650
Ensembl chrNW_004624805:2,611,038...2,633,943

Map4k4

mitogen-activated protein kinase kinase kinase kinase 4

ameliorates
severity
treatment

ISO

human cell line in a mouse model
human recombinant gene and cell line in a mouse model

PMID:21196414 PMID:27010469 PMID:31922225

RGD:151347673 RGD:151347674 RGD:151347839

NCBI chrNW_004624749:6,332,686...6,495,942
Ensembl chrNW_004624749:6,332,534...6,495,942

Mapk1

mitogen-activated protein kinase 1

ISO

protein:increased expression:liver

PMID:27468214

RGD:401976278

NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757

Mapk14

mitogen-activated protein kinase 14

treatment
exacerbates

ISO

PMID:23271722 PMID:25216638

RGD:151665347 RGD:151665348

NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733

Mapk8

mitogen-activated protein kinase 8

ameliorates

ISO

protein:decreased phosphorylation:liver (human)

PMID:33875785

RGD:150340688

NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266

Mapt

microtubule associated protein tau

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624849:2,320,887...2,421,099

Marco

macrophage receptor with collagenous structure

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624732:26,203,345...26,236,001
Ensembl chrNW_004624732:26,203,219...26,236,057

Mat1a

methionine adenosyltransferase 1A

ISO

CTD Direct Evidence: marker/mechanism

PMID:12060674

NCBI chrNW_004624841:6,843,725...6,864,700
Ensembl chrNW_004624841:6,843,741...6,862,683

Mbl2

mannose binding lectin 2

no_association
susceptibility
severity

ISO

associated with viral hepatitis;DNA:polymorphisms:exon:
associated with hepatitis B;DNA:SNP:exon:
DNA:SNPs:promoter:rs7096206(human)
associated with hepatitis C;DNA:SNP: :221C>G(rs709620)(human)
protein:decreased expression:plasma
associated with hepatitis B-related cirrhosis;DNA:SNP: :rs11003123(G>A)(human)

RGD:14696813 RGD:14696814 RGD:14696829 RGD:14696833 RGD:14696835 RGD:14696836

PMID:18221301 PMID:21733090 PMID:25787238 PMID:26857650 PMID:27298104 More...

NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297

Mbtps1

membrane bound transcription factor peptidase, site 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:3,466,723...3,521,830
Ensembl chrNW_004624746:3,455,995...3,523,262

Mbtps2

membrane bound transcription factor peptidase, site 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624829:6,795,563...6,839,416
Ensembl chrNW_004624829:6,795,528...6,834,604

Mcm10

minichromosome maintenance 10 replication initiation factor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624805:5,728,781...5,766,796
Ensembl chrNW_004624805:5,728,569...5,765,862

Mcm7

minichromosome maintenance complex component 7

susceptibility

ISO

associated with hepatitis B;DNA:SNP:promoter: (rs999885) (human)
associated with hepatitis B;miRNA:increased expression:liver (human)

PMID:24416400 PMID:27298561

RGD:15042853 RGD:15042885

NCBI chrNW_004624740:16,887,699...16,895,224
Ensembl chrNW_004624740:16,887,775...16,899,934

Mcm9

minichromosome maintenance 9 homologous recombination repair factor

ISO

OMIM:114550

NCBI chrNW_004624798:11,287,882...11,370,040
Ensembl chrNW_004624798:11,290,074...11,367,495

Me1

malic enzyme 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624799:11,166,398...11,382,662

Mecp2

methyl-CpG binding protein 2

ISO

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver

PMID:11844796 PMID:26189965

RGD:2289670

NCBI chrNW_004624946:620,581...685,339
Ensembl chrNW_004624946:628,284...685,246

Med1

mediator complex subunit 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:20007298

NCBI chrNW_004624795:3,572,025...3,605,675
Ensembl chrNW_004624795:3,572,266...3,607,126

Melk

maternal embryonic leucine zipper kinase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624930:247,018...333,240

Met

MET proto-oncogene, receptor tyrosine kinase

severity
susceptibility

ISO

protein:increased expression:liver (human)
ClinVar Annotator: match by term: Hepatocellular cancer

RGD
OMIM
ClinVar

PMID:21774103 PMID:21970370 PMID:22703879 PMID:24728327 PMID:25741868 More...

RGD:152995524

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

Mfsd2a

MFSD2 lysolipid transporter A, lysophospholipid

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:22,422,520...22,435,332
Ensembl chrNW_004624764:22,422,423...22,435,416

Mki67

marker of proliferation Ki-67

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:18,935,686...18,963,907

Mlxipl

MLX interacting protein like

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:14,150,425...14,187,687
Ensembl chrNW_004624740:14,168,238...14,187,264

Mme

membrane metalloendopeptidase

ISO

PMID:8302012

RGD:13801035

NCBI chrNW_004624730:32,601,835...32,691,368
Ensembl chrNW_004624730:32,601,488...32,689,080

Mmp14

matrix metallopeptidase 14

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624820:9,667,371...9,677,488
Ensembl chrNW_004624820:9,667,262...9,677,774

Mmp2

matrix metallopeptidase 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:20084675

NCBI chrNW_004624757:1,450,680...1,479,160
Ensembl chrNW_004624757:1,448,698...1,479,255

Mmp9

matrix metallopeptidase 9

ISO

CTD Direct Evidence: marker/mechanism

PMID:20084675 PMID:21681821

RGD:8547864

NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713

Mogat2

monoacylglycerol O-acyltransferase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624817:1,450,238...1,468,503
Ensembl chrNW_004624817:1,450,300...1,468,514

Mpl

MPL proto-oncogene, thrombopoietin receptor

ISO

human cells in mouse model

PMID:23157389

RGD:126925755

NCBI chrNW_004624892:2,656,260...2,671,455
Ensembl chrNW_004624892:2,656,260...2,669,946

Mpo

myeloperoxidase

disease_progression
susceptibility

ISO

associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-463G>A(human)
associated with liver cirrhosis; DNA:SNP:promoter:-463G>A( rs2333227)(human)
CTD Direct Evidence: marker/mechanism

PMID:19731237 PMID:21907168

RGD:26923907 RGD:27095879

NCBI chrNW_004624871:121,026...131,433
Ensembl chrNW_004624871:121,026...131,323

Mro

maestro

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624778:14,352,071...14,359,861
Ensembl chrNW_004624778:14,352,856...14,359,678

Msh3

mutS homolog 3

ISO

ClinVar Annotator: match by term: Hepatocellular cancer

PMID:28492532

NCBI chrNW_004624743:1,461,952...1,581,524
Ensembl chrNW_004624743:1,461,077...1,581,180

Msh5

mutS homolog 5

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:24,453,750...24,477,574
Ensembl chrNW_004624754:24,453,902...24,473,051

Mtbp

MDM2 binding protein

ISO

CTD Direct Evidence: marker/mechanism

PMID:29765550

NCBI chrNW_004624763:18,228,820...18,299,706
Ensembl chrNW_004624763:18,228,252...18,299,925

Mtdh

metadherin

treatment

ISO

human cells in a mouse model

PMID:26351209

RGD:11096879

NCBI chrNW_004624763:4,905,261...4,967,014
Ensembl chrNW_004624763:4,905,044...4,967,014

Mthfd2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

ISO

mRNA:increased expression:liver

PMID:3878730

RGD:2302305

NCBI chrNW_004624749:29,264,577...29,276,769

Mthfr

methylenetetrahydrofolate reductase

susceptibility
disease_progression
onset

ISO

DNA:SNP,haplotype: :677C>T, 1298A>C(human)
DNA:SNPs: :677C>T, 1298A>C(human)
DNA:SNP: :677C>T(human)
DNA:SNP: :1298A>C(human)

PMID:17503006 PMID:17659576 PMID:19035314 PMID:23996892

RGD:14696703 RGD:14696704 RGD:14696707 RGD:14696708

NCBI chrNW_004624818:1,184,736...1,202,708
Ensembl chrNW_004624818:1,187,869...1,199,168

Mtor

mechanistic target of rapamycin kinase

severity

ISO

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver (human)

PMID:21147110 PMID:25371154

RGD:152995471

NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259

Mtrr

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

ISO

DNA:SNP: :66A>G(human)

PMID:19035314

RGD:14696707

NCBI chrNW_004624751:5,445,274...5,469,386
Ensembl chrNW_004624751:5,445,241...5,469,657

Mvk

mevalonate kinase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:10,837,743...10,858,758
Ensembl chrNW_004624747:10,834,306...10,857,595

Mybl2

MYB proto-oncogene like 2

ISO

CTD Direct Evidence: marker/mechanism

RGD:6903288 RGD:7240567 RGD:7240695 RGD:7241004

NCBI chrNW_004624790:10,629,771...10,665,187
Ensembl chrNW_004624790:10,630,158...10,664,982

Myc

MYC proto-oncogene, bHLH transcription factor

treatment
severity

ISO

OMIM:114550
mRNA:increased expression:liver (rat)
mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

RGD
MouseDO
CTD

PMID:9029167 PMID:12029619 PMID:15565109 PMID:21644509 PMID:22076107 More...

NCBI chrNW_004624735:27,780,338...27,784,714
Ensembl chrNW_004624735:27,780,037...27,784,806

Myd88

MYD88 innate immune signal transduction adaptor

exacerbates
treatment
ameliorates

ISO

mRNA:increased expression:liver (human)
human gene and cell in a mouse model
protein:increased expression:liver (human)
mouse cell line in a mouse model
human cell line in a mouse model
protein, mRNA:decreased expression:liver (human)

RGD:150520022 RGD:150520169 RGD:150521532 RGD:150521534 RGD:150524327 RGD:150524329 RGD:150524330 RGD:150524334 RGD:150530285

PMID:17615358 PMID:24603331 PMID:26985932 PMID:28370778 PMID:29022910 More...

NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489

Nbn

nibrin

ISO

ClinVar Annotator: match by term: Hepatocellular cancer

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chrNW_004624744:2,013,936...2,061,726
Ensembl chrNW_004624744:2,013,922...2,061,708

Ncapg

non-SMC condensin I complex subunit G

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:14,067,931...14,100,593
Ensembl chrNW_004624755:14,068,009...14,100,438

Ncaph

non-SMC condensin I complex subunit H

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:2,411,952...2,439,981
Ensembl chrNW_004624749:2,411,970...2,444,446

Ncoa2

nuclear receptor coactivator 2

exacerbates

ISO

PMID:22556267 PMID:28273073

RGD:153002573 RGD:153002576

NCBI chrNW_004624744:20,795,385...21,078,706
Ensembl chrNW_004624744:20,938,555...21,078,690

Ndc80

NDC80 kinetochore complex component

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624770:12,937,887...12,974,352
Ensembl chrNW_004624770:12,939,763...12,974,162

Neil3

nei like DNA glycosylase 3

disease_progression

ISO

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)

PMID:28284560 PMID:35693827

NCBI chrNW_004624769:8,436,526...8,480,336
Ensembl chrNW_004624769:8,448,226...8,480,439

Nek2

NIMA related kinase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:17,334,782...17,351,609
Ensembl chrNW_004624771:17,334,681...17,352,259

Nf2

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

disease_progression

ISO

DNA, protein:SNP, increased expression:intron, liver
protein:decreased expression:liver

PMID:26443326 PMID:27289045 PMID:29130106

RGD:11076529 RGD:150530489 RGD:150530504

NCBI chrNW_004624747:5,923,827...6,011,276
Ensembl chrNW_004624747:5,923,834...6,011,939

Nfe2l1

NFE2 like bZIP transcription factor 1

ISO

OMIM:114550

NCBI chrNW_004624795:4,652,221...4,663,341
Ensembl chrNW_004624795:4,652,637...4,662,454

Nfe2l2

NFE2 like bZIP transcription factor 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:22561517 PMID:31546024

RGD:21201310

NCBI chrNW_004624787:14,355,330...14,381,353
Ensembl chrNW_004624787:14,355,791...14,381,251

Nfkb1

nuclear factor kappa B subunit 1

disease_progression
treatment

ISO

associated with Chronic Hepatitis B;DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human)

PMID:19797428 PMID:25999787

RGD:152177911 RGD:40400751

NCBI chrNW_004624830:5,334,273...5,430,887
Ensembl chrNW_004624830:5,333,616...5,408,723

Nfkbia

NFKB inhibitor alpha

disease_progression
susceptibility

ISO

associated with Chronic Hepatitis B;DNA:SNPs,haplotype:3'utr,promoter: 826C>T,881A>G (rs2233406,rs3138053) (human)
CTD Direct Evidence: therapeutic
associated with hepatitis B;DNA:SNP:promoter:-826C>T (rs2233406) (human)

PMID:19797428 PMID:22022477 PMID:25223483

RGD:40400751 RGD:40902986

NCBI chrNW_004624838:1,384,337...1,387,602
Ensembl chrNW_004624838:1,384,204...1,390,205

Nkx3-1

NK3 homeobox 1

treatment

ISO

mRNA:decreased expression:liver
human gene in a mouse model

PMID:28972178

RGD:14401599

NCBI chrNW_004624758:18,874,399...18,876,982
Ensembl chrNW_004624758:18,875,475...18,876,971

Nlrc3

NLR family CARD domain containing 3

ISO

CTD Direct Evidence: marker/mechanism

PMID:30081150

NCBI chrNW_004624824:1,356,587...1,375,403
Ensembl chrNW_004624824:1,357,326...1,375,688

Nlrc5

NLR family CARD domain containing 5

ISO

protein:increased expression:liver

PMID:27338800

RGD:15003194

NCBI chrNW_004624746:28,954,009...29,030,337
Ensembl chrNW_004624746:28,954,016...29,030,322

Nnmt

nicotinamide N-methyltransferase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:9,765,582...9,783,004
Ensembl chrNW_004624784:9,765,582...9,783,004

Nos2

nitric oxide synthase 2

treatment

ISO

PMID:25999787

RGD:152177911

NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271

Notch3

notch receptor 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624901:2,292,257...2,328,433
Ensembl chrNW_004624901:2,292,640...2,328,433

Nr0b2

nuclear receptor subfamily 0 group B member 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:23811326

NCBI chrNW_004624764:10,896,728...10,899,898
Ensembl chrNW_004624764:10,892,481...10,899,215

Nr1h2

nuclear receptor subfamily 1 group H member 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:23213087 PMID:23811326 PMID:24954587 PMID:25496033

NCBI chrNW_004624832:4,136,052...4,141,648
Ensembl chrNW_004624832:4,132,904...4,140,896

Nr1h4

nuclear receptor subfamily 1 group H member 4

ISO

mRNA:splice variant(s):liver (human)
OMIM:114550
intestinally expressed human gene in mouse model
CTD Direct Evidence: marker/mechanism

RGD
MouseDO
CTD

RGD:14696796 RGD:14928330 RGD:14928334

NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834

Nras

NRAS proto-oncogene, GTPase

disease_progression
severity

ISO

human gene in mouse model
mRNA, protein:increased expression:liver (mouse, human)

PMID:21993994 PMID:30685691

RGD:14696775 RGD:14696793

NCBI chrNW_004624772:10,358,554...10,369,371

Nrg1

neuregulin 1

disease_progression

ISO

mRNA:increased expression:liver (human)
associated with hepatitis C;mRNA:altered expression:liver (human

PMID:17393520 PMID:27514687

RGD:39456104 RGD:39456110

NCBI chrNW_004624780:11,297,306...11,525,236
Ensembl chrNW_004624780:11,301,182...12,424,066

Nrp1

neuropilin 1

disease_progression

ISO

protein:decreased expression:liver

PMID:25333267

RGD:126848812

NCBI chrNW_004624805:8,438,485...8,574,845
Ensembl chrNW_004624805:8,438,498...8,574,508

Nuf2

NUF2 component of NDC80 kinetochore complex

disease_progression
treatment

ISO

CTD Direct Evidence: marker/mechanism

PMID:28284560 PMID:30653265 PMID:31933938

RGD:28867240 RGD:28912742

NCBI chrNW_004624826:1,794,084...1,831,009
Ensembl chrNW_004624826:1,798,737...1,831,112

Nusap1

nucleolar and spindle associated protein 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:8,510,628...8,541,007
Ensembl chrNW_004624804:8,510,739...8,540,306

Oit3

oncoprotein induced transcript 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:6,624,612...6,652,039
Ensembl chrNW_004624754:6,624,353...6,654,282

Olfml2a

olfactomedin like 2A

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:10,356,950...10,386,053
Ensembl chrNW_004624760:10,361,778...10,379,949

Olfml2b

olfactomedin like 2B

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624826:440,584...477,986
Ensembl chrNW_004624826:440,026...478,037

Orc1

origin recognition complex subunit 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624859:833,360...863,631
Ensembl chrNW_004624859:833,793...863,539

Otc

ornithine transcarbamylase

severity

ISO

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624762:17,038,223...17,104,853
Ensembl chrNW_004624762:17,038,223...17,104,965

Pafah1b1

platelet activating factor acetylhydrolase 1b regulatory subunit 1

disease_progression

ISO

mRNA,protein:decreased expression:liver:

PMID:21569763

RGD:12790589

NCBI chrNW_004624786:5,223,890...5,306,033
Ensembl chrNW_004624786:5,224,982...5,302,436

Pamr1

peptidase domain containing associated with muscle regeneration 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:11,681,209...11,753,310
Ensembl chrNW_004624767:11,681,203...11,754,194

Park7

Parkinsonism associated deglycase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042

Parp1

poly(ADP-ribose) polymerase 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:18695907

NCBI chrNW_004624807:446,662...478,571
Ensembl chrNW_004624807:446,647...479,069

Pbk

PDZ binding kinase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:22,603,076...22,625,817
Ensembl chrNW_004624758:22,603,039...22,625,763

Pck1

phosphoenolpyruvate carboxykinase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:23,985,257...23,990,354
Ensembl chrNW_004624741:23,985,675...23,989,790

Pclaf

PCNA clamp associated factor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:8,195,256...8,207,357
Ensembl chrNW_004624781:8,195,451...8,206,187

Pcna

proliferating cell nuclear antigen

treatment

ISO

protein:increased expression:liver:

PMID:23219601 PMID:25999787

RGD:10448993 RGD:152177911

NCBI chrNW_004624741:6,143,584...6,148,055
Ensembl chrNW_004624741:6,143,332...6,148,898

Pdcd1

programmed cell death 1

disease_progression

ISO

associated with hepatitis B
associated with hepatitis B;DNA:SNP: : +8669 A>G (human)

PMID:21912640 PMID:27034168

RGD:40818257 RGD:41410800

NCBI chrNW_004624847:5,732,922...5,741,908
Ensembl chrNW_004624847:5,732,767...5,742,269

Pdgfb

platelet derived growth factor subunit B

ISO

CTD Direct Evidence: marker/mechanism

PMID:20506153

NCBI chrNW_004624752:9,072,471...9,088,289
Ensembl chrNW_004624752:9,072,512...9,088,593

Pdgfrl

platelet derived growth factor receptor like

ISO

ClinVar Annotator: match by term: Hepatocellular carcinoma

OMIM
ClinVar

PMID:7898930

NCBI chrNW_004624769:21,617,268...21,668,709
Ensembl chrNW_004624769:21,616,954...21,668,771

Pdia3

protein disulfide isomerase family A member 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:10,754,978...10,784,641
Ensembl chrNW_004624804:10,755,103...10,784,337

Pdk4

pyruvate dehydrogenase kinase 4

ISO

CTD Direct Evidence: marker/mechanism

PMID:28003426

NCBI chrNW_004624813:2,258,279...2,270,540
Ensembl chrNW_004624813:2,258,279...2,270,824

Pfas

phosphoribosylformylglycinamidine synthase

ISO

protein:increased activity:hepatoma (rat)
protein:increased expression:liver

PMID:6722784

RGD:5135276

NCBI chrNW_004624786:10,831,287...10,854,526
Ensembl chrNW_004624786:10,836,943...10,853,274

Pfn2

profilin 2

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624730:27,306,452...27,312,493
Ensembl chrNW_004624730:27,307,030...27,312,501

Pgd

phosphogluconate dehydrogenase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:2,261,658...2,274,878
Ensembl chrNW_004624818:2,261,940...2,274,723

Pgk1

phosphoglycerate kinase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624836:2,657,320...2,676,124
Ensembl chrNW_004624836:2,653,474...2,676,766

Phb1

prohibitin 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:5,556,728...5,565,969
Ensembl chrNW_004624795:5,556,450...5,565,988

Phf6

PHD finger protein 6

exacerbates

ISO

mRNA:increased expression:liver (human)

PMID:30888215 PMID:31329335

RGD:155260288 RGD:155260308

NCBI chrNW_004624797:14,081,381...14,140,180
Ensembl chrNW_004624797:14,081,302...14,128,487

Phlda1

pleckstrin homology like domain family A member 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:22,012,245...22,018,338

Pik3ca

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

treatment
susceptibility
no_association
severity

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:SNPs: :rs17849071,rs17849079(human)
DNA:mutation:exon:
DNA:mutations:exons:

RGD:11556371 RGD:14402404 RGD:14402405 RGD:152177911

PMID:15016963 PMID:15520168 PMID:15608678 PMID:16331247 PMID:17376864 More...

NCBI chrNW_004624730:56,895,065...56,970,563
Ensembl chrNW_004624730:56,938,215...56,966,137

Pik3cb

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

treatment

ISO

PMID:25999787

RGD:152177911

NCBI chrNW_004624730:15,226,786...15,399,097
Ensembl chrNW_004624730:15,226,379...15,355,857

Pik3r1

phosphoinositide-3-kinase regulatory subunit 1

treatment

ISO

PMID:25999787 PMID:31801250

RGD:151893509 RGD:152177911

NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610

Pik3r2

phosphoinositide-3-kinase regulatory subunit 2

treatment

ISO

PMID:25999787

RGD:152177911

NCBI chrNW_004624908:1,513,916...1,523,723
Ensembl chrNW_004624908:1,513,969...1,523,295

Pinx1

PIN2 (TERF1) interacting telomerase inhibitor 1

disease_progression

ISO

associated with Chronic Hepatitis B; DNA:SNP::rs1469557(human)

PMID:27221889

RGD:152977752

NCBI chrNW_004624758:24,589,990...24,666,355
Ensembl chrNW_004624758:24,589,743...24,666,598

Pitpnm3

PITPNM family member 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624786:7,484,829...7,568,020
Ensembl chrNW_004624786:7,485,092...7,567,993

Pitx1

paired like homeodomain 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:12,028,497...12,034,612
Ensembl chrNW_004624733:12,029,298...12,034,413

Pkm

pyruvate kinase M1/2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:1,796,909...1,823,787
Ensembl chrNW_004624781:1,796,801...1,824,144

Pkmyt1

protein kinase, membrane associated tyrosine/threonine 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:715,818...724,535
Ensembl chrNW_004624824:715,770...724,530

Pkp1

plakophilin 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:9,374,206...9,419,075
Ensembl chrNW_004624807:9,372,099...9,419,067

Plac8

placenta associated 8

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624900:134,075...157,982
Ensembl chrNW_004624900:133,889...158,050

Plau

plasminogen activator, urokinase

ISO

OMIM:114550

NCBI chrNW_004624754:7,405,637...7,415,870
Ensembl chrNW_004624754:7,408,983...7,416,559

Plcg1

phospholipase C gamma 1

ameliorates

ISO

human cell line in a mouse model

PMID:30623526

RGD:151356937

NCBI chrNW_004624919:1,766,533...1,800,130
Ensembl chrNW_004624919:1,766,149...1,803,097

Plk1

polo like kinase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624782:8,811,593...8,823,060
Ensembl chrNW_004624782:8,811,616...8,826,749

Plk4

polo like kinase 4

sexual_dimorphism

ISO

DNA:hypermethylation:promoter

PMID:21324136

RGD:27226690

NCBI chrNW_004624777:8,804,372...8,825,669
Ensembl chrNW_004624777:8,804,593...8,825,257

Plod3

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

treatment

ISO

mRNA, protein:increased expression:liver (human)

PMID:29059470

RGD:155791679

NCBI chrNW_004624740:16,074,027...16,082,139
Ensembl chrNW_004624740:16,074,141...16,082,223

Plvap

plasmalemma vesicle associated protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624908:602,388...613,445
Ensembl chrNW_004624908:601,687...614,975

Plxdc1

plexin domain containing 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:3,756,641...3,793,006
Ensembl chrNW_004624795:3,757,668...3,792,506

Pml

PML nuclear body scaffold

ameliorates
exacerbates
disease_progression

ISO

mRNA:increased expression:liver (mouse)
associated with hepatitis C
protein:increased expression:liver (human)

PMID:11511788 PMID:26118777 PMID:31144474

RGD:41404685 RGD:41404687 RGD:41404690

NCBI chrNW_004624781:464,858...498,146
Ensembl chrNW_004624781:464,658...497,775

Pms2

PMS1 homolog 2, mismatch repair system component

ISO

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624740:31,315,121...31,345,137

Pnpt1

polyribonucleotide nucleotidyltransferase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624833:5,883,300...5,923,758
Ensembl chrNW_004624833:5,883,318...5,923,758

Polg

DNA polymerase gamma, catalytic subunit

susceptibility

ISO

DNA:SNPs:introns: (rs1061316, rs758130) (human)

PMID:28457473

RGD:15039387

NCBI chrNW_004624768:16,493,123...16,509,747
Ensembl chrNW_004624768:16,491,555...16,509,900

Pon1

paraoxonase 1

disease_progression

ISO

mRNA:decreased expression:liver (human)

NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882

Pot1

protection of telomeres 1

disease_progression

ISO

associated with hepatitis B;DNA:SNP: :rs7784168(human)

PMID:23907815

RGD:152975963

NCBI chrNW_004624783:11,138,222...11,223,329
Ensembl chrNW_004624783:11,138,303...11,223,044

Ppara

peroxisome proliferator activated receptor alpha

susceptibility

ISO

associated with hepatitis B;DNA:missense mutation:cds:p.L162V (human)

PMID:19119483

RGD:15042881

NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672

Pparg

peroxisome proliferator activated receptor gamma

severity

ISO

CTD Direct Evidence: therapeutic
protein:decreased expression:liver

PMID:16374840 PMID:27451128

RGD:14694822

NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481

Ppat

phosphoribosyl pyrophosphate amidotransferase

ISO

protein:increased activity:hepatoma (rat)

PMID:6327016

RGD:5135035

NCBI chrNW_004624761:12,980,508...13,017,818
Ensembl chrNW_004624761:12,980,513...13,019,011

Ppp1r1a

protein phosphatase 1 regulatory inhibitor subunit 1A

ISO

CTD Direct Evidence: marker/mechanism

PMID:15010824

NCBI chrNW_004624904:2,608,891...2,617,202
Ensembl chrNW_004624904:2,608,895...2,617,543

Ppp1r9a

protein phosphatase 1 regulatory subunit 9A

onset

ISO

protein:increased expression:liver (rat)

PMID:20935162

RGD:10002734

NCBI chrNW_004624813:1,587,567...1,951,620
Ensembl chrNW_004624813:1,588,261...1,945,788

Ppp1r9b

protein phosphatase 1 regulatory subunit 9B

severity

ISO

mRNA, protein:decreased expression:liver (human)

PMID:23591196

RGD:10043803

NCBI chrNW_004624795:6,124,273...6,137,776
Ensembl chrNW_004624795:6,124,159...6,137,955

Prc1

protein regulator of cytokinesis 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:17,266,850...17,289,051
Ensembl chrNW_004624768:17,266,964...17,288,430

Prdm1

PR/SET domain 1

disease_progression

ISO

associated with hepatitis B;
associated with hepatitis B;DNA:SNP: :rs1010273(human)

PMID:31100710 PMID:31376415

RGD:150530465 RGD:150530466

NCBI chrNW_004624780:16,205,056...16,227,382
Ensembl chrNW_004624780:16,204,838...16,227,390

Prdx1

peroxiredoxin 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:27517622

NCBI chrNW_004624906:1,405,253...1,414,980
Ensembl chrNW_004624906:1,405,253...1,414,926

Prdx2

peroxiredoxin 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624901:407,240...410,902
Ensembl chrNW_004624901:406,257...410,866

Prdx6

peroxiredoxin 6

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:8,282,622...8,293,799
Ensembl chrNW_004624771:8,282,062...8,294,340

Prex2

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

exacerbates

ISO

mRNA:increased expression:liver (human)
protein:increased expression:liver (human)
mRNA:decreased expression:liver (human)

PMID:25151370 PMID:28000796 PMID:28205209 PMID:31776854

RGD:151665185 RGD:151665186 RGD:151665188 RGD:151665343

NCBI chrNW_004624744:22,941,194...23,208,987
Ensembl chrNW_004624744:22,946,979...23,172,122

Prkn

parkin RBR E3 ubiquitin protein ligase

severity

ISO

protein:decreased expression:liver (human)

PMID:28862485

RGD:13432206

NCBI chrNW_004624855:430,148...1,992,121
Ensembl chrNW_004624855:430,260...1,989,747

Prl

prolactin

onset

ISO

protein:increased expression:serum (human)

PMID:22392353

RGD:125097525

NCBI chrNW_004624756:4,585,542...4,593,285

Prom1

prominin 1

ISO

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624755:15,765,162...15,886,023
Ensembl chrNW_004624755:15,771,286...15,886,348

Ptch1

patched 1

severity
disease_progression

ISO

PMID:18538319 PMID:22911366

RGD:150523837 RGD:150523842

NCBI chrNW_004624753:16,929,503...16,995,255
Ensembl chrNW_004624753:16,935,251...16,995,389

Pten

phosphatase and tensin homolog

exacerbates
severity
treatment

ISO

associated with hepatitis C, liver cirrhosis;protein:decreased expression:liver (human)
OMIM:114550
associated with hepatitis B;protein:decreased expression:liver (human)
CTD Direct Evidence: marker/mechanism

RGD
MouseDO
CTD

PMID:12115563 PMID:12673720 PMID:27022031 PMID:29303510 PMID:30690477 More...

RGD:127285591 RGD:127285603 RGD:127285610 RGD:151893509 RGD:152995524

NCBI chrNW_004624791:13,975,235...14,056,900

Ptgs2

prostaglandin-endoperoxide synthase 2

severity
treatment
susceptibility

ISO

protein:increased expression:liver, cytosol
mRNA,protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism
DNA:SNP:promoter:-1195A>G (rs689466) (human)

RGD:14695010 RGD:14695011 RGD:14695012 RGD:152177911 RGD:2300283

PMID:11872629 PMID:12024111 PMID:14563831 PMID:15800977 PMID:16374840 More...

NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728

Pth1r

parathyroid hormone 1 receptor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:74,371,614...74,392,344
Ensembl chrNW_004624730:74,371,294...74,390,262

Ptk2

protein tyrosine kinase 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:14578863 PMID:17203219

RGD:2292584

NCBI chrNW_004624735:15,356,911...15,713,219
Ensembl chrNW_004624735:15,461,178...15,714,071

Ptpn13

protein tyrosine phosphatase non-receptor type 13

susceptibility
disease_progression

ISO

DNA:SNP: :p.Y2081D(human)

PMID:16489062 PMID:26801674

RGD:152176666 RGD:152599190

NCBI chrNW_004624872:3,183,381...3,406,339
Ensembl chrNW_004624872:3,226,000...3,405,805

Ptprb

protein tyrosine phosphatase receptor type B

disease_progression

ISO

mRNA:decreased expression:liver (human)

PMID:30237408

RGD:151361293

NCBI chrNW_004624750:27,188,858...27,320,470
Ensembl chrNW_004624750:27,188,729...27,316,150

Pttg1

PTTG1 regulator of sister chromatid separation, securin

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:29,134,720...29,147,261

Pycard

PYD and CARD domain containing

ISO

CTD Direct Evidence: marker/mechanism

PMID:17471463

NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000

Pygl

glycogen phosphorylase L

ISO

CTD Direct Evidence: marker/mechanism

PMID:2885971

NCBI chrNW_004624731:17,990,877...18,028,351
Ensembl chrNW_004624731:17,990,977...18,028,186

Rac1

Rac family small GTPase 1

exacerbates

ISO

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)
mRNA:increased expression:liver (human)

PMID:18506888 PMID:20522449 PMID:33482578

RGD:153298967 RGD:153350129

NCBI chrNW_004624740:30,912,841...30,933,882
Ensembl chrNW_004624740:30,911,598...30,934,025

Racgap1

Rac GTPase activating protein 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624816:2,268,879...2,303,305
Ensembl chrNW_004624816:2,273,856...2,303,375

Rad21

RAD21 cohesin complex component

susceptibility
treatment
exacerbates

ISO

associated with hepatitis c, liver cirrhosis;mRNA:increased expression:liver (human)
human cells in a mouse model
protein:increased expression:liver (human)

PMID:28434945 PMID:30698808 PMID:32596342 PMID:33251678

RGD:150520026 RGD:150520029 RGD:150520030 RGD:150520035

NCBI chrNW_004624763:15,131,106...15,157,512
Ensembl chrNW_004624763:15,131,005...15,158,155

Rad50

RAD50 double strand break repair protein

ISO

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:16385572 PMID:18281469 PMID:19409520 PMID:24894818 PMID:25452441 More...

NCBI chrNW_004624733:39,445,083...39,544,415
Ensembl chrNW_004624733:39,447,461...39,544,409

Rad52

RAD52 homolog, DNA repair protein

onset
susceptibility

ISO

mRNA,protein:increased expression:liver (human)
associated with hepatitis B;DNA:SNP:3'utr: (rs7963551) (human)

PMID:24729511 PMID:31719794

RGD:151361199 RGD:151361207

NCBI chrNW_004624735:9,123,599...9,153,373

Rad54l

RAD54 like

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:2,164,711...2,194,262
Ensembl chrNW_004624906:2,165,780...2,193,764

Rara

retinoic acid receptor alpha

ISO

CTD Direct Evidence: marker/mechanism

PMID:18026104

NCBI chrNW_004624795:2,935,432...2,975,226
Ensembl chrNW_004624795:2,934,731...2,967,232

Rb1

RB transcriptional corepressor 1

treatment

ISO

CTD Direct Evidence: marker/mechanism

PMID:12029619 PMID:14961299 PMID:33841550

NCBI chrNW_004624748:6,358,588...6,533,217
Ensembl chrNW_004624748:6,358,180...6,533,249

Rbm10

RNA binding motif protein 10

disease_progression

ISO

mRNA:decreased expression:liver

PMID:32572914

RGD:151356975

NCBI chrNW_004624887:3,921,934...3,953,739
Ensembl chrNW_004624887:3,923,986...3,957,133

Rcan1

regulator of calcineurin 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:22,683,600...22,764,735
Ensembl chrNW_004624745:22,683,016...22,764,720

Recql

RecQ like helicase

disease_progression

ISO

protein:increased expression:liver

PMID:18422747

RGD:2317370

NCBI chrNW_004624752:17,183,624...17,220,954
Ensembl chrNW_004624752:17,185,129...17,220,707

Ret

ret proto-oncogene

severity

ISO

protein:increased expression:liver (human)
ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:7784092 PMID:7845675 PMID:7911697 PMID:8807338 PMID:8918855 More...

RGD:150340602

NCBI chrNW_004624922:382,462...413,227
Ensembl chrNW_004624922:382,399...413,281

Rgn

regucalcin

ISO

protein:decreased expression:liver

PMID:21683810

RGD:5509919

NCBI chrNW_004624887:3,881,624...3,900,144
Ensembl chrNW_004624887:3,883,213...3,899,277

Rictor

RPTOR independent companion of MTOR complex 2

severity

ISO

mRNA, protein:increased expression:liver (human)

PMID:25371154 PMID:29303510

RGD:152995471 RGD:152995524

NCBI chrNW_004624759:15,837,027...15,973,248
Ensembl chrNW_004624759:15,837,064...15,968,894

Rit1

Ras like without CAAX 1

ameliorates

ISO

human cells in mouse model

PMID:31247273

RGD:152999016

NCBI chrNW_004624885:1,275,765...1,284,613

Rnd3

Rho family GTPase 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624866:3,346,747...3,363,962
Ensembl chrNW_004624866:3,345,774...3,364,345

Rnf157

ring finger protein 157

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:6,031,594...6,128,112
Ensembl chrNW_004624801:6,031,594...6,128,183

Rnf43

ring finger protein 43

exacerbates

ISO

human cells in a mouse model

PMID:23136185

RGD:151361219

NCBI chrNW_004624871:191,534...259,134
Ensembl chrNW_004624871:191,546...259,120

Rnf6

ring finger protein 6

disease_progression

ISO

PMID:30496760

RGD:151665757

NCBI chrNW_004624776:12,353,441...12,365,512
Ensembl chrNW_004624776:12,354,340...12,363,505

Robo1

roundabout guidance receptor 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624874:4,234,640...5,359,333
Ensembl chrNW_004624874:4,949,538...5,357,690

Rps6

ribosomal protein S6

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:23,332,556...23,336,234
Ensembl chrNW_004624736:23,328,002...23,336,140

Rps6ka3

ribosomal protein S6 kinase A3

ISO

CTD Direct Evidence: marker/mechanism

PMID:22561517

NCBI chrNW_004624829:4,978,181...5,087,493
Ensembl chrNW_004624829:4,983,282...5,087,485

Rrm1

ribonucleotide reductase catalytic subunit M1

ISO

CTD Direct Evidence: marker/mechanism

PMID:18230555

NCBI chrNW_004624817:5,523,648...5,568,997
Ensembl chrNW_004624817:5,523,665...5,568,994

Rrm2

ribonucleotide reductase regulatory subunit M2

ISO

CTD Direct Evidence: marker/mechanism

PMID:18230555 PMID:28284560

NCBI chrNW_004624865:4,984,353...4,990,187
Ensembl chrNW_004624865:4,985,620...4,990,120

Rspo3

R-spondin 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624753:1,520,337...1,600,054
Ensembl chrNW_004624753:1,520,210...1,600,432

Rtkn

rhotekin

ISO

mRNA:increased expression:liver

PMID:27922690

RGD:19165144

NCBI chrNW_004624749:29,061,202...29,077,928
Ensembl chrNW_004624749:29,060,934...29,076,451

Rtp3

receptor transporter protein 3

ISO

CTD Direct Evidence: marker/mechanism

PMID:17693185

NCBI chrNW_004624730:74,605,692...74,609,946

Runx3

RUNX family transcription factor 3

ISO

mRNA:decreased expression:liver
CTD Direct Evidence: marker/mechanism

PMID:17094378 PMID:28458013

RGD:126775147

NCBI chrNW_004624764:9,192,067...9,218,617
Ensembl chrNW_004624764:9,191,556...9,248,252

Ryr3

ryanodine receptor 3

disease_progression

ISO

DNA:SNP:3'UTR:rs1044129(human)

PMID:26309413

RGD:155882454

NCBI chrNW_004624804:467,207...1,030,873
Ensembl chrNW_004624804:467,295...1,030,212

S100a9

S100 calcium binding protein A9

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624885:767,455...770,023
Ensembl chrNW_004624885:762,934...770,129

Sardh

sarcosine dehydrogenase

severity

ISO

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624760:2,030,835...2,070,517
Ensembl chrNW_004624760:2,032,326...2,066,584

Sav1

salvador family WW domain containing protein 1

ISO

OMIM:114550

NCBI chrNW_004624731:18,262,110...18,282,386

Scap

SREBF chaperone

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:73,926,978...73,975,337
Ensembl chrNW_004624730:73,927,010...73,975,337

Serpinb5

serpin family B member 5

disease_progression

ISO

associated with hepatitis B;

PMID:26296971

RGD:11520929

NCBI chrNW_004624792:9,196,932...9,220,147
Ensembl chrNW_004624792:9,198,657...9,221,264

Serpinf1

serpin family F member 1

ISO

associated with Human Viral Hepatitis, liver cirrhosis;protein:increased expression:serum (human)

PMID:27748324

RGD:27226704

NCBI chrNW_004624786:4,487,005...4,497,706
Ensembl chrNW_004624786:4,486,978...4,497,585

Set

SET nuclear proto-oncogene

ISO

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:26822237

NCBI chrNW_004624760:6,293,452...6,304,237

Sf3b1

splicing factor 3b subunit 1

treatment
disease_progression

ISO

protein:increased expression:liver
mRNA, protein:increased expression:liver

PMID:29954402 PMID:33038489

RGD:126790493 RGD:126790494

NCBI chrNW_004624889:2,796,351...2,835,592

Sf3b4

splicing factor 3b subunit 4

severity
treatment

ISO

mRNA, protein:increased expression:liver (human)
human cells in mouse model
mRNA, protein:increased expression:liver(human)
mRNA, protein:increased expression:liver (rat)

PMID:29059470 PMID:30391496

RGD:155791679 RGD:155804298

NCBI chrNW_004624772:17,701,930...17,706,613
Ensembl chrNW_004624772:17,701,341...17,706,550

Sfn

stratifin

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:10,859,556...10,860,876
Ensembl chrNW_004624764:10,859,667...10,860,413

Sfrp1

secreted frizzled related protein 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624780:2,133,105...2,172,301
Ensembl chrNW_004624780:2,132,960...2,174,508

Sh3gl1

SH3 domain containing GRB2 like 1, endophilin A2

ISO

CTD Direct Evidence: marker/mechanism

PMID:33838155

NCBI chrNW_004624828:5,304,887...5,330,440
Ensembl chrNW_004624828:5,305,070...5,330,440

Shc1

SHC adaptor protein 1

ISO

protein:increased expression, increased phosphorylation:hepatocyte

PMID:15375560

RGD:1643188

NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155

Shh

sonic hedgehog signaling molecule

ISO

CTD Direct Evidence: marker/mechanism

PMID:26189965

NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068

Sik2

salt inducible kinase 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:34491613

NCBI chrNW_004624784:6,728,504...6,900,557
Ensembl chrNW_004624784:6,745,595...6,895,747

Six1

SIX homeobox 1

severity

ISO

protein:increased expression:liver (human)

PMID:17008870

RGD:11561961

NCBI chrNW_004624734:40,453,445...40,457,551
Ensembl chrNW_004624734:40,453,420...40,459,671

Ska1

spindle and kinetochore associated complex subunit 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624778:13,948,567...13,968,643
Ensembl chrNW_004624778:13,953,390...13,968,683

Ska3

spindle and kinetochore associated complex subunit 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624776:16,412,683...16,450,784
Ensembl chrNW_004624776:16,413,048...16,445,892

Skp2

S-phase kinase associated protein 2

ISO

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver

PMID:12717389 PMID:19533683

RGD:2315050

NCBI chrNW_004624759:18,796,055...18,858,692
Ensembl chrNW_004624759:18,830,323...18,858,712

Slc25a47

solute carrier family 25 member 47

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:3,816,570...3,821,437
Ensembl chrNW_004624734:3,817,097...3,821,680

Slc26a6

solute carrier family 26 member 6

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:2,639,940...2,649,358
Ensembl chrNW_004624730:2,640,208...2,649,203

Slc2a1

solute carrier family 2 member 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:8364915

NCBI chrNW_004624892:2,110,310...2,148,023
Ensembl chrNW_004624892:2,117,561...2,148,037

Slc2a2

solute carrier family 2 member 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:8364915

NCBI chrNW_004624730:49,026,603...49,056,363
Ensembl chrNW_004624730:49,025,766...49,056,284

Slc38a1

solute carrier family 38 member 1

disease_progression
ameliorates

ISO

PMID:26389641

RGD:151361140

NCBI chrNW_004624816:5,988,625...6,025,987
Ensembl chrNW_004624816:5,989,601...6,025,987

Slc5a5

solute carrier family 5 member 5

ISO

CTD Direct Evidence: therapeutic

PMID:15347726 PMID:15520214

NCBI chrNW_004624908:1,401,812...1,410,471
Ensembl chrNW_004624908:1,401,829...1,409,538

Slc7a5

solute carrier family 7 member 5

ameliorates
disease_progression

ISO

mRNA:increased expression:liver

PMID:7532544 PMID:23696029 PMID:26389641

RGD:151361140 RGD:151361280 RGD:634202

NCBI chrNW_004624746:1,325,368...1,349,616

Slit2

slit guidance ligand 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:19100240

NCBI chrNW_004624755:11,470,810...11,819,800
Ensembl chrNW_004624755:11,472,377...11,819,266

Smad2

SMAD family member 2

ISO

PMID:18971187

RGD:12880056

NCBI chrNW_004624778:11,380,656...11,460,566
Ensembl chrNW_004624778:11,384,769...11,501,078

Smad4

SMAD family member 4

disease_progression

ISO

protein:decreased expression:liver
protein:increased expression:liver:

PMID:18971187 PMID:22799322 PMID:23922662 PMID:29924446

RGD:12880056 RGD:18182921 RGD:21066341 RGD:21066342

NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325

Smad7

SMAD family member 7

ISO

mRNA:increased expression:liver (human)

PMID:25602745

RGD:14401589

NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835

Smarca4

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

ISO

DNA:SNPs: :rs11879293, rs2072382 (human)

PMID:24556940

RGD:127285650

NCBI chrNW_004624828:2,893,075...2,985,968
Ensembl chrNW_004624828:2,893,096...2,985,968

Smarcb1

SWI/SNF related BAF chromatin remodeling complex subunit B1

disease_progression

ISO

mRNA:decreased expression:liver

PMID:27111394

RGD:127285647

NCBI chrNW_004624747:10,362,149...10,396,580
Ensembl chrNW_004624747:10,361,260...10,396,719

Smarcc1

SWI/SNF related BAF chromatin remodeling complex subunit C1

ameliorates

ISO

mRNA, protein:increased expression:liver (human)

PMID:32514535

RGD:151347860

NCBI chrNW_004624730:73,696,734...73,856,082
Ensembl chrNW_004624730:73,696,749...73,856,082

Smc3

structural maintenance of chromosomes 3

exacerbates

ISO

mRNA:increased editing:cds:p.K96R,p.Q103R(human)

PMID:29996118

RGD:156430111

NCBI chrNW_004624737:35,698,722...35,730,854
Ensembl chrNW_004624737:35,694,566...35,730,829

Smg9

SMG9 nonsense mediated mRNA decay factor

severity

ISO

PMID:34456727

RGD:155882446

NCBI chrNW_004624907:1,237,658...1,255,589
Ensembl chrNW_004624907:1,237,451...1,255,586

Smo

smoothened, frizzled class receptor

disease_progression

ISO

DNA:SNP: :rs3824 (human)

PMID:25944162

RGD:150340548

NCBI chrNW_004624783:7,012,385...7,039,302
Ensembl chrNW_004624783:7,011,899...7,039,921

Snai1

snail family transcriptional repressor 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:35841383

NCBI chrNW_004624790:5,509,541...5,515,240
Ensembl chrNW_004624790:5,509,311...5,515,266

Snrpe

small nuclear ribonucleoprotein polypeptide E

ISO

human gene in a mouse model

PMID:21688285

RGD:10768833

NCBI chrNW_004624807:7,079,944...7,086,973
Ensembl chrNW_004624807:7,079,090...7,087,215

Snw1

SNW domain containing 1

severity

ISO

protein:increased expression:liver (human)

PMID:23696020

RGD:11035253

NCBI chrNW_004624734:24,161,974...24,191,943
Ensembl chrNW_004624734:24,161,662...24,191,937

Snx27

sorting nexin 27

ISO

CTD Direct Evidence: marker/mechanism

PMID:36029209

NCBI chrNW_004624772:19,305,355...19,385,298
Ensembl chrNW_004624772:19,305,359...19,385,292

Soat1

sterol O-acyltransferase 1

exacerbates

ISO

associated with hepatitis B;protein:increased expression:liver (human)

PMID:30814741

RGD:126925204

NCBI chrNW_004624771:2,992,752...3,055,842
Ensembl chrNW_004624771:2,994,696...3,055,916

Soat2

sterol O-acyltransferase 2

ISO

PMID:16274362

RGD:1581190

NCBI chrNW_004624904:1,160,275...1,170,249
Ensembl chrNW_004624904:1,160,203...1,170,935

Socs1

suppressor of cytokine signaling 1

treatment

ISO

DNA:hypermethylation:CpG island, 5'untranslated region:
associated with liver cirrhosis;DNA:altered methylation:liver:

PMID:14614012 PMID:15235874 PMID:18843197 PMID:22318090

RGD:150573687 RGD:150573689 RGD:150573700 RGD:150573703

NCBI chrNW_004624824:8,444,877...8,446,628

Socs2

suppressor of cytokine signaling 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:13,333,393...13,339,018

Socs3

suppressor of cytokine signaling 3

ISO

CTD Direct Evidence: marker/mechanism

PMID:16831601

NCBI chrNW_004624801:7,841,230...7,843,912
Ensembl chrNW_004624801:7,840,889...7,843,860

Sod1

superoxide dismutase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:20,032,003...20,037,958
Ensembl chrNW_004624745:20,032,011...20,037,958

Sod2

superoxide dismutase 2

disease_progression
susceptibility

ISO

CTD Direct Evidence: marker/mechanism
protein:increased expression:saliva
associated with liver cirrhosis; DNA:SNP:cds:p.Ala16Val(rs1799725)(human)

RGD:1581242 RGD:26923907 RGD:26923955 RGD:27095881

PMID:15869407 PMID:16767786 PMID:18760346 PMID:19731237 PMID:21472284 More...

NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367

Sox30

SRY-box transcription factor 30

exacerbates
disease_progression

ISO

PMID:30312695

RGD:151660341

NCBI chrNW_004624733:31,774,341...31,855,539
Ensembl chrNW_004624733:31,774,616...31,807,516

Spag9

sperm associated antigen 9

ISO

associated with Human Viral Hepatitis

PMID:29344208

RGD:30296654

NCBI chrNW_004624795:6,748,513...6,863,201
Ensembl chrNW_004624795:6,745,537...6,863,173

Spc25

SPC25 component of NDC80 kinetochore complex

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624787:6,608,403...6,624,533
Ensembl chrNW_004624787:6,608,039...6,624,597

Spock1

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

ameliorates

ISO

human cells in mouse model

PMID:30710422

RGD:153344549

NCBI chrNW_004624733:9,556,024...10,080,703
Ensembl chrNW_004624733:9,556,763...10,080,703

Spop

speckle type BTB/POZ protein

exacerbates

ISO

human cells in mouse model
mRNA:decreased expression:liver (human)

PMID:26156804 PMID:33209975

RGD:11074965 RGD:153298924

NCBI chrNW_004624795:5,698,131...5,769,209

Spp1

secreted phosphoprotein 1

disease_progression

ISO

mRNA:increased expression:liver (human)

PMID:16047475 PMID:35693827

RGD:153344586 RGD:1581375

NCBI chrNW_004624872:4,505,796...4,513,247
Ensembl chrNW_004624872:4,505,522...4,513,742

Sprtn

SprT-like N-terminal domain

ISO

CTD Direct Evidence: marker/mechanism

PMID:25261934

NCBI chrNW_004624775:18,382,718...18,397,411
Ensembl chrNW_004624775:18,384,276...18,397,399

Src

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

ISO

PMID:9581679

RGD:150521543

NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132

Srebf1

sterol regulatory element binding transcription factor 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:14563831 PMID:21147110

NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465

Srebf2

sterol regulatory element binding transcription factor 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:6,815,075...6,871,674
Ensembl chrNW_004624752:6,816,468...6,871,567

Srf

serum response factor

ISO

PMID:9570363

RGD:1581428

NCBI chrNW_004624754:16,371,995...16,381,287

Srpx

sushi repeat containing protein X-linked

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:17,240,899...17,347,430
Ensembl chrNW_004624762:17,240,816...17,347,523

Srsf2

serine and arginine rich splicing factor 2

disease_progression
treatment

ISO

PMID:28082404 PMID:29278882 PMID:32372053

RGD:150429663 RGD:150429666 RGD:150429692

NCBI chrNW_004624801:6,575,322...6,578,429
Ensembl chrNW_004624801:6,575,325...6,578,468

St6gal1

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

ISO

protein:increased activity:liver:

PMID:9331085

RGD:10043141

NCBI chrNW_004624730:69,746,207...69,871,020
Ensembl chrNW_004624730:69,745,865...69,845,367

Stab2

stabilin 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:4,866,438...5,016,958
Ensembl chrNW_004624750:4,866,792...5,016,335

Stat1

signal transducer and activator of transcription 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:22488367

NCBI chrNW_004624854:5,067,578...5,106,052
Ensembl chrNW_004624854:5,067,535...5,102,106

Stat3

signal transducer and activator of transcription 3

ISO

protein:increased phosphorylation:liver (mouse)

PMID:28100771

RGD:127285675

NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200

Stat4

signal transducer and activator of transcription 4

susceptibility

ISO

CTD Direct Evidence: marker/mechanism
Hepatitis B, Chronic; DNA:SNP: intron 3: (rs7574865) (human)

PMID:23242368 PMID:26745093

RGD:11553302

NCBI chrNW_004624854:4,975,724...5,056,940
Ensembl chrNW_004624854:4,976,507...5,057,391

Stc2

stanniocalcin 2

disease_progression

ISO

mRNA:increased expression:liver (human)

NCBI chrNW_004624733:16,773,422...16,787,475
Ensembl chrNW_004624733:16,773,644...16,785,214

Stim1

stromal interaction molecule 1

ISO

mRNA:increased expression:liver (human)

PMID:23211538

RGD:152995401

NCBI chrNW_004624817:5,291,111...5,522,732
Ensembl chrNW_004624817:5,291,717...5,522,864

Stmn1

stathmin 1

disease_progression

ISO

CTD Direct Evidence: marker/mechanism

PMID:28284560 PMID:28982915

RGD:21408578

NCBI chrNW_004624764:9,996,119...10,001,253
Ensembl chrNW_004624764:9,996,124...10,001,197

Tacc3

transforming acidic coiled-coil containing protein 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:25,683,314...25,695,102
Ensembl chrNW_004624755:25,683,137...25,692,504

Tagln2

transgelin 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,331,075...1,338,445

Taldo1

transaldolase 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:19436114

NCBI chrNW_004624766:21,758,821...21,766,052
Ensembl chrNW_004624766:21,758,821...21,766,027

Tatdn1

TatD DNase domain containing 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:30,667,293...30,714,863

Tbx3

T-box transcription factor 3

severity
ameliorates
disease_progression

ISO

protein:increased expression:liver (human)
human cells in mouse model

PMID:22811581 PMID:26922018 PMID:29295731 PMID:30578408 PMID:33577921

RGD:151361112 RGD:151361114 RGD:151361122 RGD:151361123 RGD:151361132

NCBI chrNW_004624747:18,128,003...18,142,366
Ensembl chrNW_004624747:18,128,028...18,142,451

Tcf19

transcription factor 19

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:24,766,212...24,770,136
Ensembl chrNW_004624754:24,765,742...24,770,135

Tcim

transcriptional and immune response regulator

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624780:3,514,082...3,515,411
Ensembl chrNW_004624780:3,515,018...3,515,335

Tedc2

tubulin epsilon and delta complex 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:209,758...215,362
Ensembl chrNW_004624824:209,879...218,659

Tek

TEK receptor tyrosine kinase

ISO

protein:increased expression

PMID:16951510

RGD:1601490

NCBI chrNW_004624736:31,345,774...31,473,727

Tep1

telomerase associated protein 1

disease_progression
susceptibility

ISO

associated with hepatitis B;DNA:SNPs: :rs1713449,rs1760898, rs872072 (human)
DNA:SNP:intron:rs1760893(human)

PMID:23907815 PMID:27305982

RGD:152975963 RGD:152977750

NCBI chrNW_004624825:4,770,678...4,812,879
Ensembl chrNW_004624825:4,774,662...4,812,769

Tert

telomerase reverse transcriptase

susceptibility
disease_progression
no_association
treatment

ISO

DNA:mutations, polymorphisms:promoter,intron, exon:rs2736100,rs2736098(human)
ClinVar Annotator: match by term: Hepatocellular carcinoma
associated with hepatitis B;DNA:SNP: :rs13167280 (human)
DNA:SNPs::rs2736098(human)
DNA:mutations:promoter:
DNA:SNP,mutations:promoter:rs2853669 (-245T >C), (-124C > T),(-146C > T)human

RGD:11564803 RGD:14696767 RGD:14696768 RGD:14696769 RGD:14696770 RGD:150530496 RGD:152975963

PMID:17175353 PMID:19184104 PMID:23000435 PMID:23907815 PMID:25123086 More...

NCBI chrNW_004624751:624,569...647,198

Tet1

tet methylcytosine dioxygenase 1

ISO

protein:decreased expression:liver

PMID:23671639

RGD:9586747

NCBI chrNW_004624754:2,846,479...2,966,845
Ensembl chrNW_004624754:2,873,456...2,965,097

Tet2

tet methylcytosine dioxygenase 2

ameliorates
severity
disease_progression

ISO

human cells in mouse model
mRNA, protein:decreased expression:liver (human)
mRNA:decreased expression:liver (human)
mRNA, protein:increased expression:liver (human)

PMID:26366235 PMID:29331390 PMID:30070373 PMID:33097695

RGD:150429595 RGD:150429597 RGD:150429684 RGD:150429689

NCBI chrNW_004624830:3,446,331...3,543,450
Ensembl chrNW_004624830:3,446,141...3,519,084

Tfpi2

tissue factor pathway inhibitor 2

ISO

CTD Direct Evidence: marker/mechanism

PMID:17464989 PMID:28284560

NCBI chrNW_004624813:571,592...577,268
Ensembl chrNW_004624813:571,414...577,858

Tfrc

transferrin receptor

ISO

mRNA:increased expression:liver

PMID:16953838

RGD:2292036

NCBI chrNW_004624730:61,282,650...61,313,487
Ensembl chrNW_004624730:61,285,334...61,313,550

Tgfa

transforming growth factor alpha

ISO

CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental

PMID:9029167 PMID:9060843 PMID:15565109

RGD:2317471

NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318

Tgfb1

transforming growth factor beta 1

ISO

mRNA:increased expression:liver (mouse)
CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:28100771

RGD:127285675

NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605

Tgfb2

transforming growth factor beta 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643

Tgfbr2

transforming growth factor beta receptor 2

ISO

mRNA, protein:decreased expression:liver

PMID:14585397

RGD:1601598

NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959

Tgm3

transglutaminase 3

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:3,543,887...3,585,600
Ensembl chrNW_004624741:3,543,982...3,585,109

tyrosine hydroxylase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154

Them4

thioesterase superfamily member 4

ISO

CTD Direct Evidence: therapeutic

PMID:23392203

NCBI chrNW_004624772:19,673,079...19,704,635
Ensembl chrNW_004624772:19,673,066...19,698,710

Thy1

Thy-1 cell surface antigen

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:14,779,533...14,784,315
Ensembl chrNW_004624784:14,780,698...14,784,897

Ticrr

TOPBP1 interacting checkpoint and replication regulator

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:16,669,847...16,716,335
Ensembl chrNW_004624768:16,670,390...16,715,697

Timd4

T cell immunoglobulin and mucin domain containing 4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:32,381,189...32,482,874

Tk1

thymidine kinase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:7,685,003...7,692,949
Ensembl chrNW_004624801:7,685,017...7,692,872

Tlr2

toll like receptor 2

susceptibility

ISO

associated with Hepatitis C, Chronic;DNA:deletion:promoter:-196 to -174(human)

PMID:21500195 PMID:22859216 PMID:27183918

RGD:15090813 RGD:15090815 RGD:18337266

NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833

Tlr3

toll like receptor 3

disease_progression

ISO

PMID:23197495

RGD:21079421

NCBI chrNW_004624769:16,925,969...16,945,250
Ensembl chrNW_004624769:16,925,984...16,941,196

Tlr4

toll like receptor 4

susceptibility

ISO

DNA:SNPs, haplotype: :multiples
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs1057317(human)
protein:increased expression:liver:

PMID:21559380 PMID:25179842 PMID:27022031 PMID:28578348

RGD:14700552 RGD:14700557 RGD:14700558

NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120

Tlr7

toll like receptor 7

ISO

CTD Direct Evidence: marker/mechanism

PMID:24990399

NCBI chrNW_004624882:1,375,216...1,379,705

Tmem70

transmembrane protein 70

ISO

CTD Direct Evidence: marker/mechanism

PMID:27914986

NCBI chrNW_004624744:17,256,749...17,265,507
Ensembl chrNW_004624744:17,259,245...17,266,115

Tnf

tumor necrosis factor

disease_progression

ISO

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver, blood serum (mouse)

PMID:26569409 PMID:26890368 PMID:27022031

RGD:11344640 RGD:14975171

NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531

Tnfsf10

TNF superfamily member 10

ISO

CTD Direct Evidence: therapeutic

PMID:17326159

NCBI chrNW_004624730:50,534,284...50,550,279
Ensembl chrNW_004624730:50,531,915...50,550,528

Tnfsf9

TNF superfamily member 9

ISO

PMID:17325342

RGD:2317348

NCBI chrNW_004624828:3,615,860...3,623,377

Tnik

TRAF2 and NCK interacting kinase

disease_progression

ISO

protein:increased phosphorylation:liver, nucleus (human)

PMID:25160513

RGD:151347837

NCBI chrNW_004624730:49,087,876...49,497,981
Ensembl chrNW_004624730:49,090,222...49,497,646

Tonsl

tonsoku like, DNA repair protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:12,413,953...12,426,193

Tp53

tumor protein p53

treatment

ISO

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA

RGD
OMIM
ClinVar

PMID:253702 PMID:960674 PMID:1349102 PMID:1349175 PMID:1359493 More...

NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218

Tp73

tumor protein p73

exacerbates
treatment

ISO

mRNA:increased expression:liver (human)
protein:decreased phosphorylation:liver (human)
human cells in a mouse model

PMID:14760085 PMID:19664633 PMID:25371988 PMID:27359056 PMID:31429776

RGD:151347579 RGD:151347592 RGD:151347593 RGD:151347594 RGD:151347596

NCBI chrNW_004624818:6,775,588...6,817,187
Ensembl chrNW_004624818:6,775,599...6,809,289

Tpx2

TPX2 microtubule nucleation factor

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:707,267...772,543
Ensembl chrNW_004624741:709,322...772,423

Traf7

TNF receptor associated factor 7

treatment

ISO

mRNA:increased expression:liver

PMID:31730901

RGD:151356961

NCBI chrNW_004624913:79,423...100,301
Ensembl chrNW_004624913:79,423...100,279

Traip

TRAF interacting protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:3,749,183...3,775,062
Ensembl chrNW_004624730:3,748,894...3,774,489

Trim24

tripartite motif containing 24

ISO

CTD Direct Evidence: marker/mechanism

PMID:18026104

NCBI chrNW_004624765:18,966,663...19,079,857

Trip13

thyroid hormone receptor interactor 13

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624751:439,195...459,033
Ensembl chrNW_004624751:439,119...459,080

Troap

trophinin associated protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624816:2,853,799...2,861,374
Ensembl chrNW_004624816:2,853,715...2,861,346

Tsc1

TSC complex subunit 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:21499249

NCBI chrNW_004624760:3,479,028...3,536,612
Ensembl chrNW_004624760:3,498,692...3,532,011

Tsc2

TSC complex subunit 2

severity

ISO

protein:decreased expression:liver (human)

PMID:24119083

RGD:21079731

NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953

Tst

thiosulfate sulfurtransferase

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:10,765,126...10,772,159
Ensembl chrNW_004624752:10,765,137...10,774,800

Ttc36

tetratricopeptide repeat domain 36

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:13,913,218...13,931,581
Ensembl chrNW_004624784:13,913,225...13,931,581

Ttk

TTK protein kinase

disease_progression

ISO

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)

PMID:28284560 PMID:35693827

NCBI chrNW_004624819:6,631,697...6,682,181

Ttr

transthyretin

disease_progression

ISO

protein:decreased expression:blood serum (human)
protein:increased expression:blood serum (human)
protein:increased expression:blood serum (rat)

PMID:16240287 PMID:28876464 PMID:29534342

RGD:151356736 RGD:151664602 RGD:151665161

NCBI chrNW_004624770:1,255,401...1,262,019
Ensembl chrNW_004624770:1,251,716...1,262,213

Txnip

thioredoxin interacting protein

ISO

OMIM:114550

NCBI chrNW_004624772:17,341,918...17,345,964
Ensembl chrNW_004624772:17,341,630...17,345,960

Tyms

thymidylate synthetase

susceptibility

ISO

CTD Direct Evidence: marker/mechanism
DNA:deletion:3'UTR:1494del6(human)

PMID:17659576 PMID:18019677 PMID:18230555

RGD:14696708

NCBI chrNW_004624770:11,138,673...11,149,600
Ensembl chrNW_004624770:11,138,652...11,149,600

Uaca

uveal autoantigen with coiled-coil domains and ankyrin repeats

ISO

OMIM:114550

NCBI chrNW_004624781:3,106,658...3,189,325
Ensembl chrNW_004624781:3,106,608...3,191,870

Ube2c

ubiquitin conjugating enzyme E2 C

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624790:8,756,758...8,760,078
Ensembl chrNW_004624790:8,751,662...8,760,057

Ube2t

ubiquitin conjugating enzyme E2 T

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:8,420,739...8,429,805
Ensembl chrNW_004624807:8,425,899...8,429,516

Ubr5

ubiquitin protein ligase E3 component n-recognin 5

treatment

ISO

PMID:32087767

RGD:151665344

NCBI chrNW_004624763:19,414,582...19,530,539
Ensembl chrNW_004624763:19,414,549...19,530,517

Uchl1

ubiquitin C-terminal hydrolase L1

ISO

CTD Direct Evidence: marker/mechanism

PMID:18666234

NCBI chrNW_004624761:25,786,028...25,797,641
Ensembl chrNW_004624761:25,784,257...25,797,549

Uhrf1

ubiquitin like with PHD and ring finger domains 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:4,898,786...4,929,136
Ensembl chrNW_004624828:4,898,677...4,929,872

Umps

uridine monophosphate synthetase

ISO

CTD Direct Evidence: marker/mechanism

PMID:18230555

NCBI chrNW_004624731:761,235...780,355
Ensembl chrNW_004624731:761,210...779,321

Uroc1

urocanate hydratase 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624773:72,871...107,686
Ensembl chrNW_004624773:72,847...107,686

Usp2

ubiquitin specific peptidase 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:14,729,762...14,755,982
Ensembl chrNW_004624784:14,729,770...14,754,991

Usp4

ubiquitin specific peptidase 4

ISO

CTD Direct Evidence: marker/mechanism

PMID:35841383

NCBI chrNW_004624730:3,252,980...3,306,439
Ensembl chrNW_004624730:3,253,407...3,306,341

Vasn

vasorin

ISO

CTD Direct Evidence: marker/mechanism

PMID:25826090

NCBI chrNW_004624824:2,154,646...2,164,796
Ensembl chrNW_004624824:2,155,589...2,164,796

Vav1

vav guanine nucleotide exchange factor 1

ISO

mRNA:decreased expression:liver

PMID:2064726

RGD:2306008

NCBI chrNW_004624828:3,838,464...3,896,698
Ensembl chrNW_004624828:3,838,706...3,897,080

Vcam1

vascular cell adhesion molecule 1

ISO

CTD Direct Evidence: marker/mechanism

PMID:22922871

NCBI chrNW_004624857:3,606,573...3,625,991
Ensembl chrNW_004624857:3,606,431...3,627,063

Vdr

vitamin D receptor

susceptibility

ISO

associated with Hepatitis B, Chronic;DNA:SNP: :rs2228570(human)
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
associated with alcoholic liver cirrhosis;DNA:haplotype::

PMID:20572305 PMID:24033266 PMID:25541958 PMID:25741868 PMID:28492532

RGD:14402025 RGD:14402026

NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514

Vegfa

vascular endothelial growth factor A

treatment
susceptibility
disease_progression

ISO

protein:increased expression:serum:
DNA:SNP: :2578C>A (human)
associated with liver cirrhosis; protein:increased expression:platelet, liver:
DNA:polymorphism:promoter:-2578C>A (rs699947)(human)
protein:increased expression:liver

RGD:11527070 RGD:126848814 RGD:15003194 RGD:15003196 RGD:15003200 RGD:15014783 RGD:15036790 RGD:152177911

PMID:16835748 PMID:18392108 PMID:18544126 PMID:24445728 PMID:25999787 More...

NCBI chrNW_004624754:15,929,414...15,943,637

Vegfc

vascular endothelial growth factor C

ISO

associated with liver cirrhosis; protein:increased expression:liver:

PMID:18544126

RGD:15003200

NCBI chrNW_004624769:7,689,812...7,817,366
Ensembl chrNW_004624769:7,689,407...7,817,450

Vhl

von Hippel-Lindau tumor suppressor

disease_progression

ISO

PMID:31321740

RGD:155882550

NCBI chrNW_004624731:5,350,912...5,359,286

Vipr1

vasoactive intestinal peptide receptor 1

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:77,128,547...77,155,531
Ensembl chrNW_004624730:77,128,649...77,153,750

Vsig4

V-set and immunoglobulin domain containing 4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624898:1,268,998...1,288,756
Ensembl chrNW_004624898:1,268,886...1,289,180

Wdr62

WD repeat domain 62

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:10,309,855...10,358,018
Ensembl chrNW_004624794:10,310,129...10,348,686

Wdr76

WD repeat domain 76

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:10,844,275...10,947,234
Ensembl chrNW_004624804:10,846,384...10,907,017

Wnt2

Wnt family member 2

susceptibility

ISO

associated with hepatitis B;DNA:SNP: :rs4730775(human)

PMID:28328801

RGD:14402040

NCBI chrNW_004624827:2,045,733...2,088,284
Ensembl chrNW_004624827:2,045,595...2,089,442

Wrap53

WD repeat containing antisense to TP53

ISO

RNA:increased expression:liver:

PMID:26551349

RGD:11096781

NCBI chrNW_004624786:10,283,721...10,296,568
Ensembl chrNW_004624786:10,283,984...10,296,729

Xdh

xanthine dehydrogenase

ISO

protein:decreased activity:tumor (rat)

PMID:179860

RGD:5135059

NCBI chrNW_004624738:13,116,317...13,180,935
Ensembl chrNW_004624738:13,115,982...13,181,352

Xpo1

exportin 1

ameliorates
exacerbates
treatment

ISO

human cell line in a mouse model
mRNA:increased expression:liver (human)

PMID:25030088 PMID:27013579 PMID:31371628

RGD:151665796 RGD:151667433 RGD:151667441

NCBI chrNW_004624833:375,817...424,499
Ensembl chrNW_004624833:375,820...424,499

Xpo5

exportin 5

severity

ISO

DNA:snp, haplotype:3' utr:c.*659A>C (rs11077) (human)

PMID:24676133

RGD:11041737

NCBI chrNW_004624754:16,083,356...16,124,682
Ensembl chrNW_004624754:16,083,407...16,123,407

Xrcc1

X-ray repair cross complementing 1

susceptibility
severity
disease_progression
no_association

ISO

DNA:missense mutation:cds:c.1804C>A (p.G506A) (human)
associated with Chronic Hepatitis C;DNA:SNP:exon 14: c.1517G>C, p.506G>A (human)
DNA:SNPs:exon 9, exon 15: c.910A>G, c.1686C>G (human)
DNA:SNP:exon 13: c.1471G>A, p.E491K (human)
DNA:SNPs:cds: 194C>T, 280A>G (human)
associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R399Q (human)
DNA:missense mutation:cds:p.R399Q (rs25487) (human)
DNA:missense mutation:cds:p.R399Q (28152G>A) (rs25487) (human)
DNA:missense mutations:cds:p.R194W, p.R280H, p.R399Q (human)
DNA:missense mutations:cds:c.482C>T, c.1178G>A (p.P161L, p.R393H) (human)
associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R194W (human)
DNA:silent mutation, missense mutation:cds:c.1161G>A, c.1779C>G (p.L387L, p.S593R) (human)
DNA:SNPs:exons:c.1254C>T, c.1517G>C (human)
associated with hepatitis B;DNA:missense mutation, haplotype:cds:p.R399Q (human)

RGD:14696702 RGD:14696772 RGD:14696773 RGD:14985238 RGD:14985240 RGD:14985242 RGD:14985243 RGD:15014789 RGD:15014790 RGD:15014791 RGD:15014792 RGD:15036794 RGD:15036797 RGD:150530503 RGD:150530624 RGD:150540332 RGD:150540333

PMID:14519756 PMID:19194663 PMID:22502666 PMID:23454624 PMID:23493666 More...

NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266

Yap1

Yes1 associated transcriptional regulator

ISO

CTD Direct Evidence: marker/mechanism

PMID:29698666

NCBI chrNW_004624878:621,214...776,363

Ythdf2

YTH N6-methyladenosine RNA binding protein F2

ISO

CTD Direct Evidence: marker/mechanism

PMID:28104805

NCBI chrNW_004624764:12,533,317...12,567,514
Ensembl chrNW_004624764:12,533,257...12,567,514

Ywhaz

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

severity

ISO

PMID:27811373

RGD:14700875

NCBI chrNW_004624763:7,722,275...7,723,482

Zc3h12d

zinc finger CCCH-type containing 12D

ISO

CTD Direct Evidence: marker/mechanism

PMID:34545456

NCBI chrNW_004624785:8,588,480...8,613,199

Zfhx3

zinc finger homeobox 3

disease_progression
severity

ISO

associated with Chronic Hepatitis B;protein:decreased expression:blood serum (human)
human cell line in a mouse model

PMID:20534899 PMID:32277050

RGD:151361162 RGD:151361169

NCBI chrNW_004624746:15,094,890...15,330,653
Ensembl chrNW_004624746:15,098,960...15,254,127

Zfp36

ZFP36 ring finger protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:12,732,222...12,738,006
Ensembl chrNW_004624794:12,734,191...12,737,971

Zic2

Zic family member 2

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624793:11,162,835...11,167,497
Ensembl chrNW_004624793:11,163,916...11,167,457

Zic4

Zic family member 4

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:24,416,601...24,436,312
Ensembl chrNW_004624730:24,416,490...24,439,579

Zic5

Zic family member 5

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624793:11,171,431...11,186,415
Ensembl chrNW_004624793:11,176,946...11,189,003

Znf23

zinc finger protein 23

ISO

CTD Direct Evidence: marker/mechanism

PMID:21965783

NCBI chrNW_004624746:13,633,182...13,676,121
Ensembl chrNW_004624746:13,633,902...13,639,348

Zwint

ZW10 interacting kinetochore protein

ISO

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624791:7,528,452...7,534,182
Ensembl chrNW_004624791:7,528,426...7,534,553

aflatoxins-related hepatocellular carcinoma

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ephx1

epoxide hydrolase 1

ISO

associated with estrogen excess;protein:increased activity;liver (rat)

PMID:6133380

RGD:152998935

NCBI chrNW_004624835:6,161,930...6,181,016
Ensembl chrNW_004624835:6,162,111...6,168,714

Ggt1

gamma-glutamyltransferase 1

ISO

associated with estrogen excess;protein:increased activity;liver (rat)

PMID:6133380

RGD:152998935

NCBI chrNW_004624747:10,030,034...10,048,554

childhood hepatocellular carcinoma

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Met

MET proto-oncogene, receptor tyrosine kinase

ISO

ClinVar Annotator: match by term: Pediatric hepatocellular carcinoma

PMID:9927037

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

fibrolamellar carcinoma

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ca12

carbonic anhydrase 12

ISO

mRNA:increased expression:liver

PMID:28304380

RGD:153352326

NCBI chrNW_004624781:9,140,753...9,195,651
Ensembl chrNW_004624781:9,140,837...9,196,400

Ctnnb1

catenin beta 1

ISO

protein:increased tyrosine phosphorylation:exon:

PMID:19101982

RGD:14402052

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

Fgfr1

fibroblast growth factor receptor 1

ISO

protein:increased expression:liver:

PMID:24925055

RGD:11055933

NCBI chrNW_004624780:5,161,245...5,212,641
Ensembl chrNW_004624780:5,161,073...5,213,870

Prkaca

protein kinase cAMP-activated catalytic subunit alpha

ISO

mRNA,protein:increased expression:liver (human)

PMID:27027723

RGD:151347845

NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744

hepatocellular clear cell carcinoma

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Idh1

isocitrate dehydrogenase (NADP(+)) 1

disease_progression

ISO

DNA:misssense mutation:cds:p.Arg132Cys(human)
DNA:polymorphism: :rs12478635(human)

PMID:25355558 PMID:28403884

RGD:14974227 RGD:14974228

NCBI chrNW_004624765:7,806,560...7,825,520

Idh2

isocitrate dehydrogenase (NADP(+)) 2

disease_progression

ISO

DNA:polymorphism: :rs11632348(human)

PMID:25355558

RGD:14974228

NCBI chrNW_004624768:17,094,649...17,111,333
Ensembl chrNW_004624768:17,094,655...17,111,397

Lep

leptin

ISO

mRNA:increased expression:liver:

PMID:20723213

RGD:14696785

NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727

Lepr

leptin receptor

ISO

mRNA:increased expression:liver

PMID:20723213

RGD:14696785

NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049

Tert

telomerase reverse transcriptase

disease_progression

ISO

mRNA:increased expression:liver:

PMID:20723213 PMID:28460432

RGD:14696783 RGD:14696785

NCBI chrNW_004624751:624,569...647,198

mixed fibrolamellar hepatocellular carcinoma

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Prkaca

protein kinase cAMP-activated catalytic subunit alpha

susceptibility

ISO