RGD DISEASE ONTOLOGY - ANNOTATIONS |
|
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
|
Term: | hepatocellular carcinoma |
|
Accession: | DOID:684
|
browse the term
|
Definition: | A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO) |
Synonyms: | exact_synonym: | Childhood Hepatocellular Carcinoma; HCC; Hepatocellular Cancer; Hepatocellular Carcinoma, Childhood Type, Somatic; LCC; adult liver cancer; adult liver cancers; hepatocellular cancers; hepatocellular carcinomas; hepatoma; hepatomas; liver cell carcinoma; liver cell carcinomas |
| narrow_synonym: | HEPATOBLASTOMA; HEPATOBLASTOMA CAUSED BY SOMATIC MUTATION; hepatitis B virus induced hepatocellular carcinoma; hepatitis C virus induced hepatocellular carcinoma; hepatitis virus-related hepatocellular carcinoma |
| primary_id: | MESH:D006528 |
| alt_id: | MIM:114550 |
| xref: | EFO:0000182; EFO:0000189; EFO:0008503; EFO:0008504; EFO:0008505; ICD-O:M8170/3; ICDO:8170/3; NCI:C129298; NCI:C24029; NCI:C3099; NCI:C38756; NCI:C60416; ORDO:88673 |
For additional species annotation, visit the
Alliance of Genome Resources.
|
|
|
|
G |
A2m |
alpha-2-macroglobulin |
|
ISO |
mRNA,protein:increased expression:liver: CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:15509519 PMID:15509519 |
RGD:1358261 |
NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
|
|
G |
A530016L24Rik |
RIKEN cDNA A530016L24 gene |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr12:112,455,829...112,466,362
Ensembl chr12:112,455,882...112,466,361
|
|
G |
Abca1 |
ATP-binding cassette, sub-family A member 1 |
severity |
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:16941710 PMID:30580964 |
RGD:1598532, RGD:24922199 |
NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
|
|
G |
Abcb1a |
ATP-binding cassette, sub-family B member 1A |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism DNA:polymorphism: : c.1465C > T(human) DNA:polymorphism: :c.3751G>A(human) |
CTD RGD |
PMID:17510421 PMID:25625052 PMID:23488625 PMID:24175826 |
RGD:11041138, RGD:14700904, RGD:14700905 |
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
|
|
G |
Abcb4 |
ATP-binding cassette, sub-family B member 4 |
|
ISO IAGP |
CTD Direct Evidence: marker/mechanism OMIM:114550 |
CTD MouseDO |
PMID:22022477 |
|
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
|
|
G |
Abcc3 |
ATP-binding cassette, sub-family C member 3 |
|
ISO |
mRNA:increased expression:liver |
RGD |
PMID:25842354 |
RGD:11535155 |
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
|
|
G |
Abce1 |
ATP-binding cassette, sub-family E member 1 |
|
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:21932399 |
RGD:11041873 |
NCBI chr 8:80,410,071...80,438,369
Ensembl chr 8:80,410,091...80,438,369
|
|
G |
Abl1 |
c-abl oncogene 1, non-receptor tyrosine kinase |
|
IMP |
|
RGD |
PMID:32171747 |
RGD:126907997 |
NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239
|
|
G |
Acaca |
acetyl-Coenzyme A carboxylase alpha |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
|
|
G |
Ace |
angiotensin I converting enzyme |
susceptibility |
ISO |
CTD Direct Evidence: therapeutic DNA:insertion/deletion:intron 16: |
CTD RGD |
PMID:16328049 PMID:25208933 |
RGD:11343535 |
NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
|
|
G |
Acer3 |
alkaline ceramidase 3 |
disease_progression |
ISO |
|
RGD |
PMID:30097213 |
RGD:35673325 |
NCBI chr 7:97,863,015...97,970,415
Ensembl chr 7:97,855,596...97,970,415
|
|
G |
Acly |
ATP citrate lyase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826
|
|
G |
Aco2 |
aconitase 2, mitochondrial |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
|
|
G |
Acox1 |
acyl-Coenzyme A oxidase 1, palmitoyl |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12771043 PMID:15565109 |
|
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
|
|
G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531
|
|
G |
Actb |
actin, beta |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 PMID:21472284 |
|
NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
|
|
G |
Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19514085 |
|
NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001
|
|
G |
Adamts13 |
ADAM metallopeptidase with thrombospondin type 1 motif 13 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:26,863,363...26,899,638
Ensembl chr 2:26,863,428...26,899,640
|
|
G |
Add1 |
adducin 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr 5:34,731,008...34,789,652
Ensembl chr 5:34,731,008...34,789,652
|
|
G |
Adgrg7 |
adhesion G protein-coupled receptor G7 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr16:56,544,972...56,616,369
Ensembl chr16:56,544,972...56,616,218
|
|
G |
Adh4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
susceptibility |
ISO |
DNA:SNP:intron:+276T>G (rs1501299) (human) |
RGD |
PMID:23740135 |
RGD:14401720 |
NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
|
|
G |
Adra1a |
adrenergic receptor, alpha 1a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
|
|
G |
Adra2b |
adrenergic receptor, alpha 2b |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:127,205,099...127,209,141
Ensembl chr 2:127,205,128...127,209,141
|
|
G |
Afp |
alpha fetoprotein |
severity disease_progression treatment |
ISO |
protein:increased expression:serum (human) associated with hepatitis B CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:9029167 PMID:15276417 PMID:24012840 PMID:28284560 PMID:32961231 PMID:22147961 PMID:28611981 PMID:25968302 PMID:22392353 PMID:25999787 More...
|
RGD:14401581, RGD:126790579, RGD:126790583, RGD:125097525, RGD:152177911 |
NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
|
|
G |
Aicda |
activation-induced cytidine deaminase |
|
IGI |
|
RGD |
PMID:18997814 |
RGD:127285629 |
NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
|
|
G |
Ak3 |
adenylate kinase 3 |
|
ISO |
protein:decreased expression:liver |
RGD |
PMID:17203974 |
RGD:13842477 |
NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361
|
|
G |
Akr1a1 |
aldo-keto reductase family 1, member A1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:32805337 |
|
NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
|
|
G |
Akr1b1 |
aldo-keto reductase family 1 member B |
|
ISO |
protein:increased expression:liver (human) protein:increased expression:liver (rat) |
RGD |
PMID:19422879 PMID:21683810 |
RGD:8548685, RGD:5509919 |
NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
|
|
G |
Akr1b10 |
aldo-keto reductase family 1, member B10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
|
|
G |
Akr1c21 |
aldo-keto reductase family 1, member C21 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
|
|
G |
Akt1 |
thymoma viral proto-oncogene 1 |
treatment |
ISO |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Hepatocellular cancer |
CTD ClinVar RGD |
PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 PMID:18954143 PMID:19418217 PMID:19487299 PMID:19853286 PMID:20233444 PMID:20453058 PMID:21464312 PMID:21512767 PMID:21793738 PMID:22538770 PMID:22610119 PMID:22722201 PMID:22722839 PMID:22980975 PMID:23237847 PMID:23348505 PMID:23700467 PMID:23728071 PMID:23934607 PMID:24190505 PMID:24657128 PMID:25157968 PMID:25741868 PMID:26619011 PMID:28492532 PMID:32045588 PMID:31801250 PMID:25999787 More...
|
RGD:151893509, RGD:152177911 |
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
|
|
G |
Akt2 |
thymoma viral proto-oncogene 2 |
|
ISO IEP |
protein:increased phosphorylation:liver cancer cell (rat) protein:increased phosphorylation:liver (mouse) |
RGD |
PMID:19309364 PMID:28100771 |
RGD:2313299, RGD:127285675 |
NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
|
|
G |
Alb |
albumin |
susceptibility |
ISO |
associated with hepatitis C;protein:decreased expression:serum protein:decreased expression:serum (human) |
RGD |
PMID:23892757 PMID:29040987 PMID:22392353 |
RGD:11035269, RGD:14694841, RGD:125097525 |
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
|
|
G |
Aldh2 |
aldehyde dehydrogenase 2, mitochondrial |
susceptibility severity no_association |
ISO |
associated with alcoholic liver cirrhosis;DNA:missense mutation:cds:p.E487K (human) DNA:missense mutation:cds, exon 12:p.E487K (human) associated with hepatitis C:DNA:SNP:exon 12 (human) protein:decreased expression: liver (human) mRNA, protein:decreased expression:liver (human) DNA:missense mutation:cds: (rs671) (human) associated with hepatitis B;DNA;missense mutation, haplotype:cds: (rs671) (human) DNA:missense mutation:exon 12: (human) associated with alcohol use disorder;DNA:missense mutation:cds: (human) |
RGD |
PMID:25778454 PMID:1916152 PMID:12940444 PMID:26150517 PMID:28027570 PMID:29765251 PMID:26827895 PMID:10737710 PMID:18439068 More...
|
RGD:11054822, RGD:14696699, RGD:14696778, RGD:14696779, RGD:15036809, RGD:14700899, RGD:15042857, RGD:15042859, RGD:15042862 |
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
|
|
G |
Aldh7a1 |
aldehyde dehydrogenase family 7, member A1 |
severity |
ISO |
mRNA:altered expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr18:56,657,794...56,706,112
Ensembl chr18:56,642,759...56,706,023
|
|
G |
Aldoc |
aldolase C, fructose-bisphosphate |
|
ISO |
mRNA:increased expression:liver |
RGD |
PMID:3830170 |
RGD:2301136 |
NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
|
|
G |
Alx4 |
aristaless-like homeobox 4 |
ameliorates |
ISO |
mRNA, protein:decreased expression:liver |
RGD |
PMID:28081728 PMID:31132711 PMID:31132711 |
RGD:153323329, RGD:153323330, RGD:153323330 |
NCBI chr 2:93,472,779...93,511,686
Ensembl chr 2:93,472,729...93,511,684
|
|
G |
Angptl6 |
angiopoietin-like 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:20,785,104...20,791,116
Ensembl chr 9:20,785,104...20,791,023
|
|
G |
Ank3 |
ankyrin 3, epithelial |
|
IEP |
protein:decreased expression:liver |
RGD |
PMID:26652480 |
RGD:153344559 |
NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268
|
|
G |
Anln |
anillin, actin binding protein |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:22,243,305...22,302,132
Ensembl chr 9:22,243,308...22,300,484
|
|
G |
Antxr1 |
anthrax toxin receptor 1 |
treatment |
IDA |
|
RGD |
PMID:20650339 |
RGD:9684932 |
NCBI chr 6:87,110,835...87,312,757
Ensembl chr 6:87,110,835...87,312,803
|
|
G |
Anxa10 |
annexin A10 |
disease_progression |
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 8:62,510,076...62,576,227
Ensembl chr 8:62,510,076...62,576,184
|
|
G |
Anxa2 |
annexin A2 |
|
ISO |
mRNA, protein:increased expression:liver (human) |
RGD |
PMID:33675609 |
RGD:152999436 |
NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077
|
|
G |
Anxa4 |
annexin A4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566
|
|
G |
Anxa6 |
annexin A6 |
disease_progression |
ISO |
associated with tumor vascularization; protein:decreased expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr11:54,869,779...54,924,297
Ensembl chr11:54,869,934...54,924,271
|
|
G |
Apc |
APC, WNT signaling pathway regulator |
|
ISO IAGP |
OMIM:114550 DNA:hypermethylation ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma CTD Direct Evidence: marker/mechanism |
OMIM MouseDO ClinVar CTD RGD |
PMID:1316610 PMID:8381579 PMID:8381580 PMID:9536098 PMID:9824584 PMID:11247896 PMID:11466687 PMID:15311282 PMID:15459959 PMID:17293347 PMID:17489848 PMID:17576681 PMID:18199528 PMID:19793053 PMID:20223039 PMID:20685668 PMID:21859464 PMID:21901162 PMID:22135120 PMID:22425061 PMID:22431159 PMID:22447671 PMID:22703879 PMID:23159591 PMID:23460355 PMID:23484150 PMID:24033266 PMID:24448499 PMID:24573554 PMID:24599579 PMID:24728327 PMID:25186627 PMID:25479140 PMID:25590978 PMID:25637381 PMID:25741868 PMID:25925381 PMID:25980754 PMID:26207792 PMID:26447891 PMID:26467025 PMID:26530882 PMID:26580448 PMID:26690363 PMID:26845104 PMID:26900293 PMID:27028212 PMID:27081525 PMID:27150160 PMID:27600092 PMID:28051113 PMID:28127413 PMID:28135048 PMID:28135145 PMID:28195569 PMID:28492532 PMID:29641532 PMID:29684080 PMID:30267214 PMID:30374176 PMID:31428572 PMID:32390703 PMID:34426522 PMID:35189564 PMID:35264596 PMID:28203651 More...
|
RGD:14402050 |
NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605
|
|
G |
Apcs |
amyloid P component, serum |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr 1:172,721,528...172,722,516
Ensembl chr 1:172,721,528...172,722,608
|
|
G |
Apex1 |
apurinic/apyrimidinic endonuclease 1 |
treatment |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:25109342 PMID:33841550 |
RGD:152998960 |
NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
|
|
G |
Apln |
apelin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:47,114,023...47,123,730
Ensembl chr X:47,114,023...47,123,730
|
|
G |
Apoa1 |
apolipoprotein A-I |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism protein:decreased expression:plasma (human) associated with hepatitis B; |
CTD RGD |
PMID:21472284 PMID:23935864 PMID:31211449 |
RGD:25671438, RGD:153350082 |
NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
|
|
G |
Apoa2 |
apolipoprotein A-II |
|
ISO |
associated with hepatitis B; mRNA:increased expression:liver |
RGD |
PMID:31211449 |
RGD:153350082 |
NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948
|
|
G |
Apoa4 |
apolipoprotein A-IV |
disease_progression |
ISO |
associated with hepatitis B; |
RGD |
PMID:31211449 |
RGD:153350082 |
NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
|
|
G |
Apoc1 |
apolipoprotein C-I |
disease_progression |
ISO |
associated with hepatitis B; |
RGD |
PMID:31211449 |
RGD:153350082 |
NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585
|
|
G |
Apoc2 |
apolipoprotein C2 |
|
ISO |
associated with hepatitis B; mRNA:increased expression:liver |
RGD |
PMID:31211449 |
RGD:153350082 |
NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866
|
|
G |
Apoc3 |
apolipoprotein C-III |
susceptibility disease_progression |
ISO |
associated with Chronic Hepatitis B;DNA:SNP: :rs2854116(human) associated with hepatitis B; |
RGD |
PMID:27547913 PMID:31211449 |
RGD:153344620, RGD:153350082 |
NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934
|
|
G |
Apoc4 |
apolipoprotein C-IV |
disease_progression |
ISO |
associated with hepatitis B; |
RGD |
PMID:31211449 |
RGD:153350082 |
NCBI chr 7:19,412,009...19,415,385
Ensembl chr 7:19,412,008...19,415,404
|
|
G |
Apoe |
apolipoprotein E |
|
IEP |
protein:increased expression:liver, serum (mouse) |
RGD |
PMID:21644509 |
RGD:6903288 |
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
|
|
G |
Apof |
apolipoprotein F |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:128,104,568...128,107,119
Ensembl chr10:128,103,866...128,106,022
|
|
G |
Aprt |
adenine phosphoribosyl transferase |
|
ISO |
protein:increased activity:hepatoma (rat) |
RGD |
PMID:6327016 |
RGD:5135035 |
NCBI chr 8:123,301,376...123,303,646
Ensembl chr 8:123,301,374...123,303,648
|
|
G |
Ar |
androgen receptor |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:18639551 |
|
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
|
|
G |
Arg1 |
arginase, liver |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) |
RGD |
PMID:17210712 PMID:30901224 |
RGD:4140476, RGD:152995286 |
NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
|
|
G |
Arhgap11a |
Rho GTPase activating protein 11A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:113,661,837...113,679,006
Ensembl chr 2:113,661,837...113,679,006
|
|
G |
Arhgap44 |
Rho GTPase activating protein 44 |
exacerbates |
ISO |
protein:decreased expression:liver (human) |
RGD |
PMID:31136984 |
RGD:401901276 |
NCBI chr11:64,892,865...65,053,779
Ensembl chr11:64,892,865...65,053,787
|
|
G |
Arhgef39 |
Rho guanine nucleotide exchange factor 39 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:43,496,139...43,508,747
Ensembl chr 4:43,496,142...43,499,695
|
|
G |
Arid1a |
AT-rich interaction domain 1A |
treatment exacerbates |
ISO IMP |
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:liver (human) mRNA, protein:decreased expression:liver (human) associated with non-alcoholic steatohepatitis human gene in mouse model |
CTD RGD |
PMID:22561517 PMID:22634756 PMID:22922871 PMID:26589513 PMID:25975202 PMID:29113912 PMID:26569409 PMID:29136504 PMID:29136504 More...
|
RGD:125097485, RGD:125097495, RGD:125097519, RGD:11344640, RGD:126790634, RGD:126790634 |
NCBI chr 4:133,406,319...133,484,682
Ensembl chr 4:133,406,319...133,484,080
|
|
G |
Arid1b |
AT-rich interaction domain 1B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22634756 |
|
NCBI chr17:5,044,481...5,397,931
Ensembl chr17:5,044,607...5,397,931
|
|
G |
Arid2 |
AT-rich interaction domain 2 |
disease_progression exacerbates |
ISO |
CTD Direct Evidence: marker/mechanism associated with hepatitis B;protein:decreased expression:liver |
CTD RGD |
PMID:21822264 PMID:22634756 PMID:32071245 PMID:27351279 PMID:28498550 PMID:25701229 More...
|
RGD:150340708, RGD:150340711, RGD:150340712, RGD:150429631 |
NCBI chr15:96,185,403...96,303,344
Ensembl chr15:96,185,399...96,302,873
|
|
G |
Arid3a |
AT-rich interaction domain 3A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:35179300 |
|
NCBI chr10:79,762,877...79,790,852
Ensembl chr10:79,762,877...79,790,852
|
|
G |
Arrb2 |
arrestin, beta 2 |
treatment |
ISO |
|
RGD |
PMID:33841550 |
RGD:152998960 |
NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654
|
|
G |
Asf1b |
anti-silencing function 1B histone chaperone |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:84,682,323...84,696,824
Ensembl chr 8:84,682,136...84,696,826
|
|
G |
Asl |
argininosuccinate lyase |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088
|
|
G |
Asns |
asparagine synthetase |
|
ISO |
protein:increased activity:serum (rat) |
RGD |
PMID:10081 |
RGD:2316006 |
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
|
|
G |
Aspm |
abnormal spindle microtubule assembly |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28284560 PMID:18676753 |
RGD:13439743 |
NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829
|
|
G |
Ass1 |
argininosuccinate synthetase 1 |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) |
RGD |
PMID:12359751 PMID:30901224 |
RGD:4140479, RGD:152995286 |
NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
|
|
G |
Atg101 |
autophagy related 101 |
disease_progression |
ISO |
|
RGD |
PMID:35592424 |
RGD:153350091 |
NCBI chr15:101,182,182...101,188,855
Ensembl chr15:101,182,153...101,188,826
|
|
G |
Atg7 |
autophagy related 7 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29191453 |
|
NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
|
|
G |
Atm |
ataxia telangiectasia mutated |
exacerbates |
ISO |
CTD Direct Evidence: marker/mechanism protein:increased expression:liver (human) |
CTD RGD |
PMID:12866955 PMID:19919837 |
RGD:126781750 |
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
|
|
G |
Atp5pb |
ATP synthase peripheral stalk-membrane subunit b |
|
ISO |
associated with hepatitis C |
RGD |
PMID:18932288 |
RGD:14696822 |
NCBI chr 3:105,850,014...105,866,579
Ensembl chr 3:105,850,014...105,867,415
|
|
G |
Atp5pd |
ATP synthase peripheral stalk subunit d |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr11:115,306,517...115,310,775
Ensembl chr11:115,306,515...115,310,788
|
|
G |
Atp7b |
ATPase, copper transporting, beta polypeptide |
onset |
ISO |
|
RGD |
PMID:8291609 |
RGD:15036817 |
NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
|
|
G |
Aurkb |
aurora kinase B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490
|
|
G |
Axin1 |
axin 1 |
disease_progression |
ISO IMP |
CTD Direct Evidence: marker/mechanism associated with Hepatitis B, Chronic,DNA:SNP, haplotype:exon:(rs1805105) T>C (human) protein:decreased expression:liver (human) ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma |
OMIM CTD ClinVar RGD |
PMID:10700176 PMID:25741868 PMID:25822088 PMID:28492532 PMID:37582359 PMID:10700176 PMID:26968103 PMID:22960659 PMID:31514071 More...
|
RGD:1300371, RGD:14402039, RGD:150530481, RGD:150530482 |
NCBI chr17:26,350,294...26,414,784
Ensembl chr17:26,357,662...26,414,785
|
|
G |
Axin2 |
axin 2 |
|
ISO |
protein:increased expression:liver: |
RGD |
PMID:11809809 |
RGD:151356508 |
NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
|
|
G |
Azgp1 |
alpha-2-glycoprotein 1, zinc |
disease_progression |
ISO |
mRNA:decreased expression:liver |
RGD |
PMID:22625427 PMID:27993894 PMID:26902423 |
RGD:153350130, RGD:153350132, RGD:153350133 |
NCBI chr 5:137,979,783...137,988,495
Ensembl chr 5:137,979,782...137,988,495
|
|
G |
Azin1 |
antizyme inhibitor 1 |
disease_progression |
ISO |
RNA:increased editing:liver |
RGD |
PMID:23291631 |
RGD:14700705 |
NCBI chr15:38,487,674...38,523,506
Ensembl chr15:38,487,671...38,519,510
|
|
G |
Banf1 |
BAF nuclear assembly factor 1 |
treatment |
ISO IMP |
mRNA, protein:increased expression:liver (rat) mRNA, protein:increased expression:liver (human) |
RGD |
PMID:29059470 PMID:29059470 PMID:29059470 |
RGD:155791679, RGD:155791679, RGD:155791679 |
NCBI chr19:5,414,661...5,416,904
Ensembl chr19:5,414,666...5,417,196
|
|
G |
Bax |
BCL2-associated X protein |
treatment |
ISO |
|
RGD |
PMID:33841550 |
RGD:152998960 |
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
|
|
G |
Bcl2 |
B cell leukemia/lymphoma 2 |
treatment |
IEP ISO |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:28100771 PMID:33841550 |
RGD:127285675, RGD:152998960 |
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
|
|
G |
Bcl2l1 |
BCL2-like 1 |
treatment |
ISO IEP |
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:increased expression:liver (mouse) |
CTD RGD |
PMID:10629087 PMID:11509945 PMID:28100771 PMID:33841550 |
RGD:127285675, RGD:152998960 |
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
|
|
G |
Bco2 |
beta-carotene oxygenase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481
|
|
G |
Bcorl1 |
BCL6 co-repressor-like 1 |
disease_progression |
ISO |
|
RGD |
PMID:29679906 PMID:26879601 |
RGD:150340705, RGD:11556159 |
NCBI chr X:47,430,235...47,496,945
Ensembl chr X:47,430,235...47,496,926
|
|
G |
Bhmt |
betaine-homocysteine methyltransferase |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
|
|
G |
Bhmt2 |
betaine-homocysteine methyltransferase 2 |
severity |
ISO |
mRNA:altered expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr13:93,792,605...93,810,810
Ensembl chr13:93,792,228...93,810,810
|
|
G |
Bid |
BH3 interacting domain death agonist |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15289866 |
|
NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
ameliorates exacerbates treatment |
ISO |
human cell line in a mouse model associated with hepatitis B;mRNA, protein:increased expression:liver (human) |
RGD |
PMID:30368883 PMID:22682366 PMID:22820591 PMID:33310033 PMID:30210622 |
RGD:152998937, RGD:152998984, RGD:152998986, RGD:152998988, RGD:152999010 |
NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:increased expression:liver (human) |
CTD RGD |
PMID:16086872 PMID:20514400 PMID:31964418 |
RGD:153344516 |
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
|
|
G |
Birc7 |
baculoviral IAP repeat-containing 7 |
exacerbates |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:31964418 |
RGD:153344516 |
NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803
|
|
G |
Blzf1 |
basic leucine zipper nuclear factor 1 |
disease_progression |
ISO |
|
RGD |
PMID:26342799 |
RGD:14398326 |
NCBI chr 1:164,117,368...164,135,056
Ensembl chr 1:164,117,369...164,135,058
|
|
G |
Bmi1 |
Bmi1 polycomb ring finger oncogene |
treatment |
ISO |
|
RGD |
PMID:26919246 |
RGD:14928318 |
NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440
|
|
G |
Bmper |
BMP-binding endothelial regulator |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:23,134,372...23,396,511
Ensembl chr 9:23,134,372...23,396,496
|
|
G |
Braf |
Braf transforming gene |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27222248 |
|
NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397
|
|
G |
Bsg |
basigin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36574092 |
|
NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803
|
|
G |
Btg2 |
BTG anti-proliferation factor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18393292 |
|
NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
|
|
G |
Bub1 |
BUB1, mitotic checkpoint serine/threonine kinase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
|
|
G |
Bub1b |
BUB1B, mitotic checkpoint serine/threonine kinase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
|
|
G |
C3 |
complement component 3 |
|
ISO |
|
RGD |
PMID:23245919 |
RGD:11040806 |
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
|
|
G |
C9 |
complement component 9 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 PMID:28284560 |
|
NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232
|
|
G |
Cab39 |
calcium binding protein 39 |
disease_progression |
ISO |
|
RGD |
PMID:28605041 PMID:28605041 |
RGD:14398832, RGD:14398832 |
NCBI chr 1:85,707,796...85,779,298
Ensembl chr 1:85,721,162...85,779,297
|
|
G |
Cad |
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
|
ISO |
DNA:amplification:cds (rat) mRNA:increased expression:liver |
RGD |
PMID:2914957 PMID:2888462 PMID:7053379 |
RGD:5132587, RGD:2303530, RGD:10755426 |
NCBI chr 5:31,211,964...31,235,823
Ensembl chr 5:31,212,124...31,235,823
|
|
G |
Cadm1 |
cell adhesion molecule 1 |
|
ISO |
DNA, mRNA, protein:hypermethylation, decreased expression:promoter, liver |
RGD |
PMID:17428255 |
RGD:2289095 |
NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413
|
|
G |
Cadm2 |
cell adhesion molecule 2 |
disease_progression |
ISO |
mRNA, protein:decreased expression:liver |
RGD |
PMID:24240726 |
RGD:15092075 |
NCBI chr16:66,452,302...67,417,825
Ensembl chr16:66,452,307...67,417,796
|
|
G |
Calml3 |
calmodulin-like 3 |
severity |
ISO |
protein:decreased expression:liver (human) |
RGD |
PMID:29445139 |
RGD:151665319 |
NCBI chr13:3,852,893...3,854,318
Ensembl chr13:3,852,896...3,854,316
|
|
G |
Calr |
calreticulin |
exacerbates treatment |
ISO |
protein:increased expression:liver (human) human cells and recombinant gene in a mouse model |
RGD |
PMID:27055635 PMID:12096119 PMID:24997628 |
RGD:150521681, RGD:150521690, RGD:150521691 |
NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
|
|
G |
Camk2n1 |
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
ISO |
|
RGD |
PMID:23651211 |
RGD:18337283 |
NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434
|
|
G |
Cap2 |
cyclase associated actin cytoskeleton regulatory protein 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:46,655,379...46,803,757
Ensembl chr13:46,655,324...46,803,757
|
|
G |
Capn3 |
calpain 3 |
|
ISO |
mRNA:decreased expression:skeletal muscle |
RGD |
PMID:10806331 |
RGD:1600777 |
NCBI chr 2:120,294,074...120,335,400
Ensembl chr 2:120,294,053...120,335,399
|
|
G |
Car12 |
carbonic anhydrase 12 |
disease_progression ameliorates |
ISO IMP |
mRNA:altered expression:liver |
RGD |
PMID:35362480 PMID:35362480 PMID:31934040 PMID:29900055 |
RGD:153352325, RGD:153352325, RGD:153352328, RGD:155226869 |
NCBI chr 9:66,619,026...66,674,127
Ensembl chr 9:66,620,968...66,674,127
|
|
G |
Car2 |
carbonic anhydrase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
|
|
G |
Car9 |
carbonic anhydrase 9 |
|
ISO |
mRNA:altered expression:liver |
RGD |
PMID:29900055 |
RGD:155226869 |
NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
|
|
G |
Carm1 |
coactivator-associated arginine methyltransferase 1 |
|
ISO |
mRNA,protein:increased expression:liver: |
RGD |
PMID:23912631 |
RGD:9586718 |
NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919
|
|
G |
Casp3 |
caspase 3 |
treatment |
ISO |
|
RGD |
PMID:29133031 PMID:33841550 |
RGD:13782296, RGD:152998960 |
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
|
|
G |
Casp8 |
caspase 8 |
treatment severity |
ISO |
associated with hepatitis B;DNA:insertion/deletion:promoter: (rs3834129) (human) CTD Direct Evidence: marker/mechanism |
OMIM CTD RGD |
PMID:29133031 PMID:28643196 |
RGD:13782296, RGD:14695027 |
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
|
|
G |
Casp9 |
caspase 9 |
treatment |
ISO |
|
RGD |
PMID:29133031 |
RGD:13782296 |
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
|
|
G |
Cat |
catalase |
disease_progression |
ISO |
associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-262T>C (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:33010264 PMID:21907168 |
RGD:27095879 |
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
|
|
G |
Cbfb |
core binding factor beta |
|
ISO |
mRNA:decreased expression:liver |
RGD |
PMID:17094378 |
RGD:126775147 |
NCBI chr 8:105,897,306...105,944,621
Ensembl chr 8:105,897,306...105,944,621
|
|
G |
Cbl |
Casitas B-lineage lymphoma |
disease_progression |
ISO |
|
RGD |
PMID:26474280 |
RGD:11536137 |
NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346
|
|
G |
Cbr1 |
carbonyl reductase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21056497 |
|
NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
|
|
G |
Cbx2 |
chromobox 2 |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr11:118,913,845...118,922,101
Ensembl chr11:118,913,788...118,922,096
|
|
G |
Cbx4 |
chromobox 4 |
disease_progression |
ISO |
protein:increased expression:cytoplasm: |
RGD |
PMID:24838576 PMID:23943028 |
RGD:9586738, RGD:9586739 |
NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047
|
|
G |
Cbx7 |
chromobox 7 |
|
ISO |
mRNA:decreased expression:liver |
RGD |
PMID:22041561 |
RGD:9587355 |
NCBI chr15:79,800,005...79,855,344
Ensembl chr15:79,800,008...79,855,320
|
|
G |
Ccbe1 |
collagen and calcium binding EGF domains 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:66,189,926...66,424,909
Ensembl chr18:66,178,373...66,435,812
|
|
G |
Ccl1 |
C-C motif chemokine ligand 1 |
|
IEP |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:26569409 |
RGD:11344640 |
NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516
|
|
G |
Ccl12 |
C-C motif chemokine ligand 12 |
|
IEP |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:26569409 |
RGD:11344640 |
NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
treatment |
ISO IMP |
RNA:increased expression:liver |
RGD |
PMID:27980102 PMID:27980102 PMID:12679798 PMID:22402625 |
RGD:14995459, RGD:14995459, RGD:14995468, RGD:14995927 |
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
|
|
G |
Ccl3 |
C-C motif chemokine ligand 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16284949 |
|
NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
treatment susceptibility |
IMP ISO |
DNA:polymorphisms:promoter:-403G>A,-28C>G (human) associated with alcoholic liver cirrhosis;DNA:SNP:promoter:-403G>A(human) |
RGD |
PMID:28011329 PMID:22374185 PMID:21610221 |
RGD:14995306, RGD:14995333, RGD:14995338 |
NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
|
|
G |
Ccl9 |
C-C motif chemokine ligand 9 |
|
IEP |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:26569409 |
RGD:11344640 |
NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462
|
|
G |
Ccn1 |
cellular communication network factor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17699798 |
|
NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
|
|
G |
Ccna1 |
cyclin A1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12029619 |
|
NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
|
|
G |
Ccnb1 |
cyclin B1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
|
|
G |
Ccnb2 |
cyclin B2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
|
|
G |
Ccnd1 |
cyclin D1 |
susceptibility |
ISO IEP |
associated with Hepatitis B, Chronic;DNA:SNP:splice-site mutation:870G>A (human) mRNA:increased expression:liver (mouse) |
RGD |
PMID:25851350 PMID:28100771 |
RGD:14401586, RGD:127285675 |
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
|
|
G |
Ccnd2 |
cyclin D2 |
severity disease_progression susceptibility |
ISO |
associated with hepatitis B DNA:hypermethylation:CpG site associated with Chronic Hepatitis C;DNA:SNP: :rs1049606(human) |
RGD |
PMID:33320844 PMID:33320844 PMID:31059558 PMID:22004425 |
RGD:151664743, RGD:151664743, RGD:151665109, RGD:151665169 |
NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
|
|
G |
Ccne1 |
cyclin E1 |
ameliorates |
ISO IEP IMP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:12029619 PMID:22634754 PMID:17196522 PMID:28100771 PMID:29551768 |
RGD:2289277, RGD:127285675, RGD:153297807 |
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
|
|
G |
Ccnf |
cyclin F |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:24,441,518...24,470,333
Ensembl chr17:24,441,172...24,470,458
|
|
G |
Ccng1 |
cyclin G1 |
treatment disease_progression severity |
ISO IMP |
protein:increased expression:liver (human) human cells in mouse model protein:decreased expression:liver (human) |
RGD |
PMID:25431954 PMID:24034575 PMID:26345095 PMID:23804702 PMID:23804702 PMID:33543294 PMID:19584283 PMID:22835824 PMID:27982046 More...
|
RGD:151356922, RGD:151356932, RGD:151356933, RGD:151356967, RGD:151356967, RGD:151356970, RGD:151356981, RGD:151361198, RGD:151361200 |
NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
|
|
G |
Ccng2 |
cyclin G2 |
|
IMP |
|
RGD |
PMID:27982046 |
RGD:151361200 |
NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090
|
|
G |
Ccr1 |
C-C motif chemokine receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16284949 |
|
NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729
|
|
G |
Cd163 |
CD163 antigen |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486
|
|
G |
Cd209b |
CD209b antigen |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:3,967,655...3,976,841
Ensembl chr 8:3,967,655...3,976,844
|
|
G |
Cd274 |
CD274 antigen |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism associated with hepatitis B associated with hepatitis B |
CTD RGD |
PMID:22396772 PMID:30267213 PMID:21912640 |
RGD:40818240, RGD:41410800 |
NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
|
|
G |
Cd276 |
CD276 antigen |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:16217749 |
|
NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720
|
|
G |
Cd34 |
CD34 antigen |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587
|
|
G |
Cd40lg |
CD40 ligand |
|
IMP |
|
RGD |
PMID:19016771 |
RGD:2313413 |
NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402
|
|
G |
Cd5l |
CD5 antigen-like |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:87,265,188...87,278,381
Ensembl chr 3:87,265,188...87,278,380
|
|
G |
Cd68 |
CD68 antigen |
severity |
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:28656201 |
RGD:40924686 |
NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
|
|
G |
Cdc20 |
cell division cycle 20 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549
|
|
G |
Cdc25c |
cell division cycle 25C |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
|
|
G |
Cdc27 |
cell division cycle 27 |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma |
ClinVar |
|
|
NCBI chr11:104,393,350...104,441,371
Ensembl chr11:104,393,571...104,441,446
|
|
G |
Cdc45 |
cell division cycle 45 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737
|
|
G |
Cdc6 |
cell division cycle 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
|
|
G |
Cdca5 |
cell division cycle associated 5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr19:6,135,127...6,141,803
Ensembl chr19:6,135,013...6,141,807
|
|
G |
Cdca8 |
cell division cycle associated 8 |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104
|
|
G |
Cdh1 |
cadherin 1 |
severity |
ISO IMP |
DNA:hypermethylation mRNA:increased expression:liver protein:decreased expression:liver |
RGD |
PMID:17295234 PMID:30697077 PMID:30697077 PMID:24840851 PMID:18837082 |
RGD:2289638, RGD:14402045, RGD:14402045, RGD:14402046, RGD:14402047 |
NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
|
|
G |
Cdh13 |
cadherin 13 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18425332 PMID:18553387 PMID:28284560 |
|
NCBI chr 8:119,010,150...120,051,668
Ensembl chr 8:119,010,472...120,051,660
|
|
G |
Cdk1 |
cyclin dependent kinase 1 |
|
ISO |
protein:increased expression:liver (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28284560 PMID:19136513 |
RGD:2316317 |
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
|
|
G |
Cdk12 |
cyclin dependent kinase 12 |
exacerbates |
ISO |
mRNA, protein:increased expression:liver (human) |
RGD |
PMID:31519701 |
RGD:151361172 |
NCBI chr11:98,093,259...98,171,941
Ensembl chr11:98,093,885...98,169,330
|
|
G |
Cdk13 |
cyclin dependent kinase 13 |
onset |
ISO |
DNA:amplification: : |
RGD |
PMID:22912832 |
RGD:155641228 |
NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682
|
|
G |
Cdk14 |
cyclin dependent kinase 14 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22922871 |
|
NCBI chr 5:4,853,384...5,430,650
Ensembl chr 5:4,853,391...5,470,312
|
|
G |
Cdk4 |
cyclin dependent kinase 4 |
treatment |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:26189965 PMID:33841550 |
RGD:152998960 |
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
|
|
G |
Cdkn1a |
cyclin dependent kinase inhibitor 1A |
|
IAGP |
OMIM:114550 |
MouseDO |
|
|
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
|
|
G |
Cdkn1b |
cyclin dependent kinase inhibitor 1B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20698225 |
|
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
|
|
G |
Cdkn1c |
cyclin dependent kinase inhibitor 1C |
severity |
ISO |
protein:decreased expression:liver (human) |
RGD |
PMID:26606000 |
RGD:11354707 |
NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
|
|
G |
Cdkn2a |
cyclin dependent kinase inhibitor 2A |
severity |
ISO |
Protein:increased expression:liver DNA:hypermethylation:promoter DNA:hypermethylation:exon Protein:decreased expression:liver CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA |
RGD CTD ClinVar |
PMID:7780957 PMID:8521414 PMID:9185756 PMID:9324288 PMID:10491434 PMID:14508519 PMID:16234564 PMID:16317707 PMID:16896043 PMID:21462282 PMID:25157968 PMID:25741868 PMID:25780468 PMID:25822088 PMID:26225579 PMID:26467025 PMID:26619011 PMID:28284560 PMID:28492532 PMID:33010264 PMID:35001868 PMID:16317707 PMID:12359353 PMID:11301474 More...
|
RGD:1600816, RGD:1600816, RGD:1600822, RGD:8552680 |
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
|
|
G |
Cdkn2b |
cyclin dependent kinase inhibitor 2B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33010264 |
|
NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
|
|
G |
Cdkn2c |
cyclin dependent kinase inhibitor 2C |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
|
|
G |
Cdkn3 |
cyclin dependent kinase inhibitor 3 |
severity treatment |
ISO |
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver protein:decreased expression:liver associated with alcoholism; protein:increased expression:liver |
CTD RGD |
PMID:28284560 PMID:22390936 PMID:27314282 PMID:23292002 PMID:23292002 |
RGD:15090800, RGD:15090801, RGD:15090802, RGD:15090802 |
NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
|
|
G |
Cdt1 |
chromatin licensing and DNA replication factor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:123,294,754...123,299,869
Ensembl chr 8:123,294,754...123,300,293
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16288022 PMID:21785164 |
|
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
|
ISO |
CTD Direct Evidence: marker/mechanism mRNA: increased expression:liver (human) |
CTD RGD |
PMID:14563831 PMID:30659195 |
RGD:40903042 |
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
|
|
G |
Cebpd |
CCAAT/enhancer binding protein delta |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14563831 |
|
NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
|
|
G |
Celsr3 |
cadherin, EGF LAG seven-pass G-type receptor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:108,703,244...108,730,168
Ensembl chr 9:108,703,519...108,730,168
|
|
G |
Cenpa |
centromere protein A |
|
ISO |
CTD Direct Evidence: marker/mechanism protein:increased expression:liver (human) |
CTD RGD |
PMID:28284560 PMID:21956590 |
RGD:36947377 |
NCBI chr 5:30,824,214...30,832,181
Ensembl chr 5:30,824,121...30,832,174
|
|
G |
Cenpe |
centromere protein E |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:134,918,324...134,979,301
Ensembl chr 3:134,918,298...134,979,372
|
|
G |
Cenpf |
centromere autoantigen F |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283
|
|
G |
Cenpm |
centromere protein M |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr15:82,115,694...82,128,974
Ensembl chr15:82,117,980...82,128,949
|
|
G |
Cenpu |
centromere protein U |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:47,005,054...47,033,603
Ensembl chr 8:47,005,063...47,033,042
|
|
G |
Cenpw |
centromere protein W |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:30,072,005...30,076,599
Ensembl chr10:30,070,565...30,076,556
|
|
G |
Cep131 |
centrosomal protein 131 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:119,955,247...119,977,684
Ensembl chr11:119,955,256...119,977,653
|
|
G |
Cep164 |
centrosomal protein 164 |
susceptibility |
ISO |
associated with Chronic Hepatitis C;DNA:SNP: :rs573455 (human) |
RGD |
PMID:22004425 |
RGD:151665169 |
NCBI chr 9:45,678,244...45,739,984
Ensembl chr 9:45,678,244...45,739,989
|
|
G |
Ces1d |
carboxylesterase 1D |
disease_progression |
ISO |
protein:decreased expression:liver (human) mRNA, protein:decreased expression:liver tumor (human) associated with tumor vascularization; protein:decreased expression:liver tumor (human) |
RGD |
PMID:24259486 PMID:19658107 PMID:30901224 |
RGD:152995276, RGD:152995279, RGD:152995286 |
NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
|
|
G |
Cfp |
complement factor properdin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:20,791,693...20,797,794
Ensembl chr X:20,791,693...20,797,794
|
|
G |
Chaf1b |
chromatin assembly factor 1, subunit B (p60) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr16:93,680,801...93,703,003
Ensembl chr16:93,680,789...93,703,003
|
|
G |
Chd4 |
chromodomain helicase DNA binding protein 4 |
exacerbates |
ISO |
mRNA:increased expression:liver (human) protein:increased expression:liver (human) |
RGD |
PMID:28486105 PMID:26095183 |
RGD:153323299, RGD:11571740 |
NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554
|
|
G |
Chd5 |
chromodomain helicase DNA binding protein 5 |
|
ISO |
mRNA:decreased expression:liver |
RGD |
PMID:26517514 |
RGD:11537550 |
NCBI chr 4:152,423,103...152,474,651
Ensembl chr 4:152,423,108...152,474,651
|
|
G |
Ckap2l |
cytoskeleton associated protein 2-like |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:129,110,130...129,139,148
Ensembl chr 2:129,110,130...129,139,132
|
|
G |
Ckap4 |
cytoskeleton-associated protein 4 |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:increased expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr10:84,362,169...84,369,752
Ensembl chr10:84,362,169...84,369,926
|
|
G |
Cldn1 |
claudin 1 |
severity |
IEP |
protein:increased expression:liver (human) protein:decreased expression:liver (human) associated with liver cirrhosis;protein:increased expression:liver (human) |
RGD |
PMID:24815833 PMID:17270214 PMID:24696415 |
RGD:26884345, RGD:26884348, RGD:26884352 |
NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591
|
|
G |
Clec1b |
C-type lectin domain family 1, member b |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:129,374,260...129,382,376
Ensembl chr 6:129,374,260...129,386,298
|
|
G |
Clec4g |
C-type lectin domain family 4, member g |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:3,757,066...3,770,695
Ensembl chr 8:3,757,064...3,770,651
|
|
G |
Clptm1l |
CLPTM1-like |
susceptibility disease_progression |
ISO |
DNA:SNPs::rs401681(human) DNA:SNP: :rs401681(human) |
RGD |
PMID:25339005 PMID:29042796 |
RGD:150530496, RGD:150537100 |
NCBI chr13:73,752,121...73,768,758
Ensembl chr13:73,752,125...73,768,724
|
|
G |
Cltrn |
collectrin, amino acid transport regulator |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:162,873,183...162,901,855
Ensembl chr X:162,871,826...162,901,856
|
|
G |
Cndp1 |
carnosine dipeptidase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:84,628,509...84,668,359
Ensembl chr18:84,628,634...84,668,220
|
|
G |
Cnot9 |
CCR4-NOT transcription complex, subunit 9 |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular carcinoma |
ClinVar |
PMID:26619011 |
|
NCBI chr 1:74,545,192...74,570,001
Ensembl chr 1:74,545,217...74,570,001
|
|
G |
Cntnap4 |
contactin associated protein-like 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:113,296,523...113,609,339
Ensembl chr 8:113,296,675...113,609,349
|
|
G |
Col15a1 |
collagen, type XV, alpha 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:47,207,744...47,313,165
Ensembl chr 4:47,208,161...47,313,167
|
|
G |
Col18a1 |
collagen, type XVIII, alpha 1 |
severity |
ISO |
Protein:increased expression |
RGD |
PMID:15739185 |
RGD:1600906 |
NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382
|
|
G |
Colec10 |
collectin sub-family member 10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr15:54,274,170...54,329,755
Ensembl chr15:54,274,170...54,329,754
|
|
G |
Comt |
catechol-O-methyltransferase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15341023 |
|
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
|
|
G |
Cops5 |
COP9 (constitutive photomorphogenic), subunit 5 (Arabidopsis) |
severity |
ISO |
CTD Direct Evidence: marker/mechanism protein:increased expression:liver (human) |
CTD RGD |
PMID:20698225 PMID:26606000 |
RGD:11354707 |
NCBI chr 1:10,094,825...10,108,384
Ensembl chr 1:10,094,826...10,108,393
|
|
G |
Cox7b2 |
cytochrome c oxidase subunit 7B2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 5:71,600,166...71,705,548
Ensembl chr 5:71,600,167...71,705,548
|
|
G |
Cp |
ceruloplasmin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19229483 |
|
NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
|
|
G |
Cpeb3 |
cytoplasmic polyadenylation element binding protein 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr19:36,996,742...37,185,018
Ensembl chr19:36,998,691...37,186,000
|
|
G |
Cps1 |
carbamoyl-phosphate synthetase 1 |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418
|
|
G |
Crebbp |
CREB binding protein |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: LIVER CELL CARCINOMA |
ClinVar |
PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 PMID:23685749 PMID:23778141 PMID:25741868 PMID:26087898 PMID:26619011 PMID:27257180 PMID:28492532 PMID:28970362 PMID:29551561 PMID:33560380 More...
|
|
NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861
|
|
G |
Crhbp |
corticotropin releasing hormone binding protein |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:95,567,884...95,581,339
Ensembl chr13:95,567,879...95,581,432
|
|
G |
Crp |
C-reactive protein, pentraxin-related |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
|
|
G |
Csf1r |
colony stimulating factor 1 receptor |
severity exacerbates |
ISO |
DNA:hypomethylation:promoter (human) protein:increased expression: liver (human) protein:increased expression:liver (human) |
RGD |
PMID:32724427 PMID:32760707 PMID:11412385 PMID:14969845 |
RGD:150524282, RGD:150524286, RGD:150524301, RGD:150524302 |
NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
|
|
G |
Csf2 |
colony stimulating factor 2 (granulocyte-macrophage) |
treatment |
IMP |
|
RGD |
PMID:12731087 |
RGD:10450243 |
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
|
|
G |
Csk |
c-src tyrosine kinase |
|
ISO |
protein:decreased expression:liver |
RGD |
PMID:9918913 |
RGD:5134372 |
NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914
|
|
G |
Csmd1 |
CUB and Sushi multiple domains 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:15,942,538...17,586,908
Ensembl chr 8:15,942,537...17,585,602
|
|
G |
Cspg4 |
chondroitin sulfate proteoglycan 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154
|
|
G |
Csrnp1 |
cysteine-serine-rich nuclear protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:119,800,229...119,813,808
Ensembl chr 9:119,800,229...119,813,724
|
|
G |
Ctla4 |
cytotoxic T-lymphocyte-associated protein 4 |
susceptibility |
ISO |
protein:increased expression:CD4+ and CD8+ T cells: DNA:SNPs: :rs231775,rs231725(human) |
RGD |
PMID:28648905 PMID:23432218 |
RGD:14398741, RGD:14398742 |
NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
|
|
G |
Ctnnb1 |
catenin beta 1 |
susceptibility severity exacerbates |
ISO |
DNA:mutation:exon 3 CTD Direct Evidence: marker/mechanism associated with Hepatitis B, Chronic,DNA:SNP, haplotype: :rs3864004 (human) associated with hepatitis B;DNA:SNPs: :rs3864004,rs11564475(human) protein:increased expression:liver: DNA:Mutations:exon: DNA:missense mutations:exon 3:multiple (human) ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA |
OMIM CTD ClinVar RGD |
PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 PMID:10027390 PMID:10192393 PMID:10391090 PMID:10398436 PMID:10435629 PMID:10655994 PMID:10666372 PMID:11351304 PMID:11930117 PMID:11950921 PMID:12124804 PMID:15133491 PMID:19234609 PMID:20118494 PMID:21147764 PMID:21903672 PMID:23033978 PMID:23265383 PMID:24614104 PMID:24728327 PMID:24788118 PMID:25157968 PMID:25326635 PMID:25326669 PMID:25741868 PMID:25822088 PMID:26350204 PMID:26502894 PMID:26619011 PMID:26822237 PMID:27738331 PMID:27915094 PMID:27959697 PMID:28284560 PMID:28333917 PMID:28492532 PMID:28575650 PMID:29682453 PMID:30640974 PMID:31526516 PMID:10435629 PMID:26968103 PMID:28328801 PMID:19101982 PMID:19101982 PMID:27276713 More...
|
RGD:734850, RGD:14402039, RGD:14402040, RGD:14402052, RGD:14402052, RGD:150429592 |
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
|
|
G |
Ctsb |
cathepsin B |
|
ISO |
|
RGD |
PMID:15641152 |
RGD:2315605 |
NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
|
|
G |
Ctsd |
cathepsin D |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
|
|
G |
Ctsl |
cathepsin L |
|
ISO |
|
RGD |
PMID:15641152 |
RGD:2315605 |
NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
|
|
G |
Cux1 |
cut-like homeobox 1 |
|
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:30561038 |
RGD:152985541 |
NCBI chr 5:136,276,989...136,596,429
Ensembl chr 5:136,276,989...136,596,344
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
disease_progression treatment |
ISO IDA |
|
RGD |
PMID:28592115 PMID:28638480 PMID:27245433 |
RGD:27095889, RGD:27095898, RGD:27095899 |
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
|
|
G |
Cxcl11 |
chemokine (C-X-C motif) ligand 11 |
|
IEP |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:26569409 |
RGD:11344640 |
NCBI chr 5:92,507,403...92,511,155
Ensembl chr 5:92,507,403...92,513,344
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 PMID:28284560 |
|
NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
|
|
G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364
|
|
G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
disease_progression susceptibility |
ISO |
protein:increased expression:liver (human) mRNA:increased expression:liver (human) DNA:SNPs, haplotype:multiple CTD Direct Evidence: marker/mechanism|therapeutic |
CTD RGD |
PMID:12432545 PMID:35776891 PMID:26078356 PMID:30523154 PMID:24381110 |
RGD:11526468, RGD:26884364, RGD:26884366 |
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
treatment severity |
ISO |
human cells in mouse model protein:increased expression:liver (human) |
RGD |
PMID:30034941 PMID:33574707 |
RGD:151665331, RGD:151665327 |
NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
|
|
G |
Cyld |
CYLD lysine 63 deubiquitinase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21109933 |
|
NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15341023 |
|
NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15341023 |
|
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
|
|
G |
Cyp26b1 |
cytochrome P450, 26, retinoic acid B1 |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890
|
|
G |
Cyp2b10 |
cytochrome P450, family 2, subfamily b, polypeptide 10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
|
|
G |
Cyp2c29 |
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
|
|
G |
Cyp2c38 |
cytochrome P450, family 2, subfamily c, polypeptide 38 |
susceptibility |
ISO |
associated with hepatitis C; DNA:polymorphisms: : |
RGD |
PMID:11021356 |
RGD:124713413 |
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism associated with alcohol dependence DNA, mRNA:SNP, Decreased expression:liver: rs2031920 (human) |
CTD RGD |
PMID:15162526 PMID:20364586 PMID:29765251 |
RGD:14700882, RGD:14700899 |
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
|
|
G |
Cyp39a1 |
cytochrome P450, family 39, subfamily a, polypeptide 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:43,978,263...44,062,322
Ensembl chr17:43,978,316...44,062,322
|
|
G |
Dab2ip |
disabled 2 interacting protein |
severity |
ISO |
mRNA:decreased expression:liver (human) protein:decreased expression:liver (human) |
RGD |
PMID:31176165 PMID:22168621 |
RGD:151665110, RGD:151665148 |
NCBI chr 2:35,448,285...35,621,006
Ensembl chr 2:35,448,278...35,621,006
|
|
G |
Dbh |
dopamine beta hydroxylase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
|
|
G |
Dcn |
decorin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005
|
|
G |
Ddr1 |
discoidin domain receptor family, member 1 |
severity |
IMP ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:33173221 PMID:33173221 |
RGD:151347691, RGD:151347691 |
NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513
|
|
G |
Ddr2 |
discoidin domain receptor family, member 2 |
treatment disease_progression |
ISO |
|
RGD |
PMID:33969575 PMID:26362312 |
RGD:150429748, RGD:11086753 |
NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331
|
|
G |
Ddx3x |
DEAD box helicase 3, X-linked |
exacerbates sexual_dimorphism |
IMP ISO |
associated with hepatitis B; mRNA,protein:decreased expression:liver (human) |
RGD |
PMID:30297359 PMID:16301996 |
RGD:151356499, RGD:151356660 |
NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291
|
|
G |
Depdc1a |
DEP domain containing 1a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:159,201,042...159,235,690
Ensembl chr 3:159,201,070...159,235,592
|
|
G |
Depdc1b |
DEP domain containing 1B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:108,452,592...108,526,100
Ensembl chr13:108,452,866...108,544,316
|
|
G |
Depdc5 |
DEP domain containing 5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21725309 |
|
NCBI chr 5:33,020,996...33,151,581
Ensembl chr 5:33,021,045...33,151,580
|
|
G |
Dhfr |
dihydrofolate reductase |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer |
ClinVar |
PMID:28492532 |
|
NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561
|
|
G |
Dicer1 |
dicer 1, ribonuclease type III |
susceptibility |
ISO |
associated with hepatitis B; DNA:SNP: :rs1057035 T>C (human) |
RGD |
PMID:23868705 |
RGD:149735346 |
NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211
|
|
G |
Dipk2b |
divergent protein kinase domain 2B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:18,280,406...18,327,657
Ensembl chr X:18,281,120...18,327,636
|
|
G |
Dlgap5 |
DLG associated protein 5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr14:47,625,238...47,655,657
Ensembl chr14:47,625,236...47,655,864
|
|
G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
|
IEP |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:26569409 |
RGD:11344640 |
NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262
|
|
G |
Dmgdh |
dimethylglycine dehydrogenase precursor |
disease_progression |
ISO |
associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr13:93,810,944...93,889,331
Ensembl chr13:93,810,941...93,889,341
|
|
G |
Dnajc6 |
DnaJ heat shock protein family (Hsp40) member C6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:101,353,751...101,499,996
Ensembl chr 4:101,353,828...101,499,996
|
|
G |
Dnase1l3 |
deoxyribonuclease 1-like 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr14:14,475,014...14,504,586
Ensembl chr14:14,475,200...14,505,240
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
|
ISO |
mRNA, protein:increased expression:liver |
RGD |
PMID:11844796 |
RGD:2289670 |
NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
|
|
G |
Dnmt3a |
DNA methyltransferase 3A |
|
ISO |
protein:increased expression:liver: mRNA, protein:increased expression:liver |
RGD |
PMID:15885882 PMID:11844796 |
RGD:9588598, RGD:2289670 |
NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
|
|
G |
Dnmt3b |
DNA methyltransferase 3B |
|
ISO |
mRNA:increased expression:liver: mRNA, protein:increased expression:liver |
RGD |
PMID:15885882 PMID:11844796 |
RGD:9588598, RGD:2289670 |
NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650
|
|
G |
Dpyd |
dihydropyrimidine dehydrogenase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18019677 |
|
NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573
|
|
G |
Dsn1 |
DSN1 homolog, MIS12 kinetochore complex component |
disease_progression |
ISO |
|
RGD |
PMID:30136646 |
RGD:27372884 |
NCBI chr 2:156,836,982...156,848,995
Ensembl chr 2:156,837,185...156,849,074
|
|
G |
Dtl |
denticleless E3 ubiquitin protein ligase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:191,269,468...191,307,656
Ensembl chr 1:191,269,468...191,307,656
|
|
G |
Dynlrb1 |
dynein light chain roadblock-type 1 |
|
ISO |
|
RGD |
PMID:11750132 |
RGD:13208527 |
NCBI chr 2:155,078,453...155,092,197
Ensembl chr 2:155,078,453...155,092,197
|
|
G |
Dynlrb2 |
dynein light chain roadblock-type 2 |
|
ISO |
|
RGD |
PMID:11750132 |
RGD:13208527 |
NCBI chr 8:117,231,754...117,242,654
Ensembl chr 8:117,231,713...117,242,654
|
|
G |
E2f1 |
E2F transcription factor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12029619 PMID:15565109 PMID:28284560 |
|
NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
|
|
G |
E2f8 |
E2F transcription factor 8 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344
|
|
G |
Eaf2 |
ELL associated factor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20564326 |
|
NCBI chr16:36,613,246...36,695,275
Ensembl chr16:36,613,246...36,695,365
|
|
G |
Ecm1 |
extracellular matrix protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881
|
|
G |
Ect2 |
ect2 oncogene |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:27,151,371...27,207,971
Ensembl chr 3:27,151,371...27,208,027
|
|
G |
Eef2 |
eukaryotic translation elongation factor 2 |
exacerbates |
ISO |
protein:increased expression, increased phosphorylation:liver (human) |
RGD |
PMID:28060762 |
RGD:153298915 |
NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332
|
|
G |
Efemp1 |
epidermal growth factor-containing fibulin-like extracellular matrix protein 1 |
disease_progression |
ISO |
protein:decreased expression:liver: |
RGD |
PMID:23936443 |
RGD:10401793 |
NCBI chr11:28,803,154...28,876,743
Ensembl chr11:28,803,204...28,876,743
|
|
G |
Eftud2 |
elongation factor Tu GTP binding domain containing 2 |
severity ameliorates |
ISO |
|
RGD |
PMID:34282556 PMID:34282556 |
RGD:155791664, RGD:155791664 |
NCBI chr11:102,729,298...102,771,999
Ensembl chr11:102,729,299...102,771,811
|
|
G |
Egf |
epidermal growth factor |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism associated with liver cirrhosis;DNA:SNP:5'UTR: (rs4444903) (human) associated with hepatitis B;DNA:SNP:exon: (rs11569017) (human) |
CTD RGD |
PMID:9029167 PMID:18167406 PMID:23790025 |
RGD:14695013, RGD:14695014 |
NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
|
|
G |
Egfr |
epidermal growth factor receptor |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:9029167 PMID:11355950 |
RGD:126781769 |
NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
|
|
G |
Egr1 |
early growth response 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
|
|
G |
Egr2 |
early growth response 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018
|
|
G |
Ehd3 |
EH-domain containing 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:74,111,836...74,139,088
Ensembl chr17:74,111,129...74,139,089
|
|
G |
Eif3h |
eukaryotic translation initiation factor 3, subunit H |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14578863 |
|
NCBI chr15:51,649,956...51,728,901
Ensembl chr15:51,649,954...51,728,919
|
|
G |
Enah |
ENAH actin regulator |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35030977 |
RGD:155791678 |
NCBI chr 1:181,723,949...181,848,132
Ensembl chr 1:181,723,949...181,847,555
|
|
G |
Eng |
endoglin |
|
ISO |
protein:increased expression:liver (rat) |
RGD |
PMID:20368095 |
RGD:7257538 |
NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681
|
|
G |
Eno1 |
enolase 1, alpha non-neuron |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
|
|
G |
Ep300 |
E1A binding protein p300 |
|
ISO |
protein:increased expression:liver (rat) |
RGD |
PMID:17083329 |
RGD:2312274 |
NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
|
|
G |
Epas1 |
endothelial PAS domain protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26735578 |
|
NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838
|
|
G |
Epcam |
epithelial cell adhesion molecule |
severity |
ISO |
protein:increased expression:liver |
RGD |
PMID:24616575 |
RGD:14695007 |
NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557
|
|
G |
Ephb1 |
Eph receptor B1 |
|
IEP |
protein:increased phosphorylation:liver (mouse) |
RGD |
PMID:28100771 |
RGD:127285675 |
NCBI chr 9:101,799,327...102,231,892
Ensembl chr 9:101,799,327...102,231,892
|
|
G |
Ephx1 |
epoxide hydrolase 1, microsomal |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:7892276 |
|
NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
|
|
G |
Epo |
erythropoietin |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
|
|
G |
Eps8l3 |
EPS8-like 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:107,781,177...107,800,216
Ensembl chr 3:107,784,545...107,800,216
|
|
G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
disease_progression |
ISO |
|
RGD |
PMID:11355950 |
RGD:126781769 |
NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521
|
|
G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
|
ISO |
DNA:insertion/deletion:3'UTR:rs6147150 (human) |
RGD |
PMID:22294845 |
RGD:126781763 |
NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218
|
|
G |
Ercc1 |
excision repair cross-complementing rodent repair deficiency, complementation group 1 |
|
ISO |
mRNA, protein:increased expression:liver (human) |
RGD |
PMID:15922480 |
RGD:155598683 |
NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
|
|
G |
Ercc2 |
excision repair cross-complementing rodent repair deficiency, complementation group 2 |
susceptibility disease_progression |
ISO |
DNA:SNPs:exon 23: p.K751Q (human) DNA:SNPs:exon 23: p.K751Q (human) DNA:SNPs:exon 23: p.K751Q (rs13181) (human) DNA:SNP:cd: 312A>G (human) |
RGD |
PMID:19919686 PMID:25531380 PMID:28598207 PMID:28927037 |
RGD:25671459, RGD:25671460, RGD:25671461, RGD:150530503 |
NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619
|
|
G |
Ereg |
epiregulin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:35776891 |
|
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signalling 1 |
|
ISO |
DNA:hypomethylation: CpG islands: |
RGD |
PMID:20165882 |
RGD:14694974 |
NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
|
|
G |
Erp29 |
endoplasmic reticulum protein 29 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569
|
|
G |
Esm1 |
endothelial cell-specific molecule 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:113,346,193...113,354,638
Ensembl chr13:113,346,193...113,354,632
|
|
G |
Esr1 |
estrogen receptor 1 (alpha) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 PMID:28284560 |
|
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
|
|
G |
Etfa |
electron transferring flavoprotein, alpha polypeptide |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 9:55,361,720...55,419,528
Ensembl chr 9:55,361,792...55,419,527
|
|
G |
Exo1 |
exonuclease 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
|
|
G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
susceptibility |
ISO |
mRNA:increased expression:liver (human) DNA:SNPs: :multiple CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28284560 PMID:34545456 PMID:24211739 PMID:26517514 PMID:24040354 PMID:25226601 More...
|
RGD:10755339, RGD:11537550, RGD:126779595, RGD:126779608 |
NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275
|
|
G |
F2 |
coagulation factor II |
severity |
ISO |
CTD Direct Evidence: marker/mechanism associated with liver cirrhosis;protein:altered expression, altered processing:liver (human) |
CTD RGD |
PMID:2821104 PMID:7620113 |
RGD:14975114 |
NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
|
|
G |
Fabp5 |
fatty acid binding protein 5, epidermal |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667
|
|
G |
Fam180a |
family with sequence similarity 180, member A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:35,289,678...35,303,076
Ensembl chr 6:35,289,603...35,303,076
|
|
G |
Fam83d |
family with sequence similarity 83, member D |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:158,610,011...158,628,557
Ensembl chr 2:158,610,013...158,628,557
|
|
G |
Fancd2 |
Fanconi anemia, complementation group D2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:113,508,622...113,573,981
Ensembl chr 6:113,508,643...113,573,978
|
|
G |
Fanci |
Fanconi anemia, complementation group I |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:79,042,056...79,100,013
Ensembl chr 7:79,041,677...79,100,012
|
|
G |
Fas |
Fas cell surface death receptor |
treatment |
ISO IMP |
protein:increased expression:liver: |
RGD |
PMID:29634416 PMID:11274632 PMID:30737368 |
RGD:13792608, RGD:14700677, RGD:14700700 |
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
|
|
G |
Fasl |
Fas ligand |
|
ISO |
protein:increased expression:liver: |
RGD |
PMID:11274632 |
RGD:14700677 |
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
|
|
G |
Fasn |
fatty acid synthase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14563831 PMID:15543204 PMID:21147110 |
|
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
|
|
G |
Fat1 |
FAT atypical cadherin 1 |
disease_progression |
ISO |
mRNA,protein:increased expression:liver (human) |
RGD |
PMID:24590895 |
RGD:151347630 |
NCBI chr 8:45,386,137...45,505,294
Ensembl chr 8:45,388,484...45,505,294
|
|
G |
Fate1 |
fetal and adult testis expressed 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15580283 |
|
NCBI chr X:71,016,592...71,032,652
Ensembl chr X:71,016,592...71,032,652
|
|
G |
Fbp1 |
fructose bisphosphatase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22039417 |
|
NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
|
|
G |
Fbxl18 |
F-box and leucine-rich repeat protein 18 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 5:142,852,701...142,882,696
Ensembl chr 5:142,852,701...142,881,176
|
|
G |
Fbxo11 |
F-box protein 11 |
exacerbates ameliorates |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:32657545 PMID:29518611 |
RGD:152025263, RGD:152025259 |
NCBI chr17:88,298,287...88,373,473
Ensembl chr17:88,298,287...88,372,719
|
|
G |
Fcna |
ficolin A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042
|
|
G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
|
|
G |
Fes |
feline sarcoma oncogene |
exacerbates |
ISO |
DNA:hypermethylation:promoter (human) |
RGD |
PMID:31038805 |
RGD:153323297 |
NCBI chr 7:80,027,506...80,037,702
Ensembl chr 7:80,027,504...80,037,694
|
|
G |
Fgf15 |
fibroblast growth factor 15 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25822088 |
|
NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
|
|
G |
Fgf3 |
fibroblast growth factor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25822088 |
|
NCBI chr 7:144,392,349...144,397,085
Ensembl chr 7:144,391,820...144,398,173
|
|
G |
Fgf4 |
fibroblast growth factor 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25822088 |
|
NCBI chr 7:144,415,123...144,418,982
Ensembl chr 7:144,401,104...144,418,980
|
|
G |
Fgfr1 |
fibroblast growth factor receptor 1 |
treatment |
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma CTD Direct Evidence: marker/mechanism |
ClinVar CTD RGD |
PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156 PMID:36029209 PMID:16452204 PMID:21573021 PMID:20155451 More...
|
RGD:25330358, RGD:25440476, RGD:25440478 |
NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
|
|
G |
Fgfr2 |
fibroblast growth factor receptor 2 |
severity |
ISO |
associated with hepatitis B;DNA:SNPs: promoter, intron:rs308379, rs1219648 (human) |
RGD |
PMID:30952770 |
RGD:38501096 |
NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
|
|
G |
Fgfr4 |
fibroblast growth factor receptor 4 |
treatment |
ISO |
|
RGD |
PMID:32677805 |
RGD:150520166 |
NCBI chr13:55,300,631...55,316,572
Ensembl chr13:55,300,453...55,316,572
|
|
G |
Fh1 |
fumarate hydratase 1 |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular carcinoma |
ClinVar |
PMID:10896297 PMID:15221078 PMID:16876016 PMID:17182618 PMID:18313410 PMID:19151755 PMID:20301679 PMID:21445611 PMID:25637381 PMID:25741868 PMID:28492532 PMID:28747166 More...
|
|
NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201
|
|
G |
Fhit |
fragile histidine triad gene |
|
ISO |
|
RGD |
PMID:12112319 |
RGD:632723 |
NCBI chr14:11,307,718...12,919,681
Ensembl chr14:11,307,738...12,919,681
|
|
G |
Flt3 |
FMS-like tyrosine kinase 3 |
ameliorates |
ISO |
human cells in mouse model |
RGD |
PMID:27511526 |
RGD:149735514 |
NCBI chr 5:147,267,551...147,337,299
Ensembl chr 5:147,267,551...147,337,299
|
|
G |
Flvcr1 |
feline leukemia virus subgroup C cellular receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:190,738,029...190,758,387
Ensembl chr 1:190,738,044...190,758,355
|
|
G |
Fos |
FBJ osteosarcoma oncogene |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9029167 PMID:28284560 |
|
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
|
|
G |
Fosb |
FBJ osteosarcoma oncogene B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
|
|
G |
Fosl2 |
fos-like antigen 2 |
|
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:30086463 PMID:32048611 |
RGD:153344517, RGD:153344521 |
NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186
|
|
G |
Foxa1 |
forkhead box A1 |
susceptibility disease_progression sexual_dimorphism |
ISO |
DNA:VNTR, SNPs, haplotypes:multiple: protein:decreased expression:liver |
RGD |
PMID:29208003 PMID:31400761 PMID:25965836 |
RGD:151665820, RGD:151665752, RGD:11054501 |
NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702
|
|
G |
Foxm1 |
forkhead box M1 |
|
IAGP ISO |
OMIM:114550 CTD Direct Evidence: marker/mechanism |
MouseDO CTD |
PMID:15082532 PMID:17173139 PMID:28284560 |
|
NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109
|
|
G |
Foxo1 |
forkhead box O1 |
|
ISO |
mRNA:decreased expression:liver |
RGD |
PMID:28972178 |
RGD:14401599 |
NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
|
|
G |
Foxp1 |
forkhead box P1 |
treatment |
ISO |
|
RGD |
PMID:25156538 |
RGD:9587823 |
NCBI chr 6:98,902,303...99,510,587
Ensembl chr 6:98,902,299...99,499,682
|
|
G |
Foxp3 |
forkhead box P3 |
|
ISO |
protein:increased expression:liver |
RGD |
PMID:21086571 |
RGD:38548919 |
NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484
|
|
G |
Fst |
follistatin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12203361 PMID:19363144 |
|
NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487
|
|
G |
Fth1 |
ferritin heavy polypeptide 1 |
|
ISO |
mRNA:increased expression:liver (rat) |
RGD |
PMID:9054589 |
RGD:632698 |
NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
|
|
G |
Fubp1 |
far upstream element (FUSE) binding protein 1 |
exacerbates ameliorates |
ISO |
mRNA:increased expression:liver (human) human cell line in a mouse model associated with Chronic Hepatitis C;mRNA:increased expression:liver (human) |
RGD |
PMID:31587040 PMID:19637194 PMID:25995247 |
RGD:151361188, RGD:151361194, RGD:151361196 |
NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463
|
|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
treatment |
ISO |
associated with Glycogen Storage Disease IA, human gene in a mouse model |
RGD |
PMID:28096054 |
RGD:14695537 |
NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
|
|
G |
G6pdx |
glucose-6-phosphate dehydrogenase X-linked |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:25473368 PMID:35693827 |
RGD:10449118, RGD:153344586 |
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
|
|
G |
Gabrd |
gamma-aminobutyric acid (GABA) A receptor, subunit delta |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:155,469,437...155,482,528
Ensembl chr 4:155,469,437...155,482,569
|
|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16767786 PMID:21472284 |
|
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
|
|
G |
Gc |
vitamin D binding protein |
susceptibility |
ISO |
protein:increased expression:liver associated with Hepatitis B, Chronic;DNA:SNP: :rs7041(human) |
RGD |
PMID:21683810 PMID:25541958 |
RGD:5509919, RGD:14402025 |
NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757
|
|
G |
Gdf15 |
growth differentiation factor 15 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20512989 |
|
NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
|
|
G |
Gdf2 |
growth differentiation factor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23936038 PMID:28284560 |
|
NCBI chr14:33,662,996...33,669,155
Ensembl chr14:33,662,996...33,669,155
|
|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
disease_progression |
ISO |
HBV associated RNA,protein:increased expression, activity:liver: |
RGD |
PMID:11940314 PMID:27793641 PMID:10572675 |
RGD:14701040, RGD:14701041, RGD:14701048 |
NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034
|
|
G |
Ghr |
growth hormone receptor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974
|
|
G |
Gins1 |
GINS complex subunit 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:150,751,482...150,773,200
Ensembl chr 2:150,747,320...150,773,200
|
|
G |
Gjb1 |
gap junction protein, beta 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17978847 |
|
NCBI chr X:100,419,982...100,429,235
Ensembl chr X:100,419,984...100,429,235
|
|
G |
Gjb2 |
gap junction protein, beta 2 |
|
ISO |
DNA, mRNA:promoter hypermethylation, decreased expression:liver |
RGD |
PMID:17295234 |
RGD:2289638 |
NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159
|
|
G |
Gli1 |
GLI-Kruppel family member GLI1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26189965 |
|
NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
|
|
G |
Glul |
glutamate-ammonia ligase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
|
|
G |
Gm266 |
predicted gene 266 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr12:111,451,043...111,452,257
Ensembl chr12:111,451,043...111,452,257
|
|
G |
Gmnn |
geminin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906
|
|
G |
Gmps |
guanine monophosphate synthetase |
|
ISO |
protein:increased activity:hepatoma (rat) |
RGD |
PMID:6861338 |
RGD:5135537 |
NCBI chr 3:63,871,054...63,928,975
Ensembl chr 3:63,883,527...63,930,000
|
|
G |
Gnao1 |
guanine nucleotide binding protein, alpha O |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016
|
|
G |
Gnas |
GNAS complex locus |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer |
ClinVar |
PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 PMID:7739708 PMID:8766942 PMID:9626141 PMID:10571700 PMID:11093740 PMID:12727968 PMID:12970318 PMID:15126527 PMID:15952988 PMID:16507630 PMID:16543670 PMID:17873334 PMID:20197676 PMID:21835143 PMID:23403822 PMID:23536913 PMID:23843956 PMID:24855271 PMID:25157968 PMID:25719192 PMID:25741868 PMID:26341786 PMID:26574629 PMID:26619011 PMID:27398169 PMID:27506760 PMID:28492532 PMID:29991465 PMID:30702195 More...
|
|
NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537
|
|
G |
Gnaz |
guanine nucleotide binding protein, alpha z subunit |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:74,803,009...74,852,739
Ensembl chr10:74,803,009...74,852,739
|
|
G |
Gnmt |
glycine N-methyltransferase |
|
IAGP ISO |
OMIM:114550 CTD Direct Evidence: marker/mechanism |
MouseDO CTD |
PMID:19146867 PMID:31086990 |
|
NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094
|
|
G |
Golm1 |
golgi membrane protein 1 |
severity |
ISO |
protein:increased expression:serum mRNA, protein:increased expression:liver |
RGD |
PMID:21140449 PMID:21443671 |
RGD:401827118, RGD:401827119 |
NCBI chr13:59,782,810...59,823,598
Ensembl chr13:59,782,440...59,823,625
|
|
G |
Gpc1 |
glypican 1 |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 1:92,759,367...92,787,933
Ensembl chr 1:92,759,367...92,788,501
|
|
G |
Gpc3 |
glypican 3 |
severity treatment disease_progression exacerbates |
ISO |
CTD Direct Evidence: marker/mechanism protein:increased expression:liver protein:increased expression:serum mRNA:increased expression:Peripheral Blood (human) mRNA,protein:increased expression:peripheral blood mononuclear cell,blood serum, liver (human) protein:increased expression:blood serum (human) protein:increased expression:liver (human) |
CTD RGD |
PMID:16698587 PMID:27286460 PMID:28284560 PMID:19496787 PMID:25449037 PMID:25449037 PMID:21438004 PMID:23558072 PMID:28801286 PMID:22883669 More...
|
RGD:243065134, RGD:14695019, RGD:14695020, RGD:14695020, RGD:243065125, RGD:243065131, RGD:243065135, RGD:243065139 |
NCBI chr X:51,361,303...51,702,851
Ensembl chr X:51,361,303...51,702,827
|
|
G |
Gpm6a |
glycoprotein m6a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:55,232,469...55,513,913
Ensembl chr 8:55,407,878...55,513,906
|
|
G |
Gpr158 |
G protein-coupled receptor 158 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:21,372,378...21,835,355
Ensembl chr 2:21,372,353...21,835,358
|
|
G |
Gpr182 |
G protein-coupled receptor 182 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:127,585,471...127,587,667
Ensembl chr10:127,583,145...127,587,601
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
severity susceptibility no_association |
ISO |
associated with hepatitis C;DNA:missense mutation:CDS:p.P198L (rs1050450) (human) associated with alcoholic liver cirrhosis;DNA:missense mutation:CDS:p.P198L (human) |
RGD |
PMID:26990426 PMID:16510607 PMID:19929244 PMID:25894370 |
RGD:11533013, RGD:151708729, RGD:152995483, RGD:152998906 |
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
|
|
G |
Gpx3 |
glutathione peroxidase 3 |
severity disease_progression |
ISO |
mRNA,protein:decreased expression:liver, blood plasma (human) DNA:hypermethylation |
RGD |
PMID:25333265 PMID:25445749 PMID:27570561 |
RGD:151665355, RGD:151665509, RGD:401827855 |
NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
|
|
G |
Grb7 |
growth factor receptor bound protein 7 |
exacerbates |
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:17634422 |
RGD:151347655 |
NCBI chr11:98,337,660...98,346,199
Ensembl chr11:98,337,220...98,346,199
|
|
G |
Gstm1 |
glutathione S-transferase, mu 1 |
susceptibility no_association |
ISO |
DNA:deletion:cds (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:7892276 PMID:11859714 PMID:20683151 PMID:20672314 |
RGD:7488953, RGD:14700951, RGD:14700979 |
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
|
|
G |
Gstp1 |
glutathione S-transferase, pi 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism DNA:increased methylation:promoter |
CTD RGD |
PMID:9029167 PMID:22536438 |
RGD:14401712 |
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
|
|
G |
Gstt1 |
glutathione S-transferase, theta 1 |
susceptibility no_association |
ISO |
DNA:deletion |
RGD |
PMID:23053942 PMID:20683151 PMID:20672314 |
RGD:14401714, RGD:14700951, RGD:14700979 |
NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
|
|
G |
Gtse1 |
G two S phase expressed protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774
|
|
G |
Gys2 |
glycogen synthase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:142,368,339...142,418,856
Ensembl chr 6:142,368,339...142,418,835
|
|
G |
H19 |
H19, imprinted maternally expressed transcript |
|
ISO |
mRNA:increased expression:liver |
RGD |
PMID:17393425 |
RGD:2306187 |
NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917
|
|
G |
H2-Aa |
histocompatibility 2, class II antigen A, alpha |
susceptibility |
ISO |
associated with Hepatitis B, Chronic;DNA:SNP: :rs9272105(human) associated with Hepatitis B, Chronic;DNA:SNPs, haplotype: : rs9275572, rs2596542(human) |
RGD |
PMID:30160782 PMID:24204805 |
RGD:14398839, RGD:14401561 |
NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
|
|
G |
H2-Ab1 |
histocompatibility 2, class II antigen A, beta 1 |
treatment |
ISO |
associated with hepatitis B associated with hepatitis C;DNA:SNPs,haplotypes |
RGD |
PMID:27288300 PMID:28921602 |
RGD:14928325, RGD:14974233 |
NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
|
|
G |
H2-Pa |
histocompatibility 2, P region alpha locus |
|
ISO |
DNA:hypomethylation: CpG islands: |
RGD |
PMID:20165882 |
RGD:14694974 |
NCBI chr17:34,303,587...34,304,826
Ensembl chr17:34,303,575...34,304,797
|
|
G |
Hamp |
hepcidin antimicrobial peptide |
|
ISO IEP IDA |
CTD Direct Evidence: marker/mechanism mRNA:decreased expression:liver (human) DNA:hypermethylation,hypomethylation:promoter |
CTD RGD |
PMID:28284560 PMID:29235098 PMID:29235098 |
RGD:15042879, RGD:15042879 |
NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
|
|
G |
Hao2 |
hydroxyacid oxidase 2, kidney |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:98,781,835...98,802,692
Ensembl chr 3:98,781,837...98,800,555
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
|
|
G |
Havcr2 |
hepatitis A virus cellular receptor 2 |
disease_progression |
ISO |
associated with hepatitis B;DNA:SNP: : ���1516 G>T (human) |
RGD |
PMID:27034168 |
RGD:40818257 |
NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082
|
|
G |
Hdac2 |
histone deacetylase 2 |
disease_progression |
ISO |
mRNA:increased expression:liver: |
RGD |
PMID:24448241 |
RGD:9590206 |
NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885
|
|
G |
Hdac4 |
histone deacetylase 4 |
|
ISO |
mRNA:increased expression:liver: |
RGD |
PMID:21837748 |
RGD:9681451 |
NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
|
|
G |
Hfe |
homeostatic iron regulator |
disease_progression |
ISO |
associated with Liver Cirrhosis;DNA:missense mutation:cds:p.C282Y (human) |
RGD |
PMID:20019189 PMID:29642405 |
RGD:2317357, RGD:14746967 |
NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837
|
|
G |
Hgf |
hepatocyte growth factor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9932610 PMID:11896611 |
|
NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
|
|
G |
Hgfac |
hepatocyte growth factor activator |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr 5:35,198,853...35,205,805
Ensembl chr 5:35,198,853...35,205,805
|
|
G |
Hhip |
Hedgehog-interacting protein |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18559595 |
|
NCBI chr 8:80,692,480...80,784,637
Ensembl chr 8:80,692,480...80,784,635
|
|
G |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
treatment disease_progression |
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:19335982 PMID:26078356 PMID:31321740 |
RGD:9068886, RGD:11526468, RGD:155882550 |
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
|
|
G |
Hilpda |
hypoxia inducible lipid droplet associated |
disease_progression |
ISO |
mRNA, protein:increased expression:liver (human) human cells in mouse model mRNA:increased expression:liver (human) |
RGD |
PMID:31142329 PMID:31142329 PMID:30205391 PMID:35693827 |
RGD:153344574, RGD:153344574, RGD:153344577, RGD:153344586 |
NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445
|
|
G |
Hjurp |
Holliday junction recognition protein |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:88,186,578...88,205,366
Ensembl chr 1:88,190,193...88,205,355
|
|
G |
Hmgb2 |
high mobility group box 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20851854 |
|
NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9207284 PMID:21147110 |
|
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
|
|
G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 |
disease_progression |
ISO |
|
RGD |
PMID:28867541 |
RGD:14975299 |
NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
|
|
G |
Hmmr |
hyaluronan mediated motility receptor (RHAMM) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249
|
|
G |
Hnf1a |
HNF1 homeobox A |
treatment |
IMP |
human cell line in mouse model |
RGD |
PMID:29466992 |
RGD:14700664 |
NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153
|
|
G |
Hnf4a |
hepatic nuclear factor 4, alpha |
|
ISO |
protein:decreased expression:liver: |
RGD |
PMID:20876809 PMID:20876809 |
RGD:12904747, RGD:12904747 |
NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
|
|
G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
|
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:23633480 |
RGD:9685423 |
NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119
|
|
G |
Hnrnpa2b1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
|
ISO |
protein:increased expression:liver (human) mRNA:increased expression:liver (rat) |
RGD |
PMID:20604928 PMID:23633480 |
RGD:9685422, RGD:9685423 |
NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874
|
|
G |
Hnrnpab |
heterogeneous nuclear ribonucleoprotein A/B |
severity |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:24638979 |
RGD:10059322 |
NCBI chr11:51,490,927...51,497,708
Ensembl chr11:51,490,927...51,497,674
|
|
G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
|
ISO |
protein:increased expression:liver (human) protein:increased expression:liver (rat) |
RGD |
PMID:20102719 PMID:22318685 |
RGD:10042969, RGD:10042977 |
NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797
|
|
G |
Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
|
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:23633480 |
RGD:9685423 |
NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
|
|
G |
Hnrnpl |
heterogeneous nuclear ribonucleoprotein L |
|
ISO |
associated with Hepatitis B |
RGD |
PMID:24125732 |
RGD:9999429 |
NCBI chr 7:28,507,971...28,521,693
Ensembl chr 7:28,507,966...28,521,691
|
|
G |
Hotair |
HOX transcript antisense RNA (non-protein coding) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21327457 |
|
NCBI chr15:102,852,497...102,856,381
Ensembl chr15:102,852,494...102,856,165
|
|
G |
Hoxa10 |
homeobox A10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:52,208,177...52,217,658
Ensembl chr 6:52,208,177...52,217,834
|
|
G |
Hoxa13 |
homeobox A13 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:52,235,833...52,237,865
Ensembl chr 6:52,234,674...52,237,788
|
|
G |
Hoxd9 |
homeobox D9 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:74,528,107...74,530,552
Ensembl chr 2:74,528,071...74,530,552
|
|
G |
Hp |
haptoglobin |
|
ISO |
protein:increased expression:saliva protein:decreased expression:liver (human) |
RGD |
PMID:31041878 PMID:24259486 |
RGD:27095881, RGD:152995276 |
NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804
|
|
G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
|
ISO |
protein:increased activity:hepatoma (rat) |
RGD |
PMID:6327016 |
RGD:5135035 |
NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536
|
|
G |
Hras |
Harvey rat sarcoma virus oncogene |
treatment |
ISO IEP |
CTD Direct Evidence: marker/mechanism protein:increased expression:liver (human) human cells in a mouse model human plasmid in a mouse model mRNA:increased expression:liver (mouse) ClinVar Annotator: match by term: Hepatocellular cancer ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma |
CTD ClinVar RGD |
PMID:8200073 PMID:9311599 PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 PMID:16443854 PMID:16835863 PMID:16881968 PMID:16969868 PMID:17054105 PMID:17211612 PMID:17384584 PMID:17412879 PMID:17601930 PMID:17979197 PMID:18039947 PMID:18042262 PMID:18247425 PMID:18978862 PMID:19206176 PMID:19213030 PMID:19255327 PMID:19371735 PMID:19382114 PMID:19669404 PMID:19773371 PMID:20118494 PMID:20301680 PMID:20660566 PMID:20859122 PMID:20937837 PMID:20979192 PMID:21438134 PMID:21495179 PMID:21686750 PMID:21834037 PMID:21850009 PMID:22087699 PMID:22256804 PMID:22317973 PMID:22420426 PMID:22495892 PMID:22499344 PMID:22683711 PMID:22726224 PMID:22926243 PMID:23093928 PMID:23096712 PMID:23406027 PMID:23429430 PMID:23751039 PMID:23884457 PMID:24006476 PMID:24033266 PMID:24129065 PMID:24169525 PMID:24224811 PMID:24390138 PMID:24803665 PMID:25157968 PMID:25326635 PMID:25741868 PMID:25815234 PMID:25914166 PMID:26467025 PMID:26619011 PMID:26778095 PMID:27195699 PMID:27283355 PMID:27444071 PMID:27517622 PMID:27589201 PMID:28027064 PMID:28139825 PMID:28284560 PMID:28492532 PMID:29493581 PMID:30055033 PMID:30138938 PMID:30191474 PMID:31222966 PMID:31394527 PMID:31560489 PMID:31564432 PMID:31775759 PMID:32371413 PMID:32732226 PMID:33027564 PMID:33372952 PMID:34008892 PMID:34958143 PMID:168335863 PMID:15806265 PMID:10791191 PMID:23555816 PMID:2219132 More...
|
RGD:14688054, RGD:14688055, RGD:14694809, RGD:14694810 |
NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
|
|
G |
Hspa5 |
heat shock protein 5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 PMID:29698666 |
|
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
|
|
G |
Hspa9 |
heat shock protein 9 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410
|
|
G |
Hspb1 |
heat shock protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417
|
|
G |
Htatip2 |
HIV-1 Tat interactive protein 2 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:16799960 |
|
NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723
|
|
G |
Htra1 |
HtrA serine peptidase 1 |
exacerbates disease_progression |
ISO |
protein:decreased expression:liver (human) mRNA:decreased expression:liver (human) |
RGD |
PMID:20943460 PMID:26403966 |
RGD:152985524, RGD:152985529 |
NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
severity |
ISO |
protein:increased expression:serum |
RGD |
PMID:26109813 |
RGD:11056752 |
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
|
|
G |
Idh1 |
isocitrate dehydrogenase 1 (NADP+), soluble |
|
ISO |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Hepatocellular cancer |
CTD ClinVar |
PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 PMID:21352804 PMID:21446021 PMID:21472284 PMID:22160010 PMID:22397365 PMID:22417203 PMID:22898539 PMID:23558169 PMID:24606448 PMID:25043048 PMID:25157968 PMID:25741868 PMID:26619011 PMID:27993330 PMID:30231226 PMID:36201590 More...
|
|
NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
|
|
G |
Idh2 |
isocitrate dehydrogenase 2 (NADP+), mitochondrial |
disease_progression |
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer |
ClinVar RGD |
PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 PMID:22397365 PMID:22417203 PMID:22616558 PMID:22898539 PMID:23949315 PMID:24606448 PMID:25157968 PMID:26619011 PMID:24716838 More...
|
RGD:14985249 |
NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
|
|
G |
Ier2 |
immediate early response 2 |
|
ISO |
mRNA, protein:decreased expression:liver (human) |
RGD |
PMID:32009420 |
RGD:153323326 |
NCBI chr 8:85,387,960...85,389,481
Ensembl chr 8:85,387,960...85,389,483
|
|
G |
Ifna1 |
interferon alpha 1 |
susceptibility |
ISO |
CTD Direct Evidence: therapeutic associated with hepatitis B; DNA:SNP:: ( rs1831583) (human) |
CTD RGD |
PMID:17088986 PMID:17971768 PMID:18665156 PMID:29080269 |
RGD:21406429 |
NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893
|
|
G |
Ifna2 |
interferon alpha 2 |
susceptibility |
ISO |
associated with hepatitis B; DNA:SNP:enhancer: (rs649053) (human) |
RGD |
PMID:29080269 |
RGD:21406429 |
NCBI chr 4:88,601,444...88,602,016
Ensembl chr 4:88,601,118...88,602,149
|
|
G |
Ifng |
interferon gamma |
|
IEP |
mRNA:increased expression:liver (mouse) |
RGD |
PMID:26569409 |
RGD:11344640 |
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
|
|
G |
Igbp1 |
immunoglobulin (CD79A) binding protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21339737 |
|
NCBI chr X:99,537,897...99,559,731
Ensembl chr X:99,537,897...99,559,731
|
|
G |
Igf1 |
insulin-like growth factor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
|
|
G |
Igf1r |
insulin-like growth factor I receptor |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism DNA:SNPs, haplotype: : |
CTD RGD |
PMID:17441810 PMID:23958494 PMID:24758241 |
RGD:14985227 |
NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
|
|
G |
Igf2 |
insulin-like growth factor 2 |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism associated with hepatitis B;DNA:SNPs:intron, 3'utr:+2482A>C, +820A>G (human) |
CTD RGD |
PMID:12532445 PMID:16092956 PMID:17554210 PMID:16750516 |
RGD:2311523, RGD:14401723 |
NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
|
|
G |
Igf2bp1 |
insulin-like growth factor 2 mRNA binding protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:95,847,989...95,896,770
Ensembl chr11:95,847,989...95,896,766
|
|
G |
Igf2bp3 |
insulin-like growth factor 2 mRNA binding protein 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891
|
|
G |
Igf2r |
insulin-like growth factor 2 receptor |
disease_progression no_association treatment |
ISO |
DNA:mutation:G1449V (human) CTD Direct Evidence: marker/mechanism protein:increased expression:serum: DNA:loss of heterozygosity:liver DNA:loss of heterozygosity,mutations:liver: associated with hepatitis B virus; mRNA:decreased expression:liver: ClinVar Annotator: match by term: Hepatocellular carcinoma |
OMIM CTD ClinVar RGD |
PMID:9722161 PMID:15057872 PMID:25741868 PMID:7493029 PMID:29940770 PMID:18322954 PMID:10347113 PMID:30720132 PMID:11981765 PMID:12736721 More...
|
RGD:1624323, RGD:14985218, RGD:14985219, RGD:14985220, RGD:14985221, RGD:14985222, RGD:14985225 |
NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551
|
|
G |
Igfals |
insulin-like growth factor binding protein, acid labile subunit |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:25,096,818...25,100,985
Ensembl chr17:25,084,971...25,100,984
|
|
G |
Ikbkg |
inhibitor of kappaB kinase gamma |
treatment |
IMP ISO |
protein:decreased expression:liver (human) |
RGD |
PMID:29551768 PMID:22176836 PMID:25173965 PMID:17292824 PMID:24971483 PMID:22922425 More...
|
RGD:153297807, RGD:153297813, RGD:153305943, RGD:153305945, RGD:11079569, RGD:153305947 |
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
|
|
G |
Ikzf1 |
IKAROS family zinc finger 1 |
ameliorates |
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:25301737 |
RGD:150540326 |
NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926
|
|
G |
Il10 |
interleukin 10 |
treatment |
ISO |
|
RGD |
PMID:23822114 PMID:26890368 |
RGD:7365006, RGD:14975171 |
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
|
|
G |
Il12a |
interleukin 12a |
susceptibility |
ISO |
associated with hepatitis C;DNA:SNP:3'UTR: rs568408( G>A)(human) associated with hepatitis B; DNA:SNP, haplotype:3′UTR::rs568408(human) |
RGD |
PMID:27819525 PMID:20521253 PMID:26631030 |
RGD:25440490, RGD:25440491, RGD:25440501 |
NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
|
|
G |
Il15ra |
interleukin 15 receptor, alpha chain |
disease_progression |
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 2:11,709,992...11,739,129
Ensembl chr 2:11,710,101...11,739,128
|
|
G |
Il18 |
interleukin 18 |
severity disease_progression susceptibility |
ISO |
associated with hepatitis C;DNA:SNPs, haplotype:promoter:-607C>A, -137G>C(human) DNA:SNP:promoter:-137G>C(rs187238)(human) associated with hepatitis B, chronic;DNA:SNP:promoter:-607C>A(human) |
RGD |
PMID:29341496 PMID:26893476 PMID:27429592 PMID:27470888 |
RGD:14695526, RGD:11538094, RGD:14695540, RGD:14696663 |
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
|
|
G |
Il18r1 |
interleukin 18 receptor 1 |
|
ISO IMP |
mRNA:decreased expression:liver |
RGD |
PMID:26893476 PMID:26893476 |
RGD:11538094, RGD:11538094 |
NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014
|
|
G |
Il1b |
interleukin 1 beta |
susceptibility |
ISO |
DNA:polymorphism:promoter:-31T>C (human) |
RGD |
PMID:21653279 |
RGD:7401222 |
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
|
|
G |
Il1rap |
interleukin 1 receptor accessory protein |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr16:26,400,259...26,548,878
Ensembl chr16:26,400,454...26,548,867
|
|
G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
|
|
G |
Il2 |
interleukin 2 |
treatment |
ISO |
|
RGD |
PMID:10933975 PMID:9449371 |
RGD:8693323, RGD:14747035 |
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
|
|
G |
Il21 |
interleukin 21 |
|
ISO |
associated with hepatitis B;DNA:SNPS, haplotype:(rs13143866, rs2221903, rs907715) (human) |
RGD |
PMID:25892873 |
RGD:127285359 |
NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
|
|
G |
Il6 |
interleukin 6 |
treatment disease_progression |
ISO IEP |
CTD Direct Evidence: marker/mechanism DNA:SNP: :rs2069852 (human) mRNA,protein:increased expression:liver, blood serum (mouse) |
CTD RGD |
PMID:17615358 PMID:20818158 PMID:26297436 PMID:27022031 PMID:27368337 PMID:26569409 More...
|
RGD:14975289, RGD:11344640 |
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
|
|
G |
Il6st |
interleukin 6 signal transducer |
|
ISO |
|
RGD |
PMID:15780071 |
RGD:1626706 |
NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620
|
|
G |
Ing3 |
inhibitor of growth family, member 3 |
treatment |
ISO |
|
RGD |
PMID:25156538 |
RGD:9587823 |
NCBI chr 6:21,948,002...21,976,037
Ensembl chr 6:21,949,570...21,976,037
|
|
G |
Inmt |
indolethylamine N-methyltransferase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:55,147,612...55,151,975
Ensembl chr 6:55,147,611...55,152,028
|
|
G |
Inpp4b |
inositol polyphosphate-4-phosphatase, type II |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29415082 |
|
NCBI chr 8:82,068,895...82,865,553
Ensembl chr 8:82,069,185...82,854,543
|
|
G |
Ins1 |
insulin I |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
|
|
G |
Ins2 |
insulin II |
|
ISO |
associated with Chronic Hepatitis C;mRNA:decreased expression:liver (human) |
RGD |
PMID:33132693 |
RGD:150340613 |
NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
|
|
G |
Insr |
insulin receptor |
|
ISO |
mRNA, protein:increased expression:liver (human, rat) human cells in a mouse model |
RGD |
PMID:23633480 PMID:29610518 |
RGD:9685423, RGD:14700930 |
NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
|
|
G |
Iqgap1 |
IQ motif containing GTPase activating protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20977743 |
|
NCBI chr 7:80,361,331...80,453,288
Ensembl chr 7:80,361,331...80,475,722
|
|
G |
Iqgap2 |
IQ motif containing GTPase activating protein 2 |
|
ISO IAGP |
CTD Direct Evidence: marker/mechanism OMIM:114550 |
CTD MouseDO |
PMID:20977743 |
|
NCBI chr13:95,763,685...96,028,788
Ensembl chr13:95,763,682...96,028,991
|
|
G |
Iqgap3 |
IQ motif containing GTPase activating protein 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:87,989,309...88,028,355
Ensembl chr 3:87,989,278...88,028,355
|
|
G |
Irf2 |
interferon regulatory factor 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22561517 |
|
NCBI chr 8:47,192,751...47,300,493
Ensembl chr 8:47,192,767...47,300,493
|
|
G |
Irs1 |
insulin receptor substrate 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:1311924 PMID:23958494 |
|
NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
|
|
G |
Irs2 |
insulin receptor substrate 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16127164 |
|
NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
|
|
G |
Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 |
|
NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717
|
|
G |
Itih4 |
inter alpha-trypsin inhibitor, heavy chain 4 |
disease_progression |
ISO |
associated with hepatitis B;protein:decreased expression:serum |
RGD |
PMID:24836184 |
RGD:40903002 |
NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310
|
|
G |
Jag1 |
jagged 1 |
|
ISO |
protein:increased expression:liver |
RGD |
PMID:30660174 |
RGD:14694832 |
NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564
|
|
G |
Jak1 |
Janus kinase 1 |
|
ISO |
|
RGD |
PMID:23788652 |
RGD:150524353 |
NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479
|
|
G |
Jak2 |
Janus kinase 2 |
severity exacerbates ameliorates treatment |
IEP ISO IMP |
mRNA:decreased expression:liver (human) protein:increased phosphorylation:liver (human) protein:increased phosphorylation:liver (mouse) associated with Diseases of the Aged and non-alcoholic fatty liver disease L-JAK2 KO |
RGD |
PMID:25420511 PMID:22392353 PMID:22821478 PMID:31393852 PMID:28100771 PMID:29486150 More...
|
RGD:18182928, RGD:125097525, RGD:127285621, RGD:127285655, RGD:127285675, RGD:127285672 |
NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
|
|
G |
Jdp2 |
Jun dimerization protein 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20214788 |
|
NCBI chr12:85,645,190...85,686,652
Ensembl chr12:85,645,801...85,686,652
|
|
G |
Jun |
jun proto-oncogene |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20214788 |
|
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
|
|
G |
Jund |
jun D proto-oncogene |
|
ISO |
associated with HBV;protein:increased expression:liver (human) |
RGD |
PMID:15927205 |
RGD:153297768 |
NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265
|
|
G |
Kat2b |
K(lysine) acetyltransferase 2B |
severity |
ISO |
protein:decreased expression:liver (human) |
RGD |
PMID:23643089 |
RGD:9590314 |
NCBI chr17:53,873,802...53,979,749
Ensembl chr17:53,873,889...53,979,748
|
|
G |
Kbtbd11 |
kelch repeat and BTB (POZ) domain containing 11 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:15,059,408...15,083,333
Ensembl chr 8:15,061,025...15,083,333
|
|
G |
Kcnh1 |
potassium voltage-gated channel, subfamily H (eag-related), member 1 |
|
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:17022810 |
RGD:9693723 |
NCBI chr 1:191,871,759...192,192,467
Ensembl chr 1:191,873,082...192,192,467
|
|
G |
Kcnn2 |
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950
|
|
G |
Kdm1a |
lysine (K)-specific demethylase 1A |
severity |
ISO |
mRNA, protein:increased expression:liver (human) |
RGD |
PMID:23236241 |
RGD:9681002 |
NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034
|
|
G |
Kdm3a |
lysine (K)-specific demethylase 3A |
|
ISO |
mRNA:increased expression:liver (human) |
RGD |
PMID:21607773 |
RGD:9590222 |
NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974
|
|
G |
Kdm5c |
lysine demethylase 5C |
exacerbates |
ISO |
protein:increased expression:liver (human) |
RGD |
PMID:26503415 |
RGD:11530160 |
NCBI chr X:151,015,698...151,062,098
Ensembl chr X:151,016,016...151,057,531
|
|
G |
Kdm6a |
lysine (K)-specific demethylase 6A |
ameliorates |
ISO |
human cells in a mouse model |
RGD |
PMID:32765772 |
RGD:150429729 |
NCBI chr X:18,027,101...18,147,061
Ensembl chr X:18,028,814...18,146,175
|
|
G |
Kdm8 |
lysine (K)-specific demethylase 8 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:125,043,788...125,062,823
Ensembl chr 7:125,043,848...125,061,441
|
|
G |
Kdr |
kinase insert domain protein receptor |
treatment disease_progression |
ISO |
DNA:SNPs: :rs1870377, rs2071559, rs2305948 (human) protein:increased expression:liver protein:decreased expression:liver associated with alcoholic liver cirrhosis;DNA:SNP: :1416A>T (human) |
RGD |
PMID:25182707 PMID:19177438 PMID:25333267 PMID:23660204 PMID:24445728 |
RGD:126848806, RGD:126848810, RGD:126848812, RGD:126848813, RGD:126848814 |
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
|
|
G |
Kif11 |
kinesin family member 11 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr19:37,364,830...37,410,311
Ensembl chr19:37,364,851...37,410,307
|
|
G |
Kif14 |
kinesin family member 14 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:136,394,044...136,483,676
Ensembl chr 1:136,394,081...136,459,249
|
|
G |
Kif15 |
kinesin family member 15 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:122,780,146...122,847,798
Ensembl chr 9:122,780,111...122,847,798
|
|
G |
Kif18a |
kinesin family member 18A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:109,111,165...109,172,094
Ensembl chr 2:109,111,083...109,172,092
|
|
G |
Kif18b |
kinesin family member 18B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:102,796,344...102,815,960
Ensembl chr11:102,796,355...102,815,950
|
|
G |
Kif1b |
kinesin family member 1B |
severity susceptibility |
ISO |
mRNA, protein:decreased expression:liver (human) DNA:snp:intron:c.2537+518A>G (rs17401966) (human) |
RGD |
PMID:26217094 PMID:27122668 |
RGD:11052488, RGD:12738461 |
NCBI chr 4:149,260,776...149,392,762
Ensembl chr 4:149,260,776...149,392,150
|
|
G |
Kif20a |
kinesin family member 20A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
|
|
G |
Kif23 |
kinesin family member 23 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056
|
|
G |
Kif2c |
kinesin family member 2C |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:117,016,830...117,039,821
Ensembl chr 4:117,016,836...117,039,836
|
|
G |
Kif4 |
kinesin family member 4 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:99,669,693...99,770,878
Ensembl chr X:99,669,343...99,770,820
|
|
G |
Kifc1 |
kinesin family member C1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:34,094,640...34,109,607
Ensembl chr17:34,094,633...34,109,635
|
|
G |
Klf4 |
Kruppel-like transcription factor 4 (gut) |
disease_progression treatment |
ISO |
|
RGD |
PMID:22677193 PMID:22677193 |
RGD:14402023, RGD:14402023 |
NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466
|
|
G |
Klrb1 |
killer cell lectin-like receptor subfamily B member 1 |
disease_progression |
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:35693827 |
RGD:153344586 |
NCBI chr 6:128,683,056...128,701,293
Ensembl chr 6:128,682,799...128,700,022
|
|
G |
Kmt2a |
lysine (K)-specific methyltransferase 2A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22634756 |
|
NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594
|
|
G |
Kmt2b |
lysine (K)-specific methyltransferase 2B |
|
ISO |
DNA:insertions, translocations:intron:IVS3, multiple (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:22634754 PMID:18320596 |
RGD:9588597 |
NCBI chr 7:30,268,280...30,288,371
Ensembl chr 7:30,268,283...30,288,151
|
|
G |
Kmt2c |
lysine (K)-specific methyltransferase 2C |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22634756 |
|
NCBI chr 5:25,476,793...25,703,853
Ensembl chr 5:25,476,796...25,703,781
|
|
G |
Kras |
Kirsten rat sarcoma viral oncogene homolog |
induced |
ISO |
CTD Direct Evidence: marker/mechanism aflatoxin B1 induced:DNA:transversion,transition mutations:cds: mRNA,protein:increased expression:liver ClinVar Annotator: match by term: Hepatocellular cancer |
CTD ClinVar RGD |
PMID:2278970 PMID:3122217 PMID:11286481 PMID:11563603 PMID:12460918 PMID:15696205 PMID:16361624 PMID:16434492 PMID:16618717 PMID:18316791 PMID:18794081 PMID:19075190 PMID:19114683 PMID:19679400 PMID:20921462 PMID:20921465 PMID:21228335 PMID:22407852 PMID:22722830 PMID:23325582 PMID:25157968 PMID:26619011 PMID:30891959 PMID:8446626 PMID:29275358 More...
|
RGD:11568697, RGD:14398750 |
NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
|
|
G |
Krt18 |
keratin 18 |
|
IAGP |
OMIM:114550 |
MouseDO |
|
|
NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
|
|
G |
Lcat |
lecithin cholesterol acyltransferase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
|
|
G |
Lect2 |
leukocyte cell-derived chemotaxin 2 |
ameliorates |
IEP ISO |
protein:increased expression:blood serum (mouse) protein:increased expression:blood serum (human) human cells in mouse model |
RGD |
PMID:24892551 PMID:24892551 PMID:21394108 |
RGD:153323333, RGD:153323333, RGD:153323335 |
NCBI chr13:56,676,772...56,696,373
Ensembl chr13:56,690,277...56,696,315
|
|
G |
Lep |
leptin |
susceptibility severity |
IAGP IEP |
DNA:SNP:enhancer:-2548G>A (rs7799039) (human) protein:increased expression:liver (human) |
RGD |
PMID:28452232 PMID:18573568 |
RGD:15039399, RGD:25330348 |
NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
|
|
G |
Lepr |
leptin receptor |
susceptibility |
ISO |
associated with Hepatitis B, Chronic;DNA:SNPs:cds:p.Gln223Arg, Lys109Arg (human) |
RGD |
PMID:23090836 |
RGD:21079466 |
NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
|
|
G |
Letm1 |
leucine zipper-EF-hand containing transmembrane protein 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:23392203 |
|
NCBI chr 5:33,897,017...33,940,061
Ensembl chr 5:33,897,017...33,940,161
|
|
G |
Lifr |
LIF receptor alpha |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr15:7,120,091...7,226,970
Ensembl chr15:7,120,095...7,226,970
|
|
G |
LOC110806267 |
Tert 5' regulatory region |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular carcinoma |
ClinVar |
PMID:28492532 PMID:28677271 |
|
NCBI chr13:73,770,663...73,775,510
|
|
G |
Loxl3 |
lysyl oxidase-like 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:35841383 |
|
NCBI chr 6:83,011,186...83,029,547
Ensembl chr 6:83,011,154...83,029,543
|
|
G |
Lpar1 |
lysophosphatidic acid receptor 1 |
|
ISO |
|
RGD |
PMID:19000703 |
RGD:2317680 |
NCBI chr 4:58,435,252...58,554,601
Ensembl chr 4:58,435,255...58,553,898
|
|
G |
Lrat |
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 3:82,799,889...82,811,281
Ensembl chr 3:82,799,886...82,811,280
|
|
G |
Lrp1b |
low density lipoprotein-related protein 1B |
exacerbates |
ISO |
protein:increased expression:liver (human) DNA:mutations:multiple: (human) |
RGD |
PMID:33324588 PMID:33391418 |
RGD:150429776, RGD:150429785 |
NCBI chr 2:40,485,302...42,543,747
Ensembl chr 2:40,485,258...42,543,636
|
|
G |
Lrrc1 |
leucine rich repeat containing 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:77,338,103...77,453,749
Ensembl chr 9:77,338,105...77,452,152
|
|
G |
Lrrc56 |
leucine rich repeat containing 56 |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma |
ClinVar |
PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 PMID:16443854 PMID:16835863 PMID:16881968 PMID:16969868 PMID:17054105 PMID:17211612 PMID:17384584 PMID:17412879 PMID:17601930 PMID:17979197 PMID:18039947 PMID:18042262 PMID:18247425 PMID:18978862 PMID:19206176 PMID:19213030 PMID:19255327 PMID:19371735 PMID:19382114 PMID:19669404 PMID:19773371 PMID:20301680 PMID:20660566 PMID:20859122 PMID:20937837 PMID:20979192 PMID:21438134 PMID:21495179 PMID:21686750 PMID:21834037 PMID:21850009 PMID:22087699 PMID:22256804 PMID:22317973 PMID:22420426 PMID:22495892 PMID:22499344 PMID:22683711 PMID:22726224 PMID:22926243 PMID:23093928 PMID:23096712 PMID:23406027 PMID:23429430 PMID:23751039 PMID:23884457 PMID:24006476 PMID:24033266 PMID:24129065 PMID:24169525 PMID:24224811 PMID:24390138 PMID:24803665 PMID:25157968 PMID:25326635 PMID:25741868 PMID:25815234 PMID:25914166 PMID:26467025 PMID:26619011 PMID:26778095 PMID:27195699 PMID:27283355 PMID:27444071 PMID:27589201 PMID:28027064 PMID:28139825 PMID:28492532 PMID:29493581 PMID:30055033 PMID:30138938 PMID:30191474 PMID:31222966 PMID:31394527 PMID:31560489 PMID:31564432 PMID:31775759 PMID:32371413 PMID:32732226 PMID:33027564 PMID:33372952 PMID:34008892 PMID:34958143 PMID:168335863 More...
|
|
NCBI chr 7:140,774,024...140,789,968
Ensembl chr 7:140,774,070...140,789,968
|
|
G |
Lrrc59 |
leucine rich repeat containing 59 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30705370 |
|
NCBI chr11:94,520,603...94,536,049
Ensembl chr11:94,520,593...94,536,042
|
|
G |
Lyve1 |
lymphatic vessel endothelial hyaluronan receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:110,449,814...110,462,160
Ensembl chr 7:110,449,814...110,462,446
|
|
G |
Lztr1 |
leucine-zipper-like transcriptional regulator, 1 |
|
ISO |
DNA:missense mutation:cds, liver (human) |
RGD |
PMID:28622513 |
RGD:151893487 |
NCBI chr16:17,326,124...17,344,197
Ensembl chr16:17,326,552...17,344,197
|
|
G |
Mad2l1 |
MAD2 mitotic arrest deficient-like 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204
|
|
G |
Magea3 |
MAGE family member A3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:153,731,176...153,742,027
Ensembl chr X:153,731,539...153,732,501
|
|
G |
Magea5 |
MAGE family member A5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:153,836,057...153,846,147
Ensembl chr X:153,836,057...153,846,141
|
|
G |
Magea6 |
MAGE family member A6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:153,706,891...153,719,070
Ensembl chr X:153,707,008...153,718,983
|
|
G |
Magec2 |
MAGE family member C2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr X:61,326,566...61,335,690
Ensembl chr X:61,327,105...61,335,684
|
|
G |
Malat1 |
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26735578 |
|
NCBI chr19:5,845,718...5,852,700
Ensembl chr19:5,845,717...5,852,706
|
|
G |
Map2k2 |
mitogen-activated protein kinase kinase 2 |
exacerbates |
ISO |
mRNA:increased expression:liver (human) protein:increased expression:liver, cytosol (rat) |
RGD |
PMID:33553243 PMID:9397988 |
RGD:150530475, RGD:150530477 |
NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
|
|
G |
Map2k4 |
mitogen-activated protein kinase kinase 4 |
|
ISO |
protein:decreased expression:liver (human) |
RGD |
PMID:32850377 |
RGD:150429765 |
NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123
|
|
G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
exacerbates |
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:31310010 |
RGD:150573714 |
NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527
|
|
G |
Map3k8 |
mitogen-activated protein kinase kinase kinase 8 |
ameliorates |
IMP |
|
RGD |
PMID:26560698 |
RGD:11342977 |
NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015
|
|
G |
Map4k4 |
mitogen-activated protein kinase kinase kinase kinase 4 |
ameliorates severity treatment |
ISO |
human cell line in a mouse model human recombinant gene and cell line in a mouse model |
RGD |
PMID:21196414 PMID:27010469 PMID:31922225 |
RGD:151347673, RGD:151347674, RGD:151347839 |
NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470
|
|
G |
Mapk1 |
mitogen-activated protein kinase 1 |
|
ISO |
protein:increased expression:liver |
RGD |
PMID:27468214 |
RGD:401976278 |
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
|
|
G |
Mapk14 |
mitogen-activated protein kinase 14 |
treatment exacerbates |
IMP |
|
RGD |
PMID:25216638 PMID:23271722 |
RGD:151665347, RGD:151665348 |
NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
ameliorates |
ISO |
protein:decreased phosphorylation:liver (human) |
RGD |
PMID:33875785 |
RGD:150340688 |
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
|
|
G |
Mapt |
microtubule-associated protein tau |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
|
|
G |
Marco |
macrophage receptor with collagenous structure |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753
|
|
G |
Mat1a |
methionine adenosyltransferase 1A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12060674 |
|
NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369
|
|
G |
Mbl2 |
mannose-binding lectin (protein C) 2 |
severity susceptibility no_association |
ISO |
associated with hepatitis C;DNA:SNP: :221C>G(rs709620)(human) associated with hepatitis B-related cirrhosis;DNA:SNP: :rs11003123(G>A)(human) associated with viral hepatitis;DNA:polymorphisms:exon: DNA:SNPs:promoter:rs7096206(human) protein:decreased expression:plasma associated with hepatitis B;DNA:SNP:exon: |
RGD |
PMID:21733090 PMID:27298104 PMID:18221301 PMID:25787238 PMID:27557564 PMID:26857650 More...
|
RGD:14696813, RGD:14696814, RGD:14696829, RGD:14696833, RGD:14696835, RGD:14696836 |
NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087
|
|
G |
Mbtps1 |
membrane-bound transcription factor peptidase, site 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14563831 |
|
NCBI chr 8:120,234,890...120,285,603
Ensembl chr 8:120,234,895...120,285,474
|
|
G |
Mbtps2 |
membrane-bound transcription factor peptidase, site 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14563831 |
|
NCBI chr X:156,330,818...156,381,711
Ensembl chr X:156,318,367...156,381,711
|
|
G |
Mcm10 |
minichromosome maintenance 10 replication initiation factor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602
|
|
G |
Mcm2 |
minichromosome maintenance complex component 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
|
|
G |
Mcm7 |
minichromosome maintenance complex component 7 |
susceptibility |
IAGP IEP |
associated with hepatitis B;DNA:SNP:promoter: (rs999885) (human) associated with hepatitis B;miRNA:increased expression:liver (human) |
RGD |
PMID:24416400 PMID:27298561 |
RGD:15042885, RGD:15042853 |
NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684
|
|
G |
Mcm9 |
minichromosome maintenance 9 homologous recombination repair factor |
|
IAGP |
OMIM:114550 |
MouseDO |
|
|
NCBI chr10:53,412,411...53,507,251
Ensembl chr10:53,412,411...53,506,535
|
|
G |
Mdm2 |
transformed mouse 3T3 cell double minute 2 |
susceptibility |
ISO |
DNA:transversion:promoter:g.-309T>G (human) |
RGD |
PMID:20019189 |
RGD:2317357 |
NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
|
|
G |
Me1 |
malic enzyme 1, NADP(+)-dependent, cytosolic |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
|
|
G |
Mecp2 |
methyl CpG binding protein 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:liver |
CTD RGD |
PMID:26189965 PMID:11844796 |
RGD:2289670 |
NCBI chr X:73,070,198...73,129,296
Ensembl chr X:73,070,198...73,129,296
|
|
G |
Med1 |
mediator complex subunit 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20007298 |
|
NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119
|
|
G |
Melk |
maternal embryonic leucine zipper kinase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:44,300,876...44,364,301
Ensembl chr 4:44,300,876...44,364,675
|
|
G |
Met |
met proto-oncogene |
severity susceptibility |
ISO IMP |
protein:increased expression:liver (rat) mRNA:increased expression:liver, carcinoma (human) CTD Direct Evidence: marker/mechanism protein:increased expression:liver (human) ClinVar Annotator: match by term: Hepatocellular cancer |
CTD ClinVar OMIM RGD |
PMID:21774103 PMID:21970370 PMID:22703879 PMID:24728327 PMID:25741868 PMID:28259294 PMID:28492532 PMID:29641532 PMID:32045588 PMID:17311762 PMID:9927037 PMID:17154373 PMID:29303510 PMID:29303510 More...
|
RGD:2317495, RGD:1600123, RGD:2317575, RGD:152995524, RGD:152995524 |
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
|
|
G |
Mfsd2a |
MFSD2 lysolipid transporter A, lysophospholipid |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:122,840,643...122,855,844
Ensembl chr 4:122,840,643...122,854,981
|
|
G |
Mir106b |
microRNA 106b |
disease_progression severity |
IEP |
miRNA:decreased expression:liver (human) miRNA:increased expression:plasma (human) miRNA:increased expression:serum (human) miRNA:increased expression:liver (human) |
RGD |
PMID:28958640 PMID:25894380 PMID:28611524 PMID:31406464 |
RGD:15042874, RGD:15042875, RGD:15042876, RGD:15042877 |
NCBI chr 5:138,163,999...138,164,080
Ensembl chr 5:138,163,999...138,164,080
|
|
G |
Mir107 |
microRNA 107 |
treatment onset |
ISO |
RNA:decreased expression:liver: RNA:increased expression:liver: |
RGD |
PMID:30738047 PMID:27773820 PMID:26191213 PMID:28079796 |
RGD:14975277, RGD:14975278, RGD:11066920, RGD:14975300 |
NCBI chr19:34,798,087...34,798,173
Ensembl chr19:34,798,087...34,798,173
|
|
G |
Mir122 |
microRNA 122 |
severity |
ISO |
CTD Direct Evidence: marker/mechanism associated with hepatitis B miRNA:decreased expression:liver protein:decreased expression:liver (human) mRNA:decreased expression:blood (human) |
CTD RGD |
PMID:16924677 PMID:25269820 PMID:25422324 PMID:19584283 PMID:27528885 |
RGD:14394424, RGD:14401603, RGD:151356981, RGD:151361113 |
NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997
|
|
G |
Mir125a |
microRNA 125a |
treatment severity |
IEP ISO |
RNA:increased expression:liver: |
RGD |
PMID:30257386 PMID:30257386 PMID:29951066 |
RGD:21403677, RGD:21403677, RGD:21403679 |
NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141
|
|
G |
Mir127 |
microRNA 127 |
|
ISO |
miRNA:decreased expression:liver (human) |
RGD |
PMID:24854842 |
RGD:152995355 |
NCBI chr12:109,559,280...109,559,349
Ensembl chr12:109,559,280...109,559,349
|
|
G |
Mir130b |
microRNA 130b |
severity |
ISO |
miRNA:increased expression:liver |
RGD |
PMID:25387077 |
RGD:14694845 |
NCBI chr16:16,941,925...16,942,006
Ensembl chr16:16,941,925...16,942,006
|
|
G |
Mir133a-1 |
microRNA 133a-1 |
disease_progression |
ISO |
mRNA:decreased expression:liver (human) human cells in mouse model |
RGD |
PMID:30086463 PMID:30086463 |
RGD:153344517, RGD:153344517 |
NCBI chr18:10,782,909...10,782,976
Ensembl chr18:10,782,909...10,782,976
|
|
G |
Mir133b |
microRNA 133b |
severity |
ISO |
mRNA:decreased expression:liver(human) |
RGD |
PMID:30391496 |
RGD:155804298 |
NCBI chr 1:20,752,993...20,753,111
Ensembl chr 1:20,752,993...20,753,111
|
|
G |
Mir136 |
microRNA 136 |
exacerbates |
ISO |
RNA:decreased expression:liver (human) |
RGD |
PMID:28849100 |
RGD:153345547 |
NCBI chr12:109,561,761...109,561,822
Ensembl chr12:109,561,761...109,561,822
|
|
G |
Mir139 |
microRNA 139 |
|
ISO |
RNA:decreased expression:liver (human) |
RGD |
PMID:30710422 |
RGD:153344549 |
NCBI chr 7:101,124,583...101,124,650
Ensembl chr 7:101,124,583...101,124,650
|
|
G |
Mir145a |
microRNA 145a |
severity |
IEP |
miRNA:decreased expression:liver (human) |
RGD |
PMID:30572504 |
RGD:15039395 |
NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965
|
|
G |
Mir146 |
microRNA 146 |
sexual_dimorphism susceptibility |
ISO |
associated with hepatitis B;miRNA:SNP:exon: (rs2910164) (human) miRNA:SNP: (human) associated with hepatitis B;miRNA:SNP: (human) |
RGD |
PMID:18711148 PMID:24816919 PMID:24615520 |
RGD:126925148, RGD:126925158, RGD:126925187 |
NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
|
|
G |
Mir150 |
microRNA 150 |
|
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:30205391 |
RGD:153344577 |
NCBI chr 7:44,771,181...44,771,245
Ensembl chr 7:44,771,181...44,771,245
|
|
G |
Mir152 |
microRNA 152 |
disease_progression |
ISO |
miRNA:decreased expression:liver |
RGD |
PMID:30967300 PMID:26531720 |
RGD:19165146, RGD:21066331 |
NCBI chr11:96,741,219...96,741,291
Ensembl chr11:96,741,219...96,741,291
|
|
G |
Mir154 |
microRNA 154 |
|
ISO |
RNA:decreased expression:liver (human) |
RGD |
PMID:33195697 |
RGD:152995478 |
NCBI chr12:109,704,867...109,704,932
Ensembl chr12:109,704,867...109,704,932
|
|
G |
Mir155 |
microRNA 155 |
disease_progression |
ISO |
miRNA:decreased expression:peripheral blood mononuclear cell miRNA:increased expression:serum associated with hepatitis C;DNA:SNP: :rs767649 (human) |
RGD |
PMID:27035278 PMID:27035278 PMID:28074870 PMID:30710754 PMID:29528577 PMID:27531892 More...
|
RGD:21079433, RGD:21079433, RGD:21079477, RGD:21081523, RGD:24922222, RGD:25671465 |
NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092
|
|
G |
Mir18 |
microRNA 18 |
severity |
IEP |
miRNA:increased expression:liver (human) associated with hepatitis B;miRNA:increased expression:liver (human) associated with Hepatitis C, Chronic;miRNA:increased expression:serum (human) |
RGD |
PMID:19027010 PMID:30519035 PMID:30191950 PMID:24975878 PMID:29455432 |
RGD:15039398, RGD:15039400, RGD:15039389, RGD:15039401, RGD:15039404 |
NCBI chr14:115,281,283...115,281,378
Ensembl chr14:115,281,283...115,281,378
|
|
G |
Mir181c |
microRNA 181c |
|
IEP |
miRNA:decreased expression:liver (human) |
RGD |
PMID:31114379 |
RGD:15042894 |
NCBI chr 8:84,905,502...84,905,590
Ensembl chr 8:84,905,502...84,905,590
|
|
G |
Mir18b |
microRNA 18b |
severity |
IEP |
miRNA:increased expression:liver (human) |
RGD |
PMID:23496901 |
RGD:15039403 |
NCBI chr X:51,831,208...51,831,290
Ensembl chr X:51,831,208...51,831,290
|
|
G |
Mir193a |
microRNA 193a |
disease_progression exacerbates |
ISO |
miRNA:decreased expression:liver (human) RNA:increased expression:blood serum (human) DNA:hypomethylation |
RGD |
PMID:26263159 PMID:30710422 PMID:32960907 PMID:28036298 |
RGD:11070076, RGD:153344549, RGD:153344563, RGD:153344564 |
NCBI chr11:79,602,795...79,602,860
Ensembl chr11:79,602,795...79,602,860
|
|
G |
Mir195a |
microRNA 195a |
severity |
IEP IMP |
miRNA:decreased expression:liver (human) miRNA:decreased expression:liver (mouse) |
RGD |
PMID:25607636 PMID:25607636 |
RGD:15042896, RGD:15042896 |
NCBI chr11:70,125,868...70,125,961
Ensembl chr11:70,125,868...70,125,961
|
|
G |
Mir196a-2 |
microRNA 196a-2 |
susceptibility |
ISO |
associated with hepatitis B, chronic; DNA:SNP: : (rs12304647) DNA:SNP: : (rs11614913) |
RGD |
PMID:21692953 PMID:24248733 |
RGD:14401594 RGD:14401595 |
NCBI chr15:102,881,785...102,881,869
Ensembl chr15:102,881,785...102,881,869
|
|
G |
Mir199b |
microRNA 199b |
disease_progression |
ISO |
miRNA:decreased expression:liver |
RGD |
PMID:30536310 |
RGD:14694833 |
NCBI chr 2:32,208,472...32,208,581
Ensembl chr 2:32,208,472...32,208,581
|
|
G |
Mir200b |
microRNA 200b |
treatment disease_progression |
ISO |
mRNA:decreased expression:liver DNA:hypermethylation:promoter |
RGD |
PMID:26919246 PMID:26919246 PMID:28383782 PMID:28383782 PMID:28383782 |
RGD:14928318, RGD:14928318, RGD:14928322, RGD:14928322, RGD:14928322 |
NCBI chr 4:156,140,138...156,140,207
Ensembl chr 4:156,140,138...156,140,207
|
|
G |
Mir20a |
microRNA 20a |
|
ISO |
associated with Human Viral Hepatitis |
RGD |
PMID:30623908 |
RGD:25823145 |
NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695
|
|
G |
Mir212 |
microRNA 212 |
disease_progression ameliorates |
ISO |
|
RGD |
PMID:25965836 PMID:25965836 |
RGD:11054501, RGD:11054501 |
NCBI chr11:75,064,214...75,064,304
Ensembl chr11:75,064,214...75,064,304
|
|
G |
Mir21a |
microRNA 21a |
severity treatment |
ISO |
miRNA:increased expression:liver |
RGD |
PMID:20447717 PMID:24963487 PMID:21749846 |
RGD:14695022, RGD:40925952, RGD:41404642 |
NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
|
|
G |
Mir22 |
microRNA 22 |
severity disease_progression |
ISO |
in male; RNA:increased expression:liver: |
RGD |
PMID:23766411 PMID:27811373 PMID:21750200 |
RGD:14700874, RGD:14700875, RGD:14700876 |
NCBI chr11:75,354,542...75,354,636
Ensembl chr11:75,354,542...75,354,636
|
|
G |
Mir221 |
microRNA 221 |
disease_progression treatment |
ISO IEP |
|
RGD |
PMID:25817558 PMID:29713162 PMID:29713162 PMID:22009537 PMID:28096271 PMID:28096271 PMID:28096271 PMID:31801250 More...
|
RGD:11086123, RGD:18337267, RGD:18337267, RGD:18337273, RGD:18337275, RGD:18337275, RGD:18337275, RGD:151893509 |
NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627
|
|
G |
Mir222 |
microRNA 222 |
disease_progression severity |
ISO |
|
RGD |
PMID:24124720 PMID:20103675 |
RGD:151709003, RGD:151709004 |
NCBI chr X:19,013,132...19,013,210
Ensembl chr X:19,013,132...19,013,210
|
|
G |
Mir223 |
microRNA 223 |
disease_progression |
IMP ISO |
associated with high-fat diet, associated with Chronic HepatitisC; RNA:decreased expression:serum: associated with Chronic Hepatitis B; RNA:decreased expression:serum: RNA:increased expression:serum: |
RGD |
PMID:30964207 PMID:28982915 PMID:25391771 PMID:24595450 PMID:21229610 |
RGD:21408549, RGD:21408578, RGD:21408580, RGD:21408583, RGD:21408591 |
NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532
|
|
G |
Mir224 |
microRNA 224 |
severity |
IEP |
miRNA:increased expression:liver (human) associated with hepatitis B;miRNA:increased expression:liver (human) miRNA:increased expression:plasma (human) |
RGD |
PMID:23922662 PMID:22459148 PMID:23913306 PMID:24923856 PMID:27462777 |
RGD:18182921, RGD:18182922, RGD:18182923, RGD:18182924, RGD:18182926 |
NCBI chr X:71,304,637...71,304,718
Ensembl chr X:71,304,637...71,304,718
|
|
G |
Mir23a |
microRNA 23a |
|
ISO |
miRNA:increased expression:liver |
RGD |
PMID:22318941 |
RGD:14694846 |
NCBI chr 8:84,935,147...84,935,221
Ensembl chr 8:84,935,147...84,935,221
|
|
G |
Mir23b |
microRNA 23b |
|
ISO |
DNA:hypermethylation |
RGD |
PMID:28036298 |
RGD:153344564 |
NCBI chr13:63,448,298...63,448,371
Ensembl chr13:63,448,298...63,448,371
|
|
G |
Mir25 |
microRNA 25 |
severity |
IEP |
miRNA:increased expression:liver (human) associated with hepatitis B;miRNA:increased expression:serum (human) associated with hepatitis B;miRNA:increased expression:liver (human) |
RGD |
PMID:30191950 PMID:24593846 PMID:21098710 PMID:27298561 |
RGD:15039389, RGD:15042897, RGD:15042899, RGD:15042853 |
NCBI chr 5:138,163,583...138,163,666
Ensembl chr 5:138,163,583...138,163,666
|
|
G |
Mir27a |
microRNA 27a |
severity treatment |
ISO |
human cell line in a mouse model human miRNA and cell line in a mouse model |
RGD |
PMID:29143999 PMID:30083261 |
RGD:14696659, RGD:14696660 |
NCBI chr 8:84,935,301...84,935,387
Ensembl chr 8:84,935,301...84,935,387
|
|
G |
Mir29a |
microRNA 29a |
severity |
ISO |
associated with hepatitis B;miRNA:increased expression:liver (human) |
RGD |
PMID:23285022 PMID:23285022 |
RGD:15042850, RGD:15042850 |
NCBI chr 6:31,039,595...31,039,682
Ensembl chr 6:31,039,595...31,039,682
|
|
G |
Mir302d |
microRNA 302d |
ameliorates |
ISO |
Human cells in mouse model |
RGD |
PMID:28352351 |
RGD:152998975 |
NCBI chr 3:127,339,273...127,339,338
Ensembl chr 3:127,339,273...127,339,338
|
|
G |
Mir31 |
microRNA 31 |
severity |
ISO |
RNA:decreased expression:liver (human) miRNA:decreased expression:liver (human) miRNA:decreased expression:liver (rat) |
RGD |
PMID:28623129 PMID:25797269 PMID:25797269 |
RGD:152998991, RGD:11085965, RGD:11085965 |
NCBI chr 4:88,828,794...88,828,899
Ensembl chr 4:88,828,794...88,828,899
|
|
G |
Mir340 |
microRNA 340 |
|
ISO |
miRNA:decreased expression:liver |
RGD |
PMID:27998770 |
RGD:18936991 |
NCBI chr11:49,960,529...49,960,626
Ensembl chr11:49,960,529...49,960,626
|
|
G |
Mir34a |
microRNA 34a |
treatment |
ISO |
human cell line in a mouse model miRNA:decreased expression:liver |
RGD |
PMID:25217526 PMID:29328457 |
RGD:14694835, RGD:14694836 |
NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012
|
|
G |
Mir411 |
microRNA 411 |
disease_progression |
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:30086881 |
RGD:152999437 |
NCBI chr12:109,676,609...109,676,690
Ensembl chr12:109,676,609...109,676,690
|
|
G |
Mir432 |
microRNA 432 |
disease_progression |
ISO |
mRNA:decreased expression:liver (human) |
RGD |
PMID:25797263 PMID:33675609 PMID:30086881 |
RGD:11087457, RGD:152999436, RGD:152999437 |
NCBI chr12:109,561,390...109,561,464
Ensembl chr12:109,561,390...109,561,464
|
|
G |
Mir455 |
microRNA 455 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:35286011 |
|
NCBI chr 4:63,175,088...63,175,169
Ensembl chr 4:63,175,088...63,175,169
|
|
G |
Mir494 |
microRNA 494 |
disease_progression |
ISO |
|
RGD |
PMID:25820676 |
RGD:155900754 |
NCBI chr12:109,681,752...109,681,836
Ensembl chr12:109,681,752...109,681,836
|
|
G |
Mir539 |
microRNA 539 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:27717846 |
|
NCBI chr12:109,694,563...109,694,636
Ensembl chr12:109,694,563...109,694,636
|
|
G |
Mir615 |
microRNA 615 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22819824 |
|
NCBI chr15:102,923,342...102,923,433
Ensembl chr15:102,923,342...102,923,433
|
|
G |
Mir665 |
microRNA 665 |
disease_progression |
ISO |
mRNA:increased expression:liver (human) associated with metastasis; human cells in mouse model |
RGD |
PMID:30237408 PMID:30237408 |
RGD:151361293, RGD:151361293 |
NCBI chr12:109,552,748...109,552,841
Ensembl chr12:109,552,748...109,552,841
|
|
G |
Mir93 |
microRNA 93 |
severity |
IEP |
associated with hepatitis B;miRNA:increased expression:liver (human) |
RGD |
PMID:27298561 PMID:28592130 |
RGD:15042853, RGD:15042900 |
NCBI chr 5:138,163,785...138,163,872
Ensembl chr 5:138,163,785...138,163,872
|
|
G |
Mir96 |
microRNA 96 |
severity |
IEP |
miRNA:increased expression:liver (human) |
RGD |
PMID:28892647 PMID:25813403 |
RGD:15042901, RGD:15042902 |
NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550
|
|
G |
Mirlet7c-1 |
microRNA let7c-1 |
|
ISO |
miRNA:decreased expression:liver |
RGD |
PMID:22289550 |
RGD:14695021 |
NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638
|
|
G |
Mki67 |
antigen identified by monoclonal antibody Ki 67 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
|
|
G |
Mlxipl |
MLX interacting protein-like |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236
|
|
G |
Mme |
membrane metallo endopeptidase |
|
ISO |
|
RGD |
PMID:8302012 |
RGD:13801035 |
NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
|
|
G |
Mmp14 |
matrix metallopeptidase 14 (membrane-inserted) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33010264 |
|
NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20084675 |
|
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
|
IMP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20084675 PMID:21681821 |
RGD:8547864 |
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
|
|
G |
Mogat2 |
monoacylglycerol O-acyltransferase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 7:98,868,291...98,887,818
Ensembl chr 7:98,868,291...98,887,826
|
|
G |
Mpl |
myeloproliferative leukemia virus oncogene |
|
IMP |
human cells in mouse model |
RGD |
PMID:23157389 |
RGD:126925755 |
NCBI chr 4:118,299,609...118,314,771
Ensembl chr 4:118,299,612...118,314,710
|
|
G |
Mpo |
myeloperoxidase |
susceptibility disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism associated with liver cirrhosis; DNA:SNP:promoter:-463G>A( rs2333227)(human) associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-463G>A(human) |
CTD RGD |
PMID:19731237 PMID:19731237 PMID:21907168 |
RGD:26923907, RGD:27095879 |
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
|
|
G |
Mro |
maestro |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr18:73,992,465...74,014,405
Ensembl chr18:73,992,456...74,014,404
|
|
G |
Msh3 |
mutS homolog 3 |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer |
ClinVar |
PMID:28492532 |
|
NCBI chr13:92,348,387...92,491,515
Ensembl chr13:92,348,380...92,491,511
|
|
G |
Msh5 |
mutS homolog 5 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721
|
|
G |
mt-Co1 |
cytochrome c oxidase I, mitochondrial |
|
ISO |
|
RGD |
PMID:2548155 |
RGD:2302301 |
NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
|
|
G |
mt-Nd5 |
NADH dehydrogenase 5, mitochondrial |
|
ISO |
mRNA:increased expression:liver |
RGD |
PMID:2507335 |
RGD:2302316 |
NCBI chr MT:11,742...13,565
Ensembl chr MT:11,742...13,565
|
|
G |
Mt2 |
metallothionein 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17363595 PMID:28284560 |
|
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
|
|
G |
Mtbp |
Mdm2, transformed 3T3 cell double minute p53 binding protein |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29765550 |
|
NCBI chr15:55,420,800...55,489,819
Ensembl chr15:55,420,804...55,489,819
|
|
G |
Mtdh |
metadherin |
treatment |
ISO |
human cells in a mouse model |
RGD |
PMID:26351209 |
RGD:11096879 |
NCBI chr15:34,082,613...34,143,683
Ensembl chr15:34,082,840...34,145,770
|
|
G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase |
|
ISO |
mRNA:increased expression:liver |
RGD |
PMID:3878730 |
RGD:2302305 |
NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890
|
|
G |
Mthfr |
methylenetetrahydrofolate reductase |
susceptibility disease_progression onset |
ISO |
DNA:SNP,haplotype: :677C>T, 1298A>C(human) DNA:SNP: :677C>T(human) DNA:SNP: :1298A>C(human) DNA:SNPs: :677C>T, 1298A>C(human) |
RGD |
PMID:17503006 PMID:23996892 PMID:19035314 PMID:17659576 |
RGD:14696703, RGD:14696704, RGD:14696707, RGD:14696708 |
NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
severity |
ISO |
CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:liver (human) |
CTD RGD |
PMID:21147110 PMID:25371154 |
RGD:152995471 |
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
|
|
G |
Mtrr |
5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
susceptibility |
ISO |
DNA:SNP: :66A>G(human) |
RGD |
PMID:19035314 |
RGD:14696707 |
NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268
|
|
G |
Mvk |
mevalonate kinase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
|
|
G |
Mybl2 |
myeloblastosis oncogene-like 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:162,896,246...162,926,608
Ensembl chr 2:162,896,607...162,926,608
|
|
G |
Myc |
myelocytomatosis oncogene |
treatment severity |
IMP ISO IAGP |
mRNA:increased expression:liver (rat) mRNA:increased expression:liver (human) CTD Direct Evidence: marker/mechanism OMIM:114550 |
CTD MouseDO RGD |
PMID:9029167 PMID:12029619 PMID:15565109 PMID:29698666 PMID:21644509 PMID:22129741 PMID:22076107 PMID:22434528 More...
|
RGD:6903288, RGD:7240567, RGD:7240695, RGD:7241004 |
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
|
|
G |
Myd88 |
myeloid differentiation primary response gene 88 |
exacerbates ameliorates treatment |
ISO IMP |
mRNA:increased expression:liver (human) protein, mRNA:decreased expression:liver (human) human cell line in a mouse model protein:increased expression:liver (human) mouse cell line in a mouse model human gene and cell in a mouse model |
RGD |
PMID:29022910 PMID:28370778 PMID:17615358 PMID:33575076 PMID:32144747 PMID:31068809 PMID:26985932 PMID:31074165 PMID:24603331 More...
|
RGD:150520022, RGD:150520169, RGD:150521532, RGD:150521534, RGD:150524327, RGD:150524329, RGD:150524330, RGD:150524334, RGD:150530285 |
NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
|
|
G |
Nat2 |
N-acetyltransferase 2 (arylamine N-acetyltransferase) |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236
|
|
G |
Nbn |
nibrin |
|
ISO |
ClinVar Annotator: match by term: Hepatocellular cancer |
ClinVar |
PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 PMID:10848790 PMID:10852373 PMID:11093281 PMID:11279524 PMID:11953735 PMID:12123493 PMID:12505263 PMID:12833396 PMID:12845677 PMID:14973119 PMID:15185344 PMID:15279809 PMID:16033915 PMID:16544999 PMID:17103455 PMID:18606567 PMID:18940477 PMID:19635536 PMID:19908051 PMID:20444919 PMID:22131123 PMID:22293976 PMID:22373003 PMID:22491912 PMID:22941933 PMID:23317186 PMID:24033266 PMID:24113799 PMID:25485873 PMID:25741868 PMID:25980754 PMID:26083025 PMID:26467025 PMID:26822949 PMID:26845104 PMID:27150568 PMID:27616075 PMID:28492532 PMID:28873162 PMID:29368341 PMID:29419426 PMID:30426508 PMID:31173646 PMID:32295079 PMID:33050356 PMID:33471974 PMID:33471991 PMID:33840814 PMID:34072463 PMID:34072659 PMID:34544220 PMID:35309086 More...
|
|
NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589
|
|
G |
Ncapg |
non-SMC condensin I complex, subunit G |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 5:45,827,212...45,858,491
Ensembl chr 5:45,827,261...45,857,888
|
|
G |
Ncaph |
non-SMC condensin I complex, subunit H |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
|
|
G |
Ncoa2 |
nuclear receptor coactivator 2 |
exacerbates |
IMP |
|
RGD |
PMID:28273073 PMID:22556267 |
RGD:153002573, RGD:153002576 |
NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
|
|
G |
Ndc80 |
NDC80 kinetochore complex component |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:71,803,095...71,833,852
Ensembl chr17:71,803,095...71,833,852
|
|
G |
Neil3 |
nei like 3 (E. coli) |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver (human) |
CTD RGD |
PMID:28284560 PMID:35693827 |
RGD:153344586 |
NCBI chr 8:54,039,902...54,092,100
Ensembl chr 8:54,039,902...54,092,100
|
|
G |
Nek2 |
NIMA (never in mitosis gene a)-related expressed kinase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162
|
|
G |
Nf2 |
neurofibromin 2 |
disease_progression |
ISO |
DNA, protein:SNP, increased expression:intron, liver protein:decreased expression:liver |
RGD |
PMID:29130106 PMID:27289045 PMID:26443326 |
RGD:150530489, RGD:150530504, RGD:11076529 |
NCBI chr11:4,715,845...4,799,544
Ensembl chr11:4,715,845...4,799,536
|
|
G |
Nfe2l1 |
nuclear factor, erythroid derived 2,-like 1 |
|
IAGP |
OMIM:114550 |
MouseDO |
|
|
NCBI chr11:96,708,239...96,720,810
Ensembl chr11:96,708,240...96,720,794
|
|
G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Hepatocellular carcinoma |
CTD ClinVar RGD |
PMID:22561517 PMID:26619011 PMID:29018201 PMID:31546024 |
RGD:21201310 |
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
|
|
G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
disease_progression treatment |
ISO |
associated with Chronic Hepatitis B;DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human) |
RGD |
PMID:19797428 PMID:25999787 |
RGD:40400751, RGD:152177911 |
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
|
|
G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
disease_progression susceptibility |
ISO |
CTD Direct Evidence: therapeutic associated with Chronic Hepatitis B;DNA:SNPs,haplotype:3'utr,promoter: 826C>T,881A>G (rs2233406,rs3138053) (human) associated with hepatitis B;DNA:SNP:promoter:-826C>T (rs2233406) (human) |
CTD RGD |
PMID:22022477 PMID:19797428 PMID:25223483 |
RGD:40400751, RGD:40902986 |
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
|
|
G |
Nkx3-1 |
NK3 homeobox 1 |
treatment |
ISO |
mRNA:decreased expression:liver human gene in a mouse model |
RGD |
PMID:28972178 PMID:28972178 |
RGD:14401599, RGD:14401599 |
NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111
|
|
G |
Nlrc3 |
NLR family, CARD domain containing 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30081150 |
|
NCBI chr16:3,762,871...3,796,881
Ensembl chr16:3,762,871...3,794,496
|
|
G |
Nlrc5 |
NLR family, CARD domain containing 5 |
|
ISO |
protein:increased expression:liver |
RGD |
PMID:27338800 |
RGD:15003194 |
NCBI chr 8:95,160,963...95,253,900
Ensembl chr 8:95,160,984...95,253,900
|
|
G |
Nme1 |
NME/NM23 nucleoside diphosphate kinase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21472284 |
|
NCBI chr11:93,849,751...93,859,341
Ensembl chr11:93,847,805...93,859,347
|
|
G |
Nnmt |
nicotinamide N-methyltransferase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453
|
|
G |
Nos2 |
nitric oxide synthase 2, inducible |
treatment |
ISO |
|
RGD |
PMID:25999787 |
RGD:152177911 |
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
|
|
G |
Notch3 |
notch 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr17:32,339,794...32,385,869
Ensembl chr17:32,339,794...32,385,826
|
|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23811326 |
|
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
|
|
G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21147110 |
|
NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375
|
|
G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
|
ISO IAGP IMP |
CTD Direct Evidence: marker/mechanism OMIM:114550 mRNA:splice variant(s):liver (human) intestinally expressed human gene in mouse model |
CTD MouseDO RGD |
PMID:23811326 PMID:25496033 PMID:23811326 PMID:23213087 PMID:24954587 |
RGD:14696796, RGD:14928330, RGD:14928334 |
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
|
|
G |
Nras |
neuroblastoma ras oncogene |
disease_progression severity |
ISO |
human gene in mouse model mRNA, protein:increased expression:liver (mouse, human) ClinVar Annotator: match by term: Hepatocellular cancer |
ClinVar RGD |
PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 PMID:8120410 PMID:10821536 PMID:12460918 PMID:12727991 PMID:14508525 PMID:15899789 PMID:16273091 PMID:16291983 PMID:16434492 PMID:17699718 PMID:18390968 PMID:18633438 PMID:18668139 PMID:18948947 PMID:19075190 PMID:19657110 PMID:19880792 PMID:19966803 PMID:20130576 PMID:20149136 PMID:20179705 PMID:20406486 PMID:20619739 PMID:20736745 PMID:21107323 PMID:21305640 PMID:21576590 PMID:21729679 PMID:21829508 PMID:22407852 PMID:22499344 PMID:22718121 PMID:22761467 PMID:22773810 PMID:23076151 PMID:23392294 PMID:23400451 PMID:23414587 PMID:23515407 PMID:23538902 PMID:23569304 PMID:23614898 PMID:24006476 PMID:24033266 PMID:24148783 PMID:24370118 PMID:24671188 PMID:25157968 PMID:25348872 PMID:25695684 PMID:25741868 PMID:26619011 PMID:26821351 PMID:27050078 PMID:28492532 PMID:28780248 PMID:21993994 PMID:30685691 More...
|
RGD:14696775, RGD:14696793 |
NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230
|
|
G |
Nrg1 |
neuregulin 1 |
disease_progression |
ISO |
associated with hepatitis C;mRNA:altered expression:liver (human mRNA:increased expression:liver (human) |
RGD |
PMID:17393520 PMID:27514687 |
RGD:39456104, RGD:39456110 |
NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825 Ensembl chr 8:32,304,579...33,374,825
|
|
G |
Nrp1 |
neuropilin 1 |
disease_progression |
ISO |
protein:decreased expression:liver |
RGD |
PMID:25333267 |
RGD:126848812 |
NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844
|
|
G |
Nuf2 |
NUF2, NDC80 kinetochore complex component |
treatment disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28284560 PMID:30653265 PMID:31933938 |
RGD:28867240, RGD:28912742 |
NCBI chr 1:169,325,503...169,359,033
Ensembl chr 1:169,325,503...169,359,033
|
|
G |
Nusap1 |
nucleolar and spindle associated protein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:119,449,205...119,480,646
Ensembl chr 2:119,448,779...119,481,725
|
|
G |
Oit3 |
oncoprotein induced transcript 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr10:59,258,782...59,277,601
Ensembl chr10:59,258,780...59,277,600
|
|
G |
Olfml2a |
olfactomedin-like 2A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:38,821,992...38,850,597
Ensembl chr 2:38,821,990...38,853,765
|
|
G |
Olfml2b |
olfactomedin-like 2B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 1:170,472,101...170,510,356
Ensembl chr 1:170,472,101...170,510,358
|
|
G |
Orc1 |
origin recognition complex, subunit 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
|
|
G |
Otc |
ornithine transcarbamylase |
severity |
ISO |
mRNA:altered expression:liver tumor (human) |
RGD |
PMID:30901224 |
RGD:152995286 |
NCBI chr X:10,118,584...10,187,275
Ensembl chr X:10,118,544...10,187,263
|
|
G |
Pafah1b1 |
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 |
disease_progression |
ISO |
mRNA,protein:decreased expression:liver: |
RGD |
PMID:21569763 |
RGD:12790589 |
NCBI chr11:74,564,775...74,615,210
Ensembl chr11:74,564,775...74,615,496
|
|
G |
Pamr1 |
peptidase domain containing associated with muscle regeneration 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr 2:102,380,325...102,473,386
Ensembl chr 2:102,380,357...102,473,386
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase family, member 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18695907 |
|
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
|
|
G |
Pbk |
PDZ binding kinase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28284560 |
|
NCBI chr14:66,043,337...66,055,271
Ensembl chr14:66,043,286...66,055,271
|
|
G |
Pck1 |
phosphoenolpyruvate carboxykinase 1, cytosolic |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19363144 PMID:28284560 |
|
NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
|
|
G |
Pclaf |
PCNA clamp associated factor |
| |