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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:tauopathy
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Accession:DOID:680 term browser browse the term
Definition:A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain. (DO)
Synonyms:exact_synonym: tauopathies
 primary_id: MESH:D024801
For additional species annotation, visit the Alliance of Genome Resources.


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tauopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5 cyclin dependent kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26945731 NCBI chrNW_004955491:5,491,744...5,497,280
Ensembl chrNW_004955491:5,491,744...5,497,280
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:26945731 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
JBrowse link
G Hdac1 histone deacetylase 1 ISO protein:increased expression:brain: RGD PMID:22918830 RGD:9590098 NCBI chrNW_004955452:10,636,366...10,668,873
Ensembl chrNW_004955452:10,636,366...10,670,864
JBrowse link
G Mapt microtubule associated protein tau treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10604746 PMID:11889249 PMID:14595660 PMID:22874558 PMID:24556215 More... RGD:13800888 RGD:13800905 RGD:8158094 NCBI chrNW_004955478:10,222,439...10,271,439
Ensembl chrNW_004955478:10,225,823...10,271,442
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:brain, blood vessel (mouse) RGD PMID:21839061 RGD:6771210 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
JBrowse link
G Ppp2r5d protein phosphatase 2 regulatory subunit B'delta ISO RGD PMID:21482799 RGD:13515115 NCBI chrNW_004955437:8,968,517...8,987,680
Ensembl chrNW_004955437:8,968,565...8,986,654
JBrowse link
Alzheimer's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:1627256 RGD:10046060 NCBI chrNW_004955442:9,422,849...9,516,054
Ensembl chrNW_004955442:9,422,849...9,516,103
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 ISO RGD PMID:15024730 RGD:1300323 NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 PMID:28492532 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Abcb1 ATP binding cassette subfamily B member 1 ISO RGD PMID:25991605 RGD:13801010 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO RGD PMID:25991605 RGD:13801010 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290
JBrowse link
G Abi3 ABI family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28714976 NCBI chrNW_004955451:12,241,084...12,248,857 JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO protein:increased expression:brain: RGD PMID:19700222 RGD:8693570 NCBI chrNW_004955513:652,048...799,182
Ensembl chrNW_004955513:653,252...799,239
JBrowse link
G Acadvl acyl-CoA dehydrogenase very long chain ISO protein:decreased expression:brain RGD PMID:25260493 RGD:10047114 NCBI chrNW_004955467:9,684,070...9,689,454
Ensembl chrNW_004955467:9,684,250...9,689,356
JBrowse link
G Ache acetylcholinesterase (Cartwright blood group) ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:16581404 PMID:22944069 PMID:23047022 RGD:5509844 NCBI chrNW_004955573:79,606...85,799
Ensembl chrNW_004955573:80,298...85,799
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:cerebral cortex, hippocampus
CTD
RGD
PMID:23296102 PMID:24792732 PMID:30820047 RGD:13703032 RGD:13703037 NCBI chrNW_004955450:15,853,372...15,927,966
Ensembl chrNW_004955450:15,853,366...15,928,200
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 onset ISO protein:decreased expression:cerebral cortex, hippocampus
DNA:missense mutation: :p.R215I (rs142946965) (human)
RGD PMID:24792732 PMID:29988083 RGD:13703037 RGD:13782143 NCBI chrNW_004955487:5,180,241...5,218,298
Ensembl chrNW_004955487:5,180,252...5,218,216
JBrowse link
G Adam2 ADAM metallopeptidase domain 2 ISO protein:increased expression:brain RGD PMID:10686596 RGD:10047127 NCBI chrNW_004955403:50,046,262...50,115,004
Ensembl chrNW_004955403:50,046,004...50,117,201
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO protein:decreased expression:hippocampus RGD PMID:24792732 RGD:13703037 NCBI chrNW_004955463:14,545,425...14,646,498
Ensembl chrNW_004955463:14,545,589...14,645,419
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:26,524,487...26,533,038
Ensembl chrNW_004955407:26,524,130...26,533,038
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:26,597,165...26,643,972
Ensembl chrNW_004955407:26,603,479...26,643,103
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:cerebrospinal fluid, plasma
protein:increased expression:plasma
RGD PMID:20727007 PMID:22213409 RGD:5686377 RGD:5686881 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
JBrowse link
G Adnp activity dependent neuroprotector homeobox ISO RGD PMID:17720885 PMID:18199809 RGD:2312791 RGD:2312792 NCBI chrNW_004955445:7,498,223...7,530,828
Ensembl chrNW_004955445:7,492,257...7,531,862
JBrowse link
G Adra1a adrenoceptor alpha 1A susceptibility ISO RGD PMID:114750 RGD:5688374 NCBI chrNW_004955403:49,394,173...49,485,881
Ensembl chrNW_004955403:49,399,127...49,485,934
JBrowse link
G Adrb3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R (human) RGD PMID:17440948 RGD:2311642 NCBI chrNW_004955463:13,663,064...13,665,553 JBrowse link
G Ager advanced glycosylation end-product specific receptor treatment ISO protein:increased expression:hippocampus (rat)
protein:increased expression:brain (human)
mRNA:increased expression:hippocampus, cerebral cortex (mouse)
RGD PMID:8751438 PMID:21593432 PMID:22745485 PMID:23164356 PMID:23396166 RGD:1300365 RGD:6784502 RGD:7244266 RGD:7244287 RGD:7245965 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
JBrowse link
G Agt angiotensinogen ISO protein:increased expression:cerebrospinal fluid RGD PMID:21297254 RGD:5129180 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
JBrowse link
G Agtr1 angiotensin II receptor type 1 treatment ISO protein:decreased expression:substantia nigra: RGD PMID:8666063 PMID:21929736 RGD:10047395 RGD:10047397 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO mRNA:increased expression:frontal cortex (human)
protein:altered expression:hippocampus (mouse)
RGD PMID:16340083 PMID:19084047 RGD:2313023 RGD:2313045 NCBI chrNW_004955437:157,509...158,919 JBrowse link
G Aifm1 apoptosis inducing factor mitochondria associated 1 ISO protein:increased expression:basal forebrain,amygdala:
protein:increased expression:cortex,nucleus:
RGD PMID:22536549 PMID:24915960 RGD:10053592 RGD:10053593 NCBI chrNW_004955473:4,891,955...4,925,705
Ensembl chrNW_004955473:4,891,955...4,926,428
JBrowse link
G Akap5 A-kinase anchoring protein 5 ISO protein:increased expression:cell soma, dendritic arbor (human) RGD PMID:10460255 RGD:2313287 NCBI chrNW_004955466:5,411,190...5,422,043
Ensembl chrNW_004955466:5,411,650...5,412,960
JBrowse link
G Akr7a2 aldo-keto reductase family 7 member A2 ISO protein:increased expression:superior, middle temporal gyrus; RGD PMID:11597610 RGD:14349051 NCBI chrNW_004955452:6,844...13,868 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO protein:increased tyrosine phosphorylation:cerebral cortex RGD PMID:18023354 RGD:5509085 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member onset ISO RGD PMID:15126281 RGD:1599042 NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899
JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO protein:increased expression:brain RGD PMID:15111312 PMID:20570249 RGD:5509595 RGD:5509620 NCBI chrNW_004955467:10,032,792...10,039,789 JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 ISO RGD PMID:23910655 RGD:14390071 NCBI chrNW_004955422:1,455,392...1,644,368
Ensembl chrNW_004955422:1,455,380...1,644,452
JBrowse link
G Amfr autocrine motility factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22313999 NCBI chrNW_004955433:14,172,871...14,205,484
Ensembl chrNW_004955433:14,172,808...14,212,110
JBrowse link
G Anxa5 annexin A5 ISO protein:increased expression: plasma
protein:increased expression:brain, plasma
RGD PMID:20648654 RGD:7242030 NCBI chrNW_004955428:18,873,782...18,907,955
Ensembl chrNW_004955428:18,873,782...18,907,955
JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 susceptibility
no_association
ISO mRNA:altered expression:brain:
DNA:mutations::multiple
DNA:deletion:intron:
DNA:polymorphism:intron:
RGD PMID:9799084 PMID:10723070 PMID:11099823 PMID:12727304 RGD:10054028 RGD:10054031 RGD:10054036 RGD:2301212 NCBI chrNW_004955414:22,121,867...22,137,849
Ensembl chrNW_004955414:22,117,470...22,137,849
JBrowse link
G Apbb2 amyloid beta precursor protein binding family B member 2 onset ISO DNA:SNPs: :rs13133980,rs17443013(human) RGD PMID:15714520 RGD:9684954 NCBI chrNW_004955443:6,513,762...6,786,247
Ensembl chrNW_004955443:6,513,980...6,783,014
JBrowse link
G Apc APC regulator of WNT signaling pathway ISO protein:increased expression:astrocyte RGD PMID:11547943 RGD:6484525 NCBI chrNW_004955418:2,567,804...2,675,062
Ensembl chrNW_004955418:2,566,975...2,674,832
JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit treatment ISO RGD PMID:28588301 PMID:29926633 RGD:13703122 RGD:13703123 NCBI chrNW_004955413:506,297...509,787
Ensembl chrNW_004955413:506,297...509,787
JBrowse link
G Aph1b aph-1 homolog B, gamma-secretase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955450:12,000,682...12,022,183
Ensembl chrNW_004955450:12,000,424...12,022,071
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 ISO RGD PMID:8086458 RGD:734582 NCBI chrNW_004955412:31,043,320...31,075,617
Ensembl chrNW_004955412:31,043,320...31,075,617
JBrowse link
G Apoa1 apolipoprotein A1 resistance ISO DNA: : :transgenic model RGD PMID:19863188 PMID:20847045 RGD:5508212 RGD:5508218 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298
JBrowse link
G Apoa4 apolipoprotein A4 no_association ISO DNA:missense mutation:cds:p.Q360H (human)
DNA:snp, haplotype:cds:p.S147N (rs5104) (human)
RGD PMID:9272683 PMID:10559562 PMID:16013913 PMID:21356380 RGD:5685638 RGD:5685661 RGD:5685681 RGD:5685682 NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701
JBrowse link
G Apoc1 apolipoprotein C1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11825674 PMID:29107063 PMID:30319691 RGD:1578472 NCBI chrNW_004955555:2,005,962...2,007,239 JBrowse link
G Apod apolipoprotein D ISO protein:increased expression:cerebrospinal fluid, hippocampus RGD PMID:9751198 RGD:2311209 NCBI chrNW_004955420:13,553,254...13,570,357
Ensembl chrNW_004955420:13,553,058...13,573,690
JBrowse link
G Apoe apolipoprotein E susceptibility
treatment
no_association
ISO DNA:SNP: :APOEe4(human)
ClinVar Annotator: match by term: Alzheimer disease, early onset
DNA:polymorphism:promoter:-491A>T,-427T>C(human)
DNA:missense mutations, haplotype:cds:p.C112R, (rs7412) (human)
RGD
ClinVar
PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... RGD:10427727 RGD:12904712 RGD:6903233 RGD:7771594 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G App amyloid beta precursor protein susceptibility
treatment
ISO ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, early onset | ClinVar Annotator: match by term: Alzheimer disease, protection against | ClinVar Annotator: match by term: Alzheimer's disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
associated with hypertension
RGD
ClinVar
PMID:1303239 PMID:1303275 PMID:1307241 PMID:1415269 PMID:1520398 More... RGD:13782047 RGD:1599199 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Aqp4 aquaporin 4 ISO RGD PMID:21107133 RGD:5148012 NCBI chrNW_004955772:1,160...10,709
Ensembl chrNW_004955772:1,159...10,709
JBrowse link
G Arc activity regulated cytoskeleton associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18503570 NCBI chrNW_004955454:1,379,998...1,383,414
Ensembl chrNW_004955454:1,379,998...1,383,414
JBrowse link
G Ass1 argininosuccinate synthase 1 ISO protein:increased expression:brain, glial cell (human) RGD PMID:11556547 RGD:4139898 NCBI chrNW_004955513:443,372...485,190
Ensembl chrNW_004955513:445,462...485,190
JBrowse link
G Atf2 activating transcription factor 2 ISO RGD PMID:9138733 PMID:15878807 RGD:10047399 RGD:10047400 NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218
JBrowse link
G Atm ATM serine/threonine kinase disease_progression ISO RGD PMID:23861893 RGD:10047419 NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha onset
treatment
ISO protein:increased modification:inferior parietal cortex (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19374891 PMID:25561935 RGD:13703046 RGD:13703056 NCBI chrNW_004955402:31,652,226...31,662,114
Ensembl chrNW_004955402:31,651,960...31,662,762
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta ISO RGD PMID:28474567 RGD:13792588 NCBI chrNW_004955495:6,664,394...6,666,693
Ensembl chrNW_004955495:6,664,394...6,666,693
JBrowse link
G Atp5mg ATP synthase membrane subunit g ISO RGD PMID:28474567 RGD:13792588 NCBI chrNW_004955412:19,555,736...19,563,094 JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:25,601,253...25,609,933
Ensembl chrNW_004955407:25,601,083...25,609,888
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP treatment ISO RGD PMID:30266287 RGD:14696823 NCBI chrNW_004955407:33,288,194...33,298,817 JBrowse link
G Atp6v0e1 ATPase H+ transporting V0 subunit e1 ISO RGD PMID:23211594 RGD:10401913 NCBI chrNW_004955408:25,667,703...25,703,550
Ensembl chrNW_004955408:25,667,703...25,703,550
JBrowse link
G Atp7a ATPase copper transporting alpha ISO mRNA:decreased expression:pituitary gland, vascular plexus (rat) RGD PMID:20027333 RGD:8657017 NCBI chrNW_004955557:1,355,471...1,515,725
Ensembl chrNW_004955557:1,355,397...1,515,393
JBrowse link
G Atr ATR serine/threonine kinase ISO RGD PMID:23861893 RGD:10047419 NCBI chrNW_004955508:3,337,036...3,440,313
Ensembl chrNW_004955508:3,337,432...3,440,257
JBrowse link
G Bace1 beta-secretase 1 treatment
susceptibility
ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:12824768 PMID:16407166 PMID:28763060 PMID:29038004 RGD:1358439 RGD:13782077 RGD:13782083 NCBI chrNW_004955412:18,596,643...18,620,089
Ensembl chrNW_004955412:18,596,643...18,620,362
JBrowse link
G Bace2 beta-secretase 2 susceptibility ISO mRNA,protein:increased expression:gyrus:
DNA:SNP,haplotype:exon:
RGD PMID:16023140 PMID:22074738 RGD:13782172 RGD:13782180 NCBI chrNW_004955407:40,792,089...40,879,872
Ensembl chrNW_004955407:40,792,887...40,874,760
JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 PMID:15339646 RGD:10053639 RGD:10053642 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 ISO protein:decreased expression:cerebral cortex, postsynaptic density (human) RGD PMID:23537733 RGD:11576299 NCBI chrNW_004955506:1,868,624...1,936,786
Ensembl chrNW_004955506:1,868,624...1,936,786
JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 RGD:10053642 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997
JBrowse link
G Barhl1 BarH like homeobox 1 ISO protein:decreased expression:brain RGD PMID:28956815 RGD:14390165 NCBI chrNW_004955513:1,955,906...1,970,110
Ensembl chrNW_004955513:1,959,634...1,966,247
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:8990132 PMID:16265626 PMID:17639989 PMID:18077176 PMID:21585051 More... RGD:10054039 RGD:10054047 RGD:10054049 RGD:13782186 RGD:13782188 RGD:2293073 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
JBrowse link
G Bcan brevican ISO protein:altered modification:brain RGD PMID:20180882 RGD:14392785 NCBI chrNW_004955545:2,723,780...2,739,334
Ensembl chrNW_004955545:2,723,780...2,739,450
JBrowse link
G Bche butyrylcholinesterase severity ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:16973370 PMID:22012848 PMID:23022600 RGD:5687327 RGD:5688056 NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970
JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO protein:increased expression:temporal cortex, membrane
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9507158 PMID:16265626 PMID:17639989 PMID:18077176 PMID:21585051 More... RGD:10053642 RGD:10054047 RGD:10054049 RGD:11522767 RGD:13782186 RGD:13782188 RGD:2293073 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
JBrowse link
G Bcl2l1 BCL2 like 1 ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 RGD:10053642 NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
JBrowse link
G Bdnf brain derived neurotrophic factor no_association
onset
treatment
ISO DNA:polymorphisms: :196G>A (p.V66M), 270C>T (human)
DNA:SNP:CDS:rs1048218 (human)
protein:decreased expression:parietal cortex
DNA:polymorphisms, haplotypes: :196G>A (p.V66M), 270C>T, 11757G>C (human)
DNA:polymorphism: :p.V66M (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12654514 PMID:16565926 PMID:16627933 PMID:17344400 PMID:18780967 More... RGD:10058980 RGD:10059343 RGD:10059345 RGD:10059346 RGD:10059402 RGD:4891131 RGD:5508228 NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588
JBrowse link
G Becn1 beclin 1 ISO protein:decreased expression:gray matter RGD PMID:18497889 PMID:20863706 RGD:6483101 RGD:6483102 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730
JBrowse link
G Bin1 bridging integrator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460841 PMID:33589840 NCBI chrNW_004955459:3,376,149...3,423,157
Ensembl chrNW_004955459:3,399,611...3,422,621
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19463786 RGD:10414082 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303
JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO protein:increased expression:microglia: RGD PMID:9792236 RGD:9586059 NCBI chrNW_004955478:6,990,816...7,088,751
Ensembl chrNW_004955478:6,990,833...7,086,721
JBrowse link
G Brip1 BRCA1 interacting helicase 1 ISO associated with Down Syndrome;protein:increased ubiquitination:frontal cortex (human) RGD PMID:25391381 RGD:11252150 NCBI chrNW_004955451:2,705,834...2,820,610
Ensembl chrNW_004955451:2,707,793...2,818,592
JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:18,927,211...18,939,576
Ensembl chrNW_004955407:18,927,211...18,941,424
JBrowse link
G C1qb complement C1q B chain ISO mRNA:increased expression:microglial cell RGD PMID:1362796 RGD:1599518 NCBI chrNW_004955452:2,765,844...2,771,695
Ensembl chrNW_004955452:2,769,752...2,772,534
JBrowse link
G C2 complement C2 ISO DNA:SNP, haplotype: :p.E318D (rs9332739) (human) RGD PMID:22300950 RGD:7401250 NCBI chrNW_004955437:449,171...460,898
Ensembl chrNW_004955437:448,672...460,519
JBrowse link
G C3 complement C3 ISO DNA:SNP: :rs22300199 (human) RGD PMID:22300950 RGD:7401250 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
JBrowse link
G C5ar1 complement C5a receptor 1 ISO protein:decreased expression:brain RGD PMID:12759460 RGD:5130177 NCBI chrNW_004955574:1,221,942...1,229,634
Ensembl chrNW_004955574:1,221,187...1,231,655
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO protein:decreased expression:brain RGD PMID:23403102 RGD:13782264 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506
JBrowse link
G Calm1 calmodulin 1 ISO protein:decreased expression:cerebellar cortex:
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:11470324 RGD:13792493 NCBI chrNW_004955438:12,842,437...12,854,028
Ensembl chrNW_004955438:12,842,437...12,854,028
JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha ISO RGD PMID:15621017 RGD:13681926 NCBI chrNW_004955415:4,247,307...4,307,402
Ensembl chrNW_004955415:4,247,014...4,307,458
JBrowse link
G Capn1 calpain 1 onset ISO protein:increased activity:brain: RGD PMID:8622780 PMID:11231011 RGD:13792495 RGD:13792663 NCBI chrNW_004955422:20,006,448...20,026,984
Ensembl chrNW_004955422:20,004,426...20,025,708
JBrowse link
G Capn2 calpain 2 ISO protein:increased expression:cytosol RGD PMID:9654354 RGD:13792661 NCBI chrNW_004955520:1,287,829...1,315,318
Ensembl chrNW_004955520:1,286,356...1,315,328
JBrowse link
G Casp2 caspase 2 ISO RGD PMID:12633148 RGD:13782269 NCBI chrNW_004955494:353,572...369,207
Ensembl chrNW_004955494:353,310...368,873
JBrowse link
G Casp3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:10319819 PMID:12633148 PMID:18077176 PMID:29587274 PMID:29642617 More... RGD:13782186 RGD:13782188 RGD:13782269 RGD:13782291 RGD:734692 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp6 caspase 6 ISO RGD PMID:12633148 RGD:13782269 NCBI chrNW_004955496:575,839...584,287
Ensembl chrNW_004955496:577,832...584,287
JBrowse link
G Casp7 caspase 7 ISO DNA:SNPs, haplotype RGD PMID:12633148 PMID:26621834 RGD:11344490 RGD:13782269 NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524
JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:12633148 PMID:16772874 PMID:29642617 RGD:13782268 RGD:13782269 RGD:13782291 NCBI chrNW_004955403:322,082...348,591
Ensembl chrNW_004955403:322,555...347,053
JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:12633148 PMID:29777699 RGD:13782186 RGD:13782269 NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738
JBrowse link
G Cass4 Cas scaffold protein family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30320580 PMID:33589840 NCBI chrNW_004955445:2,771,130...2,809,815
Ensembl chrNW_004955445:2,771,586...2,809,952
JBrowse link
G Cast calpastatin ISO protein:decreased expression:brain RGD PMID:19020018 PMID:20595388 RGD:5509799 RGD:5509809 NCBI chrNW_004955418:15,859,951...15,974,141
Ensembl chrNW_004955418:15,862,729...15,916,169
JBrowse link
G Ccdc6 coiled-coil domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955425:13,344,926...13,444,802 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:cerebrum, blood vessels (human) RGD PMID:18440671 RGD:4890025 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
JBrowse link
G Ccng1 cyclin G1 ISO protein:increased expression:brain, neuron RGD PMID:12214116 RGD:2316025 NCBI chrNW_004955408:16,846,050...16,850,365 JBrowse link
G Cd2ap CD2 associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 PMID:30320580 NCBI chrNW_004955437:12,005,399...12,087,014
Ensembl chrNW_004955437:11,983,311...12,091,100
JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:16563568 RGD:6893531 NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:21414686 RGD:5490302 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:frontal cortex, astrocyte RGD PMID:11755016 RGD:8547803 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:10817927 RGD:5688277 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042
JBrowse link
G Cdk5 cyclin dependent kinase 5 treatment ISO DNA:SNP:intron:g.149800G>C (human) RGD PMID:15917097 PMID:28085018 PMID:28269780 RGD:13508590 RGD:13782365 RGD:13792587 NCBI chrNW_004955491:5,491,744...5,497,280
Ensembl chrNW_004955491:5,491,744...5,497,280
JBrowse link
G Cdk5r1 cyclin dependent kinase 5 regulatory subunit 1 ISO DNA:SNP:3' UTR:rs735555 (human) RGD PMID:19154537 PMID:24725413 PMID:28578378 RGD:13782362 RGD:13782363 RGD:13782364 NCBI chrNW_004955481:7,408,089...7,411,813
Ensembl chrNW_004955481:7,408,205...7,409,128
JBrowse link
G Cdk7 cyclin dependent kinase 7 ISO protein:increased expression:neuron: RGD PMID:11124424 RGD:10059352 NCBI chrNW_004955446:54,401...87,884
Ensembl chrNW_004955446:54,448...90,191
JBrowse link
G Cebpa CCAAT enhancer binding protein alpha ISO mRNA:increased expression:hippocampus (human)
protein:decreased expression:forebrain, hindbrain (mouse)
RGD PMID:14769913 PMID:21492414 RGD:10401190 RGD:10401224 NCBI chrNW_004955468:3,046,544...3,049,217
Ensembl chrNW_004955468:3,047,931...3,049,080
JBrowse link
G Cebpb CCAAT enhancer binding protein beta treatment ISO mRNA:increased expression:hippocampus CA1 (human) RGD PMID:12391607 PMID:23911420 RGD:10401229 RGD:10401268 NCBI chrNW_004955445:8,060,432...8,061,289 JBrowse link
G Cftr CF transmembrane conductance regulator ISO protein:decreased expression:hypothalamus RGD PMID:14757935 RGD:11566025 NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
JBrowse link
G Chat choline O-acetyltransferase ISO DNA:polymorphism:CDS:4G>A RGD PMID:12401548 PMID:16834974 RGD:1358495 RGD:1600851 NCBI chrNW_004955556:650,290...695,135
Ensembl chrNW_004955556:650,279...693,276
JBrowse link
G Chodl chondrolectin ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:19,483,569...19,507,270
Ensembl chrNW_004955407:19,483,561...19,508,328
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:15465084 RGD:1358509 NCBI chrNW_004955528:825,314...840,994
Ensembl chrNW_004955528:825,308...841,270
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:15465084 PMID:18071042 RGD:1358509 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17192785 NCBI chrNW_004955545:1,065,457...1,077,056
Ensembl chrNW_004955545:1,065,457...1,077,526
JBrowse link
G Cib1 calcium and integrin binding 1 ISO protein:decreased expression:brain (human) RGD PMID:15885068 RGD:10401854 NCBI chrNW_004955416:15,102,632...15,106,372
Ensembl chrNW_004955416:15,102,632...15,106,372
JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:snp:intron:c.982+247G>C (rs1554483) (human)
DNA:snp:intron:c.560-1279C>G (rs4580704) (human)
DNA:snp:3' utr:c.3111T>C (human)
RGD PMID:23357097 PMID:23781009 PMID:23912676 RGD:10401861 RGD:10401862 RGD:10401872 NCBI chrNW_004955447:15,394,496...15,537,969
Ensembl chrNW_004955447:15,454,630...15,530,906
JBrowse link
G Clu clusterin ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:28492532 PMID:29476165 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase ISO RGD PMID:21918687 RGD:6483333 NCBI chrNW_004955451:16,115,137...16,119,261
Ensembl chrNW_004955451:16,114,454...16,118,622
JBrowse link
G Crebbp CREB binding protein treatment ISO protein:increased phosphorylation:hippocampus: RGD PMID:17760871 PMID:21149712 RGD:10059608 RGD:10059609 NCBI chrNW_004955442:13,559,496...13,691,913
Ensembl chrNW_004955442:13,559,496...13,692,004
JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: therapeutic
protein:decreased expression:cerebral cortex (human)
CTD
RGD
PMID:7477348 RGD:5508831 NCBI chrNW_004955444:12,989,210...12,991,300 JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:30279455 NCBI chrNW_004955415:4,434,486...4,462,505
Ensembl chrNW_004955415:4,434,453...4,461,751
JBrowse link
G Csnk1a1 casein kinase 1 alpha 1 ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:10514399 RGD:10395229 NCBI chrNW_004955415:4,921,356...4,966,705
Ensembl chrNW_004955415:4,921,852...4,966,705
JBrowse link
G Csnk1d casein kinase 1 delta severity ISO protein:increased expression:CA1 field of hippocampus:
mRNA,protein:increased expression:brain:
RGD PMID:10514399 PMID:10814741 RGD:10395229 RGD:10395230 NCBI chrNW_004955506:904,659...936,293
Ensembl chrNW_004955506:904,660...935,330
JBrowse link
G Csnk1e casein kinase 1 epsilon ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:10514399 RGD:10395229 NCBI chrNW_004955413:24,560,889...24,591,669 JBrowse link
G Cst3 cystatin C susceptibility ISO protein:decreased expression:serum (human)
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:15907478 PMID:17192785 PMID:18026100 PMID:18824671 RGD:1358533 RGD:2314333 NCBI chrNW_004955415:30,507,972...30,512,109 JBrowse link
G Ctnnb1 catenin beta 1 treatment ISO protein:decreased expression:hippocampus
protein:increased expression:neuron,cytoplasm:
protein:decreased expression:nucleus:
RGD PMID:11226152 PMID:12610652 PMID:15781969 RGD:10395258 RGD:10395276 RGD:1302533 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449
JBrowse link
G Ctsd cathepsin D ISO protein:decreased expression:lymphocyte: RGD PMID:11304834 PMID:15907478 RGD:1358532 RGD:1358533 NCBI chrNW_004955422:13,576,315...13,584,267 JBrowse link
G Ctss cathepsin S ISO RGD PMID:7717452 RGD:5686914 NCBI chrNW_004955413:99,279...124,793
Ensembl chrNW_004955413:99,159...124,042
JBrowse link
G Cxadr CXADR Ig-like cell adhesion molecule ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:18,894,853...18,927,129
Ensembl chrNW_004955407:18,867,797...18,907,331
JBrowse link
G Cyyr1 cysteine and tyrosine rich 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:26,208,335...26,313,566
Ensembl chrNW_004955407:26,212,801...26,313,249
JBrowse link
G Dbn1 drebrin 1 disease_progression ISO protein:decreased expression:hippocampus,neuronal spine:
protein:decreased expression:hippocampal formation:
mRNA:decreased expression:parietal cortex, temporal cortex, hippocampus:
RGD PMID:8838578 PMID:17912741 PMID:18338803 RGD:10395286 RGD:10398820 RGD:10398821 NCBI chrNW_004955408:29,695,442...29,705,417
Ensembl chrNW_004955408:29,696,266...29,705,416
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 treatment ISO RGD PMID:28863860 RGD:150519888 NCBI chrNW_004955583:820,893...838,515
Ensembl chrNW_004955583:820,931...841,654
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23042211 NCBI chrNW_004955464:4,533,928...4,557,893
Ensembl chrNW_004955464:4,533,928...4,558,133
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO RGD PMID:24156266 RGD:13792688 NCBI chrNW_004955467:9,691,733...9,715,872
Ensembl chrNW_004955467:9,690,469...9,715,872
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase susceptibility ISO DNA:polymorphisms: : RGD PMID:10227647 RGD:1358587 NCBI chrNW_004955523:660,413...680,878
Ensembl chrNW_004955523:661,738...680,802
JBrowse link
G Dnm1 dynamin 1 ISO mRNA,protein:decreased expression:hippocampus, temporal cortex
protein:decreased expression:hippocampus,entorhinal cortex:
denntate gyrus, hippocampus, entorhinal cortex
RGD PMID:20847448 RGD:13506238 NCBI chrNW_004955570:752,335...781,770
Ensembl chrNW_004955570:752,335...781,770
JBrowse link
G Dnm1l dynamin 1 like ISO protein:decreased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chrNW_004955505:3,025,742...3,081,491
Ensembl chrNW_004955505:3,023,018...3,081,680
JBrowse link
G Dpysl2 dihydropyrimidinase like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19374891 NCBI chrNW_004955403:49,188,259...49,306,916
Ensembl chrNW_004955403:49,188,205...49,307,810
JBrowse link
G Drd1 dopamine receptor D1 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chrNW_004955408:28,003,229...28,006,595
Ensembl chrNW_004955408:28,003,229...28,006,595
JBrowse link
G Drd2 dopamine receptor D2 ISO protein:decreased expression:blood, lymphocyte RGD PMID:11087905 RGD:5686416 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573
JBrowse link
G Drd3 dopamine receptor D3 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chrNW_004955427:14,219,519...14,252,178
Ensembl chrNW_004955427:14,219,594...14,252,178
JBrowse link
G Drd4 dopamine receptor D4 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chrNW_004955476:11,424,347...11,426,962
Ensembl chrNW_004955476:11,424,411...11,426,960
JBrowse link
G Drd5 dopamine receptor D5 ISO protein:increased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chrNW_004955514:5,450,495...5,452,282 JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO protein:increased expression:brain RGD PMID:9402150 RGD:13207349 NCBI chrNW_004955538:1,388,595...1,458,166
Ensembl chrNW_004955538:1,390,137...1,458,025
JBrowse link
G E2f1 E2F transcription factor 1 ISO protein:increased expression:cerebral cortex,cytoplasm: RGD PMID:11939591 RGD:10401093 NCBI chrNW_004955422:27,638,625...27,643,261
Ensembl chrNW_004955422:27,633,827...27,642,241
JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:15340356 RGD:1580902 NCBI chrNW_004955452:1,653,783...1,704,619
Ensembl chrNW_004955452:1,651,316...1,751,489
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 ISO protein:increased expression:CA1field of hippocampus: RGD PMID:8750861 RGD:10401216 NCBI chrNW_004955528:717,338...726,383
Ensembl chrNW_004955528:717,338...729,692
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO protein:hyperphosphorylation:brain: RGD PMID:1331687 RGD:10401652 NCBI chrNW_004955495:4,800,103...4,807,714
Ensembl chrNW_004955495:4,799,922...4,807,252
JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO RGD PMID:16098202 RGD:10401651 NCBI chrNW_004955493:865,830...922,765
Ensembl chrNW_004955493:865,830...922,765
JBrowse link
G Egf epidermal growth factor ISO protein:decreased expression:platelet RGD PMID:21875409 RGD:10059680 NCBI chrNW_004955496:325,954...401,430
Ensembl chrNW_004955496:328,075...401,569
JBrowse link
G Egfr epidermal growth factor receptor treatment ISO RGD PMID:23019586 RGD:10059684 NCBI chrNW_004955456:321,222...456,431 JBrowse link
G Egr1 early growth response 1 treatment ISO protein:increased expression:temporal cortex, hippocampus (human) RGD PMID:21489990 PMID:21969301 PMID:23642031 RGD:10395277 RGD:10395279 RGD:5131647 NCBI chrNW_004955418:2,001,509...2,005,269
Ensembl chrNW_004955418:2,002,699...2,005,007
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 ISO protein:increased threonine phosphorylation:hippocampus RGD PMID:15567511 PMID:24315369 RGD:10395344 RGD:10395348 NCBI chrNW_004955441:4,908,318...4,944,343 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha severity ISO protein:increased phosphorylation:hippocampus
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16691116 PMID:16954686 PMID:17406652 PMID:24315369 RGD:10395316 RGD:10395343 RGD:10395344 NCBI chrNW_004955466:2,838,785...2,855,443
Ensembl chrNW_004955466:2,838,785...2,855,172
JBrowse link
G Elk1 ETS transcription factor ELK1 ISO RGD PMID:20126313 RGD:7488914 NCBI chrNW_004955516:431,081...444,871
Ensembl chrNW_004955516:430,775...444,871
JBrowse link
G Eno1 enolase 1 ISO protein:increased S-glutathionylation, decreased activity:inferior parietal cortex
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17387692 PMID:19374891 RGD:13792613 NCBI chrNW_004955486:4,275,371...4,287,152
Ensembl chrNW_004955486:4,274,238...4,289,809
JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA:increased expression:temporal cortex (human) RGD PMID:23585551 RGD:7327146 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933
JBrowse link
G Epha1 EPH receptor A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 NCBI chrNW_004955494:256,008...268,777
Ensembl chrNW_004955494:255,162...268,777
JBrowse link
G Epha4 EPH receptor A4 ISO protein:decreased expression:hippocampus RGD PMID:19542617 RGD:6218956 NCBI chrNW_004955453:12,099,800...12,240,199
Ensembl chrNW_004955453:12,099,757...12,240,199
JBrowse link
G Ephb2 EPH receptor B2 ameliorates ISO RGD PMID:21113149 RGD:12859080 NCBI chrNW_004955452:2,844,713...2,986,790
Ensembl chrNW_004955452:2,844,713...2,980,445
JBrowse link
G Ephx1 epoxide hydrolase 1 ISO protein:increased expression:hippocampus RGD PMID:16630050 RGD:5688388 NCBI chrNW_004955520:116,363...142,983
Ensembl chrNW_004955520:116,363...128,665
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22004348 PMID:23813967 RGD:10395389 RGD:10400882 NCBI chrNW_004955573:203,875...206,078
Ensembl chrNW_004955573:203,441...206,355
JBrowse link
G Epor erythropoietin receptor ISO protein:increased expression:brain, astrocyte RGD PMID:17483696 RGD:10395387 NCBI chrNW_004955495:2,293,587...2,299,302
Ensembl chrNW_004955495:2,293,540...2,298,715
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO protein:increased expression:brain RGD PMID:9714461 RGD:5688738 NCBI chrNW_004955555:2,355,005...2,369,599
Ensembl chrNW_004955555:2,355,005...2,369,599
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO protein:increased expression:brain RGD PMID:9714461 RGD:5688738 NCBI chrNW_004955459:3,210,936...3,238,401
Ensembl chrNW_004955459:3,210,479...3,242,576
JBrowse link
G Esr1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10558867 PMID:17192785 RGD:1358612 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
JBrowse link
G Esr2 estrogen receptor 2 susceptibility ISO protein:decreased expression:choroid plexus
mRNA:increased expression:cerebral cortex
DNA:SNPs:3' utr: (rs4986938), (rs1255953) (human)
DNA:snps:introns:IVS3-1880C>T, IVS4+1231C>T (rs1271573, rs1256043) (human)
RGD PMID:15082146 PMID:15916731 PMID:15944651 PMID:17132983 RGD:5508768 RGD:5508772 RGD:5508784 RGD:8693346 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8333868 NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517
JBrowse link
G Fabp3 fatty acid binding protein 3 ISO protein:decreased expression:cerebral cortex (human) RGD PMID:15068254 RGD:1578460 NCBI chrNW_004955452:9,851,182...9,858,735
Ensembl chrNW_004955452:9,846,689...9,861,971
JBrowse link
G Fadd Fas associated via death domain ISO RGD PMID:16085017 RGD:13782385 NCBI chrNW_004955422:16,026,323...16,035,808
Ensembl chrNW_004955422:16,031,280...16,036,281
JBrowse link
G Fas Fas cell surface death receptor ISO DNA:snp:promoter:g.-670G>A (human)
protein:increased expression:brain, plaque (human)
RGD PMID:11129341 PMID:12742739 RGD:1358615 RGD:8663481 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO RGD PMID:20079650 RGD:5509878 NCBI chrNW_004955415:11,151,330...11,245,554
Ensembl chrNW_004955415:11,151,266...11,247,344
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:9748519 RGD:10402073 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111
JBrowse link
G Fis1 fission, mitochondrial 1 ISO protein:increased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chrNW_004955456:16,057,158...16,060,623
Ensembl chrNW_004955456:16,038,221...16,060,623
JBrowse link
G Foxo3 forkhead box O3 ISO mRNA:increased expression:brain:
protein:increased expression:hippocampal neuron (mouse)
protein:altered expression:cortical neuron,nucleus:
protein:increased expression:lymphoblast,nucleus:
RGD PMID:23153928 PMID:23585551 PMID:23661003 PMID:28157684 RGD:10402185 RGD:10402187 RGD:11061905 RGD:7327146 NCBI chrNW_004955411:33,655,958...33,770,829
Ensembl chrNW_004955411:33,655,958...33,770,829
JBrowse link
G Fxyd6 FXYD domain containing ion transport regulator 6 ISO RGD PMID:19760337 RGD:13801191 NCBI chrNW_004955412:19,053,627...19,090,582
Ensembl chrNW_004955412:19,052,801...19,090,582
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO protein:decreased expression:cerebral cortex, soluble fraction (human) RGD PMID:14999081 PMID:15708437 RGD:1358600 RGD:1358602 NCBI chrNW_004955411:36,403,156...36,597,660
Ensembl chrNW_004955411:36,401,842...36,512,054
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:25,609,840...25,641,886
Ensembl chrNW_004955407:25,609,972...25,641,879
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase susceptibility
onset
ISO DNA:SNP:5' utr:rs3741916 (human)
DNA:snps:5' utr, intron: (rs3741916, rs1060621) (human)
protein:decreased activity:cerebral cortex, cerebellum
protein:increased S-glutathionylation, decreased activity:inferior parietal cortex
DNA:SNPs, haplotypes: :rs740850, rs1060620 (human)
protein:decreased activity:cerebral cortex, hippocampus
RGD PMID:15507493 PMID:17324518 PMID:17387692 PMID:18340469 PMID:20864222 More... RGD:1358618 RGD:13792604 RGD:13792611 RGD:13792612 RGD:13792613 RGD:13792614 NCBI chrNW_004955413:4,162,467...4,166,783
Ensembl chrNW_004955413:4,162,467...4,166,783
JBrowse link
G Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic onset ISO CTD Direct Evidence: marker/mechanism
DNA:snps:promoter, intron: (rs4806173, rs12984928) (human)
CTD
RGD
PMID:15507493 PMID:17192785 RGD:1358618 NCBI chrNW_004955468:4,757,080...4,773,675
Ensembl chrNW_004955468:4,756,972...4,775,757
JBrowse link
G Gcg glucagon ISO RGD PMID:23035082 RGD:10402366 NCBI chrNW_004955449:11,708,152...11,716,429
Ensembl chrNW_004955449:11,708,152...11,716,429
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO mRNA, protein:alternate form, decreased expression:brain RGD PMID:22081608 RGD:5688777 NCBI chrNW_004955426:22,386,613...22,412,324
Ensembl chrNW_004955426:22,386,450...22,412,324
JBrowse link
G Ghrh growth hormone releasing hormone treatment ISO RGD PMID:23211425 RGD:10401233 NCBI chrNW_004955422:24,481,246...24,490,529 JBrowse link
G Glud1 glutamate dehydrogenase 1 ISO protein:increased expression, decreased oxidation:brain
protein:increased expression:brain
RGD PMID:16298240 PMID:16341942 RGD:6484555 RGD:6484556 NCBI chrNW_004955510:5,987,811...6,021,001 JBrowse link
G Glul glutamate-ammonia ligase ISO protein:increased oxidation:brain
protein:increased expression:cerebrospinal fluid:significant increase in active protein vs normal patients and controls with other neurological disorders
RGD PMID:1361232 PMID:12160938 RGD:2301427 RGD:2301429 NCBI chrNW_004955406:21,266,383...21,274,546
Ensembl chrNW_004955406:21,266,383...21,275,309
JBrowse link
G Grid2ip Grid2 interacting protein ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chrNW_004955460:13,161,761...13,189,175
Ensembl chrNW_004955460:13,153,961...13,189,207
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:24156266 RGD:13792688 NCBI chrNW_004955513:5,154,864...5,178,636
Ensembl chrNW_004955513:5,154,864...5,178,636
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:24156266 RGD:13792688 NCBI chrNW_004955442:8,171,114...8,565,187
Ensembl chrNW_004955442:8,174,232...8,562,059
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B no_association ISO DNA:SNP, haplotype: :rs1806201 (human)
DNA:SNP: :2664C>T (rs1806201) (human)
DNA:SNPs:promoter, exon, 3' utr:-200T>G (rs1019385), 2664C>T (rs1806201), 5072G>T (rs890) (human)
DNA:SNP:promoter:-421C>A (rs3764028) (human)
DNA:SNPs:promoter:-200T>G (rs1019385), -1447T>C, -1497G>A (rs12368476) (human)
RGD PMID:18303265 PMID:18983893 PMID:24156266 PMID:24292895 RGD:13792688 RGD:13792709 RGD:13792713 RGD:13792714 NCBI chrNW_004955413:10,358,931...10,780,004
Ensembl chrNW_004955413:10,376,597...10,779,145
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO DNA: deletion: exons 7,8: heterozygote RGD PMID:18522748 RGD:5688375 NCBI chrNW_004955551:43,918...255,118
Ensembl chrNW_004955551:44,156...254,534
JBrowse link
G Grn granulin precursor severity
onset
ISO mRNA, protein:increased expression:microglia, neuron:
ClinVar Annotator: match by term: Alzheimer disease
DNA:deletion:exon:c.154delA(human)
RGD
ClinVar
PMID:16199547 PMID:16862116 PMID:16950801 PMID:19557827 PMID:20142525 More... RGD:5509601 RGD:5509606 NCBI chrNW_004955451:17,368,600...17,371,981
Ensembl chrNW_004955451:17,368,428...17,372,377
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha treatment ISO RGD PMID:18410522 PMID:22623685 RGD:10401797 RGD:10401801 NCBI chrNW_004955555:668,641...676,351
Ensembl chrNW_004955555:667,973...676,351
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO CTD Direct Evidence: marker/mechanism
DNA:altered methylation:CpG island:
protein:decreased phosphorylation:hippocampus:
DNA:SNP:promoter:rs334558 (human)
CTD
RGD
PMID:11226152 PMID:17409235 PMID:19154537 PMID:22048123 PMID:22623685 More... RGD:10045668 RGD:10045669 RGD:10045670 RGD:10401801 RGD:1302533 RGD:13782364 RGD:13792736 RGD:13792777 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO mRNA:increased expression:hippocampus
protein:decreased expression:blood
RGD PMID:10096042 PMID:17721818 PMID:19374888 PMID:21376020 RGD:10401827 RGD:10401847 RGD:10401849 RGD:10401857 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583
JBrowse link
G Gss glutathione synthetase ISO RGD PMID:15693022 RGD:5508441 NCBI chrNW_004955422:26,427,581...26,483,380
Ensembl chrNW_004955422:26,427,581...26,463,781
JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISO DNA:SNP:cds: rs7483 (human) RGD PMID:15621212 PMID:18423940 RGD:5688729 RGD:5688745 NCBI chrNW_004955435:13,253,947...13,256,965
Ensembl chrNW_004955435:13,253,947...13,256,965
JBrowse link
G Gstp1 glutathione S-transferase pi 1 onset
susceptibility
ISO DNA:polymorphisms
mRNA:decreased expression:cerebral cortex
DNA:polymorphism:exon:
RGD PMID:15805147 PMID:17911365 PMID:23211594 PMID:24584466 RGD:10401912 RGD:10401913 RGD:5490123 RGD:5490271 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 ISO RGD PMID:15571982 RGD:10401946 NCBI chrNW_004955471:11,303,478...11,349,512
Ensembl chrNW_004955471:11,303,242...11,351,190
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO protein:decreased expression:brain RGD PMID:25260493 RGD:10047114 NCBI chrNW_004955469:8,183,945...8,233,869
Ensembl chrNW_004955469:8,183,945...8,233,869
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta ISO protein:decreased_expression:vascular smooth muscle cells:little or no expression in VSMCs in arteries with amyloid deposits RGD PMID:11430884 RGD:1600786 NCBI chrNW_004955469:8,233,980...8,272,149
Ensembl chrNW_004955469:8,233,980...8,274,450
JBrowse link
G Hdac2 histone deacetylase 2 ISO protein:increased expression:hippocampus: RGD PMID:22388814 RGD:9590324 NCBI chrNW_004955526:2,739,099...2,759,640
Ensembl chrNW_004955526:2,728,377...2,759,707
JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer's disease ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:brain, microvessel (mouse)
mRNA, protein:increased expression:cerebral cortex, microvessel (human)
RGD PMID:16627934 PMID:21904637 RGD:9068875 RGD:9068888 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497
JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:23905994 RGD:10402058 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:17724290 RGD:5508460 NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745
JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:hippocampus, temporal cortex (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:7778849 PMID:11144356 RGD:1358658 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO protein:decreased expression:entorhinal cortex (human) RGD PMID:22628224 RGD:9999191 NCBI chrNW_004955458:1,530,163...1,536,874 JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 ISO protein:decreased expression:entorhinal cortex (human) RGD PMID:22628224 RGD:9999191 NCBI chrNW_004955410:28,032,193...28,042,459
Ensembl chrNW_004955410:28,032,193...28,042,459
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO protein:increased expression:brain, neuron (human) RGD PMID:10661494 RGD:10412306 NCBI chrNW_004955476:11,508,446...11,510,333
Ensembl chrNW_004955476:11,508,126...11,510,333
JBrowse link
G Hsd17b10 hydroxysteroid 17-beta dehydrogenase 10 treatment ISO protein:increased expression:brain (human)
protein:increased expression:hippocampus, neuron, mitochondria
RGD PMID:9338779 PMID:11869808 PMID:21307267 RGD:1358426 RGD:13792781 RGD:632866 NCBI chrNW_004955475:478,690...481,029
Ensembl chrNW_004955475:478,690...481,029
JBrowse link
G Hsd17b3 hydroxysteroid 17-beta dehydrogenase 3 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chrNW_004955422:23,104,752...23,251,250
Ensembl chrNW_004955422:23,101,795...23,148,999
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chrNW_004955435:22,414,605...22,421,682 JBrowse link
G Hsf1 heat shock transcription factor 1 ISO protein:altered localization:promoter (mouse)
protein:decreased expression:cerebellum (rat)
RGD PMID:23665061 PMID:24849358 RGD:10402385 RGD:10402771 NCBI chrNW_004955454:2,907,265...2,932,352
Ensembl chrNW_004955454:2,907,265...2,932,351
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO protein:decreased expression:serum (human) RGD PMID:23948885 RGD:10413860 NCBI chrNW_004955538:1,469,544...1,475,010
Ensembl chrNW_004955538:1,469,544...1,475,019
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:16,195,366...16,205,371
Ensembl chrNW_004955407:16,195,308...16,206,100
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:17050040 RGD:10402560 NCBI chrNW_004955418:1,915,985...1,931,017
Ensembl chrNW_004955418:1,915,985...1,931,017
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO mRNA,protein:increased expression:brainstem, astrocyte: RGD PMID:25772164 RGD:10402580 NCBI chrNW_004955844:8,094...9,565
Ensembl chrNW_004955844:7,790...10,004
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO protein:increased expression:mitochondrion:
protein:increased expression:cytosol, mitochondrion:
protein:increased modification:brain
RGD PMID:15802185 PMID:22753410 RGD:10402831 RGD:1624243 NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO RGD PMID:20508993 RGD:5683632 NCBI chrNW_004955446:4,913,181...4,917,726
Ensembl chrNW_004955446:4,913,884...4,915,146
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 susceptibility ISO DNA:silent mutation:cds: 267C>T (human) RGD PMID:10624811 RGD:1358662 NCBI chrNW_004955452:323,641...338,312 JBrowse link
G Htra2 HtrA serine peptidase 2 ISO protein:increased activity:frontal cortex (human) RGD PMID:21163861 RGD:5688722 NCBI chrNW_004955424:11,255,756...11,259,170
Ensembl chrNW_004955424:11,255,756...11,259,170
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO DNA:missense mutation:cds:p.K469E (human) RGD PMID:12498973 RGD:1358664 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Ide insulin degrading enzyme treatment ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:cerebrospinal fluid
associated with Insulin Resistance
RGD
CTD
PMID:12634421 PMID:17192785 PMID:26963025 PMID:28157092 PMID:28164769 More... RGD:13792790 RGD:13792792 RGD:13792793 RGD:13792798 RGD:13792800 RGD:13792824 RGD:13792829 RGD:737718 NCBI chrNW_004955425:819,461...926,440
Ensembl chrNW_004955425:847,615...926,318
JBrowse link
G Igf1 insulin like growth factor 1 susceptibility
treatment
onset
ISO DNA:polymorphism:intron: rs972936(human)
protein:decreased expression:hippocampus:
protein:increased expression:serum:
protein:altered expression:plasma,cerebral spinal fluid:
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10399774 PMID:15750215 PMID:23089282 PMID:23740209 PMID:24054991 More... RGD:10045852 RGD:10045853 RGD:10045854 RGD:10045860 RGD:10402576 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
JBrowse link
G Igf1r insulin like growth factor 1 receptor treatment
severity
ISO CTD Direct Evidence: marker/mechanism
DNA: haploinsufficiency:: full knockout dies at birth
protein:increased expression:temporal cortex:
protein:increased expression: cerebral cortex:
RGD
CTD
PMID:15750215 PMID:16274856 PMID:18479783 PMID:19487308 PMID:20409077 More... RGD:10045878 RGD:10045879 RGD:10045894 RGD:12904921 RGD:5686420 NCBI chrNW_004955416:26,101,090...26,382,660
Ensembl chrNW_004955416:26,102,628...26,382,666
JBrowse link
G Igf2 insulin like growth factor 2 treatment ISO CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:brain
CTD
RGD
PMID:15750215 PMID:16627931 PMID:21040071 PMID:24685003 PMID:24887203 RGD:10045934 RGD:10402558 RGD:10402559 RGD:5509963 NCBI chrNW_004955422:13,880,525...13,907,963
Ensembl chrNW_004955422:13,880,471...13,888,566
JBrowse link
G Igf2r insulin like growth factor 2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15750215 NCBI chrNW_004955439:20,754,915...20,874,759
Ensembl chrNW_004955439:20,752,855...20,851,281
JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 ISO protein:decreased expression:temporal cortex: RGD PMID:18479783 RGD:10045894 NCBI chrNW_004955453:16,556,873...16,584,737
Ensembl chrNW_004955453:16,557,194...16,584,634
JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 treatment ISO protein:increased expression:serum
mRNA:decreased expression:hippocampus
RGD PMID:10399774 PMID:23473966 PMID:24964199 RGD:10402570 RGD:10402572 RGD:10402576 NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO protein:increased expression:hippocampus: RGD PMID:24380241 RGD:10045941 NCBI chrNW_004955536:611,965...658,647
Ensembl chrNW_004955536:612,774...658,647
JBrowse link
G Il10 interleukin 10 treatment
susceptibility
ISO DNA:SNPs,haplotype: -1082G>A, -819T>C, -592C>A (human) RGD PMID:14746878 PMID:21803105 RGD:1358665 RGD:7364841 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il1a interleukin 1 alpha susceptibility
disease_progression
no_association
ISO protein:increased expression:microglial cell, cortical layer:
DNA:SNP:5'UTR:rs1800587(human)
RGD PMID:9775393 PMID:10716257 PMID:11402127 PMID:19158434 RGD:10045945 RGD:10045947 RGD:10046059 RGD:1358667 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
JBrowse link
G Il1b interleukin 1 beta treatment
onset
no_association
ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs1143634 (human)
DNA:SNP:promoter:-31T>C (human)
protein:increased expression:plasma
RGD
CTD
PMID:16600299 PMID:18675847 PMID:18830724 PMID:20413850 PMID:22963993 More... RGD:11522340 RGD:13792816 RGD:13792817 RGD:13792818 RGD:13792819 RGD:13792820 RGD:13793381 RGD:1626633 RGD:7204700 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8586980 PMID:8915041 RGD:10047080 RGD:10047081 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
JBrowse link
G Il4 interleukin 4 ISO DNA:polymorphisms:promoter RGD PMID:20213229 RGD:10402788 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:27088818 RGD:11062148 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Il6r interleukin 6 receptor no_association ISO DNA:SNPs:promoter, exon:-530G>T, 48867A/>C (p.D358A, rs8192284) (human)
protein:increased expression:cerebrospinal fluid, plasma
DNA:SNPs:promoter:-208G>A (rs4845617) (human)
RGD PMID:12664314 PMID:20197062 RGD:10402808 RGD:10402810 NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO protein:decreased expression:cerebrospinal fluid RGD PMID:10095017 RGD:10402847 NCBI chrNW_004955446:11,790,636...11,837,734
Ensembl chrNW_004955446:11,790,444...11,835,001
JBrowse link
G Il7 interleukin 7 ISO RGD PMID:22571981 RGD:10402933 NCBI chrNW_004955444:2,365,077...2,400,953 JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:30320580 NCBI chrNW_004955453:2,938,659...3,037,211
Ensembl chrNW_004955453:2,938,659...3,037,211
JBrowse link
G Ins insulin ISO mRNA:decreased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9443474 PMID:15750215 PMID:17448147 RGD:2298713 NCBI chrNW_004955422:13,909,408...13,910,419
Ensembl chrNW_004955422:13,909,407...13,910,419
JBrowse link
G Insr insulin receptor treatment ISO protein:altered localization:brain, neuron
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:brain
RGD
CTD
PMID:16627931 PMID:18479783 PMID:23011726 PMID:24055495 RGD:10045894 RGD:10403036 RGD:5509963 NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149
JBrowse link
G Iqck IQ motif containing K ISO CTD Direct Evidence: marker/mechanism CTD PMID:30820047 NCBI chrNW_004955442:3,428,245...3,548,718
Ensembl chrNW_004955442:3,428,259...3,519,014
JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO DNA:SNPs: :rs2656070, rs13180(human) RGD PMID:16914832 RGD:6893299 NCBI chrNW_004955450:852,554...898,908
Ensembl chrNW_004955450:852,554...900,011
JBrowse link
G Irs1 insulin receptor substrate 1 treatment
severity
ISO protein:decreased expression:hippocampus:
protein:increased expression, increased serine phosphorylation, increased tyrosine phosphorylation:hippocampus CA1
protein:increased serine phosphorylation:hippocampus
protein:altered expression:temporal cortex:
DNA:SNP:cds:rs1801278(human)
RGD PMID:18479783 PMID:22476196 PMID:22476197 PMID:22527777 PMID:23011726 More... RGD:10045894 RGD:10045932 RGD:10045935 RGD:10045939 RGD:10403036 RGD:6482860 RGD:6482861 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262
JBrowse link
G Irs2 insulin receptor substrate 2 severity ISO protein:decreased expression:temporal cortex:
mRNA:decreased expression:hippocampus:
RGD PMID:18479783 PMID:19487308 PMID:24887203 RGD:10045878 RGD:10045894 RGD:10045934 NCBI chrNW_004955404:2,531,484...2,555,383
Ensembl chrNW_004955404:2,531,484...2,555,689
JBrowse link
G Jak2 Janus kinase 2 treatment ISO RGD PMID:18813209 RGD:10403051 NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208
JBrowse link
G Jam2 junctional adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:25,531,891...25,599,551
Ensembl chrNW_004955407:25,571,570...25,599,551
JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 ISO mRNA, protein:decreased expression:neocortex (mouse) RGD PMID:21912965 RGD:9686062 NCBI chrNW_004955414:32,538,968...32,580,370
Ensembl chrNW_004955414:32,538,938...32,580,370
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 ISO mRNA:decreased expression:neocortex (mouse)
mRNA, protein:increased expression: frontal cortex
RGD PMID:15485486 PMID:21912965 RGD:10411900 RGD:9686062 NCBI chrNW_004955435:13,728,272...13,750,420
Ensembl chrNW_004955435:13,728,708...13,750,660
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 onset ISO DNA:SNP: :rs16934131 (human) RGD PMID:21480501 RGD:10412025 NCBI chrNW_004955437:14,749,808...15,457,274
Ensembl chrNW_004955437:14,749,914...15,454,028
JBrowse link
G Kl klotho treatment ISO mRNA,protein:decreased expression:cerebral choroid,serum: RGD PMID:23973442 RGD:10403049 NCBI chrNW_004955431:12,782,913...12,833,215
Ensembl chrNW_004955431:12,782,846...12,833,215
JBrowse link
G Klc1 kinesin light chain 1 susceptibility ISO DNA:SNP:intron:56836G>C (human)
DNA:SNPs: :rs8007903, rs3212079 (human)
RGD PMID:15364413 PMID:19911314 RGD:5683908 RGD:5684007 NCBI chrNW_004955538:2,462,491...2,503,398
Ensembl chrNW_004955538:2,470,473...2,503,398
JBrowse link
G Klk6 kallikrein related peptidase 6 ISO RGD PMID:12074831 PMID:12480753 RGD:1358599 RGD:1358604 NCBI chrNW_004955558:1,501,806...1,509,461
Ensembl chrNW_004955558:1,502,881...1,509,558
JBrowse link
G Klrg1 killer cell lectin like receptor G1 ISO ClinVar Annotator: match by term: ALPHA-2-MACROGLOBULIN POLYMORPHISM ClinVar PMID:1370808 PMID:1717945 PMID:9697696 PMID:9811940 PMID:15023809 More... NCBI chrNW_004955413:6,119,299...6,131,907
Ensembl chrNW_004955413:6,118,611...6,129,441
JBrowse link
G L1cam L1 cell adhesion molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16298234 RGD:6483456 NCBI chrNW_004955580:548,442...561,580
Ensembl chrNW_004955580:549,368...561,486
JBrowse link
G Ldlr low density lipoprotein receptor no_association ISO DNA:SNPs:exon:rs5925, rs5927, rs5930 (human)
DNA:SNPs:exon:rs5925, rs5930, rs11669576 (human)
DNA:SNPs:exon (human)
DNA:SNPs: :rs5925, rs2738444, rs11669576 (human)
RGD PMID:15585340 PMID:15689450 PMID:16378661 PMID:16741934 PMID:17239995 More... RGD:5490231 RGD:5490239 RGD:5490241 RGD:5490242 RGD:5490243 RGD:5490244 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056
JBrowse link
G Lep leptin treatment ISO compared to cortisol;protein:altered expression:plasma (human)
CTD Direct Evidence: therapeutic
associated with Obesity
RGD
CTD
PMID:9755363 PMID:20157255 PMID:25296496 RGD:10053617 RGD:10053632 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
JBrowse link
G Lipc lipase C, hepatic type no_association ISO DNA:SNPs: :rs6084 (human)
DNA:SNPs: :rs6074, rs6083, rs6084 (human)
RGD PMID:17175070 RGD:1600644 NCBI chrNW_004955450:15,947,869...16,062,449
Ensembl chrNW_004955450:15,948,187...16,048,766
JBrowse link
G Lipi lipase I ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:16,013,285...16,071,187
Ensembl chrNW_004955407:16,012,264...16,056,796
JBrowse link
G LOC102005965 cytochrome b-c1 complex subunit 1, mitochondrial ISO protein:decreased expression:temporal cortex
DNA:hypermethylation:promoter:
RGD PMID:11130185 PMID:26943237 RGD:11572212 RGD:13831335 NCBI chrNW_004955532:685,315...691,286
Ensembl chrNW_004955532:685,395...696,554
JBrowse link
G LOC102008533 cytochrome c oxidase subunit 7C, mitochondrial ISO RGD PMID:28474567 RGD:13792588 NCBI chrNW_004955418:24,413,883...24,416,530 JBrowse link
G LOC102013799 chromosome unknown open reading frame, human C21orf91 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:19,093,931...19,124,997
Ensembl chrNW_004955407:19,094,101...19,124,370
JBrowse link
G LOC102021956 alpha-2-macroglobulin no_association
onset
ISO ClinVar Annotator: match by term: ALPHA-2-MACROGLOBULIN POLYMORPHISM
DNA:polymorphism: :p.I1000V (human)
DNA:polymorphisms: :multiple
RGD
ClinVar
PMID:1370808 PMID:1717945 PMID:9697696 PMID:9811940 PMID:10319853 More... RGD:10046014 RGD:10046015 RGD:10046016 RGD:1300322 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G LOC102023780 aromatase ISO mRNA:altered expression:cerebellum, hippocampus (human)
DNA:polymorphism
RGD PMID:16882736 PMID:18180323 RGD:1600861 RGD:4889108 NCBI chrNW_004955409:3,198,622...3,313,072
Ensembl chrNW_004955409:3,266,233...3,313,142
JBrowse link
G LOC102027549 serotransferrin ISO ClinVar Annotator: match by term: Transferrin variant c1/c2 ClinVar PMID:9272172 PMID:15060098 PMID:20029940 PMID:28492532 NCBI chrNW_004955501:4,801,710...4,832,025
Ensembl chrNW_004955501:4,801,885...4,831,910
JBrowse link
G LOC102030124 cholesterol 24-hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12232784 PMID:19286353 RGD:1358575 NCBI chrNW_004955438:20,961,621...20,986,260
Ensembl chrNW_004955438:20,961,365...20,985,749
JBrowse link
G Lpl lipoprotein lipase severity
no_association
ISO DNA:polymorphism:intron
DNA:SNPs: :rs268, rs328 (human)
DNA:point mutations: :p.N291S, p.S447X (human)
DNA, mRNA:SNP, decreased expression: :rs285 (human)
DNA:SNPs: :multiple
RGD PMID:10206232 PMID:12133567 PMID:15331147 PMID:16013913 PMID:16965549 More... RGD:13793392 RGD:13793393 RGD:13793395 RGD:13793396 RGD:13793397 RGD:13799353 RGD:5685661 NCBI chrNW_004955403:43,646,084...43,672,116
Ensembl chrNW_004955403:43,646,084...43,673,967
JBrowse link
G Lrp1 LDL receptor related protein 1 treatment ISO DNA:SNP:exon 3:C>T (human) RGD PMID:9635959 PMID:19150622 PMID:29115637 RGD:1358747 RGD:13799352 RGD:13800553 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146
JBrowse link
G Lrp1b LDL receptor related protein 1B onset ISO mRNA:increased expression:hippocampus (mouse) RGD PMID:23150673 RGD:151665140 NCBI chrNW_004955440:7,048,527...8,475,566
Ensembl chrNW_004955440:7,050,135...8,475,122
JBrowse link
G Lrp8 LDL receptor related protein 8 no_association ISO DNA:polymorphism:exon:2622T>C (human)
DNA:polymorphisms: :multiple
RGD PMID:12399018 PMID:20208369 RGD:6483064 RGD:6483065 NCBI chrNW_004955464:5,837,002...5,912,178
Ensembl chrNW_004955464:5,837,009...5,911,672
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 onset ISO DNA:deletion:intron RGD PMID:11425005 RGD:1358749 NCBI chrNW_004955514:2,195,228...2,208,258
Ensembl chrNW_004955514:2,195,228...2,208,688
JBrowse link
G Maoa amine oxidase [flavin-containing] A ISO RGD PMID:1627256 RGD:10046060 NCBI chrNW_004955516:4,494,133...4,576,317
Ensembl chrNW_004955516:4,493,946...4,576,317
JBrowse link
G Maob monoamine oxidase B ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:1627256 PMID:7816197 PMID:21075085 RGD:10046060 NCBI chrNW_004955516:4,328,286...4,473,419
Ensembl chrNW_004955516:4,328,476...4,472,593
JBrowse link
G Map2 microtubule associated protein 2 ISO RGD PMID:22083255 RGD:6483322 NCBI chrNW_004955457:5,678,826...5,816,114
Ensembl chrNW_004955457:5,678,436...5,875,024
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment
onset
ISO mRNA:increased expression: CA2 field of hippocampus, pyramidal neuron RGD PMID:24334724 PMID:28079060 RGD:13800563 RGD:13800868 NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
JBrowse link
G Mapk10 mitogen-activated protein kinase 10 ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chrNW_004955474:3,451,656...3,772,405
Ensembl chrNW_004955474:3,624,679...3,772,458
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO mRNA:increased expression:frontal lobe cortex, hippocampus CA2 (rat) RGD PMID:17784957 PMID:20529587 RGD:10047076 RGD:10047104 NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:28079060 RGD:13800563 NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 disease_progression ISO protein:increased expression:brain,CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO protein:increased expression:brain,CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chrNW_004955408:391,094...430,638
Ensembl chrNW_004955408:391,094...430,981
JBrowse link
G Mapt microtubule associated protein tau treatment
no_association
onset
ISO ClinVar Annotator: match by term: Alzheimer disease
DNA:SNPs, haplotypes:promoter:rs242557 (human)
DNA:mutation:cds:p.R406W(human)
DNA:SNP, haplotypes:promoter:rs242557 (human)
RGD
ClinVar
PMID:18587238 PMID:19252918 PMID:19308965 PMID:23116876 PMID:27060945 More... RGD:10412701 RGD:10412704 RGD:13800904 RGD:13800908 RGD:8158097 RGD:8158105 NCBI chrNW_004955478:10,222,439...10,271,439
Ensembl chrNW_004955478:10,225,823...10,271,442
JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO protein:decreased expression:cerebrospinal fluid (human)
DNA:haplotype:promoter:
RGD PMID:9631454 PMID:23348713 RGD:12910848 RGD:4889155 NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 ISO RGD PMID:17070803 PMID:19946466 RGD:10412048 RGD:10412050 NCBI chrNW_004955429:16,012,345...16,027,151
Ensembl chrNW_004955429:16,012,173...16,027,277
JBrowse link
G Mdm4 MDM4 regulator of p53 disease_progression ISO RGD PMID:23861893 RGD:10047419 NCBI chrNW_004955406:40,346,617...40,387,977
Ensembl chrNW_004955406:40,346,588...40,387,977
JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chrNW_004955420:8,541,547...8,596,494
Ensembl chrNW_004955420:8,541,936...8,594,437
JBrowse link
G Mfn2 mitofusin 2 ISO protein:decreased expression:hippocampus (human)
protein:increased expression:hippocampus (rat)
RGD PMID:19605646 PMID:28302704 RGD:12910737 RGD:7800727 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772
JBrowse link
G Mme membrane metalloendopeptidase onset
severity
no_association
treatment
ISO DNA:SNPs, haplotypes:promoter, introns:-204G>C, IVS17-294C>T, IVS22+36C>A (human)
DNA:SNP:3' utr:rs6665 (human)
DNA:SNPs, repeats, deletion:promoter:multiple
DNA:SNPs:5' utr, 3' utr:rs3736187, rs989692, rs701109 (human)
DNA:SNPs:introns:rs1836915, rs6776185, rs6801319 (human)
DNA:SNP: :rs6797911 (human)
DNA:repeats
associated with Endotoxemia
DNA:SNPs: :multiple
DNA:SNPs, repeat:multiple:multiple
RGD PMID:11849775 PMID:12074840 PMID:12527400 PMID:15860464 PMID:17928142 More... RGD:13801009 RGD:13801010 RGD:13801011 RGD:13801012 RGD:13801019 RGD:13801020 RGD:13801021 RGD:13801022 RGD:13801023 RGD:13801024 RGD:13801033 RGD:13801034 RGD:1600813 NCBI chrNW_004955448:6,193,113...6,311,666
Ensembl chrNW_004955448:6,226,059...6,314,949
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:decreased expression:platelet RGD PMID:21875409 RGD:10059680 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:plasma (human) RGD PMID:17697439 RGD:7207052 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
JBrowse link
G Mpo myeloperoxidase ISO ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, susceptibility to ClinVar PMID:6260268 PMID:9766845 PMID:11087769 PMID:12915675 PMID:15023809 More... NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
JBrowse link
G Mrpl39 mitochondrial ribosomal protein L39 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chrNW_004955407:25,474,843...25,491,114
Ensembl chrNW_004955407:25,474,899...25,491,634
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17192785 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 ISO RGD PMID:14557245 RGD:2302388 NCBI chrNW_004955433:23,333,797...23,358,255
Ensembl chrNW_004955433:23,333,742...23,358,579
JBrowse link
G Napb NSF attachment protein beta ISO protein:decreased expression:temporal cortex RGD PMID:11244216 RGD:10412652 NCBI chrNW_004955415:30,392,692...30,427,773
Ensembl chrNW_004955415:30,392,165...30,427,773
JBrowse link
G Nbn nibrin ISO RGD PMID:15337312 RGD:2317734 NCBI chrNW_004955417:6,840,916...6,880,479
Ensembl chrNW_004955417:6,839,312...6,880,133
JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO RGD PMID:31028587 RGD:40925918 NCBI chrNW_004955412:14,630,109...14,923,847
Ensembl chrNW_004955412:14,630,443...14,923,926
JBrowse link
G Ncam2 neural cell adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:21,730,331...22,220,664
Ensembl chrNW_004955407:21,730,434...22,215,377
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO protein:altered localization RGD PMID:10873554 RGD:2314452 NCBI chrNW_004955406:22,355,717...22,384,746
Ensembl chrNW_004955406:22,355,724...22,384,864
JBrowse link
G Nck2 NCK adaptor protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046
JBrowse link
G Ncstn nicastrin onset
no_association
ISO protein:increased modification:brain
DNA:SNPs, haplotype:introns:multiple
DNA:missense mutation: :417N>Y (human)
DNA:SNP:promoter:-922G>T (rs10752637) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNPs:promoter:-796T>G, -1216C>A (human)
DNA:missense mutation, SNPs:exon, intron, 3' utr:multiple
DNA:SNP:promoter:-436C>T (human)
RGD
CTD
PMID:11992262 PMID:14642438 PMID:15157994 PMID:17192785 PMID:19394408 More... RGD:13801048 RGD:13801049 RGD:13801050 RGD:13801051 RGD:13801052 RGD:13801187 RGD:13801188 NCBI chrNW_004955468:12,111,078...12,126,404
Ensembl chrNW_004955468:12,111,078...12,127,033
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 ISO RGD PMID:28474567 RGD:13792588 NCBI chrNW_004955418:52,952...55,060
Ensembl chrNW_004955418:52,952...55,060
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 ISO RGD PMID:19760337 RGD:13801191 NCBI chrNW_004955479:5,065,948...5,080,215
Ensembl chrNW_004955479:5,064,652...5,080,215
JBrowse link
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 ISO mRNA:increased expression:blood RGD PMID:26943237 RGD:11572212 NCBI chrNW_004955413:27,485,678...27,491,757
Ensembl chrNW_004955413:27,485,678...27,491,757
JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 ISO RGD PMID:28474567 RGD:13792588 NCBI chrNW_004955403:477,138...483,122
Ensembl chrNW_004955403:477,144...483,122
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:14570706 RGD:1358651 NCBI chrNW_004955485:9,607,781...9,613,123 JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 onset ISO RGD PMID:28242297 RGD:13824970 NCBI chrNW_004955422:713,370...717,926
Ensembl chrNW_004955422:709,784...717,926
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs6859 (human)
CTD
RGD
PMID:22159054 PMID:29107063 PMID:30319691 PMID:30320580 RGD:6484658 NCBI chrNW_004955555:1,959,702...1,985,679 JBrowse link
G Nefl neurofilament light chain ISO protein:increased expression:CSF (human) RGD PMID:29368621 PMID:29391125 RGD:127284889 RGD:127285384 NCBI chrNW_004955403:47,946,413...47,951,734
Ensembl chrNW_004955403:47,946,353...47,952,026
JBrowse link
G Nefm neurofilament medium chain ISO protein:decreased glycosylation:cerebral cortex RGD PMID:17687114 RGD:9743945 NCBI chrNW_004955403:47,920,408...47,926,922 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment
onset
ISO protein:increased expression:brain, nucleus
DNA:snps, haplotype:5' utr, intron:multiple (human)
RGD PMID:19805328 PMID:20064547 PMID:22913737 PMID:23771816 RGD:10412683 RGD:10412685 RGD:10412689 RGD:6893326 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944
JBrowse link
G Ngb neuroglobin treatment ISO RGD PMID:23428737 RGD:9743955 NCBI chrNW_004955438:1,170,888...1,175,978
Ensembl chrNW_004955438:1,170,888...1,175,978
JBrowse link
G Ngf nerve growth factor ISO RGD PMID:21368378 RGD:5144128 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059
JBrowse link
G Ngfr nerve growth factor receptor treatment
no_association
ISO protein:altered expression:urine
protein:altered localization:brain
DNA:SNP:CDS:rs2072446
protein:decreased expression:basal nucleus of telencephalon, neuron
DNA:SNPs, haplotypes: :multiple
RGD PMID:2557638 PMID:8215963 PMID:10683291 PMID:18780967 PMID:19070649 More... RGD:10413891 RGD:10413892 RGD:10413893 RGD:10413894 RGD:10413895 RGD:10414073 RGD:5508225 RGD:5508228 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
JBrowse link
G Nog noggin ISO RGD PMID:19463786 RGD:10414082 NCBI chrNW_004955451:6,192,368...6,193,766
Ensembl chrNW_004955451:6,193,042...6,193,740
JBrowse link
G Nos1 nitric oxide synthase 1 susceptibility
no_association
ISO DNA:repeat:promoter
DNA:SNP:exon:-84G>A (human)
DNA:repeat:exon
RGD PMID:10964481 PMID:12384247 PMID:17418914 PMID:21098972 RGD:13824974 RGD:13824975 RGD:13824976 RGD:13824978 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566
JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:12384247 PMID:16908860 PMID:21163295 RGD:13824978 RGD:4891161 RGD:5508721 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
JBrowse link
G Nos3 nitric oxide synthase 3 onset ISO DNA:snp:cds:p.E298D (human)
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, late-onset, susceptibility to
RGD
ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... RGD:1358752 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
JBrowse link
G Npy neuropeptide Y treatment ISO protein:decreased expression:plasma
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:8592643 PMID:11709213 PMID:22266216 RGD:10431479 RGD:10432246 NCBI chrNW_004955410:26,348,388...26,355,232
Ensembl chrNW_004955410:26,348,504...26,355,297
JBrowse link
G Nrg1 neuregulin 1 disease_progression ISO RGD PMID:12528817 PMID:29295823 RGD:10449002 RGD:41404730 NCBI chrNW_004955463:8,009,436...9,037,116
Ensembl chrNW_004955463:8,009,530...9,037,116
JBrowse link
G Nrgn neurogranin ISO RGD PMID:9329454 RGD:9835394 NCBI chrNW_004955412:25,809,512...25,818,237
Ensembl chrNW_004955412:25,809,512...25,818,237
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:16,740,253...16,820,297
Ensembl chrNW_004955407:16,740,253...16,820,297
JBrowse link
G Ntf3 neurotrophin 3 ISO DNA:missense mutation:cds:p.G63E (human) RGD PMID:9502217 RGD:1358754 NCBI chrNW_004955413:3,207,669...3,273,371
Ensembl chrNW_004955413:3,207,123...3,273,491
JBrowse link
G Ntn1 netrin 1 treatment ISO RGD PMID:30066400 RGD:13782183 NCBI chrNW_004955467:7,795,175...7,991,597
Ensembl chrNW_004955467:7,794,735...7,991,695
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 disease_progression ISO mRNA:decreased expression:brain
early onset sporadic AD; DNA:SNP:CDS:rs6336
RGD PMID:18780967 PMID:21397006 RGD:5508228 RGD:5684531 NCBI chrNW_004955545:2,929,704...2,947,579
Ensembl chrNW_004955545:2,929,704...2,947,579
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 treatment ISO sporadic AD; DNA:SNP:intron:rs2289656 RGD PMID:18780967 PMID:21900882 PMID:24877042 RGD:10059402 RGD:5508228 RGD:5684548 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878
JBrowse link
G Nudt1 nudix hydrolase 1 ISO protein:decreased expression:hippocampus RGD PMID:21538080 RGD:10449033 NCBI chrNW_004955460:9,678,270...9,689,106
Ensembl chrNW_004955460:9,678,270...9,689,106
JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase ISO protein:decreased expression:brain RGD PMID:19605646 RGD:7800727 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO protein:altered localization RGD PMID:18347024 RGD:2299169 NCBI chrNW_004955414:14,365,325...14,447,470
Ensembl chrNW_004955414:14,365,157...14,450,611
JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 susceptibility ISO DNA:haplotypes:cds:rs1136410,rs1805404 (human)
protein:increased activity:brain:
DNA:haplotypes: :
RGD PMID:17290104 PMID:20486200 PMID:21616968 PMID:22051244 RGD:10413885 RGD:10413887 RGD:10413888 RGD:5510011 NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO mRNA,protein:increased expression:brain: RGD PMID:9701251 RGD:9835364 NCBI chrNW_004955405:18,434,711...18,540,710
Ensembl chrNW_004955405:18,434,711...18,540,710
JBrowse link
G Pcdh11x protocadherin 11 X-linked ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:29476165 NCBI chrNW_004955525:2,982,220...3,919,729 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 disease_progression ISO DNA:SNPs
DNA:SNP: :rs8192708(human)
RGD PMID:17440948 PMID:20574532 RGD:10427727 RGD:2311642 NCBI chrNW_004955445:1,909,012...1,914,032
Ensembl chrNW_004955445:1,908,946...1,915,002
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO mRNA:increased expression:cerebral cortex: RGD PMID:8736634 RGD:10448277 NCBI chrNW_004955439:11,480,094...11,531,842
Ensembl chrNW_004955439:11,480,101...11,531,839
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor ISO RGD PMID:14746899 RGD:1642360 NCBI chrNW_004955543:383,984...387,885
Ensembl chrNW_004955543:384,123...387,744
JBrowse link
G Pde2a phosphodiesterase 2A treatment ISO RGD PMID:22771768 RGD:10449025 NCBI chrNW_004955414:18,765,591...18,826,717
Ensembl chrNW_004955414:18,735,822...18,827,236
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO protein:increased expression:plasma: RGD PMID:22279551 RGD:10449445 NCBI chrNW_004955413:25,150,702...25,166,987
Ensembl chrNW_004955413:25,148,062...25,166,987
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 onset ISO mRNA:decreased expression:hippocampus RGD PMID:7770119 PMID:10210891 PMID:11853019 PMID:15941609 RGD:2302735 RGD:2302863 RGD:2302864 RGD:2302869 NCBI chrNW_004955455:13,217,012...13,222,370 JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25390692 NCBI chrNW_004955534:698,895...706,586
Ensembl chrNW_004955534:698,734...706,946
JBrowse link
G Phactr2 phosphatase and actin regulator 2 ISO mRNA: splice variants RGD PMID:20590401 RGD:6483097 NCBI chrNW_004955436:16,607,279...16,690,412
Ensembl chrNW_004955436:16,619,552...16,694,053
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19734902 PMID:21460841 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:20025958 RGD:6482689 NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 onset ISO DNA:polymorphism: :p.M326I (human) RGD PMID:12185156 RGD:1625215 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820
JBrowse link
G Pilra paired immunoglobin like type 2 receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955573:553,631...560,301 JBrowse link
G Plau plasminogen activator, urokinase no_association ISO ClinVar Annotator: match by term: Alzheimer disease, late-onset, susceptibility to RGD
ClinVar
PMID:12898287 PMID:15615772 PMID:15616835 PMID:16341549 PMID:19889475 More... RGD:6483807 NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:8534418 RGD:13825140 NCBI chrNW_004955415:18,210,608...18,915,099
Ensembl chrNW_004955415:18,210,662...18,915,158
JBrowse link
G Plcd1 phospholipase C delta 1 ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chrNW_004955421:4,856,366...4,880,309
Ensembl chrNW_004955421:4,856,366...4,880,309
JBrowse link
G Plcg1 phospholipase C gamma 1 ISO RGD PMID:8534418 RGD:13825140 NCBI chrNW_004955445:15,787,496...15,823,859
Ensembl chrNW_004955445:15,787,496...15,823,859
JBrowse link
G Plcg2 phospholipase C gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28714976 NCBI chrNW_004955522:4,352,890...4,480,735
Ensembl chrNW_004955522:4,358,233...4,468,986
JBrowse link
G Pnmt phenylethanolamine N-methyltransferase onset ISO DNA:snps:5' utr:g.-390G>A, g.-184G>A rs876493 (human) RGD PMID:11378842 RGD:5130171 NCBI chrNW_004955451:14,414,836...14,417,972
Ensembl chrNW_004955451:14,416,121...14,417,901
JBrowse link
G Pon1 paraoxonase 1 ISO DNA:polymorphisms:multiple SNPs RGD PMID:16319130 RGD:5509926 NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339
JBrowse link
G Pon2 paraoxonase 2 ISO DNA:SNPs:multiple
DNA:missense mutation:cds:p.C311S (human)
RGD PMID:11803456 PMID:16319130 RGD:1580219 RGD:5509926 NCBI chrNW_004955432:11,988,009...12,020,702
Ensembl chrNW_004955432:11,987,919...12,020,740
JBrowse link
G Pon3 paraoxonase 3 ISO DNA:polymorphisms:multiple SNPs RGD PMID:16319130 RGD:5509926 NCBI chrNW_004955432:11,945,383...11,983,417
Ensembl chrNW_004955432:11,942,922...11,983,504
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha no_association ISO No association found for any polymorphisms of PPARA, including rs1800206
DNA:SNP:CDS:rs1800206, p.L162V
RGD PMID:12938026 PMID:17850927 RGD:5561899 RGD:5561928 NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma no_association
susceptibility
ISO DNA:SNPs: :multiple (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:cds:p.P12A(human)
RGD
CTD
PMID:15993441 PMID:16407166 PMID:17440948 PMID:18573313 PMID:30328325 RGD:2301852 RGD:2311642 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha disease_progression ISO mRNA, protein:decreased expression:hippocampal formation (human) RGD PMID:19273754 PMID:22510382 PMID:22540007 RGD:6484260 RGD:7242017 RGD:7242180 NCBI chrNW_004955480:543,397...1,188,376
Ensembl chrNW_004955480:1,078,322...1,188,435
JBrowse link
G Ppp1r9b protein phosphatase 1 regulatory subunit 9B severity ISO protein:decreased expression:brain, synaptosome (human)
protein:decreased expression:cerebral cortex (mouse)
RGD PMID:23764848 RGD:10043802 NCBI chrNW_004955451:11,516,548...11,530,263
Ensembl chrNW_004955451:11,516,548...11,530,830
JBrowse link
G Ppp2r2b protein phosphatase 2 regulatory subunit Bbeta ISO DNA:repeat RGD PMID:21029765 RGD:5686295 NCBI chrNW_004955415:7,054,296...7,510,179
Ensembl chrNW_004955415:7,090,671...7,511,995
JBrowse link
G Ppp3r1 protein phosphatase 3 regulatory subunit B, alpha disease_progression ISO DNA:SNP: :rs1868402 (human) RGD PMID:21223993 PMID:23727081 RGD:13830878 RGD:13830879 NCBI chrNW_004955424:16,624,214...16,690,783
Ensembl chrNW_004955424:16,623,917...16,690,783
JBrowse link
G Prkcb protein kinase C beta ISO RGD PMID:8534418 RGD:13825140 NCBI chrNW_004955493:2,395,494...2,710,522
Ensembl chrNW_004955493:2,395,109...2,710,934
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase treatment ISO protein:increased expression:vessel,astrocyte: RGD PMID:19716418 PMID:24105468 RGD:10412735 RGD:10412736 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152
JBrowse link
G Prnp prion protein ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, susceptibility to ClinVar PMID:1353341 PMID:1677164 PMID:1682813 PMID:1684089 PMID:1971924 More... NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644
JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease ClinVar PMID:8773614 PMID:9384602 PMID:9851443 PMID:9851450 PMID:9915968 More... NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
G Psen2 presenilin 2 severity ISO DNA:missense mutation:cds:p.N141I (human)
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
RGD
ClinVar
PMID:9384602 PMID:10976645 PMID:11723295 PMID:14623725 PMID:15130954 More... RGD:9743900 NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234
JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:22044482 RGD:6483525 NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:cerebral cortex RGD PMID:10560656 PMID:20157512 PMID:21701788 RGD:5688147 RGD:5688156 RGD:5688249 NCBI chrNW_004955419:5,678,750...5,699,305
Ensembl chrNW_004955419:5,678,694...5,699,305
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:decreased expression:neocortex, hippocampus RGD PMID:8892355 PMID:9740394 PMID:21701788 RGD:5688147 RGD:5688252 RGD:5688254 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955403:49,856,056...49,970,800
Ensembl chrNW_004955403:49,855,541...49,973,225
JBrowse link
G Ptpn5 protein tyrosine phosphatase non-receptor type 5 severity ISO protein:increased expression:prefrontal cortex (human)
protein:increased expression:dentate gyrus (mouse)
RGD PMID:16237174 PMID:20427654 PMID:20956308 RGD:10044037 RGD:9835007 RGD:9835008 NCBI chrNW_004955414:33,381,783...33,436,974
Ensembl chrNW_004955414:33,377,322...33,437,118
JBrowse link
G Rbm11 RNA binding motif protein 11 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:16,071,186...16,082,332
Ensembl chrNW_004955407:16,071,208...16,081,949
JBrowse link
G Rcan1 regulator of calcineurin 1 ISO RGD PMID:11483593 RGD:1580889 NCBI chrNW_004955407:33,873,427...33,951,762
Ensembl chrNW_004955407:33,873,383...33,951,498
JBrowse link
G Reln reelin ISO protein: increased expression: brain
protein:increased expression:cerebrospinal fluid (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12645087 PMID:20025970 PMID:20610758 RGD:13207521 RGD:729771 NCBI chrNW_004955410:8,424,439...8,863,966
Ensembl chrNW_004955410:8,424,394...8,863,969
JBrowse link
G Runx1 RUNX family transcription factor 1 ISO associated with Down Syndrome RGD PMID:20946940 RGD:6482829 NCBI chrNW_004955407:34,108,653...34,342,657
Ensembl chrNW_004955407:34,104,035...34,342,928
JBrowse link
G S100b S100 calcium binding protein B severity ISO protein:decreased expression:cerebrospinal fluid RGD PMID:19705461 PMID:20105309 PMID:20953641 PMID:21080947 RGD:5508775 RGD:5508780 RGD:5508787 RGD:5508798 NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510
JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:16,329,838...16,377,763
Ensembl chrNW_004955407:16,329,288...16,378,062
JBrowse link
G Sell selectin L severity ISO protein:decreased expression:plasma RGD PMID:21484243 RGD:5685677 NCBI chrNW_004955462:7,591,997...7,611,408
Ensembl chrNW_004955462:7,591,366...7,612,846
JBrowse link
G Selp selectin P severity ISO protein:decreased expression:plasma RGD PMID:21484243 RGD:5685677 NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994
JBrowse link
G Serpine2 serpin family E member 2 ISO RGD PMID:2813392 RGD:2317937 NCBI chrNW_004955453:10,049,822...10,076,155
Ensembl chrNW_004955453:10,027,104...10,076,645
JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:cerebrospinal fluid, serum (human) RGD PMID:17073149 PMID:28320113 RGD:2312353 RGD:27226702 NCBI chrNW_004955481:1,414,930...1,426,436
Ensembl chrNW_004955481:1,414,930...1,426,241
JBrowse link
G Shc1 SHC adaptor protein 1 ISO protein:increased phosphorylation:neuron RGD PMID:15837797 RGD:1643185 NCBI chrNW_004955545:1,468,391...1,479,209
Ensembl chrNW_004955545:1,468,391...1,476,814
JBrowse link
G Sirt1 sirtuin 1 treatment ISO protein:increased expression:forebrain (mouse) RGD PMID:16751189 PMID:17581637 RGD:10047116 RGD:2290573 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
JBrowse link
G Sirt3 sirtuin 3 ISO mRNA:increased expression:temporal cortex
mRNA:increased expression:brain
RGD PMID:23139766 RGD:9586045 NCBI chrNW_004955476:11,794,951...11,826,244
Ensembl chrNW_004955476:11,794,951...11,826,237
JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO mRNA:decreased expression:cerebral cortex
mRNA, protein:decreased expression:frontal association cortex
RGD PMID:21333939 PMID:21743130 RGD:5686430 RGD:5686673 NCBI chrNW_004955556:696,779...698,869
Ensembl chrNW_004955556:696,974...698,566
JBrowse link
G Slc25a4 solute carrier family 25 member 4 ISO RGD PMID:21958963 RGD:9681463 NCBI chrNW_004955403:23,878,329...23,882,322
Ensembl chrNW_004955403:23,878,329...23,882,322
JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO RGD PMID:8179300 RGD:2313620 NCBI chrNW_004955537:2,408,042...2,438,788
Ensembl chrNW_004955537:2,408,042...2,439,511
JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24055495 NCBI chrNW_004955467:9,630,304...9,636,005
Ensembl chrNW_004955467:9,630,304...9,636,005
JBrowse link
G Slc30a4 solute carrier family 30 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16580781 NCBI chrNW_004955409:7,963,454...7,991,600
Ensembl chrNW_004955409:7,963,454...7,995,027
JBrowse link
G Slc30a6 solute carrier family 30 member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16580781 NCBI chrNW_004955441:528,256...567,382
Ensembl chrNW_004955441:528,234...567,382
JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO protein:altered expression:synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chrNW_004955441:7,653,107...8,037,784
Ensembl chrNW_004955441:7,656,031...7,957,640
JBrowse link
G Slc8a2 solute carrier family 8 member A2 ISO protein:altered expression:synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chrNW_004955574:1,290,907...1,315,399
Ensembl chrNW_004955574:1,288,952...1,315,401
JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO protein:altered expression:parietal cortex, synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chrNW_004955466:220,346...359,627
Ensembl chrNW_004955466:220,099...360,851
JBrowse link
G Snap91 synaptosome associated protein 91 ISO protein:decreased expression:dentate gyrus molecular layer,hippocampus,entorhinal, tempocampal corteces:
denntate gyrus, hippocampus, entorhinal cortex
RGD PMID:20847448 RGD:13506238 NCBI chrNW_004955411:11,175,587...11,301,145
Ensembl chrNW_004955411:11,175,525...11,300,950
JBrowse link
G Snca synuclein alpha ISO protein:increased expression:cerebrospinal fluid
human gene in a mouse model
RGD PMID:11572944 PMID:18577885 RGD:1302528 RGD:6478792 NCBI chrNW_004955405:854,011...962,741
Ensembl chrNW_004955405:853,946...965,403
JBrowse link
G Sncb synuclein beta ISO mRNA:decreased expression:brain RGD PMID:11578596 RGD:6480194 NCBI chrNW_004955408:28,894,204...28,903,095
Ensembl chrNW_004955408:28,894,204...28,903,095
JBrowse link
G Sncg synuclein gamma ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chrNW_004955510:5,958,276...5,961,719
Ensembl chrNW_004955510:5,958,276...5,961,719
JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 ISO protein:increased expression:cerebral cortex (human) RGD PMID:24023061 RGD:10448959 NCBI chrNW_004955559:1,618,246...1,634,144
Ensembl chrNW_004955559:1,614,039...1,634,142
JBrowse link
G Snrpa small nuclear ribonucleoprotein polypeptide A ISO protein:increased expression:cerebral cortex (human) RGD PMID:24023061 RGD:10448959 NCBI chrNW_004955578:579,087...590,010
Ensembl chrNW_004955578:579,087...590,010
JBrowse link
G Sod1 superoxide dismutase 1 ISO protein:decreased expression:frontal lobe (human)
mRNA:altered expression:hippocampus, hypothalamus (rat)
RGD PMID:20027333 PMID:22072713 RGD:8655610 RGD:8657017 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:16369462 PMID:19374891 RGD:1579972 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
G Sorl1 sortilin related receptor 1 ISO RGD PMID:15313836 RGD:1581303 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179
JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 ISO protein:decreased expression:parietal cortex (human) RGD PMID:9743567 RGD:1581317 NCBI chrNW_004955416:7,715,536...7,728,759
Ensembl chrNW_004955416:7,715,536...7,729,158
JBrowse link
G Spred2 sprouty related EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955424:19,133,568...19,250,118
Ensembl chrNW_004955424:19,133,568...19,250,118
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO protein:decreased tyrosine phosphorylation:dentate gyrus
protein:decreased tyrosine phosphorylation:dentate gyrus, CA1 field of hippocampus
RGD PMID:18813209 RGD:10403051 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687
JBrowse link
G Stox1 storkhead box 1 severity ISO protein:increased expression:CA4 field of hippocampus (human) RGD PMID:20110611 RGD:11554028 NCBI chrNW_004955437:22,122,296...22,165,848
Ensembl chrNW_004955437:22,124,272...22,165,848
JBrowse link
G Syp synaptophysin ISO protein:decreased expression:dentate gyrus molecular layer,hippocampus,entorhinal, tempocampal corteces:
denntate gyrus, hippocampus, entorhinal cortex
mRNA,protein:decreased expression:hippocampus, temporal cortex
RGD PMID:20847448 RGD:13506238 NCBI chrNW_004955543:675,294...689,579
Ensembl chrNW_004955543:675,294...689,686
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:SNP: :(rs241448)(human) RGD PMID:16595160 RGD:6482265 NCBI chrNW_004955437:1,480,217...1,499,032 JBrowse link
G Tardbp TAR DNA binding protein ISO protein:increased expression:brain
protein:increased expression, phosphorylation:motor cortex
RGD PMID:21070634 PMID:21376022 RGD:5687139 RGD:5687178 NCBI chrNW_004955486:2,656,121...2,674,808
Ensembl chrNW_004955486:2,656,121...2,674,807
JBrowse link
G Tbp TATA-box binding protein ISO protein:increased expression:hippocampus, entorhinal cortex (human) RGD PMID:15193429 RGD:5684338 NCBI chrNW_004955411:3,268,147...3,285,567
Ensembl chrNW_004955411:3,268,147...3,285,077
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase treatment ISO RGD PMID:27190010 RGD:13601984 NCBI chrNW_004955471:11,229,795...11,245,255
Ensembl chrNW_004955471:11,229,273...11,245,375
JBrowse link
G Tfam transcription factor A, mitochondrial susceptibility ISO DNA:SNP:intron:IVS4+113A>G (rs2306604) (human)
DNA:SNP: :rs1937 (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17192785 PMID:17537576 PMID:21799244 RGD:6767575 RGD:6771185 NCBI chrNW_004955425:12,106,506...12,121,625
Ensembl chrNW_004955425:12,106,877...12,120,782
JBrowse link
G Thbd thrombomodulin ISO protein:increased expression:blood RGD PMID:15760641 RGD:5685018 NCBI chrNW_004955415:30,222,830...30,226,406 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:12614934 RGD:1580169 NCBI chrNW_004955506:3,769,113...3,812,896
Ensembl chrNW_004955506:3,768,646...3,813,820
JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:16157451 RGD:1580680 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 ISO protein:decreased expression:brain cortex (human) RGD PMID:18652896 RGD:2317276 NCBI chrNW_004955523:393,632...438,114 JBrowse link
G Tmprss15 transmembrane serine protease 15 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:19,510,453...19,626,668
Ensembl chrNW_004955407:19,510,453...19,626,668
JBrowse link
G Tnf tumor necrosis factor no_association
susceptibility
onset
ISO DNA:polymorphism:promoter:multiple(human)
ClinVar Annotator: match by term: Alzheimer disease, protection against
DNA:polymorphism:promoter:-308G>A(human)
RGD
ClinVar
PMID:10400991 PMID:15468911 PMID:16516271 PMID:16908746 PMID:18834925 More... RGD:13825248 RGD:13825253 RGD:13825256 RGD:13825257 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A no_association ISO protein:increased expression:brain:
protein:increased expression:cerebrospinal fluid:
RGD PMID:17267158 PMID:17724122 PMID:20110607 PMID:21978728 RGD:13825249 RGD:13825266 RGD:13825267 RGD:13825268 NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:decreased expression:brain:
protein:increased expression:cerebrospinal fluid:
RGD PMID:20110607 PMID:21978728 RGD:13825249 RGD:13825268 NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27023435 PMID:29107063 PMID:30319691 PMID:30320580 NCBI chrNW_004955555:1,987,063...1,997,329
Ensembl chrNW_004955555:1,987,261...1,996,886
JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:17581637 RGD:2290573 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15182943 RGD:1580467 NCBI chrNW_004955414:32,803,417...32,828,682
Ensembl chrNW_004955414:32,800,477...32,828,501
JBrowse link
G Tpi1 triosephosphate isomerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19374891 NCBI chrNW_004955413:4,467,615...4,471,594
Ensembl chrNW_004955413:4,467,566...4,471,177
JBrowse link
G Tpp1 tripeptidyl peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10320038 NCBI chrNW_004955414:22,324,847...22,330,912
Ensembl chrNW_004955414:22,324,856...22,330,912
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24663666 PMID:28714976 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:16341938 RGD:1580518 NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362
JBrowse link
G Tspan14 tetraspanin 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chrNW_004955510:463,548...490,635
Ensembl chrNW_004955510:448,668...490,635
JBrowse link
G Ttr transthyretin ISO RGD PMID:16552785 RGD:1580525 NCBI chrNW_004955402:18,921,235...18,927,976
Ensembl chrNW_004955402:18,921,274...18,928,108
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 ISO RGD PMID:14722078 RGD:1580538 NCBI chrNW_004955443:6,367,519...6,379,638
Ensembl chrNW_004955443:6,367,460...6,380,462
JBrowse link
G Ucp1 uncoupling protein 1 ISO protein:decreased expression:plasma (human) RGD PMID:24498895 RGD:10045648 NCBI chrNW_004955428:3,253,363...3,282,518
Ensembl chrNW_004955428:3,274,810...3,283,237
JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chrNW_004955407:17,429,299...17,572,138
Ensembl chrNW_004955407:17,429,299...17,575,262
JBrowse link
G Vcp valosin containing protein ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:30279455 NCBI chrNW_004955472:1,111,649...1,124,076
Ensembl chrNW_004955472:1,107,164...1,124,076
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:15732116 RGD:1580571 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
G Vim vimentin ISO protein:increased expression:brain RGD PMID:19728994 RGD:6480519 NCBI chrNW_004955429:10,708,852...10,716,743
Ensembl chrNW_004955429:10,707,719...10,717,554
JBrowse link
G Vldlr very low density lipoprotein receptor ISO DNA:repeat RGD PMID:7550352 RGD:737739 NCBI chrNW_004955434:7,013,092...7,050,103
Ensembl chrNW_004955434:7,013,092...7,050,103
JBrowse link
G Vps13c vacuolar protein sorting 13 homolog C ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chrNW_004955450:13,016,933...13,178,797
Ensembl chrNW_004955450:13,016,950...13,174,990
JBrowse link
G Vsnl1 visinin like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25806004 NCBI chrNW_004955469:350,983...454,264
Ensembl chrNW_004955469:350,983...454,264
JBrowse link
G Wt1 WT1 transcription factor ISO RGD PMID:12914969 RGD:1580623 NCBI chrNW_004955476:10,464,688...10,504,473
Ensembl chrNW_004955476:10,464,616...10,504,473
JBrowse link
G Wwox WW domain containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30820047 NCBI chrNW_004955522:1,265,732...2,185,372
Ensembl chrNW_004955522:1,265,404...2,184,562
JBrowse link
G Xrn1 5'-3' exoribonuclease 1 susceptibility ISO DNA:snp:intron:c.1883+365T>C (rs1351965) (human) RGD PMID:22984654 RGD:11528589 NCBI chrNW_004955508:3,441,540...3,561,896
Ensembl chrNW_004955508:3,441,683...3,561,805
JBrowse link
Alzheimer's disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: APP POLYMORPHISM | ClinVar Annotator: match by term: Alzheimer disease type 1 | ClinVar Annotator: match by term: Early-onset familial form of Alzheimer disease OMIM
ClinVar
PMID:1303239 PMID:1303275 PMID:1415269 PMID:1520398 PMID:1634237 More... NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Hfe homeostatic iron regulator ISO OMIM NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143
JBrowse link
G Mpo myeloperoxidase ISO OMIM NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
JBrowse link
G Nos3 nitric oxide synthase 3 ISO OMIM NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
JBrowse link
G Plau plasminogen activator, urokinase ISO OMIM NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
JBrowse link
Alzheimer's disease 18 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 susceptibility ISO ClinVar Annotator: match by term: Alzheimer disease 18 OMIM
ClinVar
PMID:19608551 PMID:24055016 NCBI chrNW_004955450:15,853,372...15,927,966
Ensembl chrNW_004955450:15,853,366...15,928,200
JBrowse link
Alzheimer's disease 19 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pld3 phospholipase D family member 3 ISO ClinVar Annotator: match by term: Alzheimer disease 19 ClinVar PMID:24336208 PMID:25832408 PMID:25832410 PMID:25832411 PMID:28492532 NCBI chrNW_004955578:884,700...905,426
Ensembl chrNW_004955578:884,700...894,433
JBrowse link
Alzheimer's disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: Alzheimer disease associated with APOE E4 OMIM
ClinVar
PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
Alzheimer's disease 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO OMIM NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Kif5c kinesin family member 5C ISO protein:decreased expression:cerebellum (human) RGD PMID:24569455 RGD:12859086 NCBI chrNW_004955440:14,754,931...14,854,090
Ensembl chrNW_004955440:14,754,639...14,854,406
JBrowse link
G Lrrk2 leucine rich repeat kinase 2 ISO ClinVar Annotator: match by term: Early onset Alzheimer disease with behavioral disturbance ClinVar PMID:18412265 PMID:18688798 PMID:18716801 PMID:18781329 PMID:19699188 More... NCBI chrNW_004955505:84,324...216,923
Ensembl chrNW_004955505:81,796...216,923
JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE, FAMILIAL, 3 | ClinVar Annotator: match by term: Alzheimer disease 3 | ClinVar Annotator: match by term: Early onset Alzheimer disease with behavioral disturbance OMIM
ClinVar
PMID:1985297 PMID:2025423 PMID:2793034 PMID:7550356 PMID:7581374 More... NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
Alzheimer's disease 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: Alzheimer disease 4 | ClinVar Annotator: match by term: Alzheimer disease familial type 4 ClinVar PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease 4 ClinVar PMID:8910898 PMID:9189043 PMID:9804121 PMID:15205973 PMID:27777022 More... NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
G Psen2 presenilin 2 ISO ClinVar Annotator: match by term: Alzheimer disease 4 OMIM
ClinVar
PMID:7550356 PMID:7638622 PMID:7651536 PMID:8661049 PMID:8939861 More... NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234
JBrowse link
Alzheimer's disease 9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 susceptibility ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE 9, LATE-ONSET | ClinVar Annotator: match by term: Alzheimer disease 9 OMIM
ClinVar
PMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 PMID:28492532 More... NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Sorl1 sortilin related receptor 1 ISO ClinVar Annotator: match by term: Alzheimer disease 9 ClinVar PMID:28789839 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179
JBrowse link
Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease familial 3, with spastic paraparesis ClinVar PMID:24121961 PMID:25741868 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with spastic paraparesis and apraxia ClinVar PMID:11920851 PMID:15534188 PMID:25741868 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Unusual Plaques term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with spastic paraparesis and unusual plaques | ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with unusual plaques | ClinVar Annotator: match by term: Alzheimer disease, familial, with spastic paraparesis and unusual plaques ClinVar PMID:7550356 PMID:8755489 PMID:9172170 PMID:9546792 PMID:10720282 More... NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 OMIM
ClinVar
PMID:6681564 PMID:12080485 PMID:12754369 PMID:12925681 PMID:15883308 More... NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
JBrowse link
Presenile and Senile Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:1303239 PMID:1303275 PMID:1679289 PMID:2111584 PMID:8499923 More... NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23126199 RGD:7193138 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
progressive supranuclear palsy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21685912 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:12392790 RGD:7495833 NCBI chrNW_004955478:3,331,607...3,448,840
Ensembl chrNW_004955478:3,331,607...3,448,842
JBrowse link
G Mapt microtubule associated protein tau onset ISO ClinVar Annotator: match by term: Progressive supranuclear ophthalmoplegia OMIM
ClinVar
RGD
PMID:8673924 PMID:9629852 PMID:9641683 PMID:9736786 PMID:9789048 More... RGD:8158099 NCBI chrNW_004955478:10,222,439...10,271,439
Ensembl chrNW_004955478:10,225,823...10,271,442
JBrowse link
G Mobp myelin associated oligodendrocyte basic protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21685912 NCBI chrNW_004955420:29,902,036...29,957,364 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO protein:increased expression:pontine nucleus, neuron RGD PMID:15841414 RGD:8657142 NCBI chrNW_004955561:1,277,362...1,282,949
Ensembl chrNW_004955561:1,277,365...1,282,793
JBrowse link
G Sod1 superoxide dismutase 1 ISO protein:increased activity:brain (human) RGD PMID:11879807 RGD:8655859 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25402454 NCBI chrNW_004955506:5,569,280...5,572,164
Ensembl chrNW_004955506:5,569,302...5,570,120
JBrowse link
G Stx6 syntaxin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21685912 NCBI chrNW_004955406:20,042,552...20,089,853
Ensembl chrNW_004955406:20,048,155...20,089,906
JBrowse link
G Tardbp TAR DNA binding protein ISO RGD PMID:20512649 RGD:5687185 NCBI chrNW_004955486:2,656,121...2,674,808
Ensembl chrNW_004955486:2,656,121...2,674,807
JBrowse link
G Tra2b transformer 2 beta homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:25402454 NCBI chrNW_004955420:21,707,618...21,728,186
Ensembl chrNW_004955420:21,707,618...21,728,186
JBrowse link
Progressive Supranuclear Palsy Atypical term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule associated protein tau ISO OMIM NCBI chrNW_004955478:10,222,439...10,271,439
Ensembl chrNW_004955478:10,225,823...10,271,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13345
    disease of anatomical entity 13084
      nervous system disease 11139
        neurodegenerative disease 3404
          tauopathy 449
            Alzheimer's disease + 439
            Diffuse Neurofibrillary Tangles with Calcification 0
            progressive supranuclear palsy + 10
Path 2
Term Annotations click to browse term
  disease 13345
    disease of anatomical entity 13084
      nervous system disease 11139
        central nervous system disease 9780
          neurodegenerative disease 3404
            tauopathy 449
              Alzheimer's disease + 439
              Diffuse Neurofibrillary Tangles with Calcification 0
              progressive supranuclear palsy + 10
paths to the root