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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:amphetamine abuse
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Accession:DOID:670 term browser browse the term
Definition:A substance abuse that involves the recurring use of amphetamines despite negative consequences. (DO)
Synonyms:exact_synonym: amphetamine use disorder;   amphetamine-related disorder;   amphetamine-related disorders
 narrow_synonym: Amphetamine Addiction;   Amphetamine Dependence;   METHAMPHETAMINE USE DISORDER;   methamphetamine dependence
 primary_id: MESH:D019969
 xref: EFO:0004701;   ICD9CM:305.7
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
amphetamine abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16470869 NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:127,373,306...127,434,954
Ensembl chr 5:133,537,292...133,586,711 		JBrowse link
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189 		JBrowse link
G AK5 adenylate kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:76,499,046...76,778,856
Ensembl chr 1:78,584,653...78,863,844 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 susceptibility
no_association 		ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs3730358)
DNA:SNPs:introns: (rs2494743, 2498794) 		CTD
RGD		 PMID:15982448 PMID:31654273 RGD:407419878 RGD:407419880 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G AOAH acyloxyacyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 7:37,138,486...37,362,655
Ensembl chr 7:37,363,741...37,589,358 		JBrowse link
G ARC activity regulated cytoskeleton associated protein disease_progression ISO mRNA:increased expression:brain (mouse) RGD PMID:25959066 RGD:401938592 NCBI chr 8:139,320,366...139,323,802
Ensembl chr 8:142,367,995...142,369,185 		JBrowse link
G ARRB2 arrestin beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17233643 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G ASTN2 astrotactin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 9:87,558,337...88,538,570
Ensembl chr 9:115,912,657...116,890,931 		JBrowse link
G BDNF brain derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:frontal cortex, striatum
protein:increased expression:nucleus accumbens, ventral tegmental area
mRNA:increased expression:nucleus accumbens, dorsal striatum
protein:decreased expression:hippocampus 		CTD
RGD		 PMID:20736000 PMID:24407463 PMID:31693929 PMID:33961872 PMID:37904065 RGD:401976437 RGD:596936246 RGD:596938173 RGD:597015747 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CARTPT CART prepropeptide ISO mRNA:increased expression:striatum RGD PMID:28827541 RGD:407984842 NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229 		JBrowse link
G CAT catalase treatment ISO RGD PMID:24445072 RGD:405255657 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCHCR1 coiled-coil alpha-helical rod protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:30,888,542...30,904,382
Ensembl chr 6:31,753,777...31,772,934 		JBrowse link
G CD4 CD4 molecule ISO protein:decreased expression:spleen (rat) RGD PMID:25678251 RGD:407446373 NCBI chr12:6,920,587...6,951,814
Ensembl chr12:6,834,011...6,864,204 		JBrowse link
G CD55 CD55 molecule (Cromer blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:182,923,369...182,962,518
Ensembl chr 1:187,201,081...187,240,350 		JBrowse link
G CD8A CD8 subunit alpha ISO protein:increased expression:spleen (rat) RGD PMID:25678251 RGD:407446373 NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635 		JBrowse link
G CDH13 cadherin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:63,255,482...64,418,053
Ensembl chr16:82,883,184...83,808,996 		JBrowse link
G CDK5 cyclin dependent kinase 5 ISO protein:increased expression:ventral tegmental area, nucleus accumbens (mouse) RGD PMID:28782589 RGD:401900303 NCBI chr 7:142,640,630...142,644,785
Ensembl chr 7:154,793,344...154,797,499 		JBrowse link
G CFH complement factor H ISO protein:increased expression:serum:
protein:increased expression:serum, hippocampus: 		RGD PMID:22871478 RGD:7364944 NCBI chr 1:172,155,882...172,251,632
Ensembl chr 1:176,455,247...176,525,521 		JBrowse link
G COL28A1 collagen type XXVIII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 7:8,093,060...8,260,276
Ensembl chr 7:7,446,107...7,611,876 		JBrowse link
G COMT catechol-O-methyltransferase susceptibility ISO ClinVar Annotator: match by term: methamphetamine use disorder
DNA:SNP:cd: p.V158M (human)
DNA:SNPs,haplotypes:exon,3'utr: (rs4680, rs165599) (human) 		ClinVar
RGD		 PMID:15274053 PMID:17187009 PMID:21934638 PMID:25741868 PMID:33544778 RGD:401940124 RGD:401940147 RGD:401940150 RGD:401959602 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment ISO protein:increases activity:ventral tegmental area, nucleus accumbens (mouse)
mRNA:decreased expression:nucleus accumbens
protein:increased expression, increased phosphorylation:nucleus accumbens, ventral tegmental area 		RGD PMID:28782589 PMID:31900897 PMID:33961872 RGD:401900303 RGD:401938636 RGD:596936246 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130 		JBrowse link
G CSMD1 CUB and Sushi multiple domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:2,282,763...4,351,724
Ensembl chr 8:2,838,803...4,923,373 		JBrowse link
G CUBN cubilin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr10:17,141,464...17,446,867
Ensembl chr10:17,415,551...17,719,129 		JBrowse link
G DCSTAMP dendrocyte expressed seven transmembrane protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:100,967,757...100,985,384
Ensembl chr 8:103,121,332...103,138,223 		JBrowse link
G DRD1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18363855 PMID:19444617 NCBI chr 5:170,787,115...170,792,383
Ensembl chr 5:177,688,917...177,690,257 		JBrowse link
G DRD2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18363855 PMID:18555060 PMID:19940168 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G DRD3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19940168 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403 		JBrowse link
G DRD4 dopamine receptor D4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274053 NCBI chr11:640,401...646,775 JBrowse link
G EPHX1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19598248 NCBI chr 1:201,271,366...201,306,635
Ensembl chr 1:206,272,866...206,307,581 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 3:59,670,777...61,177,974 JBrowse link
G FKBP15 FKBP prolyl isomerase family member 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 9:84,259,335...84,321,085
Ensembl chr 9:112,637,110...112,693,319 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:nucleus accumbens,striatum
mRNA:increased expression:nucleus accumbens 		CTD
RGD		 PMID:18834549 PMID:19689456 PMID:24183790 RGD:405100720 RGD:405255667 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:ventral tegmental area, nucleus accumbens (mouse)
associated with stress related disorder;protein:increased expression:brain (rat) 		RGD PMID:27672362 PMID:28782589 PMID:31373119 RGD:401900303 RGD:401900735 RGD:401901183 NCBI chr19:42,416,781...42,424,003
Ensembl chr19:51,013,350...51,020,570 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility ISO DNA:SNPs, halotypes:intron (rs2076483,rs29221,rs715044) (human) RGD PMID:30143926 RGD:401940101 NCBI chr 6:29,405,026...29,437,108
Ensembl chr 6:30,065,119...30,095,304 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 sexual_dimorphism ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:exon 8:p.K289M (rs4480617) (human) 		CTD
RGD		 PMID:14569258 PMID:15772696 RGD:402528887 NCBI chr 5:157,436,113...157,529,586
Ensembl chr 5:164,068,122...164,222,179 		JBrowse link
G GAD1 glutamate decarboxylase 1 susceptibility ISO DNA:haplotype: :rs769404���rs701492(human) RGD PMID:27967329 RGD:401900122 NCBI chr2B:58,100,623...58,145,045
Ensembl chr2B:175,558,538...175,602,944 		JBrowse link
G GAD2 glutamate decarboxylase 2 susceptibility ISO DNA:SNP: :rs2236418(human) RGD PMID:27967329 RGD:401900122 NCBI chr10:26,392,877...26,481,859
Ensembl chr10:26,759,243...26,843,197 		JBrowse link
G GDNF glial cell derived neurotrophic factor treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:nucleus accumbens, ventral tegmental area 		CTD
RGD		 PMID:17356005 PMID:23432945 PMID:37904065 RGD:405850210 RGD:596938173 NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO methamphetamine abuse;protein:increased expression:hippocampal formation, striatum, prefrontal cortex (rat) RGD PMID:37778205 RGD:405100237 NCBI chr 5:148,879,996...149,206,914
Ensembl chr 5:154,879,080...155,204,660 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 ISO RGD PMID:16311338 RGD:596933067 NCBI chr 4:149,566,563...149,712,135
Ensembl chr 4:161,380,933...161,524,376 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr 3:51,639,792...51,652,779
Ensembl chr 3:52,873,144...52,884,395 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 ameliorates ISO RGD PMID:18991866 RGD:598099550 NCBI chr11:83,514,978...84,077,650
Ensembl chr11:87,107,788...87,868,953 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19254865 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G HDAC8 histone deacetylase 8 ISO mRNA:decreased expression:striatum (rat) RGD PMID:25452209 RGD:9681719 NCBI chr  X:61,565,790...61,811,588
Ensembl chr  X:71,649,341...71,894,896 		JBrowse link
G HS3ST4 heparan sulfate-glucosamine 3-sulfotransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 Ensembl chr16:26,067,523...26,506,875 JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO CTD Direct Evidence: therapeutic CTD PMID:10780831 NCBI chr 6:75,309,078...75,313,747
Ensembl chr 6:78,596,408...78,597,580 		JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr11:108,851,954...108,869,119
Ensembl chr11:112,695,891...112,711,695 		JBrowse link
G HTR6 5-hydroxytryptamine receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr 1:18,619,683...18,635,822
Ensembl chr 1:19,662,978...19,678,680 		JBrowse link
G IL6 interleukin 6 ISO mRNA:increased expression:ventral tegmental area RGD PMID:31282647 RGD:598092520 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G LARGE1 LARGE xylosyl- and glucuronyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr22:14,077,463...14,929,250 JBrowse link
G LINGO2 leucine rich repeat and Ig domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 9:27,760,276...29,008,800
Ensembl chr 9:28,377,472...28,379,292 		JBrowse link
G LOC100988273 cytochrome P450 2D6-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:18280655 NCBI chr22:23,022,449...23,031,627 JBrowse link
G MAP2K5 mitogen-activated protein kinase kinase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr15:46,493,139...46,760,271
Ensembl chr15:64,761,394...65,029,655 		JBrowse link
G MB myoglobin ISO RGD PMID:12935649 RGD:458925289 NCBI chr22:16,612,519...16,645,333
Ensembl chr22:34,452,451...34,463,224 		JBrowse link
G MTARC1 mitochondrial amidoxime reducing component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:196,373,028...196,405,115
Ensembl chr 1:201,407,390...201,435,186 		JBrowse link
G MTARC2 mitochondrial amidoxime reducing component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:196,333,803...196,371,147
Ensembl chr 1:201,369,424...201,405,602 		JBrowse link
G MYO5B myosin VB ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr18:43,207,387...43,575,951
Ensembl chr18:46,555,259...46,786,223 		JBrowse link
G NOS1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542708 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs7687423) (human) 		CTD
RGD		 PMID:19566775 RGD:402463941 NCBI chr 4:155,583,870...155,604,336
Ensembl chr 4:167,372,310...167,381,597 		JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO mRNA:increased expression:nucleus accumbens
protein:increased expression:frontal cortex, striatum
protein:altered expression:nucleus accumbens, ventral tegmental area 		RGD PMID:31693929 PMID:33961872 PMID:34273388 PMID:37904065 RGD:596936246 RGD:596938171 RGD:596938173 RGD:597015747 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr 6:151,827,323...151,937,658
Ensembl chr 6:156,517,661...157,088,251 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO mRNA:increased expression:nucleus accumbens RGD PMID:28827541 RGD:407984842 NCBI chr20:3,157,246...3,159,013 JBrowse link
G PCOLCE2 procollagen C-endopeptidase enhancer 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 3:139,851,001...139,922,955
Ensembl chr 3:147,442,307...147,514,234 		JBrowse link
G PDE4B phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:65,038,120...65,620,764
Ensembl chr 1:67,045,911...67,506,291 		JBrowse link
G PDE4D phosphodiesterase 4D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 5:53,510,287...55,039,181
Ensembl chr 5:55,749,214...56,670,111 		JBrowse link
G PDE6C phosphodiesterase 6C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr10:90,361,003...90,414,169
Ensembl chr10:93,871,704...93,924,654 		JBrowse link
G PDYN prodynorphin ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:nucleus acccumbens
mRNA:increased expression:central amygdaloid nucleus
mRNA:increased expression:nucleus accumbens
mRNA:altered expression:brain
DNA:repeat:promoter:rs35286251 (human) 		CTD
RGD		 PMID:12523490 PMID:16289352 PMID:16529859 PMID:22390687 PMID:27989838 RGD:401850552 RGD:401850564 RGD:401850585 RGD:401851043 RGD:401851910 NCBI chr20:2,092,171...2,108,141
Ensembl chr20:1,856,850...1,872,452 		JBrowse link
G PICK1 protein interacting with PRKCA 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 Ensembl chr22:36,796,015...36,814,469 JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15659235 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G POU5F1 POU class 5 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426 		JBrowse link
G PRDM2 PR/SET domain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:12,838,201...12,963,735
Ensembl chr 1:13,853,895...13,961,610
Ensembl chr 1:13,853,895...13,961,610 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha treatment ISO protein:increased expression, increased phosphorylation:nucleus accumbens, ventral tegmental area RGD PMID:31900897 RGD:401938636 NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882 		JBrowse link
G PROKR2 prokineticin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20576534 NCBI chr20:5,311,043...5,319,148
Ensembl chr20:5,102,997...5,106,655 		JBrowse link
G PSD3 pleckstrin and Sec7 domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:17,758,287...18,308,876
Ensembl chr 8:14,714,575...15,258,823 		JBrowse link
G RALY RALY heterogeneous nuclear ribonucleoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr20:30,285,024...30,371,039
Ensembl chr20:31,501,993...31,510,187 		JBrowse link
G RAPGEF5 Rap guanine nucleotide exchange factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 7:22,806,855...23,047,663
Ensembl chr 7:22,122,434...22,317,650 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G RGS17 regulator of G protein signaling 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 6:150,826,838...150,953,386
Ensembl chr 6:155,521,826...155,555,151 		JBrowse link
G SERPINA5 serpin family A member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr14:75,205,446...75,217,114
Ensembl chr14:94,537,115...94,548,803 		JBrowse link
G SGCZ sarcoglycan zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 8:13,317,804...14,493,908 JBrowse link
G SH3RF3 SH3 domain containing ring finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr2A:92,137,951...92,519,627
Ensembl chr2A:110,848,452...111,219,915 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 Ensembl chr 5:1,437,567...1,488,829 JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19689456 NCBI chr17:26,546,177...26,572,301
Ensembl chr17:27,050,900...27,092,882 		JBrowse link
G SLC6A9 solute carrier family 6 member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17582620 NCBI chr 1:43,298,326...43,333,345
Ensembl chr 1:44,664,839...44,704,882 		JBrowse link
G SMYD3 SET and MYND domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:221,371,348...222,125,774
Ensembl chr 1:226,737,960...227,481,191 		JBrowse link
G SNCA synuclein alpha treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:15542733 PMID:20551914 PMID:32278788 RGD:13506280 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600 		JBrowse link
G TPH2 tryptophan hydroxylase 2 ISO protein:decreased expression:hippocampus RGD PMID:26747301 RGD:597805906 NCBI chr12:69,460,883...69,557,329
Ensembl chr12:72,318,908...72,412,557 		JBrowse link
G TRPM3 transient receptor potential cation channel subfamily M member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 9:53,367,505...54,272,917
Ensembl chr 9:69,292,593...69,606,949 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO mRNA:increased expression:frontal cortex RGD PMID:20122992 RGD:598130087 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579 		JBrowse link
G USP48 ubiquitin specific peptidase 48 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 1:20,870,023...20,974,251
Ensembl chr 1:21,834,638...21,939,250 		JBrowse link
G ZNF385D zinc finger protein 385D ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr 3:21,337,891...22,298,849
Ensembl chr 3:21,666,712...21,996,645 		JBrowse link
G ZNF423 zinc finger protein 423 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18316681 NCBI chr16:29,748,405...30,118,999
Ensembl chr16:48,639,118...48,969,727 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15838
    Chemically-Induced Disorders 1273
      substance-related disorder 694
        substance abuse 245
          amphetamine abuse 96
Path 2
Term Annotations click to browse term
  disease 15838
    disease of anatomical entity 15494
      nervous system disease 13588
        central nervous system disease 12160
          brain disease 11426
            disease of mental health 8276
              substance-related disorder 694
                substance abuse 245
                  amphetamine abuse 96
paths to the root