Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:progressive multifocal leukoencephalopathy
go back to main search page
Accession:DOID:643 term browser browse the term
Definition:An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Synonyms:exact_synonym: JC Polyomavirus Encephalitis;   JC Polyomavirus Encephalopathy;   PML;   encephalopathies, JC polyomavirus;   progressive multifocal leukoencephalopathies
 primary_id: MESH:D007968
 alt_id: RDO:0005998
 xref: GARD:7468;   ICD10CM:A81.2;   ICD9CM:046.3;   NCI:C26815
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
progressive multifocal leukoencephalopathy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nefl neurofilament light chain ISO associated with relapsing-remitting multiple sclerosis;protein:increased expression:serum (human) RGD PMID:33903203 PMID:30761586 RGD:127284888, RGD:127285025 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    disease by infectious agent 1920
      viral infectious disease 1573
        Slow Virus Diseases 47
          progressive multifocal leukoencephalopathy 1
Path 2
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      nervous system disease 12154
        central nervous system disease 10420
          brain disease 9782
            encephalitis 92
              Infectious Encephalitis 70
                viral encephalitis 70
                  progressive multifocal leukoencephalopathy 1
paths to the root