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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:bronchitis
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Accession:DOID:6132 term browser browse the term
Definition:A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness. (DO)
Synonyms:exact_synonym: Bronchitides;   CI - chest infection;   acute bronchitis;   chest cold;   chest infection;   chronic bronchitis;   recurrent wheezy bronchitis
 narrow_synonym: RECURRENT BRONCHITIS
 related_synonym: acute bronchitis and bronchiolitis
 primary_id: MESH:D001991
 xref: EFO:0009661;   ICD10CM:J20;   ICD10CM:J40;   ICD10CM:J42;   ICD9CM:466.0;   ICD9CM:490;   ICD9CM:491;   NCI:C26722;   NCI:C26932;   NCI:C2911
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
bronchitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO DNA:polymorphism (human) RGD PMID:14593914 RGD:4889126 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G EGR1 early growth response 1 ISO RGD PMID:17384085 RGD:5132266 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296 		JBrowse link
G HDAC2 histone deacetylase 2 treatment ISO RGD PMID:22708526 RGD:9590258 NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585 		JBrowse link
G IFNG interferon gamma resistance ISO RGD PMID:20953328 RGD:4145525 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
bronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 ISO RGD PMID:17687719 RGD:4145098 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,033,579...150,040,731 		JBrowse link
G CCL11 chemokine (C-C motif) ligand 11 severity ISO associated with Respiratory Syncytial Virus Infections
protein:increased expression:nasal mucus		 RGD PMID:15681407 PMID:17297249 RGD:4145415 RGD:4145460 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CD40 CD40 molecule ISO RGD PMID:19470255 RGD:5132271 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G CD86 CD86 molecule ISO protein:decreased expression:myeloid dendritic cell (mouse) RGD PMID:20046053 RGD:4892291 NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310 		JBrowse link
G CRP C-reactive protein, pentraxin-related severity ISO RGD PMID:21284715 RGD:5131282 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 ISO associated with Pneumovirus Infections RGD PMID:16337014 RGD:4843953 NCBI chr  X:62,380,778...62,407,736
Ensembl chr  X:62,380,780...62,456,689 		JBrowse link
G IL17A interleukin 17A susceptibility ISO DNA:SNP:promoter:rs2275913 (human) RGD PMID:20437253 RGD:4889139 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO protein:increased expression:lung RGD PMID:8608647 RGD:4143192
G LOC110258578 interleukin-1 beta-like ISO protein:increased expression:lung RGD PMID:8608647 RGD:4143192
G MUC5B mucin 5B, oligomeric mucus/gel-forming ISO DNA:polymorphisms:promoter:rs885454,rs17235353, rs7115457 (human) RGD PMID:15709052 RGD:7349353 NCBI chr 2:807,685...842,096 JBrowse link
bronchiolitis obliterans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:17097496 RGD:4140933 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G ADORA2A adenosine A2a receptor ISO RGD PMID:19766783 RGD:4890362 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO RGD PMID:18785972 RGD:4145604 NCBI chr 6:19,345,929...19,372,972
Ensembl chr 6:19,345,941...19,348,926 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO RGD PMID:14611812 RGD:2307195 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO RGD PMID:20628341 RGD:4891471 NCBI chr 6:19,296,726...19,301,506
Ensembl chr 6:19,296,637...19,302,737 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:lung (rat) RGD PMID:14611812 PMID:19840961 RGD:2307195 RGD:4889978 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:trachea: RGD PMID:11518728 RGD:4145124 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343 		JBrowse link
G CD86 CD86 molecule ISO RGD PMID:11266944 RGD:2307206 NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310 		JBrowse link
G CSF2 colony stimulating factor 2 ISO associated with Respiratory Aspiration;protein:increased expression:serum RGD PMID:18557728 RGD:2317286 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412 PMID:16709871 RGD:5135441 RGD:5135451 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412 RGD:5135451 NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412 PMID:16709871 RGD:5135441 RGD:5135451 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:12097412 PMID:16709871 RGD:5135441 RGD:5135451 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G EDN1 endothelin 1 ISO human gene in a rat model RGD PMID:9595474 RGD:8662402 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G FOXP3 forkhead box P3 ISO mRNA:increased expression:lung RGD PMID:19840961 RGD:4889978 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) ISO RGD PMID:19737140 RGD:5135518 NCBI chr 7:74,705,499...74,708,781
Ensembl chr 7:74,705,409...74,708,790 		JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:12973103 RGD:4145412
G IFNG interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:16137903 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17182591 RGD:4146242 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL13RA1 interleukin 13 receptor subunit alpha 1 ISO RGD PMID:17182591 RGD:4146242 NCBI chr  X:97,300,960...97,353,754
Ensembl chr  X:97,300,466...97,356,133 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:17182591 RGD:4146242 NCBI chr  X:94,402,665...94,455,609
Ensembl chr  X:94,402,676...94,439,060 		JBrowse link
G IL17A interleukin 17A ISO mRNA:increased expression:trachea RGD PMID:20393404 RGD:4143277 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO protein:increased expression:lung RGD PMID:11889437 RGD:4143176
G IL4 interleukin 4 ISO protein:increased expression:serum RGD PMID:18557728 RGD:2317286 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL6 interleukin 6 ISO RGD PMID:20393404 RGD:4143277 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G MBL2 mannose binding lectin 2 resistance ISO DNA:transversion:5' utr:-290C>G rs7096206 (human) RGD PMID:19104434 RGD:4889456 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:20417130 RGD:5130759 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:16969297 RGD:5131273 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:18158963 RGD:5131450 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO associated with lung transplantation; protein:increased expression:lung RGD PMID:11112135 RGD:4892082 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO protein:increased expression:lung RGD PMID:15136885 RGD:4892068 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO associated with lung transplantation; protein:decreased expression:serum,bronchoalveolar lavage RGD PMID:11981419 RGD:5147386 NCBI chr 2:9,297,282...9,302,204
Ensembl chr 2:9,297,283...9,302,165 		JBrowse link
G SFTPD surfactant protein D ISO RGD PMID:18347569 RGD:4143500 NCBI chr14:82,051,400...82,069,258
Ensembl chr14:82,051,451...82,067,976 		JBrowse link
G TLR9 toll like receptor 9 ISO DNA:SNPs:promoter, 3' utr:g.-1485C>T (rs187084), rs352162 (human) RGD PMID:20227302 RGD:5130722 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
Chronic Bronchitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL11 chemokine (C-C motif) ligand 11 ISO RGD PMID:11991282 RGD:4145442 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CFTR CF transmembrane conductance regulator susceptibility ISO DNA:deletion: :F508del(human)
associated with pulmonary disease chronic obstructive; DNA:missense mutation:exon:p.R75Q(human)		 RGD PMID:10767489 PMID:15463907 RGD:4140475 RGD:4140484 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO DNA:SNPs: :multiple (human) RGD PMID:19386687 RGD:4891509 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 susceptibility ISO DNA:polymorphism (human) RGD PMID:15928955 RGD:4142512 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO DNA:polymorphism (human) RGD PMID:14593914 RGD:4889126 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G EDN1 endothelin 1 ISO Chronic Allergic Airway Inflammation; protein:increased secretion:bronchoalveolar lavage (mouse) RGD PMID:18631350 RGD:4145074 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G GC GC vitamin D binding protein susceptibility ISO RGD PMID:12096683 RGD:5129516 NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:bronchial epithelium (rat) RGD PMID:19507274 RGD:2308951 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IL10 interleukin 10 ISO protein:decreased expression:lung RGD PMID:19507274 RGD:2308951 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL13 interleukin 13 ISO protein:increased expression:Respiratory Mucosa RGD PMID:14582911 RGD:4759835 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL15 interleukin 15 ISO mRNA, protein:increased expression:lung RGD PMID:11742275 RGD:4990461 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G MPO myeloperoxidase ISO protein:increased expression:lung RGD PMID:11798689 RGD:5130990 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:19938219 RGD:4891494 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NPY neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:9731035 NCBI chr18:47,985,796...47,993,726
Ensembl chr18:47,985,725...47,992,667 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19263519 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
cryptogenic organizing pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:lung, macrophage (human) RGD PMID:21144722 RGD:5131112 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO protein:increased expression:lung, lymphocyte (human) RGD PMID:21144722 RGD:5131112 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147 		JBrowse link
Diffuse Panbronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:SNP:exon:p.G54D(rs1800450)(human) RGD PMID:15249448 RGD:8693755 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO protein:decreased expression:bronchiole epithelium RGD PMID:15364771 RGD:7364741 NCBI chr 2:757,897...790,321 JBrowse link
G MUC5B mucin 5B, oligomeric mucus/gel-forming ISO DNA:insertion/deletion RGD PMID:15709052 RGD:7349353 NCBI chr 2:807,685...842,096 JBrowse link
G MUCL3 mucin like 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22152429 NCBI chr 7:23,429,415...23,440,523 JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:polymorphisms:exon: RGD PMID:10323341 RGD:5147847 NCBI chr 7:25,045,085...25,056,915
Ensembl chr 7:25,045,685...25,056,300 		JBrowse link
Viral Bronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNP: :rs2787094 c.2891G>C (human) RGD PMID:19258923 RGD:4142862 NCBI chr17:32,023,102...32,038,464
Ensembl chr17:32,023,091...32,037,880 		JBrowse link
G BCL2 BCL2 apoptosis regulator severity ISO protein:increased expression:natural killer cell, T cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G BCL2L1 BCL2 like 1 severity ISO protein:increased expression:natural killer cell,t cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G C3 complement C3 resistance ISO RGD PMID:12235218 PMID:19258923 RGD:4142862 RGD:5129513 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase ISO RGD PMID:15196254 RGD:5130189 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328 		JBrowse link
G CAT catalase ISO protein:decreased expression:nasal mucus
protein:decreased expression:lung		 RGD PMID:21471094 RGD:5130770 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 susceptibility ISO protein:increased secretion:serum (human)
DNA:snp:5' utr:g.-28C>G (human)		 RGD PMID:19005677 PMID:19099677 RGD:4891881 RGD:4891884 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CD14 CD14 molecule ISO DNA:polymorphism:promoter:c.-550C>T (human) RGD PMID:17471431 RGD:4144210 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CD274 CD274 molecule treatment ISO mRNA:increased expression:lung RGD PMID:22797302 RGD:40818270 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G CSF2 colony stimulating factor 2 ISO protein:increased expression:nasal mucus RGD PMID:20088864 RGD:4143440 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO DNA:SNP: :p.T280M (human) RGD PMID:16645504 PMID:18257903 RGD:4891891 RGD:4891905 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:plasma
mRNA:increased expression:lung		 RGD PMID:12909590 PMID:20561238 RGD:2311388 RGD:5135493 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:20561238 RGD:5135493 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G FAS Fas cell surface death receptor severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
G IL15 interleukin 15 severity ISO mRNA,protein:increased expression:peripheral blood mononuclear cell,serum,dendritic cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G IL17A interleukin 17A susceptibility ISO DNA:SNP: :rs7747909(human) RGD PMID:17703412 RGD:4889847 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility ISO DNA:SNP: :c.390T>C (rs315952) (human) RGD PMID:19258923 RGD:4142862
G IL29 interleukin 29 (interferon, lambda 1) exacerbates ISO associated with respiratory syncytial virus infectious disease;mRNA:increased expression:mucosa of nasopharynx (human) RGD PMID:24389019 RGD:126848743 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
G IL33 interleukin 33 ISO protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
G IL4R interleukin 4 receptor susceptibility ISO DNA:SNPs: :rs1805011,rs2057768 (human)
associated with respiratory syncystial virus infection; DNA:polymorphism:cds:p. Q551R (human)		 RGD PMID:12508140 PMID:17703412 PMID:20404812 RGD:4889847 RGD:4889996 RGD:4890022 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G IL6 interleukin 6 ISO mRNA, protein:increased expression:respiratory system fluid/secretion RGD PMID:14738241 RGD:5128668 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IL9 interleukin 9 ISO RGD PMID:15051283 RGD:5128692 NCBI chr 2:138,048,943...138,052,588
Ensembl chr 2:138,048,943...138,052,588 		JBrowse link
G JAK3 Janus kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 susceptibility ISO DNA:SNP,haplotypes:3'utr: (rs10772271) (human) RGD PMID:29967528 RGD:39128159 NCBI chr 5:61,646,691...61,655,386
Ensembl chr 5:61,647,043...61,656,192 		JBrowse link
G LOC100737977 tumor necrosis factor receptor superfamily member 10B-like severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr14:7,344,788...7,371,086 JBrowse link
G MPO myeloperoxidase ISO RGD PMID:7841728 RGD:5130995 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G MUC1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:19856476 RGD:5131164 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691 		JBrowse link
G NFKBIA NFKB inhibitor alpha susceptibility ISO associated with respiratory syncytial virus infectious disease;DNA:SNP:promoter: (rs2233406) (human) RGD PMID:23487427 RGD:40902982 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NOS2 nitric oxide synthase 2 susceptibility ISO DNA:SNP: :rs1060826(human) RGD PMID:17703412 RGD:4889847 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G PDCD1 programmed cell death 1 ISO protein:increased expression:CD8 T cell RGD PMID:22797302 RGD:40818270 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,258...140,347,478 		JBrowse link
G POSTN periostin ISO mRNA,protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr11:13,225,183...13,258,973
Ensembl chr11:13,224,959...13,258,978 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G TLR4 toll like receptor 4 ISO protein:increased expression:monocyte
protein:decreased expression:neutrophil		 RGD PMID:14738455 PMID:19497921 RGD:4144183 RGD:4144819 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR5 toll like receptor 5 susceptibility ISO DNA:snp:cds:p.F616L rs5744174 (human) RGD PMID:19258923 RGD:4142862 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO DNA:polymorphism:promoter: c. -308A>G (human)
DNA:SNP: :rs1799724(human)
protein:increased expression:nasal lavage fluid		 RGD PMID:17703412 PMID:19849941 PMID:20088864 RGD:4143440 RGD:4143441 RGD:4889847 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TSLP thymic stromal lymphopoietin severity ISO mRNA, protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr 2:115,832,152...115,837,572 JBrowse link
G VDR vitamin D receptor susceptibility ISO DNA:SNP: :rs10735810 (human)
DNA:SNP (human)		 RGD PMID:17703412 PMID:18266602 RGD:4889843 RGD:4889847 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17415
    disease of anatomical entity 14875
      Immune & Inflammatory Diseases 4951
        Inflammation 2397
          bronchitis 88
            Chronic Bronchitis 15
            Immotile Cilia Syndrome, due to Excessively Long Cilia 0
            bronchiolitis + 77
Path 2
Term Annotations click to browse term
  disease 17415
    disease of anatomical entity 14875
      respiratory system disease 3345
        lower respiratory tract disease 2167
          lung disease 2133
            obstructive lung disease 447
              bronchitis 88
                Chronic Bronchitis 15
                Immotile Cilia Syndrome, due to Excessively Long Cilia 0
                bronchiolitis + 77
paths to the root