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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:congestive heart failure
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Accession:DOID:6000 term browser browse the term
Definition:A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Synonyms:exact_synonym: CHF;   Cardiac Failure;   Cardiac Failure Congestive;   Congestive heart disease;   Heart Decompensation;   Heart Failure;   Left Sided Heart Failure;   Myocardial Failure;   Right Sided Heart Failure;   Weak heart
 narrow_synonym: Chronic Heart Failure
 related_synonym: Beta-2-adrenoreceptor agonist, reduced response to;   Congestive heart failure and beta-blocker response, modifier of;   Congestive heart failure, modifier of
 primary_id: MESH:D006333;   RDO:0005421
 xref: ICD10CM:I50;   ICD10CM:I50.9;   ICD9CM:428;   ICD9CM:428.0;   NCI:C3080;   NCI:C50577
For additional species annotation, visit the Alliance of Genome Resources.


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congestive heart failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA1 acetyl-CoA acyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr13:22,964,844...23,020,138
Ensembl chr13:22,964,875...23,020,143
JBrowse link
G ACACA acetyl-CoA carboxylase alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,449...38,875,134
JBrowse link
G ACADS acyl-CoA dehydrogenase short chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:30827304 NCBI chr14:40,642,810...40,656,922
Ensembl chr14:40,624,213...40,659,928
JBrowse link
G ACAN aggrecan ISO mRNA:increased expression:myocardium RGD PMID:24595230 RGD:11570548 NCBI chr 7:54,449,830...54,520,606
Ensembl chr 7:54,449,588...54,520,153
JBrowse link
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 treatment ISO associated with Hypertension
CTD Direct Evidence: marker/mechanism
associated with Myocardial Infarction
RGD
CTD
PMID:15894569 PMID:18586661 PMID:19620082 PMID:22123369 RGD:12859272 RGD:2325224 RGD:6893472 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639
JBrowse link
G ACE2 angiotensin I converting enzyme 2 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:heart (human)
CTD
RGD
PMID:25973029 PMID:32227090 RGD:40818416 NCBI chr  X:12,099,849...12,152,204
Ensembl chr  X:12,099,853...12,151,275
JBrowse link
G ACLY ATP citrate lyase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr12:20,796,678...20,841,301
Ensembl chr12:20,796,749...20,841,298
JBrowse link
G ACTN2 actinin alpha 2 ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 NCBI chr14:54,670,727...54,742,717
Ensembl chr14:54,666,623...54,742,779
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 treatment ISO associated with pulmonary hypertension RGD PMID:22628376 RGD:13703064 NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism|therapeutic
associated with cardiovascular disease; protein:increased expression:plasma
RGD
CTD
PMID:18192035 PMID:19367012 PMID:22032915 PMID:26670611 RGD:5686388 RGD:5686806 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADM adrenomedullin ISO RGD PMID:12623952 RGD:704370 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
JBrowse link
G ADRA2C adrenoceptor alpha 2C ISO DNA:deletion: :322_325del(human)
ClinVar Annotator: match by term: Congestive heart failure and beta-blocker response, modifier of
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:12374873 PMID:17496726 RGD:1300355 NCBI chr 8:2,320,125...2,322,162
Ensembl chr 8:2,320,226...2,321,608
JBrowse link
G ADRB1 adrenoceptor beta 1 ISO ClinVar Annotator: match by term: Congestive heart failure and beta-blocker response, modifier of
DNA:polymorphism: :p.R389G (human)
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:7586371 PMID:10212248 PMID:12374873 PMID:14502278 PMID:15816327 PMID:16844790 PMID:17496726 PMID:19587314 PMID:21516734 RGD:5129119 RGD:737774 NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,189...124,401,739
JBrowse link
G ADRB2 adrenoceptor beta 2 ISO protein:altered localization:cardiac muscle cell
ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to
RGD
ClinVar
PMID:8383511 PMID:15284533 PMID:16596417 PMID:19587314 PMID:20185685 RGD:4144900 RGD:5129119 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,032,782...150,035,591
JBrowse link
G ADRB3 adrenoceptor beta 3 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:heart ventricle (rat)
protein:increased expression:left ventricle, myocardium (human)
CTD
RGD
PMID:11273992 PMID:15009959 PMID:17440824 PMID:21549119 RGD:5684398 RGD:5684917 NCBI chr15:48,468,803...48,478,370 JBrowse link
G AGER advanced glycosylation end-product specific receptor severity ISO protein:increased expression:plasma (human) RGD PMID:20685687 RGD:7244134 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,116...24,228,756
JBrowse link
G AGT angiotensinogen severity
treatment
onset
ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
DNA:polymorphisms: :p.M235T, p.T174M (human)
CTD
RGD
PMID:1330361 PMID:12025466 PMID:17145981 PMID:20811386 PMID:21963897 PMID:24465706 RGD:11039412 RGD:1601140 RGD:8549482 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G AGTR1 angiotensin II receptor type 1 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:17208988 PMID:18214293 PMID:18586661 PMID:21963897 RGD:8549482 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,131
JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO mRNA, protein:decreased expression:heart RGD PMID:18768398 PMID:21963897 RGD:6903846 RGD:8549482 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388
JBrowse link
G AKAP6 A-kinase anchoring protein 6 ISO RGD PMID:24812305 RGD:11251930 NCBI chr 7:66,913,541...67,462,147
Ensembl chr 7:66,915,876...67,462,089
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 9:71,895,615...72,054,898
Ensembl chr 9:71,895,630...72,054,897
JBrowse link
G ALB albumin disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11771600 PMID:22158777 RGD:11036096 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15623566 RGD:5509787 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO associated with Myocardial Infarction; mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 PMID:19546247 RGD:1642301 RGD:5509627 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ANK2 ankyrin 2 ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 NCBI chr 8:109,306,793...109,661,970 JBrowse link
G ANKRD23 ankyrin repeat domain 23 ISO associated with Cardiomyopathy, Congestive RGD PMID:15238456 RGD:2314858 NCBI chr 3:56,776,824...56,781,223
Ensembl chr 3:56,776,812...56,782,654
JBrowse link
G APCS amyloid P component, serum ISO CTD Direct Evidence: marker/mechanism CTD PMID:16129801 NCBI chr 4:90,900,585...90,901,854
Ensembl chr 4:90,898,686...90,901,875
JBrowse link
G APLN apelin ISO protein:decreased expression:plasma
associated with Hypertension, Pulmonary
protein:increased expression:ventricle myocardium
RGD PMID:16263185 PMID:17055480 PMID:17119870 RGD:1626171 RGD:1626175 RGD:1626186 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,748...106,246,378
JBrowse link
G APOA1 apolipoprotein A1 ISO protein: decreased expression: serum RGD PMID:17517342 RGD:5508219 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G APOE apolipoprotein E ISO associated with Beta-Thalassemia RGD PMID:9787187 RGD:11039487 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,259...51,377,794
JBrowse link
G ARRB1 arrestin beta 1 treatment ISO RGD PMID:21232674 RGD:5509888 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,513,856...9,597,959
JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18418421 NCBI chr 6:49,905,851...49,927,437 JBrowse link
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19776660 NCBI chr 3:18,545,064...18,568,312
Ensembl chr 3:18,547,976...18,568,313
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:19776660 PMID:21691940 RGD:6903963 NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,973
JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18179782 NCBI chr17:32,581,234...32,583,145
Ensembl chr17:32,581,230...32,583,427
JBrowse link
G AVPR2 arginine vasopressin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12145768 NCBI chr  X:124,638,433...124,640,969
Ensembl chr  X:124,638,523...124,644,630
JBrowse link
G BAMBI BMP and activin membrane bound inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr10:40,053,368...40,058,590
Ensembl chr10:40,053,354...40,060,323
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:18097624 PMID:29746994 RGD:10054097 RGD:13792577 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:18097624 PMID:29746994 RGD:10054097 RGD:13792577 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BECN1 beclin 1 treatment ISO RGD PMID:18619688 RGD:11560532 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO associated with Hypertension;protein:decreased expression:cardiac muscle cell RGD PMID:16257070 RGD:2293134 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,237...3,755,188
JBrowse link
G BNIP3 BCL2 interacting protein 3 treatment ISO RGD PMID:23508759 RGD:11561982 NCBI chr14:140,362,123...140,371,951
Ensembl chr14:140,362,127...140,371,881
JBrowse link
G C4H1orf226 chromosome 4 C1orf226 homolog ISO mRNA:increased expression:brain RGD PMID:21831995 RGD:7327163 NCBI chr 4:88,129,231...88,471,741
Ensembl chr 4:88,140,953...88,471,994
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr 5:69,016,954...69,448,428 JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase ISO protein:increased expression:heart left ventricle
mRNA, protein:increased expression:heart left ventricle
RGD PMID:17303764 RGD:2315913 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:29746994 RGD:13792577 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASQ2 calsequestrin 2 ISO mRNA:increased expression:sinoatrial node RGD PMID:21565973 RGD:6771208 NCBI chr 4:104,918,204...104,984,019
Ensembl chr 4:104,918,501...104,999,787
JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10618301 PMID:16105639 RGD:1581151 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CBL Cbl proto-oncogene ISO protein:increased expression:left ventricle myocardium, muscle cell (human) RGD PMID:24583314 RGD:11251947 NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,404,999...46,512,834
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:heart left ventricle
CTD
RGD
PMID:12950323 PMID:29959987 RGD:1581156 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCN2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17229371 NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,673,798...31,677,696
JBrowse link
G CCNA2 cyclin A2 ISO RGD PMID:16820573 RGD:2293348 NCBI chr 8:102,260,346...102,266,274 JBrowse link
G CCNT1 cyclin T1 ISO RGD PMID:15297879 RGD:1556509 NCBI chr 5:14,768,423...14,808,424
Ensembl chr 5:14,768,429...14,816,613
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:12719858 RGD:1581177 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,251,959...29,376,346
JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:serum RGD PMID:15716285 RGD:2314219 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,711
JBrowse link
G CDK9 cyclin dependent kinase 9 ISO protein:increased activity:ventricle:
protein:increased activity:heart:
RGD PMID:15297879 RGD:1556509 NCBI chr 1:268,277,083...268,280,493
Ensembl chr 1:268,275,891...268,281,057
JBrowse link
G CFD complement factor D ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 2:77,509,792...77,511,988
Ensembl chr 2:77,509,795...77,511,974
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO mRNA,protein:increased expression:cardiomyocyte: RGD PMID:11033112 RGD:11341730 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,615...104,844,921
JBrowse link
G CHEK2 checkpoint kinase 2 ISO protein:increased phosphorylation:heart myocardium RGD PMID:12702777 RGD:2289708 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,926,613...45,967,296
JBrowse link
G CHI3L1 chitinase 3 like 1 ISO protein:increased secretion:plasma (human) RGD PMID:19961288 RGD:4892629 NCBI chr 9:113,885,541...113,895,033
Ensembl chr 9:113,885,542...113,895,510
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr 2:16,119,794...16,131,080
Ensembl chr 2:16,122,704...16,130,821
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr17:62,424,672...62,436,646
Ensembl chr17:62,420,546...62,436,165
JBrowse link
G CIDEA cell death inducing DFFA like effector a ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 6:97,253,074...97,268,355 JBrowse link
G CORIN corin, serine peptidase ISO mRNA:decreased expression:left atrium, right atrium (rat)
mRNA:increased expression:heart (rat)
RGD PMID:15155264 PMID:15191894 RGD:1581217 RGD:1581218 NCBI chr 8:37,530,812...37,811,226
Ensembl chr 8:37,530,815...37,809,761
JBrowse link
G CRP C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:16360360 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,722,352...90,805,236
JBrowse link
G CRYAB crystallin alpha B ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:1560021 PMID:16483541 PMID:16793013 PMID:17116488 PMID:20171888 PMID:21920752 PMID:22106715 PMID:22995991 PMID:23194663 PMID:23299917 PMID:24033266 PMID:25208129 PMID:25741868 PMID:26694549 PMID:26961874 PMID:28492532 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530
JBrowse link
G CS citrate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:8922916 NCBI chr 5:21,669,778...21,700,737
Ensembl chr 5:21,666,510...21,700,736
JBrowse link
G CSF2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11732872 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15585077 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,445...22,342,163
JBrowse link
G CST3 cystatin C susceptibility ISO protein:increased expression:serum (human) RGD PMID:19539088 RGD:2314311 NCBI chr17:30,471,056...30,474,486
Ensembl chr17:30,470,855...30,474,590
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO mRNA, protein:increased expression: paraventricular nucleus of hypothalamus RGD PMID:24036597 RGD:9491792 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr 7:23,371,358...23,391,585
Ensembl chr 7:23,373,808...23,394,965
JBrowse link
G DIO3 iodothyronine deiodinase 3 ISO associated with Hypertrophy, Right Ventricular;mRNA, protein:increased expression:heart right ventricle RGD PMID:18259611 RGD:2303417
G DMD dystrophin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr  X:27,028,223...29,650,728
Ensembl chr  X:27,028,223...29,181,689
JBrowse link
G DNMT1 DNA methyltransferase 1 ISO protein:increased expression:atrium: RGD PMID:23573917 RGD:9588286 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DSTN destrin, actin depolymerizing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr17:25,998,830...26,050,354
Ensembl chr17:25,998,125...26,050,354
JBrowse link
G DYNLL1 dynein light chain LC8-type 1 ISO protein:increased expression:paraventricular nucleus RGD PMID:23832698 RGD:7257598 NCBI chr14:40,455,954...40,458,352
Ensembl chr14:40,455,985...40,459,105
JBrowse link
G ECE1 endothelin converting enzyme 1 ISO associated with myocardial ischemia
mRNA,protein:increased expression:kidney:
RGD PMID:9595392 PMID:11145756 PMID:19596829 RGD:1580911 RGD:7243876 RGD:7244244 NCBI chr 6:79,408,322...79,465,827
Ensembl chr 6:79,408,328...79,466,106
JBrowse link
G EDN1 endothelin 1 treatment
severity
ISO protein:increased secretion:plasma (human)
CTD Direct Evidence: marker/mechanism
mRNA,protein:increased expression:heart:
RGD
CTD
PMID:7967349 PMID:7969316 PMID:8149524 PMID:9861300 PMID:10199843 PMID:10973842 PMID:11136700 PMID:11707688 PMID:16360360 PMID:16762801 RGD:4144845 RGD:7244167 RGD:8661798 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G EDNRA endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28095452 NCBI chr 8:81,210,750...81,279,053
Ensembl chr 8:81,209,327...81,276,853
JBrowse link
G EDNRB endothelin receptor type B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28095452 NCBI chr11:50,073,300...50,102,879
Ensembl chr11:50,072,554...50,102,884
JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 8:112,038,670...112,190,079
Ensembl chr 8:111,750,960...112,191,274
JBrowse link
G ENDOG endonuclease G ISO mRNa:decreased expression:heart: RGD PMID:17292393 RGD:9685393 NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788
JBrowse link
G ENG endoglin treatment ISO protein:increased expression:heart left ventricle (rat) RGD PMID:20156938 RGD:7257540 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:12724418 RGD:2312280 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760
JBrowse link
G EPHX2 epoxide hydrolase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18443590 NCBI chr14:11,217,125...11,293,018
Ensembl chr14:11,216,977...11,293,412
JBrowse link
G EPO erythropoietin treatment ISO associated with Myocardial Infarction RGD PMID:20139114 RGD:10401073 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:10421602 RGD:1580989 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO associated with Aortic Valve Stenosis;mRNA, protein:decreased expression:heart myocardium RGD PMID:10421602 RGD:1580989 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,973,037...114,696,375
JBrowse link
G ESRRA estrogen related receptor alpha ISO protein:decreased expression:heart: RGD PMID:21825219 RGD:10401867 NCBI chr 2:7,803,504...7,812,868
Ensembl chr 2:7,803,510...7,813,836
JBrowse link
G EYA4 EYA transcriptional coactivator and phosphatase 4 ISO DNA:deletion:introns, exon (human)
ClinVar Annotator: match by term: Congestive heart failure
RGD
ClinVar
PMID:15735644 PMID:25741868 PMID:28492532 RGD:1598455 NCBI chr 1:30,260,784...30,575,593
Ensembl chr 1:30,261,909...30,575,559
JBrowse link
G FAS Fas cell surface death receptor treatment ISO mRNA:splice variant:heart left ventricle (human) RGD PMID:9367848 PMID:29746994 RGD:13792577 RGD:8686420 NCBI chr14:100,927,305...100,954,781 JBrowse link
G FASLG Fas ligand (TNF superfamily, member 6) treatment ISO RGD PMID:29746994 RGD:13792577 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,475
JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr12:922,405...937,560
Ensembl chr12:920,507...937,559
JBrowse link
G FBLN5 fibulin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12189163 NCBI chr 7:113,423,629...113,526,412
Ensembl chr 7:113,423,629...113,522,069
JBrowse link
G FIP1L1 factor interacting with PAPOLA and CPSF1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28347583 NCBI chr 8:40,157,263...40,235,084 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B ISO associated with Shock, Septic RGD PMID:17637193 RGD:2302075 NCBI chr 3:114,623,529...114,636,200
Ensembl chr 3:114,623,529...114,634,628
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:15623567 RGD:2293777 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit ISO RGD PMID:15623567 RGD:2293777 NCBI chr 2:6,430,158...6,436,173
Ensembl chr 2:6,430,153...6,436,173
JBrowse link
G FOXC1 forkhead box C1 ISO RGD PMID:16952980 RGD:1582564 NCBI chr 7:837,088...840,593
Ensembl chr 7:837,171...838,805
JBrowse link
G FOXC2 forkhead box C2 ISO RGD PMID:16952980 RGD:1582564 NCBI chr 6:2,552,141...2,555,041
Ensembl chr 6:2,552,862...2,554,367
JBrowse link
G FOXO1 forkhead box O1 ISO RGD PMID:16952980 RGD:1582564 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473
JBrowse link
G FOXP1 forkhead box P1 ISO RGD PMID:16952980 RGD:1582564 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,347,849...52,974,261
JBrowse link
G FOXP4 forkhead box P4 ISO RGD PMID:16952980 RGD:1582564 NCBI chr 7:36,760,643...36,793,620
Ensembl chr 7:36,754,754...36,793,527
JBrowse link
G FTH1 ferritin heavy chain 1 ISO protein:decreased expression:heart RGD PMID:18992754 RGD:2315110 NCBI chr 2:9,535,051...9,537,979 JBrowse link
G GATM glycine amidinotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16820567 NCBI chr 1:126,361,968...126,378,705
Ensembl chr 1:126,361,945...126,380,872
JBrowse link
G GCG glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:7608802 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,561...68,810,244
JBrowse link
G GDF15 growth differentiation factor 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20855664 NCBI chr 2:59,409,035...59,411,356
Ensembl chr 2:59,408,904...59,411,358
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:20572026 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
G GP91-PHOX NADPH oxidase heavy chain subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr  X:33,654,656...33,678,346
Ensembl chr  X:33,642,015...33,680,580
JBrowse link
G GPX4 glutathione peroxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GRK1 G protein-coupled receptor kinase 1 ISO RGD PMID:12456492 RGD:1600002 NCBI chr11:78,793,670...78,803,291
Ensembl chr11:78,793,777...78,803,297
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO CTD Direct Evidence: marker/mechanism
associated with Hypertrophy, Left Ventricular and Hypertension;protein:increased expression, increased activity:heart left ventricle, cytosol (rat)
mRNA:decreased expression:peripheral blood mononuclear cell (human)
CTD
RGD
PMID:9931137 PMID:11331748 PMID:26248277 PMID:26670611 PMID:29247373 RGD:11535540 RGD:13506830 RGD:1625790 RGD:737776 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 severity ISO mRNA:decreased expression:heart left ventricle (human) RGD PMID:22685168 RGD:13506835 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,985
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 severity ISO mRNA:decreased expression:peripheral blood mononuclear cell (human)
mRNA:decreased expression:heart left ventricle (human)
RGD PMID:22685168 PMID:26248277 RGD:11535540 RGD:13506835 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,602...129,347,153
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17901358 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,574
JBrowse link
G HAMP hepcidin antimicrobial peptide ISO protein:increased expression:serum, urine RGD PMID:21080339 RGD:11041621 NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,159...44,787,307
JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr14:16,460,089...16,462,979
Ensembl chr14:16,460,119...16,462,735
JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr 7:60,010,396...60,052,258
Ensembl chr 7:60,010,482...60,053,823
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:heart right ventricle (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15732037 PMID:17582388 RGD:9068910 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G HMGB1 high mobility group box 1 treatment ISO protein:decreased expression:heart RGD PMID:23708738 PMID:24204700 RGD:10402070 RGD:10402081 NCBI chr11:7,195,556...7,321,071 JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:22352330 PMID:23592614 RGD:10755584
G HP haptoglobin treatment ISO RGD PMID:23494325 RGD:11041812 NCBI chr 6:14,980,382...14,985,245 JBrowse link
G HRH2 histamine receptor H2 susceptibility ISO RGD PMID:24655024 RGD:9685523 NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,670...81,932,275
JBrowse link
G HSF1 heat shock transcription factor 1 ISO protein:altered localization:heart left ventricle (rat) RGD PMID:24285117 RGD:10402754 NCBI chr 4:463,531...486,483
Ensembl chr 4:461,559...486,473
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17481944 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,936...10,039,915
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO mRNA:increased expression:heart left ventricle RGD PMID:16002744 RGD:1600503 NCBI chr11:20,555,939...20,620,225
Ensembl chr11:20,555,961...20,619,629
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:left ventricle cardiac muscle (rat)
CTD
RGD
PMID:17936780 PMID:19023134 RGD:9698457 NCBI chr15:131,844,578...131,860,417
Ensembl chr15:131,844,928...131,860,392
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:3091246 PMID:20938210 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:12835956 RGD:1598415 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IL10 interleukin 10 treatment
disease_progression
ISO RGD PMID:16461369 PMID:23778495 PMID:28939262 RGD:14975271 RGD:1598465 RGD:7365020 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:heart RGD PMID:19527710 PMID:19909738 RGD:2325816 RGD:4831836 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism
associated with Hypertension;mRNA:increased expression:heart
associated with Diabetes Mellitus, Experimental; protein:increased expression:extracellular space (rat)
RGD
CTD
PMID:15135663 PMID:16360360 PMID:18280594 PMID:18999900 PMID:28939262 RGD:14975271 RGD:2307285 RGD:5128682 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IL6R interleukin 6 receptor ISO protein:increased expression:paraventricular hypothalamic nucleus RGD PMID:17095650 RGD:1625433 NCBI chr 4:95,322,426...95,381,393
Ensembl chr 4:95,322,426...95,381,282
JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15628829 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G ITGB1 integrin subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11884376 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795
JBrowse link
G KAT8 lysine acetyltransferase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27768893 NCBI chr 3:17,362,326...17,373,110
Ensembl chr 3:17,362,267...17,373,110
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO mRNA:increased expression:endocardium of right ventricle:
associated with Myocardial Infarction (RDO:0006167); mRNA:increased expression:heart left ventricle, septum
RGD PMID:16497176 PMID:17384445 RGD:12910696 RGD:1642301 NCBI chr13:198,051,281...198,059,444 JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 ISO associated with Hypertension, Pulmonary:mRNA:decreased expression:heart right ventricle (rat) RGD PMID:25016242 RGD:9831185 NCBI chr 9:128,429,232...128,659,662
Ensembl chr 9:128,357,160...128,659,717
JBrowse link
G KDM2A lysine demethylase 2A ISO protein:altered localization:promoter (mouse) RGD PMID:25181347 RGD:9588275 NCBI chr 2:5,238,690...5,357,799
Ensembl chr 2:5,240,287...5,357,164
JBrowse link
G LEP leptin ISO RGD PMID:18006469 RGD:5128823 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G LEPR leptin receptor ISO protein:increased phosphorylation:heart RGD PMID:18006469 RGD:5128823 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,798,979...146,896,108
JBrowse link
G LGALS3 galectin 3 ISO RGD PMID:15520318 RGD:9685214 NCBI chr 1:184,478,639...184,496,155
Ensembl chr 1:184,478,710...184,497,951
JBrowse link
G LIF LIF interleukin 6 family cytokine ISO RGD PMID:20051627 RGD:2326058 NCBI chr14:47,221,540...47,239,513
Ensembl chr14:47,221,560...47,238,749
JBrowse link
G LOC110256000 membrane primary amine oxidase-like severity ISO protein:increased expression:plasma RGD PMID:11052858 RGD:2313827 NCBI chr12:19,996,324...20,007,006 JBrowse link
G LOC110258578 interleukin-1 beta-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135663
G MAP2K7 mitogen-activated protein kinase kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21284947 NCBI chr 2:71,299,010...71,308,432
Ensembl chr 2:71,298,322...71,308,165
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased activity:heart: RGD PMID:17562954 RGD:10412331 NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,495
JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO mRNA, protein:decreased expression:heart RGD PMID:21963897 RGD:8549482 NCBI chr 1:7,527,566...7,542,110
Ensembl chr 1:7,526,653...7,528,823
JBrowse link
G MDH2 malate dehydrogenase 2 ISO RGD PMID:16786185 RGD:1582470 NCBI chr 3:10,120,121...10,132,705
Ensembl chr 3:10,120,084...10,132,830
JBrowse link
G MIR133A-1 microRNA mir-133a-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28751527 NCBI chr17:61,904,781...61,904,883
Ensembl chr17:61,904,781...61,904,883
JBrowse link
G MIR28 microRNA mir-28 ISO RNA:increased expression:heart RGD PMID:29373037 RGD:26923905 NCBI chr13:126,282,167...126,282,252
Ensembl chr13:126,282,167...126,282,252
JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:12383878 RGD:13801043 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045
JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:12892382 PMID:21866669 RGD:1582539 RGD:7207282 NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,454,000
JBrowse link
G MMP13 matrix metallopeptidase 13 disease_progression ISO protein:increased expression:left ventricle (rat)
associated with Hypertension
RGD PMID:10773234 PMID:10773235 RGD:1582587 RGD:2290467 NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,003...33,568,076
JBrowse link
G MMP14 matrix metallopeptidase 14 disease_progression ISO protein:increased expression:left ventricle (rat) RGD PMID:10773235 RGD:1582587 NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,174,500...76,185,923
JBrowse link
G MMP2 matrix metallopeptidase 2 severity ISO mRNA:increased expression:heart left ventricle
protein:increased expression:heart left ventricle, plasma
RGD PMID:10773234 PMID:16169329 PMID:20606426 RGD:1582574 RGD:2290467 RGD:8694112 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G MMP3 matrix metallopeptidase 3 ISO protein:increased expression:heart left ventricle, plasma RGD PMID:20606426 RGD:8694112 NCBI chr 9:33,446,969...33,453,995
Ensembl chr 9:33,411,065...33,454,000
JBrowse link
G MMP8 matrix metallopeptidase 8 disease_progression ISO protein:increased expression:left ventricle (rat) RGD PMID:10773235 RGD:1582587 NCBI chr 9:33,384,034...33,397,637
Ensembl chr 9:33,384,028...33,396,947
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO associated with Hypertension, Pulmonary; protein:increased expression:heart
protein:increased expression:heart left ventricle, plasma
RGD PMID:11342481 PMID:16952784 PMID:17913382 PMID:20606426 RGD:1582647 RGD:5130174 RGD:7207137 RGD:8694112 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G MSTN myostatin ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:myocardium
CTD
RGD
PMID:16968467 RGD:2303554 NCBI chr15:94,623,526...94,628,440
Ensembl chr15:94,620,269...94,628,546
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO mRNA, protein:increased expression:heart RGD PMID:20861467 RGD:10003169 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G MYH7 myosin heavy chain 7 treatment ISO associated with Myocardial Infarction RGD PMID:18088389 RGD:12792974 NCBI chr 7:75,650,841...75,672,908
Ensembl chr 7:75,650,445...75,709,232
JBrowse link
G MYOD1 myogenic differentiation 1 treatment ISO associated with Aortic Valve Stenosis RGD PMID:20060348 RGD:9686081 NCBI chr 2:41,422,522...41,424,236
Ensembl chr 2:41,415,735...41,425,234
JBrowse link
G MYOT myotilin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr 2:139,899,245...139,919,095
Ensembl chr 2:139,861,004...139,919,095
JBrowse link
G MYPN myopalladin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:22286171 PMID:23299917 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr14:71,283,271...71,388,591
Ensembl chr14:71,298,907...71,394,600
JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO mRNA, protein:increased expression:heart RGD PMID:19853610 RGD:2325979 NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,750...40,960,608
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 ISO CTD Direct Evidence: therapeutic CTD
RGD
PMID:28373008 PMID:29373037 RGD:26923905 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NGFR nerve growth factor receptor ISO associated with Myocardial Infarction ;mRNA:increased expression:heart left ventricle, septum (rat) RGD PMID:16497176 RGD:1642301 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,357
JBrowse link
G NISCH nischarin ISO RGD PMID:12021582 RGD:1581128 NCBI chr13:34,595,788...34,630,306
Ensembl chr13:34,595,891...34,630,303
JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO protein:increased expression:heart, left ventricle, sarcolemma (human) RGD PMID:11121795 RGD:5132888 NCBI chr12:27,439,529...27,445,025
Ensembl chr12:27,439,260...27,445,026
JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:15466641 PMID:23832698 RGD:1581144 RGD:7257598 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,972
JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19168511 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19168511 PMID:20304815 PMID:29351461 RGD:13504746 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G NOX1 NADPH oxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr  X:82,540,664...82,575,811
Ensembl chr  X:82,540,666...82,586,532
JBrowse link
G NOX4 NADPH oxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,195...22,776,554
JBrowse link
G NPPA natriuretic peptide A severity
treatment
ISO protein:increased expression:plasma
mRNA,protein:increased expression:heart,plasma
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:1647690 PMID:2143809 PMID:8112904 PMID:11136700 PMID:11421854 PMID:16101196 PMID:23566312 PMID:23931972 RGD:1580139 RGD:1580140 RGD:7247714 RGD:7297049 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NPPB natriuretic peptide B severity ISO mRNA,protein:increased expression:heart,plasma
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus;protein:increased expression:plasma
RGD
CTD
PMID:1831369 PMID:2143809 PMID:11136700 PMID:11279304 PMID:11421854 PMID:12628948 PMID:15732037 PMID:15860969 PMID:16101196 PMID:16333235 PMID:16360360 PMID:16762801 PMID:16777915 PMID:17257273 PMID:19650993 PMID:24535859 PMID:29959987 RGD:1580139 RGD:1580140 RGD:1642196 RGD:7247316 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO associated with Hypertension
CTD Direct Evidence: marker/mechanism
protein:decreased expression:kidney
RGD
CTD
PMID:9405681 PMID:17264312 PMID:20881240 RGD:7247730 RGD:737701 NCBI chr 4:95,957,220...95,974,253
Ensembl chr 4:95,957,228...95,973,430
JBrowse link
G NPTXR neuronal pentraxin receptor ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr 5:9,207,295...9,230,354
Ensembl chr 5:9,207,281...9,230,351
JBrowse link
G NPY neuropeptide Y ISO RGD PMID:17804485 RGD:7175103 NCBI chr18:47,985,796...47,993,726
Ensembl chr18:47,985,725...47,993,289
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 treatment ISO RGD PMID:21737535 RGD:7174712 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,937...144,956,095
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15722665 PMID:21321305 NCBI chr 8:80,303,172...80,669,050
Ensembl chr 8:80,290,715...80,669,404
JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19801490 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,627,334...53,688,332
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22503866 NCBI chr13:179,822,731...179,916,226
Ensembl chr13:179,824,862...179,915,177
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO protein:increased expression:heart left ventricle (rat) RGD PMID:22128088 RGD:9590202 NCBI chr  X:57,521,091...57,558,467
Ensembl chr  X:57,521,097...57,558,519
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr 5:61,799,356...61,809,691
Ensembl chr 5:61,799,286...61,810,624
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO protein:decreased expression:heart RGD PMID:19493956 RGD:7800717 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,823...130,719,083
JBrowse link
G P2RX4 purinergic receptor P2X 4 ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr14:31,368,542...31,387,960
Ensembl chr14:31,368,303...31,387,905
JBrowse link
G PAMR1 peptidase domain containing associated with muscle regeneration 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28751527 NCBI chr 2:25,422,390...25,591,615
Ensembl chr 2:25,423,361...25,591,617
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 treatment ISO associated with Hypertension RGD PMID:19443425 RGD:11074236 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO protein:decreased expression:heart: RGD PMID:23647599 RGD:10448278 NCBI chr 1:16,202,859...16,249,879
Ensembl chr 1:16,198,223...16,249,531
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:28347583 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,442
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19429709 NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,429,931...39,532,583
JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr14:34,523,901...34,530,238 JBrowse link
G PGF placental growth factor ISO RGD PMID:19327525 RGD:6483590 NCBI chr 7:98,149,510...98,162,784 JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12963636 PMID:15936620 RGD:6482699 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PLA2G7 phospholipase A2 group VII ISO RGD PMID:16952920 RGD:6482778 NCBI chr 7:41,488,152...41,531,383
Ensembl chr 7:41,486,843...41,531,331
JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032
JBrowse link
G PLCD1 phospholipase C delta 1 ISO RGD PMID:11181012 RGD:2300431 NCBI chr13:22,851,581...22,872,950
Ensembl chr13:22,851,584...22,865,175
JBrowse link
G PLD2 phospholipase D2 ISO protein:increased expression:heart left ventricle RGD PMID:15601581 RGD:2299908 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,896...52,087,809
JBrowse link
G PLN phospholamban treatment ISO associated with Myocardial Infarction
associated with Hypertension
RGD PMID:22947202 PMID:22970977 RGD:7327181 RGD:7327182 NCBI chr 1:43,449,354...43,458,925 JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:3026683 PMID:8277081 NCBI chr 3:113,661,712...113,668,558 JBrowse link
G PON1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,724
JBrowse link
G POSTN periostin treatment ISO mRNA:increased expression:heart RGD PMID:15381649 PMID:16414453 RGD:10040951 RGD:10040999 NCBI chr11:13,225,183...13,258,973
Ensembl chr11:13,182,272...13,259,019
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha onset ISO mRNA:decreased expression:heart (mouse)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19808358 PMID:22503866 PMID:23297372 PMID:23342071 RGD:7241838 RGD:7241843 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,961,909
JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha ISO RGD PMID:12024026 RGD:737728 NCBI chr 2:5,120,202...5,123,168
Ensembl chr 2:5,120,140...5,126,953
JBrowse link
G PPP1CC protein phosphatase 1 catalytic subunit gamma ISO protein:increased expression:heart, membrane RGD PMID:26668322 RGD:11526267 NCBI chr14:32,071,472...32,091,267
Ensembl chr14:32,070,544...32,091,499
JBrowse link
G PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A ISO CTD Direct Evidence: therapeutic CTD PMID:20071777 NCBI chr 5:19,753,850...19,763,281
Ensembl chr 5:19,753,847...19,763,288
JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO mRNA:increased expression:vastus lateralis muscle (human) RGD PMID:14567976 RGD:8693707 NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha ISO RGD PMID:10830164 RGD:1580714 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,553
JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO ClinVar Annotator: match by term: Congestive heart failure
ClinVar Annotator: match by term: Heart failure
ClinVar PMID:21409595 PMID:24033266 PMID:25741868 PMID:27532257 PMID:28492532 NCBI chr18:5,475,077...5,744,761
Ensembl chr18:5,475,077...5,744,658
JBrowse link
G PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha ISO RGD PMID:10830164 RGD:1580714 NCBI chr13:31,427,786...31,517,005
Ensembl chr13:31,426,213...31,517,122
JBrowse link
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 9:106,851,044...106,957,519
Ensembl chr 9:106,851,018...106,957,519
JBrowse link
G PRKCA protein kinase C alpha ISO protein:increased expression, increased phosphorylation:heart left ventricle RGD PMID:17556659 RGD:2292480 NCBI chr12:12,882,287...13,268,647
Ensembl chr12:12,882,064...13,263,554
JBrowse link
G PRKCB protein kinase C beta ISO associated with hypertension RGD PMID:12392998 RGD:1625516 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264
JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18926768 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,741
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G PTH parathyroid hormone ISO protein:increased expression:serum (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17162251 PMID:21939825 RGD:7242422 NCBI chr 2:45,757,398...45,760,433
Ensembl chr 2:45,757,398...45,760,415
JBrowse link
G PTI pancreatic trypsin inhibitor EXP CTD Direct Evidence: marker/mechanism CTD PMID:16436767 NCBI chr17:47,773,060...47,780,746
Ensembl chr17:47,773,060...47,849,344
JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO CTD Direct Evidence: marker/mechanism CTD PMID:28751527 NCBI chr 6:167,656,674...167,743,750
Ensembl chr 6:167,656,680...167,743,721
JBrowse link
G RAC1 Rac family small GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12642504 PMID:16155095 RGD:1581295 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,771...4,803,687
JBrowse link
G RAMP2 receptor activity modifying protein 2 ISO associated with Hypertension RGD PMID:12623952 RGD:704370 NCBI chr12:20,092,204...20,094,426
Ensembl chr12:20,092,193...20,094,474
JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO mRNA, protein:increased expression:left ventricle myocardium (human) RGD PMID:18323524 RGD:9835356 NCBI chr 5:78,101,286...78,134,150
Ensembl chr 5:78,101,289...78,134,103
JBrowse link
G RBM20 RNA binding motif protein 20 ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr14:121,058,896...121,269,824 JBrowse link
G RBP4 retinol binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,036,770...105,044,765
JBrowse link
G REN renin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1647690 PMID:7034517 PMID:20811386 NCBI chr 9:64,809,143...64,822,605
Ensembl chr 9:64,809,146...64,822,636
JBrowse link
G RETN resistin ISO CTD Direct Evidence: marker/mechanism
associated with Coronary Disease
CTD
RGD
PMID:22240747 PMID:26670611 RGD:7207075 NCBI chr 2:71,484,164...71,485,577
Ensembl chr 2:71,484,169...71,485,616
JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO RGD PMID:21297953 RGD:7327162 NCBI chr14:100,312,592...100,604,953
Ensembl chr14:100,319,225...100,604,945
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 3:125,353,063...125,493,368
Ensembl chr 3:125,353,119...125,491,963
JBrowse link
G RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator ISO mRNA, protein:decreased expression:heart RGD PMID:18056528 RGD:2311701 NCBI chr 6:27,601,692...27,605,127
Ensembl chr 6:27,601,692...27,605,083
JBrowse link
G RYR2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Congestive heart failure RGD
ClinVar
PMID:16483256 PMID:25741868 RGD:1599251 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,245...54,406,355
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO mRNA:decreased expression:ventricle myocardium RGD PMID:19584134 RGD:6484224 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,338,124...23,438,385
JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 ISO mRNA:increased expression:ventricle myocardium RGD PMID:19584134 RGD:6484224 NCBI chr 5:16,977,468...17,173,831
Ensembl chr 5:16,977,700...17,169,564
JBrowse link
G SELP selectin P ISO RGD PMID:19193626 RGD:2312309 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G SERPINE1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:24535859 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,157...71,123,299
JBrowse link
G SIRT3 sirtuin 3 ISO protein:decreased expression:heart left ventricle RGD PMID:22155497 RGD:9586040 NCBI chr 2:38,465...55,074
Ensembl chr 2:38,470...55,101
JBrowse link
G SLC2A4 solute carrier family 2 member 4 severity ISO protein:decreased expression:skeletal muscle RGD PMID:18778861 RGD:2313624 NCBI chr12:52,628,746...52,634,965
Ensembl chr12:52,628,450...52,634,967
JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO DNA:repeat:promoter (human) RGD PMID:17307423 RGD:4889438 NCBI chr12:46,285,995...46,328,377
Ensembl chr12:46,285,997...46,314,378
JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO protein:increased expression:cardiac muscle cell RGD PMID:17536604 RGD:1642720 NCBI chr 3:99,823,503...100,257,306
Ensembl chr 3:99,897,162...100,245,140
JBrowse link
G SLC9A1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:18776042 PMID:19027022 RGD:6771337 NCBI chr 6:84,373,921...84,426,447
Ensembl chr 6:84,372,649...84,426,997
JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16105639 PMID:16155095 PMID:20304815 PMID:21195081 PMID:21284947 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G SOD3 superoxide dismutase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,636...18,802,154
JBrowse link
G SOX4 SRY-box transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 7:16,886,834...16,895,488 JBrowse link
G SRF serum response factor ISO mRNA, protein:splice variant:heart RGD PMID:11893590 RGD:1581426 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,063...38,222,140
JBrowse link
G SRI sorcin ISO associated with Hypertension
protein:decreased expression:cardiac muscle cell
RGD PMID:12754254 PMID:20945956 RGD:7327198 RGD:7327200 NCBI chr 9:68,492,235...68,515,247
Ensembl chr 9:68,493,008...68,515,322
JBrowse link
G TBX20 T-box transcription factor 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr18:38,635,603...38,681,690
Ensembl chr18:38,635,617...38,677,208
JBrowse link
G TH tyrosine hydroxylase ISO protein:increased expression:paraventricular thalamic nucleus (rat) RGD PMID:7715703 PMID:21287352 RGD:5128674 RGD:737737 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,618...1,506,615
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO protein:increased expression:heart left ventricle RGD PMID:10773234 RGD:2290467 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,297
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO protein:increased expression:heart left ventricle RGD PMID:10773234 RGD:2290467 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 ISO protein:decreased expression:heart left ventricle RGD PMID:10773234 RGD:2290467 NCBI chr13:68,179,803...68,191,199
Ensembl chr13:68,179,805...68,190,942
JBrowse link
G TLR2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,991...75,446,850
JBrowse link
G TNF tumor necrosis factor treatment
severity
ISO associated with Myocardial Infarction;
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:11100001 PMID:11668085 PMID:15135663 PMID:15210453 PMID:15231041 PMID:17337591 PMID:18034274 PMID:28939262 PMID:29959987 RGD:14975271 RGD:1580213 RGD:7401241 RGD:7401242 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO mRNA, protein:incereased expression:myocardium RGD PMID:15883214 RGD:1624176 NCBI chr 4:19,850,212...19,879,132 JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16360360 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,073...64,331,909
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO human protein in rat model RGD PMID:21135513 RGD:5131262 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,149
JBrowse link
G TNNT2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12322705 PMID:17698733 NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396
JBrowse link
G TOMM70 translocase of outer mitochondrial membrane 70 ISO mRNA:decreased expression:heart
protein:increased serine phosphorylation:heart, mitochondrion
RGD PMID:24395194 PMID:25022898 RGD:13464131 RGD:13464132 NCBI chr13:158,577,026...158,629,878
Ensembl chr13:158,577,377...158,628,267
JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21284947 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G TTN titin ISO ClinVar Annotator: match by term: Heart failure
ClinVar Annotator: match by term: CHF
ClinVar Annotator: match by term: Congestive heart failure
ClinVar PMID:15802564 PMID:23396983 PMID:23486992 PMID:23861362 PMID:24033266 PMID:24055113 PMID:24231549 PMID:24271327 PMID:24503780 PMID:24569025 PMID:24578547 PMID:25589632 PMID:25741868 PMID:26272908 PMID:26383259 PMID:26467025 PMID:26498160 PMID:26516846 PMID:27194543 PMID:27843123 PMID:28256728 PMID:28492532 PMID:29361395 NCBI chr15:84,226,953...84,501,320 JBrowse link
G TTR transthyretin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:1355416 PMID:1850190 PMID:1997217 PMID:2174830 PMID:2590199 PMID:6736244 PMID:7923855 PMID:8102146 PMID:9090525 PMID:14640030 PMID:15185492 PMID:19428025 PMID:22332999 PMID:24033266 PMID:24955979 PMID:25741868 PMID:28492532 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,193...115,503,977
JBrowse link
G TUBB tubulin beta class I ISO CTD Direct Evidence: marker/mechanism CTD PMID:16155095 NCBI chr 7:23,247,827...23,252,240
Ensembl chr 7:23,245,743...23,294,218
JBrowse link
G UCN urocortin ISO protein:increased secretion:plasma (human) RGD PMID:19808377 RGD:5490589 NCBI chr 3:111,834,082...111,835,932 JBrowse link
G UCN2 urocortin 2 ISO CTD Direct Evidence: therapeutic
mRNA, protein:increased expression:myocardium (human)
CTD
RGD
PMID:12076554 PMID:16330704 RGD:5508210 NCBI chr13:31,261,196...31,261,824
Ensembl chr13:31,261,196...31,261,534
JBrowse link
G UCP1 uncoupling protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 8:86,522,028...86,526,162 JBrowse link
G UCP2 uncoupling protein 2 ISO protein:decreased expression:heart, mitochondria RGD PMID:20193183 PMID:20809120 RGD:7204424 RGD:7204426 NCBI chr 9:8,358,559...8,364,552
Ensembl chr 9:8,333,153...8,365,558
JBrowse link
G UCP3 uncoupling protein 3 ISO protein:decreased expression:heart, mitochondria RGD PMID:20809120 RGD:7204424 NCBI chr 9:8,378,023...8,389,452
Ensembl chr 9:8,378,019...8,386,211
JBrowse link
G UTS2 urotensin 2 severity ISO protein:increased expression:plasma RGD PMID:12791592 PMID:16364499 RGD:1580809 RGD:2306804 NCBI chr 6:68,552,889...68,560,827
Ensembl chr 6:68,552,887...68,559,687
JBrowse link
G VCL vinculin ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:24033266 PMID:28492532 NCBI chr14:76,700,143...76,811,875
Ensembl chr14:76,700,168...76,811,875
JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:15732037 PMID:15880336 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
G VWF von Willebrand factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,098
JBrowse link
G XDH xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19933411 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,986,528...108,080,151
JBrowse link
G YY1 YY1 transcription factor ISO RGD PMID:12754214 RGD:1580831 NCBI chr 7:121,132,168...121,170,699
Ensembl chr 7:121,131,917...121,170,697
JBrowse link
Alcohol-Induced Sudden Cardiac Failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPA2 inorganic pyrophosphatase 2 ISO OMIM NCBI chr 8:116,249,531...116,333,847
Ensembl chr 8:116,249,569...116,334,013
JBrowse link
cardiac arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 treatment ISO RGD PMID:26010685 RGD:12791997 NCBI chr 2:41,666,974...41,754,624
Ensembl chr 2:41,666,909...41,754,620
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 9:71,895,615...72,054,898
Ensembl chr 9:71,895,630...72,054,897
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:20363892 RGD:5509101
G ANK2 ankyrin 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:28492532 PMID:28600387 NCBI chr 8:109,306,793...109,661,970 JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:21383000 PMID:22840528 PMID:25527503 PMID:28492532 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,780,742...98,266,573
JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:25741868 PMID:28492532 NCBI chr10:44,321,954...44,887,410
Ensembl chr10:44,421,666...44,885,424
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:hippocampus (rat) RGD PMID:19756023 RGD:4889980 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
JBrowse link
G CEP85L centrosomal protein 85 like ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 1:43,392,630...43,564,835
Ensembl chr 1:43,392,645...43,563,695
JBrowse link
G DPP6 dipeptidyl peptidase like 6 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr18:3,148,479...3,905,845
Ensembl chr18:3,148,481...3,905,410
JBrowse link
G DSC2 desmocollin 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:18678517 PMID:23861362 PMID:24033266 PMID:24704780 PMID:25637381 PMID:25741868 PMID:27153395 PMID:28492532 NCBI chr 6:114,982,259...115,021,332
Ensembl chr 6:114,916,763...115,021,305
JBrowse link
G DSG2 desmoglein 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:20400443 PMID:23861362 PMID:24070718 PMID:25741868 PMID:28492532 PMID:28600387 NCBI chr 6:115,400,223...115,453,763
Ensembl chr 6:115,400,252...115,452,473
JBrowse link
G DSP desmoplakin ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:21606390 PMID:25525159 PMID:25741868 PMID:28492532 NCBI chr 7:4,862,649...4,915,626
Ensembl chr 7:4,862,649...4,915,615
JBrowse link
G DYNLL1 dynein light chain LC8-type 1 ISO RGD PMID:9522364 RGD:13208524 NCBI chr14:40,455,954...40,458,352
Ensembl chr14:40,455,985...40,459,105
JBrowse link
G EP300 E1A binding protein p300 ISO associated with Diabetes Mellitus; mRNA:increased expression:blood (human) RGD PMID:19577077 RGD:2312286 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760
JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:17728042 RGD:5688386 NCBI chr14:11,217,125...11,293,018
Ensembl chr14:11,216,977...11,293,412
JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:28492532 NCBI chr 7:60,010,396...60,052,258
Ensembl chr 7:60,010,482...60,053,823
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:9806674 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL18 interleukin 18 ISO RGD PMID:18679114 RGD:4889454 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G INS insulin ISO CTD Direct Evidence: therapeutic CTD PMID:17449947 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO protein:increased expression:cerebellum (rat) RGD PMID:21859719 RGD:6480675 NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,908
JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr 5:51,695,927...51,704,402
Ensembl chr 5:51,537,774...51,703,817
JBrowse link
G LOC100524391 putative methyltransferase NSUN6 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:25741868 PMID:28492532 NCBI chr10:44,884,179...44,958,024
Ensembl chr10:44,882,449...44,976,445
JBrowse link
G MYBPC3 myosin binding protein C3 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:14563344 PMID:15519027 PMID:16352453 PMID:20624503 PMID:22361390 PMID:23140321 PMID:23299917 PMID:23785128 PMID:24033266 PMID:24503780 PMID:24510615 PMID:25163546 PMID:25741868 PMID:28492532 NCBI chr 2:15,247,679...15,269,714
Ensembl chr 2:15,247,539...15,270,104
JBrowse link
G MYOM1 myomesin 1 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr 6:103,451,206...103,593,093
Ensembl chr 6:103,451,343...103,597,324
JBrowse link
G PLN phospholamban ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 1:43,449,354...43,458,925 JBrowse link
G RBM20 RNA binding motif protein 20 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:22004663 PMID:24033266 PMID:24503780 PMID:25637381 PMID:25741868 PMID:27896284 PMID:28492532 NCBI chr14:121,058,896...121,269,824 JBrowse link
G RYR2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,245...54,406,355
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:12354768 PMID:12820704 PMID:15466642 PMID:15840476 PMID:16540748 PMID:17161064 PMID:17210839 PMID:18071069 PMID:18452873 PMID:19412328 PMID:20403459 PMID:20875080 PMID:22378279 PMID:22581653 PMID:23008441 PMID:23098067 PMID:24033266 PMID:24653702 PMID:25741868 PMID:26209461 PMID:26467025 PMID:26749013 PMID:27287068 PMID:28265756 PMID:28492532 PMID:28781330 PMID:29032884 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,338,124...23,438,385
JBrowse link
G SLMAP sarcolemma associated protein ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr13:39,571,930...39,720,229
Ensembl chr13:39,571,987...39,721,895
JBrowse link
G SOD1 superoxide dismutase 1 ISO RGD PMID:15843790 RGD:1581221 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:9806674 PMID:18679114 RGD:4889454 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 treatment ISO ClinVar Annotator: match by term: Cardiac arrest RGD
ClinVar
PMID:26010685 PMID:28492532 RGD:12791997 NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,221...54,377,155
JBrowse link
G VCL vinculin ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:25741868 PMID:28492532 NCBI chr14:76,700,143...76,811,875
Ensembl chr14:76,700,168...76,811,875
JBrowse link
Cardiac Edema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22865611 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,481...42,076,746
JBrowse link
G IFT122 intraflagellar transport 122 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20493458 NCBI chr13:68,828,710...68,902,062
Ensembl chr13:68,828,705...68,902,062
JBrowse link
G UBIAD1 UbiA prenyltransferase domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23533172 NCBI chr 6:71,419,559...71,431,275
Ensembl chr 6:71,419,602...71,433,210
JBrowse link
Cardio-Renal Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR1 hepatitis A virus cellular receptor 1 susceptibility ISO protein:increased expression:kidney tubule: RGD PMID:22367506 PMID:23220287 RGD:7245477 RGD:7245950 NCBI chr16:66,162,318...66,208,868 JBrowse link
Cor pulmonale term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21450080 RGD:6767563 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,116...24,228,756
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20669672 RGD:4143386 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:serum RGD PMID:20669672 RGD:4143386 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
diastolic heart failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 susceptibility
treatment
severity
ISO DNA:insertion/deletion:intron 16:
DNS:insertion/deletion:intron: (rs1799752)
RGD PMID:14757777 PMID:19021695 PMID:19752885 RGD:40400704 RGD:40400723 RGD:40400906 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639
JBrowse link
G ADRA1D adrenoceptor alpha 1D ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr17:31,517,021...31,537,361
Ensembl chr17:31,517,021...31,537,361
JBrowse link
G AKIP1 A-kinase interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 9:513,383...537,779
Ensembl chr 9:531,544...537,707
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ANKRD23 ankyrin repeat domain 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 3:56,776,824...56,781,223
Ensembl chr 3:56,776,812...56,782,654
JBrowse link
G APLN apelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,748...106,246,378
JBrowse link
G CDC25B cell division cycle 25B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr17:31,910,824...31,929,418
Ensembl chr17:31,910,824...31,929,440
JBrowse link
G COL4A1 collagen type IV alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr11:76,858,332...76,997,409 JBrowse link
G COL8A1 collagen type VIII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr13:159,216,138...159,374,718
Ensembl chr13:159,216,138...159,374,504
JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 4:83,458,358...83,469,931
Ensembl chr 4:83,457,511...83,469,931
JBrowse link
G CYRIB CYFIP related Rac1 interactor B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 4:10,476,137...10,643,395 JBrowse link
G ELK3 ETS transcription factor ELK3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 5:87,285,237...87,355,201
Ensembl chr 5:87,285,238...87,354,196
JBrowse link
G EPN3 epsin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr12:26,812,653...26,825,485
Ensembl chr12:26,801,966...26,825,483
JBrowse link
G FHL1 four and a half LIM domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr  X:111,309,989...111,367,900
Ensembl chr  X:111,310,684...111,367,904
JBrowse link
G FIBIN fin bud initiation factor homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 2:33,328,250...33,331,752
Ensembl chr 2:33,328,250...33,331,593
JBrowse link
G FXYD3 FXYD domain containing ion transport regulator 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 6:44,647,771...44,654,377 JBrowse link
G HAMP hepcidin antimicrobial peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,159...44,787,307
JBrowse link
G KANK2 KN motif and ankyrin repeat domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 2:69,896,116...69,925,194
Ensembl chr 2:69,890,937...69,925,189
JBrowse link
G KLF9 Kruppel like factor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:223,723,613...223,747,661
Ensembl chr 1:223,720,445...223,748,226
JBrowse link
G LOC100524972 membrane-spanning 4-domains subfamily A member 6A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 2:11,373,408...11,383,704 JBrowse link
G LOC100623720 collagen alpha-1(VI) chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,240...208,313,127
JBrowse link
G MYH7 myosin heavy chain 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 7:75,650,841...75,672,908
Ensembl chr 7:75,650,445...75,709,232
JBrowse link
G NPPA natriuretic peptide A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 3:18,402,781...18,404,411
Ensembl chr 3:18,402,935...18,511,087
JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr14:48,040,848...48,051,660
Ensembl chr14:48,040,881...48,051,660
JBrowse link
G PLXND1 plexin D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr13:68,946,658...68,996,625
Ensembl chr13:68,946,661...68,996,618
JBrowse link
G PTP4A2 protein tyrosine phosphatase 4A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 6:88,419,444...88,452,757
Ensembl chr 6:88,419,387...88,452,589
JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:250,418,131...250,583,148
Ensembl chr 1:250,418,132...250,583,281
JBrowse link
G SFRP1 secreted frizzled related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748
JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 7:94,789,794...95,168,728
Ensembl chr 7:94,789,887...95,171,117
JBrowse link
G TRDN triadin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:39,180,544...39,567,245
Ensembl chr 1:39,180,879...39,567,240
JBrowse link
G WDR45 WD repeat domain 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr  X:43,150,691...43,155,981
Ensembl chr  X:43,147,476...43,156,195
JBrowse link
G ZNF532 zinc finger protein 532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:161,878,099...161,986,028
Ensembl chr 1:161,877,574...161,985,172
JBrowse link
Neonatal Pulmonary Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPS1 carbamoyl-phosphate synthase 1 susceptibility ISO ClinVar Annotator: match by term: Pulmonary hypertension, neonatal, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:11407344 PMID:14718356 PMID:15465784 PMID:16708072 PMID:17310273 PMID:20154341 PMID:21120950 PMID:21767969 PMID:25741868 PMID:28492532 NCBI chr15:113,210,038...113,339,086
Ensembl chr15:113,209,999...113,339,078
JBrowse link
Paroxysmal Dyspnea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor ISO RGD PMID:21388992 RGD:5129099 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,920...113,875,719
JBrowse link
G ADRB2 adrenoceptor beta 2 ISO ClinVar Annotator: match by term: Asthma, nocturnal, susceptibility to ClinVar PMID:7706471 PMID:9399946 PMID:9399966 PMID:9522789 PMID:11739457 PMID:14557466 PMID:15500895 PMID:15867853 PMID:16596417 PMID:28492532 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,032,782...150,035,591
JBrowse link
primary pulmonary hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR2 bone morphogenetic protein receptor type 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pulmonary hypertension, primary, dexfenfluramine-associated
ClinVar Annotator: match by term: Idiopathic and/or familial pulmonary arterial hypertension
ClinVar Annotator: match by term: Pulmonary hypertension, primary, fenfluramine-associated
CTD
ClinVar
PMID:11015450 PMID:11115378 PMID:12358323 PMID:16429395 PMID:16429403 PMID:16717148 PMID:16728714 PMID:19324947 PMID:19555857 PMID:20096498 PMID:20534176 PMID:21801371 PMID:24033266 PMID:25460361 PMID:25741868 PMID:26387786 PMID:26820968 PMID:28492532 PMID:32581362 NCBI chr15:105,971,577...106,132,496
Ensembl chr15:105,970,427...106,135,730
JBrowse link
G CAV1 caveolin 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G FOXF1 forkhead box F1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:19500772 PMID:19592680 PMID:19812545 PMID:20425831 PMID:22766610 PMID:23034409 PMID:23074687 PMID:23335808 PMID:23505205 PMID:23943206 PMID:24033266 PMID:24842713 PMID:26462560 NCBI chr 6:2,579,348...2,598,122
Ensembl chr 6:2,592,993...2,597,659
JBrowse link
G HDAC1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
G HDAC4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,627...138,614,301
JBrowse link
G HDAC5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr12:19,077,910...19,119,463
Ensembl chr12:19,077,997...19,123,140
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein ISO protein:decreased expression:lung, wall of arteriole (human) RGD PMID:20522807 RGD:9686087 NCBI chr17:35,316,518...35,317,742
Ensembl chr17:35,315,964...35,317,744
JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 3:112,322,446...112,359,212
Ensembl chr 3:112,322,446...112,359,212
JBrowse link
G SMAD9 SMAD family member 9 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr11:12,705,652...12,727,981
Ensembl chr11:12,705,359...12,763,008
JBrowse link
Primary Pulmonary Hypertension, 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:9245985 PMID:12700602 PMID:14684682 PMID:15024723 PMID:15879500 PMID:15880681 PMID:16429404 PMID:16470787 PMID:16540754 PMID:16705692 PMID:18159113 PMID:19555857 PMID:20414677 PMID:20501893 PMID:21158752 PMID:22632830 PMID:23298310 PMID:23722869 PMID:24753439 PMID:25741868 PMID:26387786 PMID:27316748 PMID:28492532 PMID:29449337 PMID:32581362 NCBI chr 5:17,267,483...17,284,155
Ensembl chr 5:17,263,907...17,286,276
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 ISO OMIM NCBI chr15:105,971,577...106,132,496
Ensembl chr15:105,970,427...106,135,730
JBrowse link
G ENG endoglin ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:18498373 PMID:23298310 PMID:24033266 PMID:25741868 PMID:26167679 PMID:26387786 PMID:28492532 PMID:30029678 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:20018952 PMID:21685056 PMID:23861362 PMID:24068186 PMID:25076992 PMID:28492532 NCBI chr 5:65,439,336...65,442,207 JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:23883380 NCBI chr 3:112,322,446...112,359,212
Ensembl chr 3:112,322,446...112,359,212
JBrowse link
G NOP58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:23579436 PMID:26387786 NCBI chr15:105,893,589...105,930,458
Ensembl chr15:105,850,294...105,930,459
JBrowse link
G SMAD1 SMAD family member 1 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:21898662 PMID:26387786 NCBI chr 8:82,907,557...82,987,909
Ensembl chr 8:82,908,527...82,968,994
JBrowse link
G SMAD4 SMAD family member 4 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:21898662 PMID:24728327 PMID:25502805 PMID:25741868 PMID:26387786 PMID:28492532 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,514,791...100,628,029
JBrowse link
G SMAD9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar NCBI chr11:12,705,652...12,727,981
Ensembl chr11:12,705,359...12,763,008
JBrowse link
G TBX4 T-box transcription factor 4 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:25741868 PMID:31151956 NCBI chr12:36,803,355...36,830,321
Ensembl chr12:36,801,730...36,830,430
JBrowse link
Primary Pulmonary Hypertension, 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD9 SMAD family member 9 ISO OMIM NCBI chr11:12,705,652...12,727,981
Ensembl chr11:12,705,359...12,763,008
JBrowse link
Primary Pulmonary Hypertension, 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1B bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension 3 ClinVar PMID:25741868 NCBI chr 8:124,536,648...125,035,841
Ensembl chr 8:124,536,648...124,841,530
JBrowse link
G CAV1 caveolin 1 ISO OMIM NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
Primary Pulmonary Hypertension, 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO OMIM NCBI chr 3:112,322,446...112,359,212
Ensembl chr 3:112,322,446...112,359,212
JBrowse link
Sudden Cardiac Death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL3 acyl-CoA synthetase long chain family member 3 disease_progression ISO RGD PMID:22661490 RGD:13831296 NCBI chr15:124,741,986...124,816,955
Ensembl chr15:124,568,383...124,817,004
JBrowse link
G ADRA2B adrenoceptor alpha 2B ISO RGD PMID:12535806 RGD:1559314 NCBI chr 3:45,760,966...45,762,306
Ensembl chr 3:45,758,268...45,764,178
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 9:71,895,615...72,054,898
Ensembl chr 9:71,895,630...72,054,897
JBrowse link
G ANK2 ankyrin 2 ISO ClinVar Annotator: match by term: Sudden cardiac death
ClinVar Annotator: match by term: Sudden cardiac arrest
RGD
ClinVar
PMID:12571597 PMID:25741868 PMID:28492532 RGD:734572 NCBI chr 8:109,306,793...109,661,970 JBrowse link
G APOB apolipoprotein B ISO RGD PMID:17045270 RGD:1601197 NCBI chr 3:117,250,096...117,316,200
Ensembl chr 3:117,250,096...117,316,200
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr 5:69,016,954...69,448,428 JBrowse link
G CEP85L centrosomal protein 85 like ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 1:43,392,630...43,564,835
Ensembl chr 1:43,392,645...43,563,695
JBrowse link
G DPP6 dipeptidyl peptidase like 6 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr18:3,148,479...3,905,845
Ensembl chr18:3,148,481...3,905,410
JBrowse link
G DSP desmoplakin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac death
CTD
ClinVar
PMID:20435227 PMID:25741868 NCBI chr 7:4,862,649...4,915,626
Ensembl chr 7:4,862,649...4,915,615
JBrowse link
G GJA1 gap junction protein alpha 1 treatment ISO RGD PMID:22093512 RGD:12910124 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,515...41,002,137
JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:23861362 PMID:27930701 PMID:28492532 NCBI chr13:18,126,471...18,176,669
Ensembl chr13:18,126,623...18,176,668
JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:21615589 PMID:23623143 PMID:23861362 PMID:24033266 PMID:24569893 PMID:25145517 PMID:25467552 PMID:25642760 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr 7:60,010,396...60,052,258
Ensembl chr 7:60,010,482...60,053,823
JBrowse link
G IL6 interleukin 6 susceptibility ISO RGD PMID:23906927 RGD:12792237 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G ITGB3 integrin subunit beta 3 ISO associated with arteriosclerosis; DNA:polymorphism:exon RGD PMID:20846430 RGD:5128476 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 ISO ClinVar Annotator: match by term: Sudden cardiac death
ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar PMID:18508782 PMID:19716085 PMID:22581653 PMID:25417810 PMID:25741868 PMID:26704558 NCBI chr18:6,242,826...6,279,154
Ensembl chr18:6,243,524...6,279,111
JBrowse link
G KNG1 kininogen 1 susceptibility ISO DNA:SNPs: : RGD PMID:19716087 RGD:10411885 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
G LMNA lamin A/C ISO CTD Direct Evidence: marker/mechanism CTD PMID:15996213 NCBI chr 4:93,899,019...93,927,255
Ensembl chr 4:93,899,026...93,949,398
JBrowse link
G MYBPC3 myosin binding protein C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20435227 NCBI chr 2:15,247,679...15,269,714
Ensembl chr 2:15,247,539...15,270,104
JBrowse link
G MYH7 myosin heavy chain 7 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:25741868 NCBI chr 7:75,650,841...75,672,908
Ensembl chr 7:75,650,445...75,709,232
JBrowse link
G MYOM1 myomesin 1 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:24033266 PMID:28492532 NCBI chr 6:103,451,206...103,593,093
Ensembl chr 6:103,451,343...103,597,324
JBrowse link
G NEBL nebulette ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr10:53,602,929...53,957,869
Ensembl chr10:53,604,600...53,958,047
JBrowse link
G PKP2 plakophilin 2 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:25741868 PMID:27532257 PMID:28492532 NCBI chr 5:41,424,687...41,509,590
Ensembl chr 5:41,424,845...41,508,868
JBrowse link
G PLN phospholamban ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 1:43,449,354...43,458,925 JBrowse link
G RYR2 ryanodine receptor 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar Annotator: match by term: Sudden cardiac death
CTD
ClinVar
PMID:23861362 PMID:24033266 PMID:25650408 PMID:25741868 PMID:26656175 PMID:27054166 PMID:27930701 PMID:28492532 PMID:31913406 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,245...54,406,355
JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr 9:50,508,194...50,532,432
Ensembl chr 9:50,508,198...50,524,628
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Sudden cardiac death
ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar PMID:15851227 PMID:16712702 PMID:18378609 PMID:18508782 PMID:19564561 PMID:19841300 PMID:20129283 PMID:22581653 PMID:22984773 PMID:23631430 PMID:23671135 PMID:23861362 PMID:24033266 PMID:24055113 PMID:25741868 PMID:25904541 PMID:28492532 PMID:30254039 PMID:32533946 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,338,124...23,438,385
JBrowse link
G SP4 Sp4 transcription factor ISO RGD PMID:11007485 RGD:1580019 NCBI chr 9:90,337,355...90,410,529
Ensembl chr 9:90,336,690...90,410,295
JBrowse link
G TMEM43 transmembrane protein 43 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac arrest
CTD
ClinVar
PMID:20435227 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr13:70,397,069...70,417,213
Ensembl chr13:70,393,219...70,417,168
JBrowse link
G TNNI3 troponin I3, cardiac type ISO ClinVar Annotator: match by term: Sudden cardiac arrest ClinVar PMID:21839045 PMID:25741868 NCBI chr 6:59,366,828...59,377,490
Ensembl chr 6:59,366,828...59,382,728
JBrowse link
G TNNT2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac death
CTD
ClinVar
PMID:17556660 PMID:23233322 PMID:24033266 PMID:24503780 PMID:25741868 PMID:28492532 NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:24019741 PMID:28492532 NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,221...54,377,155
JBrowse link
G TTN titin ISO ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar Annotator: match by term: Sudden cardiac death
ClinVar PMID:19608031 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr15:84,226,953...84,501,320 JBrowse link
Sudden Cardiac Failure, Infantile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPA2 inorganic pyrophosphatase 2 ISO OMIM NCBI chr 8:116,249,531...116,333,847
Ensembl chr 8:116,249,569...116,334,013
JBrowse link
systolic heart failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD1 ankyrin repeat domain 1 ISO ClinVar Annotator: match by term: Heart failure, systolic ClinVar PMID:19525294 PMID:23299917 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr14:102,603,777...102,612,857
Ensembl chr14:102,603,777...102,612,839
JBrowse link
G BMP10 bone morphogenetic protein 10 ISO CTD Direct Evidence: therapeutic CTD PMID:31712309 NCBI chr 3:73,519,904...73,530,448
Ensembl chr 3:73,519,934...73,529,977
JBrowse link
G DSP desmoplakin ISO ClinVar Annotator: match by term: Systolic heart failure ClinVar PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 7:4,862,649...4,915,626
Ensembl chr 7:4,862,649...4,915,615
JBrowse link
G NPPB natriuretic peptide B ISO associated with Renal Insufficiency;protein:increased expression:plasma: RGD PMID:23122795 PMID:23725445 RGD:7246908 RGD:7247627 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G TTN titin ISO ClinVar Annotator: match by term: Heart failure, systolic ClinVar PMID:23861362 PMID:24033266 PMID:25163546 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr15:84,226,953...84,501,320 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12682
    disease of anatomical entity 12220
      cardiovascular system disease 3292
        heart disease 2339
          congestive heart failure 364
            Cardiac Edema 3
            Cardio-Renal Syndrome 1
            Cor pulmonale + 21
            Paroxysmal Dyspnea 2
            cardiac arrest + 54
            diastolic heart failure 33
            rheumatic congestive heart failure 0
            systolic heart failure 5
paths to the root