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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:congestive heart failure
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Accession:DOID:6000 term browser browse the term
Definition:A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Synonyms:exact_synonym: CHF;   Cardiac Failure;   Cardiac Failure Congestive;   Congestive heart disease;   Heart Decompensation;   Heart Failure;   Left Sided Heart Failure;   Myocardial Failure;   Right Sided Heart Failure;   Weak heart
 narrow_synonym: Chronic Heart Failure
 related_synonym: Beta-2-adrenoreceptor agonist, reduced response to;   Congestive heart failure and beta-blocker response, modifier of;   Congestive heart failure, modifier of
 primary_id: MESH:D006333;   RDO:0005421
 xref: ICD10CM:I50;   ICD10CM:I50.9;   ICD9CM:428;   ICD9CM:428.0;   NCI:C3080;   NCI:C50577
For additional species annotation, visit the Alliance of Genome Resources.


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congestive heart failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA1 acetyl-CoA acyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 3:38,020,439...38,035,341 JBrowse link
G ACACA acetyl-CoA carboxylase alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr17:19,670,114...19,998,903
Ensembl chr17:19,969,205...20,297,651
JBrowse link
G ACADS acyl-CoA dehydrogenase short chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:30827304 NCBI chr12:118,309,303...118,323,489
Ensembl chr12:121,682,113...121,696,376
JBrowse link
G ACAN aggrecan ISO mRNA:increased expression:myocardium RGD PMID:24595230 RGD:11570548 NCBI chr15:67,492,494...67,563,265
Ensembl chr15:86,733,853...86,771,420
JBrowse link
G ACE angiotensin I converting enzyme treatment ISO CTD Direct Evidence: marker/mechanism
associated with Myocardial Infarction
associated with Hypertension
RGD
CTD
PMID:15894569 PMID:18586661 PMID:19620082 PMID:22123369 RGD:12859272 RGD:2325224 RGD:6893472 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:heart (human)
CTD
RGD
PMID:25973029 PMID:32227090 RGD:40818416 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891
JBrowse link
G ACLY ATP citrate lyase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr17:15,385,335...15,447,269
Ensembl chr17:15,615,994...15,664,800
JBrowse link
G ACTN2 actinin alpha 2 ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 NCBI chr 1:212,245,742...212,323,387
Ensembl chr 1:217,272,597...217,321,103
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 treatment ISO associated with pulmonary hypertension RGD PMID:22628376 RGD:13703064 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO associated with cardiovascular disease; protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:18192035 PMID:19367012 PMID:22032915 PMID:26670611 RGD:5686388 RGD:5686806 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G ADM adrenomedullin ISO RGD PMID:12623952 RGD:704370 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842
JBrowse link
G ADRA2C adrenoceptor alpha 2C ISO DNA:deletion: :322_325del(human)
ClinVar Annotator: match by term: Congestive heart failure and beta-blocker response, modifier of
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:12374873 PMID:17496726 RGD:1300355 NCBI chr 4:3,904,346...3,906,577 JBrowse link
G ADRB1 adrenoceptor beta 1 ISO DNA:polymorphism: :p.R389G (human)
ClinVar Annotator: match by term: Congestive heart failure and beta-blocker response, modifier of
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:7586371 PMID:10212248 PMID:12374873 PMID:14502278 PMID:15816327 PMID:16844790 PMID:17496726 PMID:19587314 PMID:21516734 RGD:5129119 RGD:737774 NCBI chr10:110,642,491...110,646,595 JBrowse link
G ADRB2 adrenoceptor beta 2 ISO ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to
protein:altered localization:cardiac muscle cell
RGD
ClinVar
PMID:8383511 PMID:15284533 PMID:16596417 PMID:19587314 PMID:20185685 RGD:4144900 RGD:5129119 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892
JBrowse link
G ADRB3 adrenoceptor beta 3 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:left ventricle, myocardium (human)
protein:increased expression:heart ventricle (rat)
CTD
RGD
PMID:11273992 PMID:15009959 PMID:17440824 PMID:21549119 RGD:5684398 RGD:5684917 NCBI chr 8:37,263,730...37,267,475 JBrowse link
G AGER advanced glycosylation end-product specific receptor severity ISO protein:increased expression:plasma (human) RGD PMID:20685687 RGD:7244134 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
JBrowse link
G AGT angiotensinogen onset
severity
treatment
ISO DNA:polymorphisms: :p.M235T, p.T174M (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
RGD
CTD
PMID:1330361 PMID:12025466 PMID:17145981 PMID:20811386 PMID:21963897 PMID:24465706 RGD:11039412 RGD:1601140 RGD:8549482 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G AGTR1 angiotensin II receptor type 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:17208988 PMID:18214293 PMID:18586661 PMID:21963897 RGD:8549482 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380
JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO mRNA, protein:decreased expression:heart RGD PMID:18768398 PMID:21963897 RGD:6903846 RGD:8549482 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685
JBrowse link
G AKAP6 A-kinase anchoring protein 6 ISO RGD PMID:24812305 RGD:11251930 NCBI chr14:12,978,221...13,602,732
Ensembl chr14:31,395,026...31,792,166
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 7:83,942,590...84,108,648
Ensembl chr 7:97,540,356...97,705,608
JBrowse link
G ALB albumin disease_progression ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11771600 PMID:22158777 RGD:11036096 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15623566 RGD:5509787 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO associated with Myocardial Infarction; mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 PMID:19546247 RGD:1642301 RGD:5509627 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669
JBrowse link
G ANK2 ankyrin 2 ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905
JBrowse link
G ANKRD23 ankyrin repeat domain 23 ISO associated with Cardiomyopathy, Congestive RGD PMID:15238456 RGD:2314858 NCBI chr2A:102,469,784...102,476,991
Ensembl chr2A:97,756,775...97,763,360
JBrowse link
G APCS amyloid P component, serum ISO CTD Direct Evidence: marker/mechanism CTD PMID:16129801 NCBI chr 1:134,937,472...134,938,512
Ensembl chr 1:138,734,046...138,735,093
JBrowse link
G APLN apelin ISO associated with Hypertension, Pulmonary
protein:decreased expression:plasma
protein:increased expression:ventricle myocardium
RGD PMID:16263185 PMID:17055480 PMID:17119870 RGD:1626171 RGD:1626175 RGD:1626186 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APOA1 apolipoprotein A1 ISO protein: decreased expression: serum RGD PMID:17517342 RGD:5508219 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122
JBrowse link
G APOC1 apolipoprotein C1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr19:41,862,168...41,878,231 JBrowse link
G APOE apolipoprotein E ISO associated with Beta-Thalassemia RGD PMID:9787187 RGD:11039487 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G ARRB1 arrestin beta 1 treatment ISO RGD PMID:21232674 RGD:5509888 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155
JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18418421 NCBI chr19:38,854,243...38,882,034 JBrowse link
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19776660 Ensembl chr16:29,265,516...29,290,807 JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19776660 PMID:21691940 RGD:6903963 NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923
JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18179782 NCBI chr20:3,169,094...3,172,900 JBrowse link
G AVPR2 arginine vasopressin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12145768 NCBI chr  X:143,458,693...143,461,945
Ensembl chr  X:153,346,466...153,348,840
JBrowse link
G BAMBI BMP and activin membrane bound inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr10:28,833,690...28,839,164
Ensembl chr10:29,187,857...29,193,324
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:18097624 PMID:29746994 RGD:10054097 RGD:13792577 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468
JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:18097624 PMID:29746994 RGD:10054097 RGD:13792577 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
JBrowse link
G BECN1 beclin 1 treatment ISO RGD PMID:18619688 RGD:11560532 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO associated with Hypertension;protein:decreased expression:cardiac muscle cell RGD PMID:16257070 RGD:2293134 NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159
JBrowse link
G BNIP3 BCL2 interacting protein 3 treatment ISO RGD PMID:23508759 RGD:11561982 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826
JBrowse link
G CASP1 caspase 1 ISO mRNA, protein:increased expression:heart left ventricle RGD PMID:17303764 RGD:2315913 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
JBrowse link
G CASP3 caspase 3 treatment ISO RGD PMID:29746994 RGD:13792577 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
JBrowse link
G CASQ2 calsequestrin 2 ISO mRNA:increased expression:sinoatrial node RGD PMID:21565973 RGD:6771208 NCBI chr 1:86,795,392...86,864,196
Ensembl chr 1:121,844,097...121,913,311
JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10618301 PMID:16105639 RGD:1581151 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
JBrowse link
G CBL Cbl proto-oncogene ISO protein:increased expression:left ventricle myocardium, muscle cell (human) RGD PMID:24583314 RGD:11251947 NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671
JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:heart left ventricle
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12950323 PMID:29959987 RGD:1581156 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
JBrowse link
G CCN2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17229371 NCBI chr 6:129,729,572...129,733,113
Ensembl chr 6:133,836,319...133,842,077
JBrowse link
G CCNA2 cyclin A2 ISO RGD PMID:16820573 RGD:2293348 NCBI chr 4:114,016,917...114,024,816
Ensembl chr 4:125,153,810...125,161,302
JBrowse link
G CCNT1 cyclin T1 ISO RGD PMID:15297879 RGD:1556509 NCBI chr12:40,028,334...40,057,393
Ensembl chr12:40,906,907...40,935,392
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:12719858 RGD:1581177 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:serum RGD PMID:15716285 RGD:2314219 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202
JBrowse link
G CDK9 cyclin dependent kinase 9 ISO protein:increased activity:heart:
protein:increased activity:ventricle:
RGD PMID:15297879 RGD:1556509 NCBI chr 9:98,905,468...98,909,923
Ensembl chr 9:127,580,862...127,584,935
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO mRNA,protein:increased expression:cardiomyocyte: RGD PMID:11033112 RGD:11341730 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045
JBrowse link
G CHEK2 checkpoint kinase 2 ISO protein:increased phosphorylation:heart myocardium RGD PMID:12702777 RGD:2289708 NCBI chr22:9,757,038...9,811,171 JBrowse link
G CHI3L1 chitinase 3 like 1 ISO protein:increased secretion:plasma (human) RGD PMID:19961288 RGD:4892629 NCBI chr 1:178,778,081...178,789,704
Ensembl chr 1:183,075,312...183,083,229
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr11:46,342,384...46,350,366
Ensembl chr11:46,894,615...46,896,054
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005
JBrowse link
G CIDEA cell death inducing DFFA like effector a ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr18:2,051,880...2,075,909 JBrowse link
G CORIN corin, serine peptidase ISO mRNA:increased expression:heart (rat)
mRNA:decreased expression:left atrium, right atrium (rat)
RGD PMID:15155264 PMID:15191894 RGD:1581217 RGD:1581218 NCBI chr 4:74,311,036...74,555,742
Ensembl chr 4:85,043,182...85,286,573
JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:16360360 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CRYAB crystallin alpha B ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:1560021 PMID:16483541 PMID:16793013 PMID:17116488 PMID:20171888 PMID:21920752 PMID:22106715 PMID:22995991 PMID:23194663 PMID:23299917 PMID:24033266 PMID:25208129 PMID:25741868 PMID:26694549 PMID:26961874 PMID:28492532 NCBI chr11:106,795,406...106,800,019
Ensembl chr11:110,639,442...110,644,272
JBrowse link
G CS citrate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:8922916 NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854
JBrowse link
G CSF2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11732872 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146
JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15585077 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
JBrowse link
G CST3 cystatin C susceptibility ISO protein:increased expression:serum (human) RGD PMID:19539088 RGD:2314311 NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO mRNA, protein:increased expression: paraventricular nucleus of hypothalamus RGD PMID:24036597 RGD:9491792 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 ISO protein:increased expression:heart (rat) RGD PMID:19571523 RGD:4891162 NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654
JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr 6:30,625,871...30,645,066
Ensembl chr 6:31,496,047...31,513,455
JBrowse link
G DIO3 iodothyronine deiodinase 3 ISO associated with Hypertrophy, Right Ventricular;mRNA, protein:increased expression:heart right ventricle RGD PMID:18259611 RGD:2303417 NCBI chr14:82,188,126...82,190,220 JBrowse link
G DMD dystrophin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr  X:23,728,650...26,338,849
Ensembl chr  X:31,282,415...33,492,733
JBrowse link
G DNMT1 DNA methyltransferase 1 ISO protein:increased expression:atrium: RGD PMID:23573917 RGD:9588286 NCBI chr19:9,681,847...9,745,334
Ensembl chr19:10,342,478...10,406,972
JBrowse link
G DSTN destrin, actin depolymerizing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr20:17,528,574...17,566,925
Ensembl chr20:17,506,262...17,545,331
JBrowse link
G DYNLL1 dynein light chain LC8-type 1 ISO protein:increased expression:paraventricular nucleus RGD PMID:23832698 RGD:7257598 NCBI chr12:118,078,401...118,080,822 JBrowse link
G ECE1 endothelin converting enzyme 1 ISO associated with myocardial ischemia
mRNA,protein:increased expression:kidney:
RGD PMID:9595392 PMID:11145756 PMID:19596829 RGD:1580911 RGD:7243876 RGD:7244244 NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909
JBrowse link
G EDN1 endothelin 1 treatment
severity
ISO mRNA,protein:increased expression:heart:
protein:increased secretion:plasma (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:7967349 PMID:7969316 PMID:8149524 PMID:9861300 PMID:10199843 PMID:10973842 PMID:11136700 PMID:11707688 PMID:16360360 PMID:16762801 RGD:4144845 RGD:7244167 RGD:8661798 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
JBrowse link
G EDNRA endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28095452 NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497
JBrowse link
G EDNRB endothelin receptor type B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28095452 NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286
JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 4:102,545,815...102,695,536
Ensembl chr 4:113,110,466...113,260,444
JBrowse link
G ENDOG endonuclease G ISO mRNa:decreased expression:heart: RGD PMID:17292393 RGD:9685393 NCBI chr 9:99,941,856...99,945,957 JBrowse link
G ENG endoglin treatment ISO protein:increased expression:heart left ventricle (rat) RGD PMID:20156938 RGD:7257540 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641
JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:12724418 RGD:2312280 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604
JBrowse link
G EPHX2 epoxide hydrolase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18443590 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749
JBrowse link
G EPO erythropoietin treatment ISO associated with Myocardial Infarction RGD PMID:20139114 RGD:10401073 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:10421602 RGD:1580989 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO associated with Aortic Valve Stenosis;mRNA, protein:decreased expression:heart myocardium RGD PMID:10421602 RGD:1580989 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006
JBrowse link
G ESRRA estrogen related receptor alpha ISO protein:decreased expression:heart: RGD PMID:21825219 RGD:10401867 NCBI chr11:59,662,565...59,673,789
Ensembl chr11:63,009,295...63,018,744
JBrowse link
G EYA4 EYA transcriptional coactivator and phosphatase 4 ISO DNA:deletion:introns, exon (human)
ClinVar Annotator: match by term: Congestive heart failure
RGD
ClinVar
PMID:15735644 PMID:25741868 PMID:28492532 RGD:1598455 NCBI chr 6:131,016,143...131,306,251
Ensembl chr 6:135,116,978...135,404,403
JBrowse link
G FAS Fas cell surface death receptor treatment ISO mRNA:splice variant:heart left ventricle (human) RGD PMID:9367848 PMID:29746994 RGD:13792577 RGD:8686420 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612
JBrowse link
G FASLG Fas ligand treatment ISO RGD PMID:29746994 RGD:13792577 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281
JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr17:76,483,108...76,503,148
Ensembl chr17:82,187,516...82,205,647
JBrowse link
G FBLN5 fibulin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12189163 NCBI chr14:72,504,240...72,583,160
Ensembl chr14:91,848,430...91,927,304
JBrowse link
G FIP1L1 factor interacting with PAPOLA and CPSF1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28347583 NCBI chr 4:70,495,627...70,579,059
Ensembl chr 4:77,050,858...77,133,003
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B ISO associated with Shock, Septic RGD PMID:17637193 RGD:2302075 NCBI chr2A:24,047,287...24,065,765
Ensembl chr2A:24,145,893...24,159,082
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:15623567 RGD:2293777 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit ISO RGD PMID:15623567 RGD:2293777 NCBI chr11:61,252,513...61,261,032
Ensembl chr11:64,581,841...64,589,304
JBrowse link
G FOXC1 forkhead box C1 ISO RGD PMID:16952980 RGD:1582564 NCBI chr 6:1,429,051...1,433,180 JBrowse link
G FOXC2 forkhead box C2 ISO RGD PMID:16952980 RGD:1582564 NCBI chr16:67,237,476...67,239,545 JBrowse link
G FOXO1 forkhead box O1 ISO RGD PMID:16952980 RGD:1582564 NCBI chr13:21,763,729...21,874,279 JBrowse link
G FOXP1 forkhead box P1 ISO RGD PMID:16952980 RGD:1582564 NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173
JBrowse link
G FOXP4 forkhead box P4 ISO RGD PMID:16952980 RGD:1582564 NCBI chr 6:41,133,751...41,189,709
Ensembl chr 6:42,459,420...42,496,205
JBrowse link
G FTH1 ferritin heavy chain 1 ISO protein:decreased expression:heart RGD PMID:18992754 RGD:2315110 NCBI chr11:57,329,163...57,332,248 JBrowse link
G FXYD1 FXYD domain containing ion transport regulator 1 ISO protein:increased serine phosphorylation:heart, membrane RGD PMID:26668322 RGD:11526267 NCBI chr19:32,080,180...32,089,141
Ensembl chr19:40,824,448...40,827,039
JBrowse link
G GATM glycine amidinotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16820567 NCBI chr15:24,309,045...24,326,673
Ensembl chr15:42,639,597...42,657,209
JBrowse link
G GCG glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:7608802 NCBI chr2B:49,436,379...49,446,559
Ensembl chr2B:166,806,016...166,811,155
JBrowse link
G GDF15 growth differentiation factor 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20855664 NCBI chr19:17,864,840...17,867,883
Ensembl chr19:18,835,216...18,838,470
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:20572026 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723
JBrowse link
G GPX4 glutathione peroxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr19:20,904...23,828 JBrowse link
G GRK1 G protein-coupled receptor kinase 1 ISO RGD PMID:12456492 RGD:1600002 NCBI chr13:94,816,045...94,838,509
Ensembl chr13:113,867,002...113,885,610
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO mRNA:decreased expression:peripheral blood mononuclear cell (human)
associated with Hypertrophy, Left Ventricular and Hypertension;protein:increased expression, increased activity:heart left ventricle, cytosol (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9931137 PMID:11331748 PMID:26248277 PMID:26670611 PMID:29247373 RGD:11535540 RGD:13506830 RGD:1625790 RGD:737776 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 severity ISO mRNA:decreased expression:heart left ventricle (human) RGD PMID:22685168 RGD:13506835 NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 severity ISO mRNA:decreased expression:heart left ventricle (human)
mRNA:decreased expression:peripheral blood mononuclear cell (human)
RGD PMID:22685168 PMID:26248277 RGD:11535540 RGD:13506835 NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17901358 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771
JBrowse link
G HAMP hepcidin antimicrobial peptide ISO protein:increased expression:serum, urine RGD PMID:21080339 RGD:11041621 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861
JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 4:165,755,000...165,758,735 JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:heart right ventricle (rat)
CTD
RGD
PMID:15732037 PMID:17582388 RGD:9068910 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885
JBrowse link
G HMGB1 high mobility group box 1 treatment ISO protein:decreased expression:heart RGD PMID:23708738 PMID:24204700 RGD:10402070 RGD:10402081 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:22352330 PMID:23592614 RGD:10755584 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
JBrowse link
G HRH2 histamine receptor H2 susceptibility ISO RGD PMID:24655024 RGD:9685523 NCBI chr 5:171,004,893...171,057,539
Ensembl chr 5:177,928,039...177,931,566
JBrowse link
G HSF1 heat shock transcription factor 1 ISO protein:altered localization:heart left ventricle (rat) RGD PMID:24285117 RGD:10402754 NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17481944 NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO mRNA:increased expression:heart left ventricle RGD PMID:16002744 RGD:1600503 NCBI chr13:27,976,415...28,042,941
Ensembl chr13:46,694,273...46,759,826
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:left ventricle cardiac muscle (rat)
CTD
RGD
PMID:17936780 PMID:19023134 RGD:9698457 NCBI chr2B:118,362,719...118,381,253
Ensembl chr2B:237,153,709...237,170,591
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:3091246 PMID:20938210 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:12835956 RGD:1598415 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
JBrowse link
G IL10 interleukin 10 disease_progression
treatment
ISO RGD PMID:16461369 PMID:23778495 PMID:28939262 RGD:14975271 RGD:1598465 RGD:7365020 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:heart RGD PMID:19527710 PMID:19909738 RGD:2325816 RGD:4831836 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135663 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
JBrowse link
G IL6 interleukin 6 ISO associated with Diabetes Mellitus, Experimental; protein:increased expression:extracellular space (rat)
CTD Direct Evidence: marker/mechanism
associated with Hypertension;mRNA:increased expression:heart
RGD
CTD
PMID:15135663 PMID:16360360 PMID:18280594 PMID:18999900 PMID:28939262 RGD:14975271 RGD:2307285 RGD:5128682 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor ISO protein:increased expression:paraventricular hypothalamic nucleus RGD PMID:17095650 RGD:1625433 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089
JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15628829 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G ITGB1 integrin subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11884376 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031
JBrowse link
G KAT8 lysine acetyltransferase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27768893 NCBI chr16:23,837,540...23,851,376
Ensembl chr16:31,486,098...31,500,185
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO mRNA:increased expression:endocardium of right ventricle:
associated with Myocardial Infarction (RDO:0006167); mRNA:increased expression:heart left ventricle, septum
RGD PMID:16497176 PMID:17384445 RGD:12910696 RGD:1642301 NCBI chr21:20,818,395...20,884,053 JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 ISO associated with Hypertension, Pulmonary:mRNA:decreased expression:heart right ventricle (rat) RGD PMID:25016242 RGD:9831185 NCBI chr 1:190,576,180...190,807,367
Ensembl chr 1:195,430,994...195,662,840
JBrowse link
G KDM2A lysine demethylase 2A ISO protein:altered localization:promoter (mouse) RGD PMID:25181347 RGD:9588275 NCBI chr11:62,470,549...62,616,135
Ensembl chr11:65,793,464...65,930,498
JBrowse link
G LEP leptin ISO RGD PMID:18006469 RGD:5128823 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G LEPR leptin receptor ISO protein:increased phosphorylation:heart RGD PMID:18006469 RGD:5128823 NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768
JBrowse link
G LGALS3 galectin 3 ISO RGD PMID:15520318 RGD:9685214 NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412
JBrowse link
G LIF LIF interleukin 6 family cytokine ISO RGD PMID:20051627 RGD:2326058 NCBI chr22:11,276,576...11,282,972
Ensembl chr22:29,078,862...29,095,608
JBrowse link
G LOC100978529 myosin-7 treatment ISO associated with Myocardial Infarction RGD PMID:18088389 RGD:12792974 NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763
JBrowse link
G LOC100982531 cytochrome b-245 heavy chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183
JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21284947 NCBI chr19:7,205,124...7,215,776
Ensembl chr19:8,057,598...8,066,512
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased activity:heart: RGD PMID:17562954 RGD:10412331 NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727
JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO mRNA, protein:decreased expression:heart RGD PMID:21963897 RGD:8549482 NCBI chr 6:157,774,098...157,799,983
Ensembl chr 6:162,801,416...162,802,393
JBrowse link
G MDH2 malate dehydrogenase 2 ISO RGD PMID:16786185 RGD:1582470 NCBI chr 7:67,953,759...67,973,270
Ensembl chr 7:82,497,800...82,516,526
JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:12383878 RGD:13801043 NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119
JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:12892382 PMID:21866669 RGD:1582539 RGD:7207282 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104
JBrowse link
G MMP13 matrix metallopeptidase 13 disease_progression ISO associated with Hypertension
protein:increased expression:left ventricle (rat)
RGD PMID:10773234 PMID:10773235 RGD:1582587 RGD:2290467 NCBI chr11:97,890,811...97,902,778
Ensembl chr11:101,377,001...101,387,679
JBrowse link
G MMP14 matrix metallopeptidase 14 disease_progression ISO protein:increased expression:left ventricle (rat) RGD PMID:10773235 RGD:1582587 NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058
JBrowse link
G MMP2 matrix metallopeptidase 2 severity ISO protein:increased expression:heart left ventricle, plasma
mRNA:increased expression:heart left ventricle
RGD PMID:10773234 PMID:16169329 PMID:20606426 RGD:1582574 RGD:2290467 RGD:8694112 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
JBrowse link
G MMP3 matrix metallopeptidase 3 ISO protein:increased expression:heart left ventricle, plasma RGD PMID:20606426 RGD:8694112 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354
JBrowse link
G MMP8 matrix metallopeptidase 8 disease_progression ISO protein:increased expression:left ventricle (rat) RGD PMID:10773235 RGD:1582587 NCBI chr11:97,650,408...97,663,731
Ensembl chr11:101,143,268...101,156,736
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:heart left ventricle, plasma
associated with Hypertension, Pulmonary; protein:increased expression:heart
RGD PMID:11342481 PMID:16952784 PMID:17913382 PMID:20606426 RGD:1582647 RGD:5130174 RGD:7207137 RGD:8694112 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G MSTN myostatin ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:myocardium
CTD
RGD
PMID:16968467 RGD:2303554 NCBI chr2B:77,364,927...77,452,426
Ensembl chr2B:195,283,903...195,290,922
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO mRNA, protein:increased expression:heart RGD PMID:20861467 RGD:10003169 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
JBrowse link
G MYH6 myosin heavy chain 6 treatment ISO associated with Myocardial Infarction
ClinVar Annotator: match by term: Heart failure
ClinVar Annotator: match by term: Congestive heart failure
mRNA:decreased expression:heart left ventricle
RGD
ClinVar
PMID:9410916 PMID:18088389 PMID:20656787 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 RGD:12792974 RGD:1580923 NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331
JBrowse link
G MYOD1 myogenic differentiation 1 treatment ISO associated with Aortic Valve Stenosis RGD PMID:20060348 RGD:9686081 NCBI chr11:17,772,317...17,774,884
Ensembl chr11:17,456,124...17,458,690
JBrowse link
G MYOT myotilin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr 5:133,254,644...133,274,615
Ensembl chr 5:139,386,101...139,411,960
JBrowse link
G MYPN myopalladin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:22286171 PMID:23299917 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr10:64,590,232...64,696,512
Ensembl chr10:66,902,008...67,004,967
JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO mRNA, protein:increased expression:heart RGD PMID:19853610 RGD:2325979 NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 ISO CTD Direct Evidence: therapeutic CTD
RGD
PMID:28373008 PMID:29373037 RGD:26923905 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
JBrowse link
G NGFR nerve growth factor receptor ISO associated with Myocardial Infarction ;mRNA:increased expression:heart left ventricle, septum (rat) RGD PMID:16497176 RGD:1642301 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966
JBrowse link
G NISCH nischarin ISO RGD PMID:12021582 RGD:1581128 NCBI chr 3:52,397,576...52,435,127
Ensembl chr 3:53,626,317...53,662,567
JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:15466641 PMID:23832698 RGD:1581144 RGD:7257598 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005
JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19168511 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19168511 PMID:20304815 PMID:29351461 RGD:13504746 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
JBrowse link
G NOX1 NADPH oxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr  X:90,046,023...90,076,968
Ensembl chr  X:100,182,398...100,215,192
JBrowse link
G NOX4 NADPH oxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr11:84,330,362...84,496,755 JBrowse link
G NPPA natriuretic peptide A severity
treatment
ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
mRNA,protein:increased expression:heart,plasma
CTD
RGD
PMID:1647690 PMID:2143809 PMID:8112904 PMID:11136700 PMID:11421854 PMID:16101196 PMID:23566312 PMID:23931972 RGD:1580139 RGD:1580140 RGD:7247714 RGD:7297049 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373
JBrowse link
G NPPB natriuretic peptide B severity ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism|therapeutic
mRNA,protein:increased expression:heart,plasma
associated with Diabetes Mellitus;protein:increased expression:plasma
RGD
CTD
PMID:1831369 PMID:2143809 PMID:11136700 PMID:11279304 PMID:11421854 PMID:12628948 PMID:15732037 PMID:15860969 PMID:16101196 PMID:16333235 PMID:16360360 PMID:16762801 PMID:16777915 PMID:17257273 PMID:19650993 PMID:24535859 PMID:29959987 RGD:1580139 RGD:1580140 RGD:1642196 RGD:7247316 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995
JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO protein:decreased expression:kidney
associated with Hypertension
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:9405681 PMID:17264312 PMID:20881240 RGD:7247730 RGD:737701 NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327
JBrowse link
G NPTXR neuronal pentraxin receptor ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr22:19,731,443...19,757,125 JBrowse link
G NPY neuropeptide Y ISO RGD PMID:17804485 RGD:7175103 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 treatment ISO RGD PMID:21737535 RGD:7174712 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15722665 PMID:21321305 NCBI chr 4:140,418,624...140,785,180
Ensembl chr 4:152,108,508...152,430,298
JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19801490 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22503866 NCBI chr21:1,565,149...1,801,358
Ensembl chr21:15,065,197...15,068,673
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO protein:increased expression:heart left ventricle (rat) RGD PMID:22128088 RGD:9590202 NCBI chr  X:60,798,219...60,840,948
Ensembl chr  X:70,852,687...70,894,921
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO protein:decreased expression:heart RGD PMID:19493956 RGD:7800717 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358
JBrowse link
G P2RX4 purinergic receptor P2X 4 ISO associated with Myocardial Infarction (CTD:0006167); mRNA:increased expression:heart left ventricle, septum RGD PMID:16497176 RGD:1642301 NCBI chr12:118,807,961...118,832,267
Ensembl chr12:122,178,672...122,202,959
JBrowse link
G PAMR1 peptidase domain containing associated with muscle regeneration 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28751527 NCBI chr11:35,404,636...35,498,705
Ensembl chr11:35,279,225...35,373,862
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 treatment ISO associated with Hypertension RGD PMID:19443425 RGD:11074236 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr20:53,901,738...53,907,090
Ensembl chr20:55,179,429...55,184,920
JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO protein:decreased expression:heart: RGD PMID:23647599 RGD:10448278 NCBI chr 6:147,564,783...147,623,402 JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:28347583 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19429709 NCBI chr16:1,394,447...1,463,735 JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr12:115,716,953...115,726,412
Ensembl chr12:119,093,952...119,105,054
JBrowse link
G PGF placental growth factor ISO RGD PMID:19327525 RGD:6483590 NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12963636 PMID:15936620 RGD:6482699 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614
JBrowse link
G PLA2G7 phospholipase A2 group VII ISO RGD PMID:16952920 RGD:6482778 NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212
JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
JBrowse link
G PLCD1 phospholipase C delta 1 ISO RGD PMID:11181012 RGD:2300431 NCBI chr 3:37,906,359...37,928,564
Ensembl chr 3:38,189,496...38,206,886
JBrowse link
G PLD2 phospholipase D2 ISO protein:increased expression:heart left ventricle RGD PMID:15601581 RGD:2299908 NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425
JBrowse link
G PLN phospholamban treatment ISO associated with Myocardial Infarction
associated with Hypertension
RGD PMID:22947202 PMID:22970977 RGD:7327181 RGD:7327182 NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668
JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:3026683 PMID:8277081 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706
JBrowse link
G PON1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
JBrowse link
G POSTN periostin treatment ISO mRNA:increased expression:heart RGD PMID:15381649 PMID:16414453 RGD:10040951 RGD:10040999 NCBI chr13:18,779,297...18,815,207
Ensembl chr13:37,368,030...37,407,212
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha onset ISO CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:heart (mouse)
RGD
CTD
PMID:19808358 PMID:22503866 PMID:23297372 PMID:23342071 RGD:7241838 RGD:7241843 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212
JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha ISO RGD PMID:12024026 RGD:737728 NCBI chr11:62,756,659...62,760,369
Ensembl chr11:66,068,007...66,071,611
JBrowse link
G PPP1CC protein phosphatase 1 catalytic subunit gamma ISO protein:increased expression:heart, membrane RGD PMID:26668322 RGD:11526267 NCBI chr12:108,288,158...108,311,128 JBrowse link
G PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A ISO CTD Direct Evidence: therapeutic CTD PMID:20071777 NCBI chr12:34,158,956...34,167,350
Ensembl chr12:34,882,975...34,898,218
JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO mRNA:increased expression:vastus lateralis muscle (human) RGD PMID:14567976 RGD:8693707 NCBI chr 5:129,599,606...129,629,312
Ensembl chr 5:135,751,958...135,765,786
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha ISO RGD PMID:10830164 RGD:1580714 NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205
JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO ClinVar Annotator: match by term: Heart failure
ClinVar Annotator: match by term: Congestive heart failure
ClinVar PMID:21409595 PMID:24033266 PMID:25741868 PMID:27532257 PMID:28492532 NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078
JBrowse link
G PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha ISO RGD PMID:10830164 RGD:1580714 NCBI chr 3:48,665,421...48,774,111
Ensembl chr 3:49,747,611...49,854,382
JBrowse link
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 7:99,021,209...99,140,652
Ensembl chr 7:111,748,463...111,866,044
JBrowse link
G PRKCA protein kinase C alpha ISO protein:increased expression, increased phosphorylation:heart left ventricle RGD PMID:17556659 RGD:2292480 NCBI chr17:60,246,485...60,747,158
Ensembl chr17:65,454,907...65,947,903
JBrowse link
G PRKCB protein kinase C beta ISO associated with hypertension RGD PMID:12392998 RGD:1625516 NCBI chr16:13,888,936...14,268,759
Ensembl chr16:24,091,289...24,466,203
JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18926768 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G PTH parathyroid hormone ISO protein:increased expression:serum (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17162251 PMID:21939825 RGD:7242422 NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802
JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO CTD Direct Evidence: marker/mechanism CTD PMID:28751527 NCBI chr 1:42,878,344...42,923,539
Ensembl chr 1:44,220,991...44,297,647
JBrowse link
G RAC1 Rac family small GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12642504 PMID:16155095 RGD:1581295 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G RAMP2 receptor activity modifying protein 2 ISO associated with Hypertension RGD PMID:12623952 RGD:704370 NCBI chr17:14,554,888...14,557,175
Ensembl chr17:14,779,666...14,781,481
JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO mRNA, protein:increased expression:left ventricle myocardium (human) RGD PMID:18323524 RGD:9835356 NCBI chr12:40,974,756...40,999,471
Ensembl chr12:41,848,785...41,873,252
JBrowse link
G RBM20 RNA binding motif protein 20 ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:25741868 PMID:28492532 NCBI chr10:107,240,854...107,433,749
Ensembl chr10:110,822,255...110,882,909
JBrowse link
G RBP4 retinol binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887
JBrowse link
G REN renin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1647690 PMID:7034517 PMID:20811386 NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393
JBrowse link
G RETN resistin ISO CTD Direct Evidence: marker/mechanism
associated with Coronary Disease
CTD
RGD
PMID:22240747 PMID:26670611 RGD:7207075 NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909
JBrowse link
G RNLS renalase, FAD dependent amine oxidase ISO RGD PMID:21297953 RGD:7327162 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986
JBrowse link
G RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator ISO mRNA, protein:decreased expression:heart RGD PMID:18056528 RGD:2311701 NCBI chr16:47,236,886...47,240,799 JBrowse link
G RYR2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Congestive heart failure RGD
ClinVar
PMID:16483256 PMID:25741868 RGD:1599251 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO mRNA:decreased expression:ventricle myocardium RGD PMID:19584134 RGD:6484224 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202
JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 ISO mRNA:increased expression:ventricle myocardium RGD PMID:19584134 RGD:6484224 NCBI chr12:36,950,057...37,172,235
Ensembl chr12:37,730,900...37,876,357
JBrowse link
G SELP selectin P ISO RGD PMID:19193626 RGD:2312309 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G SERPINE1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:24535859 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SIRT3 sirtuin 3 ISO protein:decreased expression:heart left ventricle RGD PMID:22155497 RGD:9586040 NCBI chr11:210,052...233,969
Ensembl chr11:255,191...278,732
JBrowse link
G SLC2A4 solute carrier family 2 member 4 severity ISO protein:decreased expression:skeletal muscle RGD PMID:18778861 RGD:2313624 NCBI chr17:7,312,605...7,319,430
Ensembl chr17:7,299,966...7,306,344
JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO DNA:repeat:promoter (human) RGD PMID:17307423 RGD:4889438 NCBI chr17:26,546,177...26,572,301
Ensembl chr17:27,050,900...27,092,882
JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO protein:increased expression:cardiac muscle cell RGD PMID:17536604 RGD:1642720 NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038
JBrowse link
G SLC9A1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18776042 PMID:19027022 RGD:6771337 NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089
JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16105639 PMID:16155095 PMID:20304815 PMID:21195081 PMID:21284947 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
G SOD3 superoxide dismutase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20304815 NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781
JBrowse link
G SOX4 SRY-box transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 6:21,422,846...21,427,779 JBrowse link
G SRF serum response factor ISO mRNA, protein:splice variant:heart RGD PMID:11893590 RGD:1581426 NCBI chr 6:42,763,099...42,773,332
Ensembl chr 6:44,057,192...44,066,768
JBrowse link
G SRI sorcin ISO protein:decreased expression:cardiac muscle cell
associated with Hypertension
RGD PMID:12754254 PMID:20945956 RGD:7327198 RGD:7327200 NCBI chr 7:80,199,719...80,214,733
Ensembl chr 7:93,850,496...93,864,029
JBrowse link
G TBX20 T-box transcription factor 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 7:35,855,969...35,878,533 JBrowse link
G TH tyrosine hydroxylase ISO protein:increased expression:paraventricular thalamic nucleus (rat) RGD PMID:7715703 PMID:21287352 RGD:5128674 RGD:737737 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO protein:increased expression:heart left ventricle RGD PMID:10773234 RGD:2290467 NCBI chr  X:40,018,190...40,022,636
Ensembl chr  X:47,914,906...47,919,419
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO protein:increased expression:heart left ventricle RGD PMID:10773234 RGD:2290467 NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649
JBrowse link
G TIMP4 TIMP metallopeptidase inhibitor 4 ISO protein:decreased expression:heart left ventricle RGD PMID:10773234 RGD:2290467 NCBI chr 3:12,079,195...12,087,485
Ensembl chr 3:12,425,429...12,433,192
JBrowse link
G TLR2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29959987 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
JBrowse link
G TNF tumor necrosis factor treatment
severity
ISO CTD Direct Evidence: marker/mechanism
associated with Myocardial Infarction;
RGD
CTD
PMID:11100001 PMID:11668085 PMID:15135663 PMID:15210453 PMID:15231041 PMID:17337591 PMID:18034274 PMID:28939262 PMID:29959987 RGD:14975271 RGD:1580213 RGD:7401241 RGD:7401242 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO mRNA, protein:incereased expression:myocardium RGD PMID:15883214 RGD:1624176 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16360360 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO human protein in rat model RGD PMID:21135513 RGD:5131262 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646
JBrowse link
G TNNT2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12322705 PMID:17698733 NCBI chr 1:176,957,298...176,976,033 JBrowse link
G TOMM70 translocase of outer mitochondrial membrane 70 ISO mRNA:decreased expression:heart
protein:increased serine phosphorylation:heart, mitochondrion
RGD PMID:24395194 PMID:25022898 RGD:13464131 RGD:13464132 NCBI chr 3:97,459,180...97,497,175
Ensembl chr 3:104,139,473...104,178,074
JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21284947 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
G TTN titin ISO ClinVar Annotator: match by term: Heart failure
ClinVar Annotator: match by term: CHF
ClinVar Annotator: match by term: Congestive heart failure
ClinVar PMID:15802564 PMID:23396983 PMID:23486992 PMID:23861362 PMID:24033266 PMID:24055113 PMID:24231549 PMID:24271327 PMID:24503780 PMID:24569025 PMID:24578547 PMID:25589632 PMID:25741868 PMID:26272908 PMID:26383259 PMID:26467025 PMID:26498160 PMID:26516846 PMID:27194543 PMID:27843123 PMID:28256728 PMID:28492532 PMID:29361395 NCBI chr2B:65,783,512...66,064,618 JBrowse link
G TTR transthyretin ISO ClinVar Annotator: match by term: Heart failure ClinVar PMID:1355416 PMID:1850190 PMID:1997217 PMID:2174830 PMID:2590199 PMID:6736244 PMID:7923855 PMID:8102146 PMID:9090525 PMID:14640030 PMID:15185492 PMID:19428025 PMID:22332999 PMID:24033266 PMID:24955979 PMID:25741868 PMID:28492532 NCBI chr18:24,809,707...24,816,713
Ensembl chr18:28,407,893...28,414,960
JBrowse link
G TUBB tubulin beta class I ISO CTD Direct Evidence: marker/mechanism CTD PMID:16155095 NCBI chr 6:30,465,367...30,470,451 JBrowse link
G UCN urocortin ISO protein:increased secretion:plasma (human) RGD PMID:19808377 RGD:5490589 NCBI chr2A:27,309,458...27,311,268
Ensembl chr2A:27,397,295...27,397,669
JBrowse link
G UCN2 urocortin 2 ISO CTD Direct Evidence: therapeutic
mRNA, protein:increased expression:myocardium (human)
CTD
RGD
PMID:12076554 PMID:16330704 RGD:5508210 NCBI chr 3:48,484,628...48,485,179 JBrowse link
G UCP1 uncoupling protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670611 NCBI chr 4:132,921,033...132,930,714
Ensembl chr 4:144,230,858...144,240,178
JBrowse link
G UCP2 uncoupling protein 2 ISO protein:decreased expression:heart, mitochondria RGD PMID:20193183 PMID:20809120 RGD:7204424 RGD:7204426 NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185
JBrowse link
G UCP3 uncoupling protein 3 ISO protein:decreased expression:heart, mitochondria RGD PMID:20809120 RGD:7204424 NCBI chr11:69,072,143...69,085,424
Ensembl chr11:72,380,180...72,389,274
JBrowse link
G UTS2 urotensin 2 severity ISO protein:increased expression:plasma RGD PMID:12791592 PMID:16364499 RGD:1580809 RGD:2306804 NCBI chr 1:6,609,104...6,616,966
Ensembl chr 1:7,854,687...7,864,688
JBrowse link
G VCL vinculin ISO ClinVar Annotator: match by term: Congestive heart failure ClinVar PMID:24033266 PMID:28492532 NCBI chr10:70,521,259...70,641,917
Ensembl chr10:73,191,375...73,311,296
JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:15732037 PMID:15880336 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G VWF von Willebrand factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153
JBrowse link
G WFDC6 WAP four-disulfide core domain 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16436767 NCBI chr20:41,871,121...41,876,428
Ensembl chr20:42,960,243...42,965,547
JBrowse link
G XDH xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19933411 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455
JBrowse link
G YY1 YY1 transcription factor ISO RGD PMID:12754214 RGD:1580831 NCBI chr14:80,859,491...80,903,651 JBrowse link
Alcohol-Induced Sudden Cardiac Failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPA2 inorganic pyrophosphatase 2 ISO OMIM NCBI chr 4:97,836,518...97,941,041
Ensembl chr 4:108,449,806...108,553,709
JBrowse link
cardiac arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 treatment ISO RGD PMID:26010685 RGD:12791997 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 7:83,942,590...84,108,648
Ensembl chr 7:97,540,356...97,705,608
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:20363892 RGD:5509101 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G ANK2 ankyrin 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:28492532 PMID:28600387 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905
JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:21383000 PMID:22840528 PMID:25527503 PMID:28492532 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482
JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:25741868 PMID:28492532 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:hippocampus (rat) RGD PMID:19756023 RGD:4889980 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
JBrowse link
G CEP85L centrosomal protein 85 like ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 6:116,270,880...116,461,166
Ensembl chr 6:120,415,944...120,603,797
JBrowse link
G DPP6 dipeptidyl peptidase like 6 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr 7:145,356,340...146,492,773
Ensembl chr 7:157,635,828...158,220,345
JBrowse link
G DSC2 desmocollin 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:18678517 PMID:23861362 PMID:24033266 PMID:24704780 PMID:25637381 PMID:25741868 PMID:27153395 PMID:28492532 NCBI chr18:24,296,505...24,332,997
Ensembl chr18:27,894,603...27,930,843
JBrowse link
G DSG2 desmoglein 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:20400443 PMID:23861362 PMID:24070718 PMID:25741868 PMID:28492532 PMID:28600387 NCBI chr18:24,716,181...24,766,837
Ensembl chr18:28,313,223...28,363,786
JBrowse link
G DSP desmoplakin ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:21606390 PMID:25525159 PMID:25741868 PMID:28492532 NCBI chr 6:7,381,046...7,426,408
Ensembl chr 6:7,664,211...7,709,391
JBrowse link
G DYNLL1 dynein light chain LC8-type 1 ISO RGD PMID:9522364 RGD:13208524 NCBI chr12:118,078,401...118,080,822 JBrowse link
G EP300 E1A binding protein p300 ISO associated with Diabetes Mellitus; mRNA:increased expression:blood (human) RGD PMID:19577077 RGD:2312286 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604
JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:17728042 RGD:5688386 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749
JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:28492532 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:9806674 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G IL18 interleukin 18 ISO RGD PMID:18679114 RGD:4889454 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
JBrowse link
G INS insulin ISO CTD Direct Evidence: therapeutic CTD PMID:17449947 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO protein:increased expression:cerebellum (rat) RGD PMID:21859719 RGD:6480675 NCBI chr 3:4,448,574...4,802,545
Ensembl chr 3:4,572,921...4,904,811
JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128
JBrowse link
G MYBPC3 myosin binding protein C3 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:14563344 PMID:15519027 PMID:16352453 PMID:20624503 PMID:22361390 PMID:23140321 PMID:23299917 PMID:23785128 PMID:24033266 PMID:24503780 PMID:24510615 PMID:25163546 PMID:25741868 PMID:28492532 NCBI chr11:47,277,799...47,299,102
Ensembl chr11:47,831,087...47,851,849
JBrowse link
G MYH6 myosin heavy chain 6 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331
JBrowse link
G MYOM1 myomesin 1 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr18:11,057,733...11,215,998
Ensembl chr18:13,368,052...13,523,834
JBrowse link
G NSUN6 NOP2/Sun RNA methyltransferase 6 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:25741868 PMID:28492532 NCBI chr10:18,864,484...18,978,297
Ensembl chr10:19,199,642...19,304,089
JBrowse link
G PLN phospholamban ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668
JBrowse link
G RBM20 RNA binding motif protein 20 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:22004663 PMID:24033266 PMID:24503780 PMID:25637381 PMID:25741868 PMID:27896284 PMID:28492532 NCBI chr10:107,240,854...107,433,749
Ensembl chr10:110,822,255...110,882,909
JBrowse link
G RYR2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:12354768 PMID:12820704 PMID:15466642 PMID:15840476 PMID:16540748 PMID:17161064 PMID:17210839 PMID:18071069 PMID:18452873 PMID:19412328 PMID:20403459 PMID:20875080 PMID:22378279 PMID:22581653 PMID:23008441 PMID:23098067 PMID:24033266 PMID:24653702 PMID:25741868 PMID:26209461 PMID:26467025 PMID:26749013 PMID:27287068 PMID:28265756 PMID:28492532 PMID:28781330 PMID:29032884 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202
JBrowse link
G SLMAP sarcolemma associated protein ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar NCBI chr 3:57,688,669...57,864,355
Ensembl chr 3:59,108,247...59,280,713
JBrowse link
G SOD1 superoxide dismutase 1 ISO RGD PMID:15843790 RGD:1581221 NCBI chr21:18,029,831...18,037,526 JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:9806674 PMID:18679114 RGD:4889454 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 treatment ISO ClinVar Annotator: match by term: Cardiac arrest RGD
ClinVar
PMID:26010685 PMID:28492532 RGD:12791997 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464
JBrowse link
G VCL vinculin ISO ClinVar Annotator: match by term: Cardiac arrest ClinVar PMID:25741868 PMID:28492532 NCBI chr10:70,521,259...70,641,917
Ensembl chr10:73,191,375...73,311,296
JBrowse link
Cardiac Edema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22865611 NCBI chr 7:31,524,933...31,538,602
Ensembl chr 7:31,644,331...31,658,141
JBrowse link
G LOC100990238 intraflagellar transport protein 122 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:20493458 NCBI chr 3:126,498,018...126,578,211
Ensembl chr 3:133,851,433...133,930,117
JBrowse link
G UBIAD1 UbiA prenyltransferase domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23533172 NCBI chr 1:10,039,415...10,161,005
Ensembl chr 1:11,260,412...11,281,381
JBrowse link
Cardio-Renal Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR1 hepatitis A virus cellular receptor 1 susceptibility ISO protein:increased expression:kidney tubule: RGD PMID:22367506 PMID:23220287 RGD:7245477 RGD:7245950 NCBI chr 5:152,429,337...152,459,800
Ensembl chr 5:158,413,073...158,442,481
JBrowse link
Cor pulmonale term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21450080 RGD:6767563 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20669672 RGD:4143386 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760
JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:serum RGD PMID:20669672 RGD:4143386 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
diastolic heart failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme severity
treatment
susceptibility
ISO DNS:insertion/deletion:intron: (rs1799752)
DNA:insertion/deletion:intron 16:
RGD PMID:14757777 PMID:19021695 PMID:19752885 RGD:40400704 RGD:40400723 RGD:40400906 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
JBrowse link
G ADRA1D adrenoceptor alpha 1D ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr20:4,242,788...4,271,295
Ensembl chr20:4,040,888...4,068,018
JBrowse link
G AKIP1 A-kinase interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr11:9,040,057...9,049,095
Ensembl chr11:8,781,702...8,790,267
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669
JBrowse link
G ANKRD23 ankyrin repeat domain 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr2A:102,469,784...102,476,991
Ensembl chr2A:97,756,775...97,763,360
JBrowse link
G APLN apelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G CDC25B cell division cycle 25B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr20:3,877,255...3,883,458
Ensembl chr20:3,626,107...3,645,179
JBrowse link
G COL4A1 collagen type IV alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529
JBrowse link
G COL6A1 collagen type VI alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr21:32,322,185...32,346,850
Ensembl chr21:45,584,096...45,607,240
JBrowse link
G COL8A1 collagen type VIII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 3:96,732,445...96,892,726
Ensembl chr 3:103,521,159...103,573,617
JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:142,974,260...142,987,071
Ensembl chr 1:146,758,325...146,770,978
JBrowse link
G CYRIB CYFIP related Rac1 interactor B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 8:126,478,020...126,653,936
Ensembl chr 8:129,209,655...129,272,844
JBrowse link
G ELK3 ETS transcription factor ELK3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr12:93,781,034...93,863,042
Ensembl chr12:97,223,198...97,276,120
JBrowse link
G EPN3 epsin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr17:44,626,114...44,636,646
Ensembl chr17:49,504,119...49,509,729
JBrowse link
G FHL1 four and a half LIM domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr  X:125,270,340...125,334,961
Ensembl chr  X:135,559,321...135,602,375
JBrowse link
G FIBIN fin bud initiation factor homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr11:26,947,970...26,950,278 JBrowse link
G FXYD3 FXYD domain containing ion transport regulator 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr19:32,036,936...32,070,374 JBrowse link
G HAMP hepcidin antimicrobial peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861
JBrowse link
G KANK2 KN motif and ankyrin repeat domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr19:10,713,582...10,746,371
Ensembl chr19:11,426,149...11,457,359
JBrowse link
G KLF9 Kruppel like factor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 9:54,387,404...54,417,095
Ensembl chr 9:69,142,283...69,170,664
JBrowse link
G LOC100978529 myosin-7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763
JBrowse link
G MS4A6A membrane spanning 4-domains A6A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr11:55,402,207...55,413,959
Ensembl chr11:58,847,867...58,860,947
JBrowse link
G MYH6 myosin heavy chain 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331
JBrowse link
G NPPA natriuretic peptide A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 Ensembl chr16:29,015,155...29,016,987 JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr22:12,305,518...12,316,434
Ensembl chr22:30,141,326...30,152,397
JBrowse link
G PLXND1 plexin D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 3:126,613,065...126,664,643 JBrowse link
G PTP4A2 protein tyrosine phosphatase 4A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 1:31,193,735...31,222,731
Ensembl chr 1:32,209,863...32,231,847
JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 9:80,528,896...80,651,629
Ensembl chr 9:108,699,761...108,787,464
JBrowse link
G SFRP1 secreted frizzled related protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SIPA1L1 signal induced proliferation associated 1 like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr14:51,909,444...52,328,719
Ensembl chr14:71,038,600...71,192,916
JBrowse link
G TRDN triadin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr 6:121,010,234...121,424,644
Ensembl chr 6:125,134,433...125,546,537
JBrowse link
G WDR45 WD repeat domain 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr  X:41,372,722...41,400,441
Ensembl chr  X:49,224,864...49,233,960
JBrowse link
G ZNF532 zinc finger protein 532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29556499 NCBI chr18:52,257,241...52,380,431
Ensembl chr18:55,640,924...55,706,365
JBrowse link
Neonatal Pulmonary Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPS1 carbamoyl-phosphate synthase 1 susceptibility ISO ClinVar Annotator: match by term: Pulmonary hypertension, neonatal, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:11407344 PMID:14718356 PMID:15465784 PMID:16708072 PMID:20154341 PMID:21767969 NCBI chr2B:97,735,486...97,936,623
Ensembl chr2B:216,136,857...216,337,728
JBrowse link
Paroxysmal Dyspnea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor ISO RGD PMID:21388992 RGD:5129099 NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760
JBrowse link
G ADRB2 adrenoceptor beta 2 ISO ClinVar Annotator: match by term: Asthma, nocturnal, susceptibility to ClinVar PMID:7706471 PMID:9399946 PMID:9399966 PMID:9522789 PMID:11739457 PMID:14557466 PMID:15500895 PMID:15867853 PMID:16596417 PMID:28492532 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892
JBrowse link
primary pulmonary hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR2 bone morphogenetic protein receptor type 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pulmonary hypertension, primary, dexfenfluramine-associated
ClinVar Annotator: match by term: Idiopathic and/or familial pulmonary arterial hypertension
ClinVar Annotator: match by term: Pulmonary hypertension, primary, fenfluramine-associated
CTD
ClinVar
PMID:11015450 PMID:11115378 PMID:12358323 PMID:16429395 PMID:16429403 PMID:16717148 PMID:16728714 PMID:19324947 PMID:19555857 PMID:20096498 PMID:20534176 PMID:21801371 PMID:24033266 PMID:25460361 PMID:25741868 PMID:26387786 PMID:26820968 PMID:28492532 PMID:32581362 NCBI chr2B:89,631,622...89,823,438
Ensembl chr2B:207,780,741...207,961,072
JBrowse link
G CAV1 caveolin 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655
JBrowse link
G FOXF1 forkhead box F1 ISO ClinVar Annotator: match by term: Primary pulmonary hypertension ClinVar PMID:19500772 PMID:19592680 PMID:19812545 PMID:20425831 PMID:22766610 PMID:23034409 PMID:23074687 PMID:23335808 PMID:23505205 PMID:23943206 PMID:24033266 PMID:24842713 PMID:26462560 NCBI chr16:67,183,416...67,188,211
Ensembl chr16:86,516,119...86,519,949
JBrowse link
G HDAC1 histone deacetylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410
JBrowse link
G HDAC4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054
JBrowse link
G HDAC5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22711276 NCBI chr17:13,273,052...13,319,695
Ensembl chr17:13,446,836...13,479,140
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein ISO protein:decreased expression:lung, wall of arteriole (human) RGD PMID:20522807 RGD:9686087 NCBI chr20:27,895,177...27,896,414
Ensembl chr20:28,535,582...28,536,311
JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr2A:26,688,938...26,729,860
Ensembl chr2A:26,780,475...26,819,123
JBrowse link
G SMAD9 SMAD family member 9 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr13:18,055,427...18,130,571
Ensembl chr13:36,486,597...36,521,646
JBrowse link
Primary Pulmonary Hypertension, 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:9245985 PMID:12700602 PMID:14684682 PMID:15024723 PMID:15879500 PMID:15880681 PMID:16429404 PMID:16470787 PMID:16540754 PMID:16705692 PMID:18159113 PMID:19555857 PMID:20414677 PMID:20501893 PMID:21158752 PMID:22632830 PMID:23298310 PMID:23722869 PMID:24753439 PMID:25741868 PMID:26387786 PMID:27316748 PMID:28492532 PMID:29449337 PMID:32581362 NCBI chr12:36,839,869...36,856,351
Ensembl chr12:37,615,888...37,631,691
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 ISO OMIM NCBI chr2B:89,631,622...89,823,438
Ensembl chr2B:207,780,741...207,961,072
JBrowse link
G ENG endoglin ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:18498373 PMID:23298310 PMID:24033266 PMID:25741868 PMID:26167679 PMID:26387786 PMID:28492532 PMID:30029678 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641
JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:20018952 PMID:21685056 PMID:23861362 PMID:24068186 PMID:25076992 PMID:28492532 NCBI chr12:5,165,057...5,168,307 JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:23883380 NCBI chr2A:26,688,938...26,729,860
Ensembl chr2A:26,780,475...26,819,123
JBrowse link
G NOP58 NOP58 ribonucleoprotein ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:23579436 PMID:26387786 NCBI chr2B:89,520,961...89,558,794
Ensembl chr2B:207,674,654...207,707,763
JBrowse link
G SMAD1 SMAD family member 1 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:21898662 PMID:26387786 NCBI chr 4:137,822,269...137,899,700
Ensembl chr 4:149,481,836...149,558,135
JBrowse link
G SMAD4 SMAD family member 4 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:21898662 PMID:24728327 PMID:25502805 PMID:25741868 PMID:26387786 PMID:28492532 NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359
JBrowse link
G SMAD9 SMAD family member 9 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar NCBI chr13:18,055,427...18,130,571
Ensembl chr13:36,486,597...36,521,646
JBrowse link
G TBX4 T-box transcription factor 4 ISO ClinVar Annotator: match by term: Pulmonary Hypertension, Primary, 1 ClinVar PMID:25741868 PMID:31151956 NCBI chr17:55,554,549...55,587,253
Ensembl chr17:60,677,518...60,705,413
JBrowse link
Primary Pulmonary Hypertension, 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD9 SMAD family member 9 ISO OMIM NCBI chr13:18,055,427...18,130,571
Ensembl chr13:36,486,597...36,521,646
JBrowse link
Primary Pulmonary Hypertension, 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1B bone morphogenetic protein receptor type 1B ISO ClinVar Annotator: match by term: Primary pulmonary hypertension 3 ClinVar PMID:25741868 NCBI chr 4:87,125,911...87,523,084
Ensembl chr 4:98,088,072...98,195,848
JBrowse link
G CAV1 caveolin 1 ISO OMIM NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655
JBrowse link
Primary Pulmonary Hypertension, 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO OMIM NCBI chr2A:26,688,938...26,729,860
Ensembl chr2A:26,780,475...26,819,123
JBrowse link
Sudden Cardiac Death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL3 acyl-CoA synthetase long chain family member 3 disease_progression ISO RGD PMID:22661490 RGD:13831296 NCBI chr2B:110,100,210...110,181,277
Ensembl chr2B:228,706,142...228,759,882
JBrowse link
G ADRA2B adrenoceptor alpha 2B ISO RGD PMID:12535806 RGD:1559314 NCBI chr2A:103,198,432...103,202,506
Ensembl chr2A:97,040,126...97,041,472
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:23861362 PMID:25741868 PMID:28492532 NCBI chr 7:83,942,590...84,108,648
Ensembl chr 7:97,540,356...97,705,608
JBrowse link
G ANK2 ankyrin 2 ISO ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar Annotator: match by term: Sudden cardiac death
RGD
ClinVar
PMID:12571597 PMID:25741868 PMID:28492532 RGD:734572 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905
JBrowse link
G APOB apolipoprotein B ISO RGD PMID:17045270 RGD:1601197 NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826
JBrowse link
G CEP85L centrosomal protein 85 like ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 6:116,270,880...116,461,166
Ensembl chr 6:120,415,944...120,603,797
JBrowse link
G DPP6 dipeptidyl peptidase like 6 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr 7:145,356,340...146,492,773
Ensembl chr 7:157,635,828...158,220,345
JBrowse link
G DSP desmoplakin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac death
CTD
ClinVar
PMID:20435227 PMID:25741868 NCBI chr 6:7,381,046...7,426,408
Ensembl chr 6:7,664,211...7,709,391
JBrowse link
G GJA1 gap junction protein alpha 1 treatment ISO RGD PMID:22093512 RGD:12910124 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:23861362 PMID:27930701 PMID:28492532 NCBI chr 3:32,026,586...32,088,512
Ensembl chr 3:32,342,776...32,404,172
JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:21615589 PMID:23623143 PMID:23861362 PMID:24033266 PMID:24569893 PMID:25145517 PMID:25467552 PMID:25642760 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285
JBrowse link
G IL6 interleukin 6 susceptibility ISO RGD PMID:23906927 RGD:12792237 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ITGB3 integrin subunit beta 3 ISO associated with arteriosclerosis; DNA:polymorphism:exon RGD PMID:20846430 RGD:5128476 NCBI chr17:10,134,450...10,194,596 JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 ISO ClinVar Annotator: match by term: Sudden cardiac death
ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar PMID:18508782 PMID:19716085 PMID:22581653 PMID:25417810 PMID:25741868 PMID:26704558 NCBI chr 7:142,528,979...142,562,074 JBrowse link
G KNG1 kininogen 1 susceptibility ISO DNA:SNPs: : RGD PMID:19716087 RGD:10411885 NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149
JBrowse link
G LMNA lamin A/C ISO CTD Direct Evidence: marker/mechanism CTD PMID:15996213 NCBI chr 1:131,456,819...131,482,275
Ensembl chr 1:135,253,700...135,311,539
JBrowse link
G LOC100978529 myosin-7 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:25741868 NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763
JBrowse link
G MYBPC3 myosin binding protein C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20435227 NCBI chr11:47,277,799...47,299,102
Ensembl chr11:47,831,087...47,851,849
JBrowse link
G MYH6 myosin heavy chain 6 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:15998695 PMID:20215591 PMID:22194935 PMID:22361390 PMID:23299917 PMID:23861362 PMID:24033266 PMID:24119082 PMID:25741868 PMID:27194543 PMID:28088328 PMID:28492532 NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331
JBrowse link
G MYOM1 myomesin 1 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:24033266 PMID:28492532 NCBI chr18:11,057,733...11,215,998
Ensembl chr18:13,368,052...13,523,834
JBrowse link
G NEBL nebulette ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr10:20,941,514...21,336,931
Ensembl chr10:21,244,693...21,632,236
JBrowse link
G PKP2 plakophilin 2 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:25741868 PMID:27532257 PMID:28492532 NCBI chr12:53,322,227...53,428,747
Ensembl chr12:55,925,174...56,030,998
JBrowse link
G PLN phospholamban ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:12639993 PMID:16235537 PMID:17655857 PMID:21167350 PMID:21332051 PMID:22137083 PMID:23861362 PMID:24033266 PMID:25611685 PMID:25741868 PMID:26535225 PMID:27532257 PMID:28492532 PMID:28600387 NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668
JBrowse link
G RYR2 ryanodine receptor 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar Annotator: match by term: Sudden cardiac death
CTD
ClinVar
PMID:23861362 PMID:24033266 PMID:25650408 PMID:25741868 PMID:26656175 PMID:27054166 PMID:27930701 PMID:28492532 PMID:31913406 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509
JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Sudden cardiac death
ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar PMID:15851227 PMID:16712702 PMID:18378609 PMID:18508782 PMID:19564561 PMID:19841300 PMID:20129283 PMID:22581653 PMID:22984773 PMID:23631430 PMID:23671135 PMID:23861362 PMID:24033266 PMID:24055113 PMID:25741868 PMID:25904541 PMID:28492532 PMID:30254039 PMID:32533946 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202
JBrowse link
G SP4 Sp4 transcription factor ISO RGD PMID:11007485 RGD:1580019 NCBI chr 7:22,113,013...22,200,012
Ensembl chr 7:21,421,259...21,512,238
JBrowse link
G TMEM43 transmembrane protein 43 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac arrest
CTD
ClinVar
PMID:20435227 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 3:14,043,369...14,062,064
Ensembl chr 3:14,383,983...14,400,587
JBrowse link
G TNNI3 troponin I3, cardiac type ISO ClinVar Annotator: match by term: Sudden cardiac arrest ClinVar PMID:21839045 PMID:25741868 NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219
JBrowse link
G TNNT2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Sudden cardiac death
CTD
ClinVar
PMID:17556660 PMID:23233322 PMID:24033266 PMID:24503780 PMID:25741868 PMID:28492532 NCBI chr 1:176,957,298...176,976,033 JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO ClinVar Annotator: match by term: Sudden cardiac death ClinVar PMID:24019741 PMID:28492532 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464
JBrowse link
G TTN titin ISO ClinVar Annotator: match by term: Sudden cardiac arrest
ClinVar Annotator: match by term: Sudden cardiac death
ClinVar PMID:19608031 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr2B:65,783,512...66,064,618 JBrowse link
Sudden Cardiac Failure, Infantile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPA2 inorganic pyrophosphatase 2 ISO OMIM NCBI chr 4:97,836,518...97,941,041
Ensembl chr 4:108,449,806...108,553,709
JBrowse link
systolic heart failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD1 ankyrin repeat domain 1 ISO ClinVar Annotator: match by term: Heart failure, systolic ClinVar PMID:19525294 PMID:23299917 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr10:87,652,254...87,661,173
Ensembl chr10:91,180,034...91,188,165
JBrowse link
G BMP10 bone morphogenetic protein 10 ISO CTD Direct Evidence: therapeutic CTD PMID:31712309 NCBI chr2A:68,901,944...68,912,559
Ensembl chr2A:70,023,655...70,034,420
JBrowse link
G DSP desmoplakin ISO ClinVar Annotator: match by term: Systolic heart failure ClinVar PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 6:7,381,046...7,426,408
Ensembl chr 6:7,664,211...7,709,391
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A disease_progression ISO protein:increased expression:serum: RGD PMID:23564583 RGD:7257646 NCBI chr 6:31,476,710...31,491,411 JBrowse link
G NPPB natriuretic peptide B ISO associated with Renal Insufficiency;protein:increased expression:plasma: RGD PMID:23122795 PMID:23725445 RGD:7246908 RGD:7247627 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995
JBrowse link
G TTN titin ISO ClinVar Annotator: match by term: Heart failure, systolic ClinVar PMID:23861362 PMID:24033266 PMID:25163546 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr2B:65,783,512...66,064,618 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12810
    disease of anatomical entity 12340
      cardiovascular system disease 3259
        heart disease 2305
          congestive heart failure 363
            Cardiac Edema 3
            Cardio-Renal Syndrome 1
            Cor pulmonale + 21
            Paroxysmal Dyspnea 2
            cardiac arrest + 55
            diastolic heart failure 34
            rheumatic congestive heart failure 0
            systolic heart failure 6
paths to the root