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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:gastrinoma
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Accession:DOID:5577 term browser browse the term
Definition:A neuroendocrine tumor that results_in an overproduction of gastric acid. (DO)
Synonyms:exact_synonym: Gastrin Producing Tumor;   Gastrin-Producing Tumors;   Gastrinomas;   Ulcerogenic Islet Cell Tumor;   gastrin cell tumour;   gastrin secreting tumor;   malignant gastrinoma
 primary_id: MESH:D015408
 xref: ICDO:8153/3;   NCI:C3050
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
gastrinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin-like growth factor I receptor ISO mRNA and protein: increased expression::poor prognosis for high expression RGD PMID:15867218 RGD:7242847 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO DNA:mutations: :
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:17961653 PMID:15944766 RGD:2317354 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Met met proto-oncogene severity ISO associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human) RGD PMID:12114431 RGD:2317605 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypomethylation:promoter (human) RGD PMID:17278096 RGD:2317340 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 ISO mRNA:decreased expression:pancreatic islet RGD PMID:8421107 PMID:12114701 RGD:2324977, RGD:2324976 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
duodenal gastrinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Men1 multiple endocrine neoplasia 1 ISO associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: : RGD PMID:17135306 RGD:2317341 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15863
      endocrine system disease 6558
        endocrine gland cancer 2611
          neuroendocrine tumor 221
            gastrinoma 5
              duodenal gastrinoma 1
              gastric gastrinoma 0
Path 2
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15863
      nervous system disease 13797
        Nervous System Neoplasms 1563
          nervous system cancer 902
            neuroectodermal tumor 478
              neuroendocrine tumor 221
                islet cell tumor 31
                  pancreatic endocrine carcinoma 14
                    gastrinoma 5
                      duodenal gastrinoma 1
                      gastric gastrinoma 0
paths to the root