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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:synovial sarcoma
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Accession:DOID:5485 term browser browse the term
Definition:A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
Synonyms:exact_synonym: Synovial Sarcomas;   Synovioma;   Synoviomas
 primary_id: MESH:D013584;   RDO:0006659
 alt_id: OMIM:300813
 xref: GARD:7721;   NCI:C3400
For additional species annotation, visit the Alliance of Genome Resources.


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synovial sarcoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator ISO CTD Direct Evidence: therapeutic CTD PMID:16450387 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Shcbp1 SHC binding and spindle associated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27572315 NCBI chr16:84,672,276...84,703,839
Ensembl chr16:84,672,321...84,703,844
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 ISO RGD PMID:26520417 RGD:11069485 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
JBrowse link
G Ss18 SS18 subunit of BAF chromatin remodeling complex ISO CTD Direct Evidence: marker/mechanism CTD PMID:9428816 PMID:27572315 PMID:7951320 RGD:1599184 NCBI chr18:5,773,042...5,835,696
Ensembl chr18:5,773,042...5,835,333
JBrowse link
G Ssx1 SSX family member 1 ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:9428816 PMID:27572315 NCBI chr  X:13,931,433...13,939,732
Ensembl chr  X:13,931,470...13,939,720
JBrowse link
G Vim vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15043115 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17205
    disease of cellular proliferation 7034
      cancer 4989
        cell type cancer 3396
          sarcoma 244
            synovial sarcoma 6
              biphasic synovial sarcoma 0
              epithelioid cell synovial sarcoma 0
              fibrous synovial sarcoma 0
              mediastinum synovial sarcoma 0
              monophasic synovial sarcoma 0
              spindle cell synovial sarcoma 0
Path 2
Term Annotations click to browse term
  disease 17205
    disease of cellular proliferation 7034
      Neoplasms by Histologic Type 4765
        Connective and Soft Tissue Neoplasms 1720
          Connective Tissue Neoplasms 1618
            connective tissue cancer 703
              synovium cancer 6
                synovial sarcoma 6
                  biphasic synovial sarcoma 0
                  epithelioid cell synovial sarcoma 0
                  fibrous synovial sarcoma 0
                  mediastinum synovial sarcoma 0
                  monophasic synovial sarcoma 0
                  spindle cell synovial sarcoma 0
paths to the root