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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:scrapie
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Accession:DOID:5434 term browser browse the term
Definition:A fatal disease of the nervous system in sheep and goats, characterized by pruritus, debility, and locomotor incoordination. It is caused by proteinaceous infectious particles called PRIONS.
Synonyms:exact_synonym: Rida
 primary_id: MESH:D012608
 xref: EFO:1001168
For additional species annotation, visit the Alliance of Genome Resources.

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scrapie term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23349890 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:27921253 RGD:13782156 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Casp3 caspase 3 ISO RGD PMID:27921253 RGD:13782156 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp9 caspase 9 ISO RGD PMID:27921253 RGD:13782156 NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO RGD PMID:22787236 RGD:13782158 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143 		JBrowse link
G Cr2 complement C3d receptor 2 ISO RGD PMID:29202042 RGD:127285805 NCBI chrNW_004955406:42,877,041...42,910,970
Ensembl chrNW_004955406:42,876,966...42,911,564 		JBrowse link
G Jak2 Janus kinase 2 ISO protein:increased expression:brain RGD PMID:17897356 RGD:6483034 NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208 		JBrowse link
G Negr1 neuronal growth regulator 1 ISO RGD PMID:29087046 RGD:40886276 NCBI chrNW_004955423:20,011,488...20,816,686
Ensembl chrNW_004955423:20,011,615...20,813,879 		JBrowse link
G Pdia3 protein disulfide isomerase family A member 3 ISO protein:increased expression:brain: RGD PMID:15772339 RGD:9999196 NCBI chrNW_004955416:10,197,957...10,221,104
Ensembl chrNW_004955416:10,198,099...10,220,792 		JBrowse link
G Prnp prion protein (Kanno blood group) onset ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11701772 PMID:18717736 PMID:19486493 PMID:21533749 PMID:29157304 RGD:15045596 NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 susceptibility ISO RGD PMID:16730863 RGD:38676483 NCBI chrNW_004955481:3,088,440...3,122,421
Ensembl chrNW_004955481:3,088,416...3,125,711 		JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11701772 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:16412998 RGD:1581331 NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO protein:increased expression:brain RGD PMID:17897356 RGD:6483034 NCBI chrNW_004955403:8,156,660...8,192,018
Ensembl chrNW_004955403:8,156,660...8,194,762 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO protein:increased tyrosine phosphorylation:brain, nucleus RGD PMID:17897356 RGD:6483034 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14338
    Animal Diseases 1263
      Sheep Diseases 15
        scrapie 15
Path 2
Term Annotations click to browse term
  disease 14338
    disease of anatomical entity 14031
      nervous system disease 12352
        central nervous system disease 11076
          neurodegenerative disease 4569
            prion disease 97
              scrapie 15
paths to the root