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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:ovarian hyperstimulation syndrome
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Accession:DOID:5425 term browser browse the term
Definition:A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
Synonyms:exact_synonym: OHSS;   Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous;   Ovarian Hyperstimulation Syndromes;   Ovarian response to FSH stimulation;   secondary Meig's syndrome
 primary_id: MESH:D016471;   RDO:0006959
 alt_id: OMIM:608115
For additional species annotation, visit the Alliance of Genome Resources.

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ovarian hyperstimulation syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 treatment IDA RGD PMID:25217874 RGD:13506956 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G F3 coagulation factor III, tissue factor severity ISO protein:increased expression:plasma RGD PMID:12695751 RGD:11340210 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fshr follicle stimulating hormone receptor ISO DNA:point mutation:exon:D567N
ClinVar Annotator: match by term: Ovarian hyperstimulation syndrome
ClinVar Annotator: match by term: Ovarian response to FSH stimulation
ClinVar Annotator: match by OMIM:608115
PMID:8894317 PMID:9402264 PMID:9769327 PMID:10022448 PMID:11036902 More... RGD:1601236 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:serum, ascites (human) RGD PMID:9322101 RGD:11062135 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kdr kinase insert domain receptor treatment IEP RGD PMID:25151950 RGD:126925217 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISS OMIM:608115 MouseDO NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human protein in a mouse model RGD PMID:23295464 RGD:8635395 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Tfpi tissue factor pathway inhibitor severity ISO protein:decreased expression:plasma RGD PMID:12695751 RGD:11340210 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Vegfa vascular endothelial growth factor A treatment IMP RGD PMID:25151950 RGD:126925217 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17445
    syndrome 8267
      ovarian hyperstimulation syndrome 9
Path 2
Term Annotations click to browse term
  disease 17445
    disease of anatomical entity 16777
      Urogenital Diseases 4422
        Female Urogenital Diseases and Pregnancy Complications 2093
          Female Urogenital Diseases 1785
            female reproductive system disease 1781
              Adnexal Diseases 808
                ovarian disease 799
                  ovarian hyperstimulation syndrome 9
paths to the root