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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:dental pulp disease
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Accession:DOID:5330 term browser browse the term
Definition:Endodontic diseases of the DENTAL PULP inside the tooth, which is distinguished from PERIAPICAL DISEASES of the tissue surrounding the root.
Synonyms:exact_synonym: dental pulp diseases;   dental pulp disorder;   disorder of pulp of tooth;   pulp disorder
 primary_id: MESH:D003788
 xref: NCI:C34530
For additional species annotation, visit the Alliance of Genome Resources.


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dental pulp calcification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dspp dentin sialophosphoprotein ISO ClinVar Annotator: match by term: Denticles | ClinVar Annotator: match by term: Pulpal dysplasia ClinVar PMID:12354781 PMID:18456718 PMID:25741868 PMID:26788535 PMID:28492532 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672 		JBrowse link
Dental Pulp Exposure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule IEP mRNA:increased expression:thalamus (rat)
mRNA:increased expression:periodontal ligament (rat)		 RGD PMID:20171363 PMID:20113783 RGD:4892246, RGD:4892210 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IEP protein:increased expression:neuron: RGD PMID:17645513 RGD:9686147 NCBI chr 2:49,495,771...49,899,702
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 IEP protein:increased expression:neuron: RGD PMID:17645513 RGD:9686147 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 IEP protein:increased expression:neuron: RGD PMID:17645513 RGD:9686147 NCBI chr 2:174,551,866...174,567,459
Ensembl chr 2:174,551,680...174,565,966 		JBrowse link
G Optn optineurin IEP mRNA:increased expression:dental pulp (rat) RGD PMID:16109995 RGD:7775038 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G S100b S100 calcium binding protein B IEP protein:increased expression:brain, astrocyte RGD PMID:20043976 RGD:5508788 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
Dentin Dysplasia, Type 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dspp dentin sialophosphoprotein ISO ClinVar Annotator: match by term: DENTIN DYSPLASIA, TYPE II OMIM
ClinVar		 PMID:25741868 PMID:28492532 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672 		JBrowse link
pulpitis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma IEP RGD PMID:12017181 RGD:10755771 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 IEP protein:increased expression:dental pulp,trigeminal ganglion: RGD PMID:19732182 RGD:8662895 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Tlr4 toll-like receptor 4 IEP protein:increased expression:ganglion: RGD PMID:24267924 RGD:7777125 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18032
    Stomatognathic Diseases 1148
      tooth disease 296
        dental pulp disease 10
          Dental Pulp Exposure 6
          Nonvital Tooth 0
          Secondary Dentin 0
          dental pulp calcification + 1
          dental pulp necrosis 0
          pulp degeneration 0
          pulpitis 3
Path 2
Term Annotations click to browse term
  disease 18032
    disease of anatomical entity 17412
      nervous system disease 13079
        sensory system disease 6469
          mouth disease 829
            tooth disease 296
              dental pulp disease 10
                Dental Pulp Exposure 6
                Nonvital Tooth 0
                Secondary Dentin 0
                dental pulp calcification + 1
                dental pulp necrosis 0
                pulp degeneration 0
                pulpitis 3
paths to the root