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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:human immunodeficiency virus infectious disease
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Accession:DOID:526 term browser browse the term
Definition:Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Synonyms:exact_synonym: HIV Infection;   HIV Infections;   HTLV III Infections;   HTLV III LAV Infections;   HTLV-III Infection;   HTLV-III-LAV Infection;   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO;   T Lymphotropic Virus Type III Infections, Human
 narrow_synonym: Congenital human immunodeficiency virus;   HIV-1 viremia, susceptibility to;   HIV-1, RESISTANCE TO;   HIV-1, SUSCEPTIBILITY TO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RESISTANCE TO;   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, DELAYED DISEASE PROGRESSION WITH INFECTION BY;   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, INCREASED PERINATAL TRANSMISSION OF;   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RAPID DISEASE PROGRESSION WITH INFECTION BY;   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RAPID PROGRESSION TO AIDS
 related_synonym: CCR5 PROMOTER POLYMORPHISM
 primary_id: MESH:D015658;   RDO:0004716
 alt_id: OMIM:609423
 xref: ICD10CM:B20;   ICD9CM:042-042.99;   NCI:C3108
For additional species annotation, visit the Alliance of Genome Resources.


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human immunodeficiency virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 treatment
severity
ISO mRNA:altered expression:brain, heart, kidney (rat)
DNA:SNPs: :4036A>G, 1236C>T (human)
RGD PMID:23133441 PMID:24472536 PMID:27334660 RGD:11041168 RGD:39456096 RGD:39456100 NCBI chrNW_004936763:1,225,355...1,308,257 JBrowse link
G Abce1 ATP binding cassette subfamily E member 1 ISO DNA:mutations:multiple (human) RGD PMID:19657357 RGD:11041871 NCBI chrNW_004936535:3,956,490...3,985,002 JBrowse link
G Adrb2 adrenoceptor beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27400929 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Alyref Aly/REF export factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936594:5,398,973...5,402,846 JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12646808 NCBI chrNW_004936542:2,111,055...2,112,626 JBrowse link
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936504:12,490,838...12,514,256 JBrowse link
G Arhgap4 Rho GTPase activating protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936809:791,275...807,448 JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936594:5,383,370...5,386,618 JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936587:2,471,344...2,549,765 JBrowse link
G Atm ATM serine/threonine kinase ISO protein:decreased expression:T cell (human) RGD PMID:31781094 RGD:126790561 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Bag3 BAG cochaperone 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17187345 NCBI chrNW_004936486:8,985,871...9,007,461 JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Birc2 baculoviral IAP repeat containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936551:5,515,904...5,535,864 JBrowse link
G Birc3 baculoviral IAP repeat containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936551:5,544,047...5,556,550 JBrowse link
G Bst2 bone marrow stromal cell antigen 2 ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, rapid progression to AIDS ClinVar
G C3 complement C3 ISO RGD PMID:7561187 RGD:11040775 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, delayed disease progression with infection by
ClinVar Annotator: match by term: Human immunodeficiency virus type 1, rapid disease progression with infection by
ClinVar PMID:10200305 PMID:12114533 PMID:12610055 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10202824 NCBI chrNW_004936596:223,660...224,739 JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936580:5,537,338...5,554,384 JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936643:2,354,799...2,368,048 JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936491:17,017,687...17,033,526 JBrowse link
G Cd274 CD274 molecule ISO RGD PMID:30161254 PMID:30236481 RGD:41412179 RGD:41412181 NCBI chrNW_004936539:132,870...145,288 JBrowse link
G Cd28 CD28 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:7492435 NCBI chrNW_004936631:335,411...363,407 JBrowse link
G Cd40 CD40 molecule ISO protein:increased expression:plasmacytoid dendritic cell RGD PMID:20559432 RGD:5490533 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Cd40lg CD40 ligand ISO RGD PMID:21177803 RGD:5490598 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Cd68 CD68 molecule disease_progression ISO associated with opioid use;protein:increased expression:brain (human) RGD PMID:22797933 RGD:41404655 NCBI chrNW_004936595:858,289...861,131 JBrowse link
G Cd8a CD8a molecule treatment ISO RGD PMID:29384862 RGD:124715453 NCBI chrNW_004936712:885,301...891,247 JBrowse link
G Cdc42 cell division cycle 42 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936476:22,717,308...22,725,127 JBrowse link
G Clic1 chloride intracellular channel 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936727:1,797,966...1,803,401 JBrowse link
G Cops6 COP9 signalosome subunit 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936543:235,087...237,779 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 susceptibility ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:25741868 NCBI chrNW_004936473:28,508,726...28,535,640 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:plasma RGD PMID:27246604 RGD:14995461 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 susceptibility ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:9430590 NCBI chrNW_004936617:4,224,131...4,239,080 JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 susceptibility ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:25741868 NCBI chrNW_004936569:715,129...716,187 JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936490:16,842,901...16,878,717 JBrowse link
G Eif3b eukaryotic translation initiation factor 3 subunit B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936823:98,056...121,489 JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936595:851,731...858,225 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936710:1,446,030...1,461,945 JBrowse link
G Eif6 eukaryotic translation initiation factor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936561:5,471,113...5,477,679 JBrowse link
G Emg1 EMG1 N1-specific pseudouridine methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936709:847,229...854,471 JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:10200468 RGD:11049451 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Fcer2 Fc fragment of IgE receptor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:11500085 NCBI chrNW_004936588:4,717,010...4,724,664 JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936591:3,998,359...4,001,491 JBrowse link
G Gc GC vitamin D binding protein disease_progression ISO RGD PMID:2883392 RGD:5509934 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Grpel1 GrpE like 1, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936477:18,883,556...18,891,108 JBrowse link
G Gtf3a general transcription factor IIIA ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936472:22,671,277...22,683,748 JBrowse link
G Hdgf heparin binding growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936580:5,899,277...5,909,309 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936835:316,767...321,999 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936476:15,830,459...15,836,994 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936531:7,702,186...7,716,428 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936543:2,110,351...2,111,896 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936472:25,855,873...25,879,062 JBrowse link
G Ifng interferon gamma susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:10202824 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 susceptibility
treatment
ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
RGD
CTD
PMID:10202824 PMID:10666520 PMID:11121048 PMID:14657422 PMID:14657427 RGD:7365087 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il15 interleukin 15 ISO protein:decreased expression:plasma RGD PMID:20028198 RGD:4892672 NCBI chrNW_004936535:6,344,348...6,358,803 JBrowse link
G Il17d interleukin 17D severity ISO Protein:increased expression:blood plasma (human) RGD PMID:28592538 RGD:40903074 NCBI chrNW_004936720:1,005,111...1,029,613 JBrowse link
G Il18 interleukin 18 treatment ISO associated with hepatitis C; protein:increased expression:serum: RGD PMID:27927859 RGD:14696653 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il19 interleukin 19 ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to ClinVar PMID:11121048 PMID:14657422 PMID:14657427 NCBI chrNW_004936557:5,765,093...5,769,853 JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:22530560 RGD:6892924 NCBI chrNW_004936501:11,100,170...11,112,112 JBrowse link
G Il27 interleukin 27 ameliorates ISO associated with hepatitis C;protein:increased expression:blood plasma (human) RGD PMID:24816922 PMID:28338007 RGD:126790518 RGD:126790553 NCBI chrNW_004936501:11,972,715...11,978,152 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936484:8,514,333...8,555,392 JBrowse link
G Il4r interleukin 4 receptor susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:serum RGD PMID:1768380 RGD:10449449 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Ilf2 interleukin enhancer binding factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936580:3,464,870...3,472,242 JBrowse link
G Ipo7 importin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936528:8,683,543...8,739,617 JBrowse link
G Kmt2e lysine methyltransferase 2E (inactive) ISO protein:increased expression:peripheral blood, T cell, CD4+ (human) RGD PMID:16046540 RGD:9588555 NCBI chrNW_004936479:18,674,657...18,764,177 JBrowse link
G Kpnb1 karyopherin subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936490:13,603,520...13,635,567 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO protein:increased tyrosine phosphorylation:T cell RGD PMID:16828835 RGD:1600221 NCBI chrNW_004936474:15,293,115...15,314,072 JBrowse link
G Lepr leptin receptor ISO protein:increased phosphorylation:peripheral blood mononuclear cell RGD PMID:12100031 RGD:21079471 NCBI chrNW_004936591:5,771,371...5,846,177 JBrowse link
G LOC101955076 low affinity immunoglobulin gamma Fc region receptor III-A susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human) RGD PMID:21187939 RGD:5508390 NCBI chrNW_004937131:42,523...49,533 JBrowse link
G LOC101964975 interleukin-8 ISO associated with pleural tuberculosis; RGD PMID:21303360 RGD:36947878 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G LOC101968920 eotaxin susceptibility ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to
CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
OMIM
ClinVar
CTD
RGD
PMID:14571188 PMID:27246604 RGD:14995461 NCBI chrNW_004936538:835,436...848,907 JBrowse link
G LOC101969065 mamu class II histocompatibility antigen, DR alpha chain ISO RGD PMID:21427211 RGD:5490157 NCBI chrNW_004936727:540,225...544,968 JBrowse link
G LOC101969640 C-reactive protein disease_progression ISO RGD PMID:22448211 RGD:6482303 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G LOC101970607 selectin P ISO RGD PMID:22156911 RGD:6218986 NCBI chrNW_004936481:17,076,660...17,112,501 JBrowse link
G LOC101976500 haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936496:2,578,598...2,698,165 JBrowse link
G Map2 microtubule associated protein 2 ISO RGD PMID:19966940 RGD:6483319 NCBI chrNW_004936845:475,406...752,600 JBrowse link
G Maz MYC associated zinc finger protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936501:12,664,861...12,668,819 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21576701 RGD:6483531 NCBI chrNW_004936486:15,561,327...15,587,109 JBrowse link
G Mvb12a multivesicular body subunit 12A ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, rapid progression to AIDS ClinVar NCBI chrNW_004936596:3,478,142...3,481,968 JBrowse link
G Myh9 myosin heavy chain 9 ISO protein:decreased expression:glomerulus RGD PMID:22313957 RGD:6903274 NCBI chrNW_004936492:4,384,215...4,466,229 JBrowse link
G Nefm neurofilament medium chain ISO protein:increased serine/threonine phosphorylation:brain RGD PMID:26033855 RGD:40886309 NCBI chrNW_004936757:1,662,905...1,668,707 JBrowse link
G Nup88 nucleoporin 88 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936677:2,385,289...2,417,398 JBrowse link
G Nutf2 nuclear transport factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936475:18,214,593...18,232,406 JBrowse link
G Odc1 ornithine decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936532:6,581,717...6,587,116 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29709520 NCBI chrNW_004936602:3,411,106...3,418,826 JBrowse link
G Oprm1 opioid receptor mu 1 ISO mRNA:increased expression:macrophage RGD PMID:17553897 RGD:2316609 NCBI chrNW_004936489:6,506,207...6,567,136 JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:30161254 RGD:41412179 NCBI chrNW_004936745:152,571...163,712 JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO RGD PMID:18096355 RGD:6482728 NCBI chrNW_004936474:6,091,978...6,095,961 JBrowse link
G Plaur plasminogen activator, urokinase receptor disease_progression ISO protein:increased expression:plasma RGD PMID:20229356 PMID:21384094 RGD:6484120 RGD:6484128 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Ppib peptidylprolyl isomerase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936471:24,633,769...24,640,246 JBrowse link
G Prf1 perforin 1 ISO DNA:SNP: :rs885822 (human) RGD PMID:20523897 PMID:21157294 RGD:6482808 RGD:6482819 NCBI chrNW_004936521:8,057,874...8,060,695 JBrowse link
G Prpf8 pre-mRNA processing factor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936538:7,780,022...7,814,575 JBrowse link
G Psma4 proteasome 20S subunit alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936471:36,508,045...36,516,033 JBrowse link
G Psma5 proteasome 20S subunit alpha 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936704:905,277...928,364 JBrowse link
G Psma6 proteasome 20S subunit alpha 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936494:9,443,176...9,467,697 JBrowse link
G Psmb10 proteasome 20S subunit beta 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936475:18,290,055...18,293,035 JBrowse link
G Psmb4 proteasome 20S subunit beta 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936580:1,610,635...1,613,357 JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936562:1,810,883...1,817,040 JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936541:4,470,210...4,475,233 JBrowse link
G Psmd13 proteasome 26S subunit, non-ATPase 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936888:78,468...91,026 JBrowse link
G Psmd3 proteasome 26S subunit, non-ATPase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936490:15,118,024...15,135,241 JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936637:2,403,456...2,413,772 JBrowse link
G Psmd8 proteasome 26S subunit, non-ATPase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936801:1,137,480...1,144,287 JBrowse link
G Psme1 proteasome activator subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936722:405,491...408,277 JBrowse link
G Psme2 proteasome activator subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936722:398,406...401,987 JBrowse link
G Psme3 proteasome activator subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936490:17,542,933...17,549,347 JBrowse link
G Psme4 proteasome activator subunit 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936491:404,921...503,783 JBrowse link
G Ptch1 patched 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878215 NCBI chrNW_004936626:4,241,993...4,301,919 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA, protein:increased expression:brain RGD PMID:21846384 RGD:5508195 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Rab11b RAB11B, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936588:5,198,659...5,210,430 JBrowse link
G Rab32 RAB32, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936489:35,620...51,809 JBrowse link
G Ran RAN, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936660:1,669,352...1,673,972 JBrowse link
G Sf3a3 splicing factor 3a subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936474:20,092,159...20,116,612 JBrowse link
G Sfpq splicing factor proline and glutamine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936474:17,776,490...17,791,966 JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16204638 NCBI chrNW_004936524:2,717,885...2,720,874 JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19720090 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936619:728,759...744,367 JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:decreased expression:uterine cervix RGD PMID:16878360 RGD:2298904 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:decreased expression:uterine cervix RGD PMID:16878360 RGD:2298904 NCBI chrNW_004936594:2,932,297...2,935,358 JBrowse link
G Srf serum response factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936476:16,779,941...16,789,499 JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936490:5,055,258...5,059,118 JBrowse link
G Srsf9 serine and arginine rich splicing factor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936668:484,922...491,576 JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO mRNA:increased expression:multiple tissues (human) RGD PMID:24367701 RGD:39128218 NCBI chrNW_004936531:8,555,966...8,562,829 JBrowse link
G Taf9 TATA-box binding protein associated factor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936480:252,435...256,609 JBrowse link
G Tlr3 toll like receptor 3 susceptibility ISO ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:21911422 PMID:22174453 PMID:24033266 NCBI chrNW_004936554:3,370,766...3,388,125 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum RGD PMID:1768380 RGD:10449449 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8811349 NCBI chrNW_004936474:814,510...889,851 JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ISO mRNA,protein:increased expression:peripheral blood mononuclear cell, macrophage, plasma RGD PMID:31260499 RGD:126925971 NCBI chrNW_004936476:18,577,825...18,583,675 JBrowse link
G U2af1 U2 small nuclear RNA auxiliary factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936500:937,537...967,791 JBrowse link
G Vdr vitamin D receptor ISO DNA:SNPs:3' UTR (human) RGD PMID:18712587 RGD:4889839 NCBI chrNW_004936512:5,741,836...5,800,999 JBrowse link
G Yy1 YY1 transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15308739 NCBI chrNW_004936604:3,911,407...3,945,405 JBrowse link
acquired immunodeficiency syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 treatment ISO DNA:haplotype: :3435T>C((rs1045642), 2677T>G (rs2032582) (human)
DNA:SNP: : rs10276036(human)
RGD PMID:23372834 PMID:24517233 RGD:11098698 RGD:39456119 NCBI chrNW_004936763:1,225,355...1,308,257 JBrowse link
G Bst2 bone marrow stromal cell antigen 2 ISO DNA:SNPs: : RGD PMID:26885809 RGD:14398494
G Cd40lg CD40 ligand treatment ISO RGD PMID:9499800 RGD:11344976 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit susceptibility ISO DNA:polymorphism:exon:p.K751Q(human) RGD PMID:20127180 RGD:5688740 NCBI chrNW_004936706:1,816,561...1,829,638 JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO associated with pulmonary tuberculosis;protein:increased expression:blood (human) RGD PMID:32369456 RGD:39939073 NCBI chrNW_004936843:658,058...672,662 JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Acquired immunodeficiency syndrome, rapid progression to
CTD
ClinVar
PMID:9612607 PMID:12854077 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Igf2 insulin like growth factor 2 ISO protein:decreased expression:plasma RGD PMID:11232005 RGD:5509969 NCBI chrNW_004936816:972,902...981,232 JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:9861562 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il4r interleukin 4 receptor ISO ClinVar Annotator: match by term: Acquired immunodeficiency syndrome, slow progression to ClinVar PMID:2278997 PMID:2307934 PMID:9620765 PMID:15712015 PMID:16189667 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 ISO protein:decreased expression:peripheral blood mononuclear cell,natural killer cell (human) RGD PMID:27382604 RGD:40818276 NCBI chrNW_004936727:1,921,452...1,924,395 JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:8548330 RGD:12904035 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:8548330 RGD:12904035 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO RGD PMID:8548330 RGD:12904035 NCBI chrNW_004936474:908,414...935,765 JBrowse link
AIDS Dementia Complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27400929 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20818790 RGD:10395393 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Gc GC vitamin D binding protein ISO associated with HIV Infections;protein:increased expression:cerebrospinal fluid: RGD PMID:17929958 RGD:5509882 NCBI chrNW_004936598:3,220,029...3,256,091 JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:neocortex RGD PMID:17678975 RGD:1626641 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Insr insulin receptor severity ISO protein:increased expression:cerebrospinal fluid, plasma RGD PMID:22629383 RGD:10403033 NCBI chrNW_004936588:4,345,306...4,453,380 JBrowse link
G Irs1 insulin receptor substrate 1 severity ISO protein:decreased tyrosine phosphorylation:cerebrospinal fluid, leukocyte RGD PMID:22629383 RGD:10403033 NCBI chrNW_004936525:9,064,442...9,125,972 JBrowse link
G Npy neuropeptide Y severity ISO protein:increased expression:cerebrospinal fluid RGD PMID:8815163 RGD:10431910 NCBI chrNW_004936478:1,289,437...1,296,819 JBrowse link
G Oprm1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27400929 NCBI chrNW_004936489:6,506,207...6,567,136 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:21368226 RGD:6482787 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO RGD PMID:25404050 RGD:38676266 NCBI chrNW_004936538:6,205,268...6,239,062 JBrowse link
AIDS-Associated Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:2 RGD:1303381 NCBI chrNW_004936479:13,252,678...13,255,570 JBrowse link
G Egf epidermal growth factor ISO RGD PMID:19357719 RGD:6906909 NCBI chrNW_004936563:1,058,803...1,181,393 JBrowse link
G LOC101976500 haptoglobin ISO protein:increased expression:urine RGD PMID:19279121 RGD:11041816 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:23678040 RGD:7245474 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Myh9 myosin heavy chain 9 ISO protein:decreased expression:glomerulus RGD PMID:22313957 RGD:6903274 NCBI chrNW_004936492:4,384,215...4,466,229 JBrowse link
G Notch4 notch receptor 4 ISO protein: increased expression: kidney RGD PMID:20706108 RGD:6480788 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin treatment ISO RGD PMID:17229913 PMID:19188342 RGD:38596324 RGD:38599164 NCBI chrNW_004936570:495,421...514,179 JBrowse link
AIDS-Related Kaposi Sarcoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:10861090 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
AIDS-Related Opportunistic Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd4 CD4 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:9546790 NCBI chrNW_004936709:997,776...1,022,791 JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9379333 NCBI chrNW_004936474:814,510...889,851 JBrowse link
HIV Encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bace1 beta-secretase 1 ISO RGD PMID:29632166 RGD:13782045 NCBI chrNW_004936542:2,514,297...2,539,088 JBrowse link
G Cd68 CD68 molecule ISO protein:increased expression:brain (human) RGD PMID:15488024 RGD:40925943 NCBI chrNW_004936595:858,289...861,131 JBrowse link
G Cdk5 cyclin dependent kinase 5 ISO protein:increased tyrosine phosphorylation:hippocampus RGD PMID:28107387 RGD:13506927 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G LOC101959175 amyloid beta precursor protein ISO RGD PMID:29632166 RGD:13782045 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Mfn1 mitofusin 1 ISO associated with HIV Infections;protein:increased expression:frontal cortex, membrane (human) RGD PMID:26611103 RGD:12910851 NCBI chrNW_004936566:3,737,315...3,775,894 JBrowse link
G Olig2 oligodendrocyte transcription factor 2 ISO RGD PMID:15579294 RGD:40902823 NCBI chrNW_004936500:9,244,595...9,247,756 JBrowse link
HIV Seropositivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aph1b aph-1 homolog B, gamma-secretase subunit susceptibility ISO DNA:SNP:CDS:p.F217L (rs1047552) (human) RGD PMID:19774691 RGD:13703126 NCBI chrNW_004936471:23,839,962...23,869,788 JBrowse link
HIV Wasting Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:7979221 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:7979221 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7979221 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:7979221 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
HIV-Associated Lipodystrophy Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO RGD PMID:12876073 RGD:8694470 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G Adrb3 adrenoceptor beta 3 ISO DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:10930169 RGD:5684895 NCBI chrNW_004936710:1,410,589...1,413,279 JBrowse link
G Il18 interleukin 18 susceptibility ISO DNA:SNPs, haplotype:promoter:-137G>C (rs187238), -607C>A (rs1946518) (human) RGD PMID:15353983 PMID:20331838 RGD:8655915 RGD:8655934 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Lmna lamin A/C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18230615 NCBI chrNW_004936580:5,374,208...5,395,442 JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO DNA:SNP RGD PMID:20852404 RGD:8549721 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18230615 NCBI chrNW_004936474:22,035,059...22,077,846 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12943
    syndrome 6826
      primary immunodeficiency disease 2165
        human immunodeficiency virus infectious disease 170
          Acute Retroviral Syndrome 0
          Coronary Artery Disease, Development of, in HIV 0
          HIV Encephalitis 6
          HIV Enteropathy 0
          HIV Seropositivity 1
          HIV Wasting Syndrome 4
          HIV-Associated Lipodystrophy Syndrome 6
          acquired immunodeficiency syndrome + 33
          diffuse infiltrative lymphocytosis syndrome 0
Path 2
Term Annotations click to browse term
  disease 12943
    disease of anatomical entity 12618
      Urogenital Diseases 3656
        Female Urogenital Diseases and Pregnancy Complications 1868
          Female Urogenital Diseases 1604
            female reproductive system disease 1600
              Sexually Transmitted Diseases 196
                Viral Sexually Transmitted Diseases 191
                  human immunodeficiency virus infectious disease 170
                    Acute Retroviral Syndrome 0
                    Coronary Artery Disease, Development of, in HIV 0
                    HIV Encephalitis 6
                    HIV Enteropathy 0
                    HIV Seropositivity 1
                    HIV Wasting Syndrome 4
                    HIV-Associated Lipodystrophy Syndrome 6
                    acquired immunodeficiency syndrome + 33
                    diffuse infiltrative lymphocytosis syndrome 0
paths to the root