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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:fibrolamellar carcinoma
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Accession:DOID:5015 term browser browse the term
Definition:A hepatocellular carcinoma characterized microscopically by laminated fibrous layers interspersed between the tumour cells. The polygonal, deeply eosinophilic tumor cells arise in non-cirrhotic livers. (DO)
Synonyms:exact_synonym: Fibrolamellar Hepatocellular Carcinoma;   fibrolamellar variant of hepatocellular carcinoma;   hepatocellular carcinoma (fibrolamellar variant);   oncocytic hepatocellular tumor
 primary_id: MESH:C537258
 xref: EFO:1000256;   NCI:C4131;   ORDO:401920
For additional species annotation, visit the Alliance of Genome Resources.

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fibrolamellar carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca12 carbonic anhydrase 12 ISO mRNA:increased expression:liver RGD PMID:28304380 RGD:153352326 NCBI chrNW_004955450:11,927,730...11,975,553
Ensembl chrNW_004955450:11,943,340...11,975,928 		JBrowse link
G Ctnnb1 catenin beta 1 ISO protein:increased tyrosine phosphorylation:exon: RGD PMID:19101982 RGD:14402052 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO protein:increased expression:liver: RGD PMID:24925055 RGD:11055933 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO mRNA,protein:increased expression:liver (human) RGD PMID:27027723 RGD:151347845 NCBI chrNW_004955415:32,794,172...32,807,944
Ensembl chrNW_004955415:32,793,718...32,812,930 		JBrowse link
mixed fibrolamellar hepatocellular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkaca protein kinase cAMP-activated catalytic subunit alpha susceptibility ISO RGD PMID:28923495 RGD:151347843 NCBI chrNW_004955415:32,794,172...32,807,944
Ensembl chrNW_004955415:32,793,718...32,812,930 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      cancer 4843
        cell type cancer 3304
          carcinoma 2808
            adenocarcinoma 1495
              hepatocellular carcinoma 826
                fibrolamellar carcinoma 4
                  mixed fibrolamellar hepatocellular carcinoma 1
Path 2
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      Neoplasms by Site 6188
        Digestive System Neoplasms 3393
          Gastrointestinal Neoplasms 3283
            gastrointestinal system cancer 2582
              hepatobiliary system cancer 958
                liver cancer 882
                  liver carcinoma 828
                    hepatocellular carcinoma 826
                      fibrolamellar carcinoma 4
                        mixed fibrolamellar hepatocellular carcinoma 1
paths to the root