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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:fibrolamellar carcinoma
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Accession:DOID:5015 term browser browse the term
Definition:A hepatocellular carcinoma characterized microscopically by laminated fibrous layers interspersed between the tumour cells. The polygonal, deeply eosinophilic tumor cells arise in non-cirrhotic livers. (DO)
Synonyms:exact_synonym: Fibrolamellar Hepatocellular Carcinoma;   Fibrolamellar variant of hepatocellular carcinoma;   Hepatocellular carcinoma (fibrolamellar variant);   Oncocytic Hepatocellular tumor
 primary_id: MESH:C537258;   RDO:0003059
 xref: NCI:C4131
For additional species annotation, visit the Alliance of Genome Resources.


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fibrolamellar carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 ISO protein:increased tyrosine phosphorylation:exon: RGD PMID:19101982 RGD:14402052 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO protein:increased expression:liver: RGD PMID:24925055 RGD:11055933 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    disease of cellular proliferation 5907
      cancer 3745
        cell type cancer 2575
          carcinoma 2068
            adenocarcinoma 1445
              hepatocellular carcinoma 722
                fibrolamellar carcinoma 2
                  mixed fibrolamellar hepatocellular carcinoma 0
Path 2
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      gastrointestinal system disease 4694
        Gastrointestinal Diseases 2625
          Gastrointestinal Neoplasms 1782
            gastrointestinal system cancer 1282
              hepatobiliary system cancer 797
                liver cancer 739
                  liver carcinoma 726
                    hepatocellular carcinoma 722
                      fibrolamellar carcinoma 2
                        mixed fibrolamellar hepatocellular carcinoma 0
paths to the root