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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nelson syndrome
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Accession:DOID:4968 term browser browse the term
Definition:A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
Synonyms:exact_synonym: Nelson's syndrome
 primary_id: MESH:D009347
 xref: GARD:7170;   ICD10CM:E24.1;   NCI:C84917
For additional species annotation, visit the Alliance of Genome Resources.


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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    syndrome 10064
      Nelson syndrome 0
Path 2
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15145
      nervous system disease 13207
        Nervous System Neoplasms 1557
          Central Nervous System Neoplasms 1372
            Brain Neoplasms 1324
              Supratentorial Neoplasms 448
                supratentorial cancer 448
                  diencephalic neoplasm 38
                    hypothalamic neoplasm 38
                      Pituitary Neoplasms 36
                        pituitary gland benign neoplasm 23
                          pituitary adenoma 23
                            functioning pituitary adenoma 18
                              ACTH-secreting pituitary adenoma 4
                                Nelson syndrome 0
paths to the root