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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:poliomyelitis
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Accession:DOID:4953 term browser browse the term
Definition:An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Synonyms:exact_synonym: Epidemic Acute Poliomyelitis;   Infantile Paralysis;   Nonpoliovirus Poliomyelitis;   Polio;   Polio Encephalitis;   acute poliomyelitis;   polios;   preparalytic poliomyelitides;   preparalytic poliomyelitis
 primary_id: MESH:D011051
 xref: GARD:7413;   ICD10CM:A80;   ICD9CM:045;   NCI:C35550
For additional species annotation, visit the Alliance of Genome Resources.


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poliomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PVR PVR cell adhesion molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:3020560 PMID:28446605 NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162
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vestibular neuronitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRP C-reactive protein disease_progression IEP RGD PMID:14636287 RGD:9491594 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      Immune & Inflammatory Diseases 3974
        Inflammation 2236
          myelitis 28
            poliomyelitis 2
              herpes zoster oticus 0
              nonparalytic poliomyelitis 0
              paralytic poliomyelitis + 0
              postpoliomyelitis syndrome 0
              vestibular neuronitis 1
Path 2
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      nervous system disease 14839
        peripheral nervous system disease 2780
          neuropathy 2573
            neuromuscular disease 2047
              motor neuron disease 423
                poliomyelitis 2
                  herpes zoster oticus 0
                  nonparalytic poliomyelitis 0
                  paralytic poliomyelitis + 0
                  postpoliomyelitis syndrome 0
                  vestibular neuronitis 1
paths to the root