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ONTOLOGY REPORT - ANNOTATIONS


Term:uremia
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Accession:DOID:4676 term browser browse the term
Definition:A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Synonyms:exact_synonym: UREMIA OF renal ORIGIN;   Uremias
 primary_id: MESH:D014511;   RDO:0005752
For additional species annotation, visit the Alliance of Genome Resources.


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uremia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1625341
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase JBrowse link 2 219,788,234 219,843,189 RGD:1598784
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:2315619
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:2314180
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:11554173
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:8662343
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:8662310
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:11554173
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:10044236
G Flt1 Fms related receptor tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:11554173
G Hnrnpd heterogeneous nuclear ribonucleoprotein D JBrowse link 14 11,256,163 11,274,684 RGD:10042968
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:11554173
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:11554173
G Mgp matrix Gla protein JBrowse link 4 170,856,783 170,860,105 RGD:11554173
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:2303558
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5508758
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:11554173
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7242742
RGD:11554173
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:2292579
G Retn resistin JBrowse link 12 2,201,909 2,203,649 RGD:7207071
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:11554173
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:11554173
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:11554173
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:11554173
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:5128603
G Tnfrsf11b TNF receptor superfamily member 11B JBrowse link 7 93,798,580 93,826,586 RGD:11554173
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:11554173
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:11554173
atypical hemolytic-uremic syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 JBrowse link 3 5,519,921 5,558,390 RGD:10449096
G Baat bile acid CoA:amino acid N-acyltransferase JBrowse link 5 64,768,397 64,777,368 RGD:8554872
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:8554872
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:7364995
RGD:8554872
RGD:11554173
RGD:7240710
RGD:11040768
G C3ar1 complement C3a receptor 1 JBrowse link 4 155,681,767 155,691,240 RGD:8554872
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:8554872
RGD:7240710
RGD:11554173
RGD:11352810
RGD:11040768
RGD:11352768
RGD:11038684
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:7242707
RGD:8554872
RGD:7240710
RGD:11554173
RGD:11040768
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:1599886
RGD:8554872
RGD:7240710
RGD:11554173
RGD:11041172
RGD:11041162
RGD:11040768
RGD:7364995
G Cfhr1 complement factor H-related 1 JBrowse link 13 56,862,666 56,877,650 RGD:8554872
RGD:11554173
RGD:7240710
RGD:11041162
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:6906889
RGD:8554872
RGD:11554173
RGD:7240710
G Dgke diacylglycerol kinase epsilon JBrowse link 10 76,375,981 76,408,224 RGD:8554872
RGD:11554173
G RGD1564614 similar to complement factor H-related protein JBrowse link 13 56,889,669 56,958,549 RGD:8554872
RGD:11554173
RGD:7240710
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:8554872
RGD:7240710
RGD:11554173
RGD:11038691
RGD:11038684
Azotemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:11554173
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:11554173
hemolytic-uremic syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11554173
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:11528527
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:7241820
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6893534
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:11352767
RGD:11531138
RGD:11352770
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:11041164
RGD:13592920
G Dgke diacylglycerol kinase epsilon JBrowse link 10 76,375,981 76,408,224 RGD:8554872
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:11554173
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:7242276
G Hp haptoglobin JBrowse link 19 42,096,255 42,100,805 RGD:1626361
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:11554173
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11554173
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6909134
RGD:6909171
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11554173
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:11530050
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:11554173
G Pla2g7 phospholipase A2 group VII JBrowse link 9 19,935,754 19,978,013 RGD:7257516
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11541069
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:11038690
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16017
    disease of anatomical entity 15273
      Urogenital Diseases 4032
        urinary system disease 0
          kidney disease 1813
            uremia 62
              Azotemia 2
              hemolytic-uremic syndrome + 29
              uremic neuropathy 0
Path 2
Term Annotations click to browse term
  disease 16017
    disease of anatomical entity 15273
      Urogenital Diseases 4032
        urinary system disease 0
          kidney disease 1813
            kidney failure 482
              uremia 62
                Azotemia 2
                hemolytic-uremic syndrome + 29
                uremic neuropathy 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.