Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:hypokalemia
go back to main search page
Accession:DOID:4500 term browser browse the term
Definition:Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
Synonyms:exact_synonym: Hypokalemias;   Hypopotassemia;   Hypopotassemias;   potassium deficiency disorder
 primary_id: MESH:D007008;   RDO:0005861
 xref: NCI:C34939
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
hypokalemia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1848636 PMID:2826064 PMID:17292646 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,032,782...150,035,591
JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: therapeutic CTD PMID:7182184 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B ISO RGD PMID:17409277 RGD:1626084 NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,593,548...14,752,310
JBrowse link
G ATP12A ATPase H+/K+ transporting non-gastric alpha2 subunit ISO RGD PMID:9729517 RGD:13838663 NCBI chr11:113,901...144,765
Ensembl chr11:114,256...143,222
JBrowse link
G CLDN10 claudin 10 ISO ClinVar Annotator: match by term: Hypokalemia ClinVar PMID:25741868 NCBI chr11:65,027,706...65,145,002
Ensembl chr11:65,027,732...65,147,242
JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:496411 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G KCNJ16 potassium inwardly rectifying channel subfamily J member 16 ISO protein:decreased expression:cortical collecting duct, distal convoluted tubule (rat) RGD PMID:28931751 RGD:38500204 NCBI chr12:10,393,172...10,538,423
Ensembl chr12:10,368,378...10,865,310
JBrowse link
G NPPB natriuretic peptide B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20339970 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11932321 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,937...144,956,095
JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:323586 PMID:1327015 PMID:4323972 PMID:6254450 PMID:6258369 More... NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418
JBrowse link
G RHCG Rh family C glycoprotein ISO protein:increased expression:outer medulla of kidney RGD PMID:21753075 RGD:9850155 NCBI chr 7:55,046,244...55,071,504
Ensembl chr 7:55,046,245...55,072,218
JBrowse link
G SST somatostatin ISO CTD Direct Evidence: therapeutic CTD PMID:2563217 NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,417...125,338,850
JBrowse link
Hypokalemic Tubulopathy and Deafness term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ16 potassium inwardly rectifying channel subfamily J member 16 ISO ClinVar Annotator: match by term: HYPOKALEMIC TUBULOPATHY AND DEAFNESS OMIM
ClinVar
PMID:33811157 NCBI chr12:10,393,172...10,538,423
Ensembl chr12:10,368,378...10,865,310
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14378
    Nutritional and Metabolic Diseases 5585
      disease of metabolism 5585
        mineral metabolism disease 685
          hypokalemia 12
            Familial Hypokalemia + 1
Path 2
Term Annotations click to browse term
  disease 14378
    Nutritional and Metabolic Diseases 5585
      disease of metabolism 5585
        acquired metabolic disease 1862
          mineral metabolism disease 685
            hypokalemia 12
              Familial Hypokalemia + 1
paths to the root