RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: rhinitis
Accession: DOID:4483
browse the term
Definition: A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip. (DO)
Synonyms: exact_synonym: nasal catarrh; rhinitides; runny nose
primary_id: MESH:D012220
xref: EFO:0008521 ; NCI:C34986
For additional species annotation, visit the
Alliance of Genome Resources .
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ADAM33
ADAM metallopeptidase domain 33
susceptibility
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:15298558 PMID:18778489
RGD:4145378 RGD:4145383
NCBI chr20:3,750,158...3,764,262
Ensembl chr20:3,508,620...3,521,628
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ANG
angiogenin
ISO
protein:increased expression:sputum
RGD
PMID:19178538
RGD:6892723
NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393
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BDKRB1
bradykinin receptor B1
ISO
RGD
PMID:12165532
RGD:5129220
NCBI chr14:76,885,923...76,894,456
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BDKRB2
bradykinin receptor B2
ISO
RGD
PMID:1890650 PMID:11149999
RGD:4891033 RGD:4891044
NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253
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BDNF
brain derived neurotrophic factor
susceptibility
ISO
DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human) mRNA:increased expression:nasal cavity epithelium
RGD
PMID:20464992 PMID:21723144
RGD:4891116 RGD:8655967
NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
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C3
complement C3
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:17345707 PMID:20109314
RGD:5129524 RGD:5129539
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
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C3AR1
complement C3a receptor 1
severity
ISO
protein:increased expression:nasal cavity
RGD
PMID:18538384
RGD:5129559
NCBI chr12:8,178,064...8,186,206
Ensembl chr12:8,220,933...8,222,381
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C5AR1
complement C5a receptor 1
ISO
RGD
PMID:18538384
RGD:5129559
NCBI chr19:44,293,612...44,310,430
Ensembl chr19:52,950,317...52,966,146
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CASP1
caspase 1
ISO
protein:increased expression:serum
RGD
PMID:12396474 PMID:20974310
RGD:5130187 RGD:5130192
NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149 Ensembl chr11:103,448,497...103,458,149
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CAT
catalase
treatment
ISO
protein:increased activity:blood,nasal cavity mucosa:
RGD
PMID:21541033
RGD:9479054
NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
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CCL1
C-C motif chemokine ligand 1
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:17982926
RGD:4145109
NCBI chr17:22,425,022...22,430,243
Ensembl chr17:22,719,425...22,722,341
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CCL17
C-C motif chemokine ligand 17
ISO
protein:increased expression:blood, mononuclear cell
RGD
PMID:17517104
RGD:4145498
NCBI chr16:37,678,518...37,689,350
Ensembl chr16:56,819,949...56,822,131
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CCL19
C-C motif chemokine ligand 19
ISO
RGD
PMID:17947663
RGD:5130909
NCBI chr 9:34,525,820...34,527,628
Ensembl chr 9:35,334,353...35,336,108
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CCL22
C-C motif chemokine ligand 22
ISO
protein:increased expression:blood, mononuclear cell
RGD
PMID:17517104
RGD:4145498
NCBI chr16:37,631,861...37,640,208
Ensembl chr16:56,765,367...56,771,213
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CCL24
C-C motif chemokine ligand 24
ISO
mRNA:increased expression:nasal cavity epithelium DNA:SNPs: :179T>C, 275C>T (human)
RGD
PMID:15580493 PMID:17982926
RGD:4145109 RGD:4891493
NCBI chr 7:68,206,688...68,210,343
Ensembl chr 7:82,263,310...82,265,480
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CCL26
C-C motif chemokine ligand 26
ISO
DNA:polymorphism: :2497T>G (human) associated with Eosinophilia;protein:increased expression:oronasal secretion (human)
RGD
PMID:15580493 PMID:24989688
RGD:11531119 RGD:4891493
NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874
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CCL8
C-C motif chemokine ligand 8
ISO
RGD
PMID:20625511
RGD:5131089
NCBI chr17:22,468,080...22,470,443
Ensembl chr17:22,761,064...22,763,933
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CCR2
C-C motif chemokine receptor 2
susceptibility
ISO
Rhinitis, Allergic, Seasonal; DNA:SNP:cds:p.V64I (human)
RGD
PMID:17135764
RGD:4145111
NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
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CCR3
C-C motif chemokine receptor 3
ISO
DNA:SNP:exon:51T>C (human) mRNA:increased expression:nose protein:increased expression:blood, T cell
RGD
PMID:17135764 PMID:17156343 PMID:20696593
RGD:4145111 RGD:4145454 RGD:4145645
NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630
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CD14
CD14 molecule
resistance susceptibility
ISO
DNA:polymorphism:promoter:c. -159c>T (human)
RGD
PMID:16950285 PMID:20109306
RGD:4144795 RGD:4144810
NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966
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CD28
CD28 molecule
ISO
RGD
PMID:21356099
RGD:5131612
NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213
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CD80
CD80 molecule
ISO
RGD
PMID:21108691
RGD:5132622
NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870
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CDC42
cell division cycle 42
ISO
mRNA:increased expression:nasal turbinate
RGD
PMID:19432938
RGD:5688273
NCBI chr 1:21,245,970...21,286,210
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CFTR
CF transmembrane conductance regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16083808
NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864
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CRHR1
corticotropin releasing hormone receptor 1
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:17597629
RGD:5130940
NCBI chr17:11,261,435...11,313,630
Ensembl chr17:11,650,057...11,701,208
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CRHR2
corticotropin releasing hormone receptor 2
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:17597629
RGD:5130940
NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220
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CTLA4
cytotoxic T-lymphocyte associated protein 4
ISO
protein:increased expression:T cell
RGD
PMID:17625281
RGD:4891512
NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
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CX3CL1
C-X3-C motif chemokine ligand 1
ISO
protein:increased expression:plasma
RGD
PMID:14657873
RGD:4891906
NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760
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CXCL6
C-X-C motif chemokine ligand 6
ISO
protein:increased expression:nasal mucus
RGD
PMID:20659080
RGD:4892030
NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402
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CYSLTR1
cysteinyl leukotriene receptor 1
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:15379985 PMID:16689996 PMID:17627772 PMID:18946234
RGD:4781451 RGD:4783198 RGD:4847512 RGD:4888516
NCBI chr X:67,412,410...67,469,366
Ensembl chr X:77,524,455...77,525,468
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CYSLTR2
cysteinyl leukotriene receptor 2
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:16689996
RGD:4783198
NCBI chr13:29,796,598...29,853,676
Ensembl chr13:48,551,757...48,552,797
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FCER1A
Fc epsilon receptor Ia
ISO
RGD
PMID:20650300
RGD:5128714
NCBI chr 1:134,655,230...134,660,961
Ensembl chr 1:138,439,921...138,458,258
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FIS1
fission, mitochondrial 1
ISO
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683
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HDC
histidine decarboxylase
ISO
DNA:SNP: :p.E644D (rs2073440) (human)
RGD
PMID:15054596 PMID:20608921
RGD:5128884 RGD:5143921
NCBI chr15:29,188,296...29,212,327
Ensembl chr15:47,510,629...47,534,577
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HNMT
histamine N-methyltransferase
no_association
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17651147
RGD:5128885
NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315
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HRH1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12167471
NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757
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IL13
interleukin 13
susceptibility disease_progression
ISO
DNA:polymorphism: :rs1800925 (human) mRNA:increased expression:nose associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human)
RGD
PMID:16120094 PMID:17088137 PMID:20358028 PMID:20484924 PMID:20696593
RGD:4145454 RGD:4145534 RGD:4145767 RGD:4159171 RGD:4206706
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
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IL13RA2
interleukin 13 receptor subunit alpha 2
ISO
RGD
PMID:17088137
RGD:4159171
NCBI chr X:104,092,993...104,146,062
Ensembl chr X:114,597,077...114,635,253
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IL15
interleukin 15
ISO
RGD
PMID:16750998
RGD:5000756
NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622
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IL16
interleukin 16
ISO
protein:increased expression:nasal cavity epithelium, serum protein:increased expression:serum
RGD
PMID:18254318 PMID:19295235
RGD:5024931 RGD:5024932
NCBI chr15:60,181,827...60,299,406
Ensembl chr15:79,122,988...79,250,861
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IL17A
interleukin 17A
ISO
protein:increased expression:nasal mucosa
RGD
PMID:19927541 PMID:20506642
RGD:4889137 RGD:4889144
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
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IL18
interleukin 18
disease_progression
ISO
protein:increased expression:serum protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid rhinitis allergic, seasonal; protein:increased expression:plasma
RGD
PMID:15934281 PMID:17305282 PMID:17323858
RGD:4889916 RGD:4889917 RGD:4889927
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
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IL1B
interleukin 1 beta
susceptibility
ISO
associated with Hypersensitivity;protein:increased expression:nasal mucus associated with Hypersensitivity;DNA:polymorphism: :-511C>T (human) mRNA:increased expression:nasal cavity epithelium
RGD
PMID:10224452 PMID:14533660 PMID:20490816
RGD:4142821 RGD:4142859 RGD:4143227
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL1RL1
interleukin 1 receptor like 1
severity
ISO
associated with Sinusitis;DNA:SNPs: :multiple (human)
RGD
PMID:19671251
RGD:5144228
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IL1RN
interleukin 1 receptor antagonist
susceptibility
ISO
associated with Hypersensitivity associated with Hypersensitivity;DNA:repeat:intron (human)
RGD
PMID:10224452 PMID:14533660 PMID:15178892
RGD:4142859 RGD:4143215 RGD:4143227
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
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IL2
interleukin 2
susceptibility
ISO
DNA:SNP:promoter:rs2069762(human)
RGD
PMID:16333313
RGD:8663473
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
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IL21
interleukin 21
ISO
RGD
PMID:17982108
RGD:5147397
NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915
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IL22
interleukin 22
severity
ISO
mRNA:increased expression:blood, mononuclear cell
RGD
PMID:21535180
RGD:5147409
NCBI chr12:65,757,069...65,762,418
Ensembl chr12:68,542,076...68,547,421
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IL23R
interleukin 23 receptor
susceptibility
ISO
DNA:SNP,haplotype: :rs7517847(human)
RGD
PMID:23696856
RGD:8549605
NCBI chr 1:66,408,839...66,502,535
Ensembl chr 1:68,293,514...68,386,815
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IL27RA
interleukin 27 receptor subunit alpha
ISO
RGD
PMID:19354069
RGD:5128480
Ensembl chr19:14,323,618...14,343,627
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IL4
interleukin 4
ISO
mRNA:increased expression:nasal cavity epithelium protein:increased expression:serum CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18826099 PMID:19672097 PMID:21208219
RGD:2317285 RGD:5128558
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
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IL4R
interleukin 4 receptor
ISO
DNA:polymorphism: :c.1432T>C (human)
RGD
PMID:15564773
RGD:4890394
Ensembl chr16:27,642,702...27,737,445
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IL5
interleukin 5
ISO
RGD
PMID:11884474
RGD:5128622
NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
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IL9
interleukin 9
ISO
RGD
PMID:20525149
RGD:5128687
NCBI chr 5:131,283,170...131,289,777
Ensembl chr 5:137,425,367...137,428,945
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LEP
leptin
ISO
RGD
PMID:19860581
RGD:5128850
NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
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LOC100972994
HLA class II histocompatibility antigen, DQ beta 1 chain
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*0602 (human)
RGD
PMID:14990915
RGD:5147798
NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
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LOC100980531
eotaxin
severity
ISO
protein:increased expression:nasal mucus associated with Sinusitis;protein:increased expression:paranasal sinus
RGD
PMID:16120080 PMID:17999785
RGD:4145411 RGD:4145455
NCBI chr17:22,495,737...22,515,144
Ensembl chr17:22,806,076...22,808,345 Ensembl chr17:22,806,076...22,808,345
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LOC100988273
cytochrome P450 2D6-like
ISO
DNA:SNP:3' utr:*1934G>A (human)
RGD
PMID:20088379
RGD:5143945
NCBI chr22:23,022,449...23,031,627
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MBL2
mannose binding lectin 2
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:18831943
RGD:8693717
NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
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MFN1
mitofusin 1
ISO
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763
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MIF
macrophage migration inhibitory factor
severity
ISO
protein:increased expression:serum, nasal mucosa
RGD
PMID:15053202 PMID:15922619
RGD:4891045 RGD:4891056
NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
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MS4A2
membrane spanning 4-domains A2
ISO
RGD
PMID:15480314
RGD:5131152
NCBI chr11:55,318,843...55,326,779
Ensembl chr11:58,764,911...58,772,567
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA:increased expression:nose
RGD
PMID:15715404 PMID:20696593
RGD:4145454 RGD:7364740
NCBI chr11:1,191,223...1,234,373
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NGF
nerve growth factor
ISO
protein:increased expression:respiratory system fluid/secretion associated with Sinusitis;protein:increased expression:respiratory system mucosa
RGD
PMID:10224365 PMID:19958603
RGD:4891064 RGD:4891115
NCBI chr 1:87,223,597...87,276,759
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NGFR
nerve growth factor receptor
ISO
protein:increased expression:blood, eosinophil
RGD
PMID:18647313
RGD:5144116
NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966
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NOD1
nucleotide binding oligomerization domain containing 1
ISO
mRNA:decreased expression:nose
RGD
PMID:20384614
RGD:5131446
NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742
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NOD2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:cds:2104C>T,2722G>C (human)
RGD
PMID:12704363
RGD:5131484
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
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NOS2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:18254476
RGD:4891910
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
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NPY
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12746121
NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657
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NTRK1
neurotrophic receptor tyrosine kinase 1
ISO
protein:increased expression:eosinophil
RGD
PMID:18647313
RGD:5144116
Ensembl chr 1:136,007,476...136,047,355
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OPA1
OPA1 mitochondrial dynamin like GTPase
ISO
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358
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PLAU
plasminogen activator, urokinase
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:21339035
RGD:8547809
NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136
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PTGDR2
prostaglandin D2 receptor 2
ISO
RGD
PMID:19230460 PMID:19608418
RGD:5135017 RGD:5135021
NCBI chr11:56,114,166...56,153,820
Ensembl chr11:59,556,460...59,557,647
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SCGB3A2
secretoglobin family 3A member 2
ISO
protein:increased expression:sputum mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:17218572 PMID:21385388
RGD:5144232 RGD:5147389
NCBI chr 5:143,319,941...143,323,625
Ensembl chr 5:149,329,201...149,333,003
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SERPINE1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:rs1799768 (human)
RGD
PMID:19063817
RGD:4144832
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
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SFTPD
surfactant protein D
susceptibility
ISO
associated with Hypersensitivity;DNA:polymorphism: :p.M11T (human)
RGD
PMID:19493231
RGD:4143494
NCBI chr10:76,275,147...76,318,952
Ensembl chr10:78,965,252...78,974,181
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TAP1
transporter 1, ATP binding cassette subfamily B member
susceptibility no_association
ISO
DNA:SNPs: :
RGD
PMID:12018331 PMID:17982230
RGD:6482262 RGD:6482274
NCBI chr 6:32,414,665...32,423,488
Ensembl chr 6:33,530,171...33,538,978
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TBXA2R
thromboxane A2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12167471
NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924
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TGFB1
transforming growth factor beta 1
ISO
associated with Sinusitis
RGD
PMID:18423831
RGD:4145277
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
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TLR2
toll like receptor 2
no_association susceptibility
ISO
associated with Sinusitis;DNA:SNPs: :multiple (human) DNA:SNPs: :597T>C, 1350T>C (human) mRNA:decreased expression:nasal mucosa:
RGD
PMID:18219831 PMID:19128592 PMID:19763595
RGD:4145354 RGD:4145356 RGD:7800742
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
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TLR6
toll like receptor 6
ISO
associated with Asthma;DNA:SNP: :rs2381289 (human)
RGD
PMID:20815312
RGD:4145352
NCBI chr 4:33,153,151...33,174,053
Ensembl chr 4:39,009,103...39,011,490
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TNF
tumor necrosis factor
ISO
mRNA:increased expression:nose
RGD
PMID:15120189 PMID:20696593
RGD:4143470 RGD:4145454
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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VEGFA
vascular endothelial growth factor A
ISO
protein:increased expression:sputum
RGD
PMID:19178538
RGD:6892723
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
G
VIP
vasoactive intestinal peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12746121 PMID:14680090
NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730
G
ABCB1
ATP binding cassette subfamily B member 1
severity
ISO
DNA:snp:exon:c.1236C>T (human)
RGD
PMID:24040855
RGD:8657076
NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238
G
ACE
angiotensin I converting enzyme
no_association
ISO
DNA:deletion:intron:IVS16+1464-1751del (human)
RGD
PMID:15112973
RGD:8142345
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
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BCL2
BCL2 apoptosis regulator
ISO
mRNA, protein:increased expression:nasal mucosa (rat)
RGD
PMID:15362690
RGD:11522724
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
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CAT
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29028686
NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
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CCL26
C-C motif chemokine ligand 26
ISO
protein:increased expression:oronasal secretion (human)
RGD
PMID:23883806
RGD:7364793
NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874
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CD40
CD40 molecule
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
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CD40LG
CD40 ligand
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202
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CLDN3
claudin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
Ensembl chr 7:80,924,731...80,925,393
G
CLDN7
claudin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr17:7,289,766...7,292,433
Ensembl chr17:7,277,313...7,281,859
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CTLA4
cytotoxic T-lymphocyte associated protein 4
treatment
ISO
RGD
PMID:10436391
RGD:11344920
NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
G
F2
coagulation factor II, thrombin
ISO
protein:increased expression:nasal mucus
RGD
PMID:21711961
RGD:5147783
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
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FCGR3A
Fc gamma receptor IIIa
susceptibility
ISO
DNA:polymorphism:exon:p.F158V(rs396991)(human)
RGD
PMID:18199088
RGD:5508449
NCBI chr 1:137,027,943...137,036,738
G
GRIA1
glutamate ionotropic receptor AMPA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr 5:148,879,996...149,206,914
Ensembl chr 5:154,879,080...155,204,660
G
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr 4:149,566,563...149,712,135
Ensembl chr 4:161,380,933...161,524,376
G
HRH1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23333628
NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757
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IFNG
interferon gamma
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Asthma
RGD CTD
PMID:12787306 PMID:18510219 PMID:29871060
RGD:10755770 RGD:7829803
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
G
IL10
interleukin 10
treatment
ISO
RGD
PMID:23253209 PMID:23883806
RGD:7364793 RGD:7364818
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL13
interleukin 13
susceptibility no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)
OMIM CTD RGD
PMID:12928861
RGD:8549516
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
G
IL13RA2
interleukin 13 receptor subunit alpha 2
ISO
protein:increased expression:serum
RGD
PMID:21462799
RGD:8549521
NCBI chr X:104,092,993...104,146,062
Ensembl chr X:114,597,077...114,635,253
G
IL17A
interleukin 17A
susceptibility
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human) DNA:snp:promoter:c.-444A>G (human)
RGD
PMID:21535180 PMID:22507625
RGD:5147409 RGD:9068429
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
G
IL18
interleukin 18
no_association severity
ISO
DNA:SNP:promoter:-140C>G (rs360721) (human) DNA:SNP:promoter:-137G>C (rs187238) (human)
RGD
PMID:22840759
RGD:8655914
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
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IL1B
interleukin 1 beta
ISO
protein:increased expression:nasal mucus
RGD
PMID:7750009
RGD:7401199
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL2
interleukin 2
ISO
RGD
PMID:12592663
RGD:8662963
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
G
IL4
interleukin 4
treatment
ISO
RGD
PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662
RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
G
IL5
interleukin 5
treatment
ISO
RGD
PMID:23934070 PMID:24620662
RGD:11354976 RGD:11522769
NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
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ITGB2
integrin subunit beta 2
treatment
ISO
RGD
PMID:12046991
RGD:9698435
NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
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MUC1
mucin 1, cell surface associated
severity
ISO
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:31425778
RGD:127345100
NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:22972875
RGD:7364746
NCBI chr11:1,191,223...1,234,373
G
NOD2
nucleotide binding oligomerization domain containing 2
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:23858718
RGD:8547523
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
G
OCLN
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342
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PON1
paraoxonase 1
severity
ISO
protein:decreased activity:plasma (human)
RGD
PMID:23406590
RGD:8547583
NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
G
PRKG1
protein kinase cGMP-dependent 1
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:24012634
RGD:7775060
NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16979129
NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
G
SCGB1A1
secretoglobin family 1A member 1
ISO
mRNA:decreased expression:nasal mucosa, lung
RGD
PMID:17882576
RGD:5144135
NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873
G
SCGB3A2
secretoglobin family 3A member 2
susceptibility
ISO
DNA:SNP: :rs7726552 (human)
RGD
PMID:21410962
RGD:5144225
NCBI chr 5:143,319,941...143,323,625
Ensembl chr 5:149,329,201...149,333,003
G
SERPINE1
serpin family E member 1
ISO
mRNA:increased expression:nasal mucosa (mouse)
RGD
PMID:21339035
RGD:8547809
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
G
TACR1
tachykinin receptor 1
ISO
mRNA:increased expression:nasal mucosa
RGD
PMID:12768696
RGD:5147835
NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
G
TGFB1
transforming growth factor beta 1
treatment
ISO
RGD
PMID:31368266
RGD:14995445
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
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TLR2
toll like receptor 2
severity
ISO
mRNA:decreased expression:nasal mucosa: DNA:polymorphism:cds:p.R753Q(human) protein:increased expression:neutrophil:
RGD
PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057
RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
G
TLR4
toll like receptor 4
susceptibility no_association treatment severity
ISO
protein:increased expression:nasal lavage,leukocyte, bone marrow: DNA:SNP: :rs1927911(human) protein:decreased expression:nasal mucosa: DNA:polymorphism: :4216G>C(human) DNA:polymorphism:cds:p.D299G(human)
RGD
PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 PMID:23639307 More...
RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
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CYP2C19
cytochrome P450 family 2 subfamily C member 19
treatment
ISO
associated with Eosinophilic Esophagitis; DNA:polymorphisms::
RGD
PMID:26416193
RGD:11352743
NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065
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IL3
interleukin 3
susceptibility
ISO
DNA:SNP: :rs40401(human)
RGD
PMID:23953855
RGD:13506915
NCBI chr 5:127,483,843...127,486,388
Ensembl chr 5:133,647,667...133,650,213
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EDN1
endothelin 1
ISO
protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human)
RGD
PMID:8845175
RGD:8661738
NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
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CD8A
CD8 subunit alpha
ameliorates
ISO
protein:decreased expression:blood, T cell (human)
RGD
PMID:24639246
RGD:124715444
NCBI chr2A:86,832,559...86,855,772
Ensembl chr2A:88,377,722...88,382,635
G
IL17A
interleukin 17A
ISO
protein:increased expression:uncinate process, nasal mucosa (human)
RGD
PMID:23613503
RGD:8696039
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
G
IL1RN
interleukin 1 receptor antagonist
susceptibility
ISO
DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human)
RGD
PMID:16549749
RGD:8549791
NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839
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MBL2
mannose binding lectin 2
ISO
protein:decreased activity:serum:
RGD
PMID:23144819
RGD:8693716
NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432
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PRG2
proteoglycan 2, pro eosinophil major basic protein
disease_progression
ISO
associated with Nasal Polyps;
RGD
PMID:24450586
RGD:13506943
NCBI chr11:52,628,289...52,631,634
Ensembl chr 3:160,118,111...160,122,002
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ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
protein:decreased expression:serum
RGD
PMID:19725899
RGD:5686851
NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
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ALB
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19389874
NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
ISO
protein:increased expression:nasal turbinate
RGD
PMID:19364335
RGD:5147461
NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607
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CAT
catalase
ISO
protein:decreased expression:plasma
RGD
PMID:20493834
RGD:5130771
NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
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CCL2
C-C motif chemokine ligand 2
ISO
protein:increased expression:nasal turbinate, mucosa (human)
RGD
PMID:9865755
RGD:8548839
NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
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CCR2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:Nasal Mucosa
RGD
PMID:17982926
RGD:4145109
NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
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CCR5
C-C motif chemokine receptor 5
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:17982926
RGD:4145109
NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
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CD40
CD40 molecule
ISO
RGD
PMID:20226305
RGD:5132269
NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
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CD86
CD86 molecule
ISO
protein:increased expression:nasal mucosa, dendritic cell (human)
RGD
PMID:17088138
RGD:4892343
NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339
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CHIA
chitinase acidic
ISO
mRNA, protein:increased expression:turbinate, mucosa (human)
RGD
PMID:20422678
RGD:5037226
NCBI chr 1:113,935,888...113,965,541
Ensembl chr 1:126,381,724...126,391,909
G
EGR1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)
RGD
PMID:19833116
RGD:5131984
NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260
G
F2RL1
F2R like trypsin receptor 1
ISO
RGD
PMID:17727088
RGD:4892590
G
GSTP1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:polymorphism:exon:p.I105V (rs1695) (human)
RGD
PMID:17181111
RGD:4142523
NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472
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HMOX1
heme oxygenase 1
ISO
mRNA, protein:increased expression: nasal mucosa
RGD
PMID:16540907
RGD:4145406
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
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ICAM1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx (human) protein:increased expression:lung, endothelium (mouse)
RGD
PMID:19047814 PMID:19968652
RGD:4145464 RGD:4145520
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053
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IL13
interleukin 13
ISO
mRNA, protein:increased expression:nasal mucosa
RGD
PMID:8520776
RGD:4782826
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
G
IL17A
interleukin 17A
severity
ISO
protein:increased expression:serum
RGD
PMID:19226302
RGD:4889151
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
G
IL18
interleukin 18
susceptibility
ISO
DNA:SNP:promoter:c. -607A>C (rs1946518) (human)
RGD
PMID:16406079
RGD:4889924
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
G
IL1A
interleukin 1 alpha
ISO
DNA:polymorphism:exon:c.4845G>T (human)
RGD
PMID:14533660
RGD:4142859
NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801
G
IL1R1
interleukin 1 receptor type 1
ISO
RGD
PMID:18637763
RGD:5037238
Ensembl chr2A:103,193,131...103,230,005
G
IL2
interleukin 2
ISO
protein:decreased expression:serum:
RGD
PMID:17608155
RGD:8662959
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
G
IL4
interleukin 4
treatment
ISO
protein:increased expression:serum
RGD
PMID:9237816 PMID:15329007 PMID:21171297
RGD:5128559 RGD:7829804 RGD:7829817
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
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IL5
interleukin 5
ISO
protein: increased levels: sputum
RGD
PMID:22186238
RGD:5687140
NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
G
MMP2
matrix metallopeptidase 2
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
G
MMP9
matrix metallopeptidase 9
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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NOS2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:14587983
RGD:4892078
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
G
NOS3
nitric oxide synthase 3
ISO
DNA:snp:promoter:g.-786T>C (human)
RGD
PMID:18086269
RGD:4892054
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
G
NR3C1
nuclear receptor subfamily 3 group C member 1
ISO
protein:altered expression:nasal mucosa
RGD
PMID:20185258
RGD:4892593
NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269
G
PPARG
peroxisome proliferator activated receptor gamma
ISO
mRNA, protein:increased expression:nasal mucosa (human)
RGD
PMID:17116814
RGD:8552811
NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
G
TBXA2R
thromboxane A2 receptor
treatment
ISO
RGD
PMID:15247523
RGD:11059532
NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924
G
ANXA1
annexin A1
ISO
associated with Nasal Polyps
RGD
PMID:22279949
RGD:7421555
NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779
G
C3
complement C3
ISO
protein:increased expression:serum
RGD
PMID:19593977
RGD:4889484
NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699
G
C4A
complement C4A (Chido/Rodgers blood group)
disease_progression
ISO
DNA:deletion: :
RGD
PMID:16879240
RGD:5688262
NCBI chr 6:31,648,710...31,655,792
G
CCL20
C-C motif chemokine ligand 20
ISO
RGD
PMID:16702571
RGD:7483585
NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225
G
HGF
hepatocyte growth factor
susceptibility
ISO
DNA:haplotype::rs38850,rs38855,rs38857(human)
RGD
PMID:20416453
RGD:8548615
NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
G
IGF1
insulin like growth factor 1
ISO
mRNA:increased expression:nose:
RGD
PMID:20713758
RGD:8548883
NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177
G
IL10
interleukin 10
ISO
protein:decreased expression:blood, mononuclear cell
RGD
PMID:23168151
RGD:7364820
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL17A
interleukin 17A
ISO
associated with Asthma;mRNA, protein:increased expression:nasal polyps (human)
RGD
PMID:19672092
RGD:4889146
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
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IL1B
interleukin 1 beta
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11197112
RGD:7401169
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
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IL22RA1
interleukin 22 receptor subunit alpha 1
susceptibility
ISO
DNA:SNPs:5' utr, intron: (rs4292900, rs16829225, rs4648936) (human)
RGD
PMID:19393422
RGD:5147411
NCBI chr 1:23,322,057...23,345,557
Ensembl chr 1:24,300,902...24,324,391
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IL4
interleukin 4
treatment
ISO
associated with Asthma
RGD
PMID:12787306
RGD:7829803
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
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MMP9
matrix metallopeptidase 9
ISO
RGD
PMID:23401274
RGD:8547880
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
treatment
ISO
RGD
PMID:19389874 PMID:23131200
RGD:7349403 RGD:7364734
NCBI chr11:1,191,223...1,234,373
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PRKRA
protein activator of interferon induced protein kinase EIF2AK2
severity
ISO
associated with Nasal Polyps
RGD
PMID:22961479
RGD:7777146
NCBI chr2B:65,689,029...65,708,493
Ensembl chr2B:183,393,819...183,413,174
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SERPINE1
serpin family E member 1
ISO
protein:increased expression:nasal mucosa (human)
RGD
PMID:21711960
RGD:6483796
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
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TLR2
toll like receptor 2
susceptibility
ISO
DNA:polymorphisms:: rs3804099,rs3804100(human) mRNA,protein:increased expression:paranasal sinus
RGD
PMID:21493395 PMID:22182736
RGD:7800733 RGD:8552975
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
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TLR4
toll like receptor 4
ISO
mRNA,protein:increased expression:paranasal sinus
RGD
PMID:22182736
RGD:7800733
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
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TNF
tumor necrosis factor
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11197112 PMID:20147558
RGD:7401169 RGD:7401236
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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LOC100972994
HLA class II histocompatibility antigen, DQ beta 1 chain
ISO
DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0301, HLA-DQB1*0302 (human)
RGD
PMID:15577839
RGD:5147654
NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:16677242
RGD:5147463
NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
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APOA4
apolipoprotein A4
resistance
ISO
protein:increased expression:blood serum (human)
RGD
PMID:20810159
RGD:5685642
NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
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BDNF
brain derived neurotrophic factor
severity
ISO
protein:increased expression:blood, nasal cavity epithelium
RGD
PMID:18266897
RGD:5144117
NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
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CCL5
C-C motif chemokine ligand 5
ISO
protein:increased expression:inferior turbinate, epithelium (human)
RGD
PMID:20459697
RGD:4891379
NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
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CMA1
chymase 1
ISO
protein:increased expression:nasal mucosa, mast cell (human)
RGD
PMID:11549546
RGD:5128839
NCBI chr14:5,277,269...5,280,335
Ensembl chr14:23,400,345...23,403,548
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FGA
fibrinogen alpha chain
ISO
RGD
PMID:21887273
RGD:5688767
NCBI chr 4:146,949,680...146,957,291
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GSTO1
glutathione S-transferase omega 1
ISO
protein:decreased expression;T lymphocyte:
RGD
PMID:21410266
RGD:5491008
NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733
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ICAM1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx, secretion (human)
RGD
PMID:20128420
RGD:4145459
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
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IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053
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IL10
interleukin 10
treatment
ISO
RGD
PMID:19505388
RGD:7365025
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
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IL18
interleukin 18
susceptibility no_association
ISO
DNA:SNPs:promoters, exon:multiple DNA:SNPs:promoters:multiple
RGD
PMID:12532106
RGD:8655871
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
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IL4
interleukin 4
ISO
protein:increased expression:serum mRNA:increased expression:nose:
RGD
PMID:7551298 PMID:9237816
RGD:7829817 RGD:8662960
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
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KDR
kinase insert domain receptor
ISO
protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148
RGD:8551771
NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
G
LOC100972994
HLA class II histocompatibility antigen, DQ beta 1 chain
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*05 (human) DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human)
RGD
PMID:9641569 PMID:22032123
RGD:7421561 RGD:7421576
NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
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MC1R
melanocortin 1 receptor
no_association
ISO
RGD
PMID:20357480
RGD:5687317
NCBI chr16:70,676,447...70,697,636
G
MMP9
matrix metallopeptidase 9
ISO
DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human)
RGD
PMID:22237587
RGD:8547819
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
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NOD1
nucleotide binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human)
RGD
PMID:16918516
RGD:5131519
NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742
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NOD2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human)
RGD
PMID:16008671
RGD:5131477
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
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SCGB1A1
secretoglobin family 1A member 1
ISO
mRNA, protein:decreased expression:nasal lavage fluid
RGD
PMID:15836756
RGD:5144234
NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873
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TLR3
toll like receptor 3
ISO
protein:decreased expression:bone marrow, blood, eosinophil (human)
RGD
PMID:19752565
RGD:5129130
NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
G
TLR4
toll like receptor 4
susceptibility
ISO
DNA:polymorphisms:cds:p.D299G, T399I (human)
RGD
PMID:18517079
RGD:4144192
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
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VEGFA
vascular endothelial growth factor A
ISO
mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid:
RGD
PMID:12633568
RGD:7483595
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
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