RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: allergic rhinitis
Accession: DOID:4481
browse the term
Definition: A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites. (DO)
Synonyms: exact_synonym: ALRH; allergic rhinitides; atopic rhinitis; non-seasonal allergic rhinitis; perenial allergic rhinitis; pollenosis
narrow_synonym: hay fever
primary_id: MESH:D065631
alt_id: OMIM:607154
xref: EFO:0005854 ; NCI:C34987 ; NCI:C79532
For additional species annotation, visit the
Alliance of Genome Resources .
G
ABCB1
ATP binding cassette subfamily B member 1
severity
ISO
DNA:snp:exon:c.1236C>T (human)
RGD
PMID:24040855
RGD:8657076
NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238
G
ACE
angiotensin I converting enzyme
no_association
ISO
DNA:deletion:intron:IVS16+1464-1751del (human)
RGD
PMID:15112973
RGD:8142345
NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853
G
BCL2
BCL2 apoptosis regulator
ISO
mRNA, protein:increased expression:nasal mucosa (rat)
RGD
PMID:15362690
RGD:11522724
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
G
CAT
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29028686
NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
G
CCL26
C-C motif chemokine ligand 26
ISO
protein:increased expression:oronasal secretion (human)
RGD
PMID:23883806
RGD:7364793
NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874
G
CD40
CD40 molecule
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
G
CD40LG
CD40 ligand
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202
G
CLDN3
claudin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
Ensembl chr 7:80,924,731...80,925,393
G
CLDN7
claudin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr17:7,289,766...7,292,433
Ensembl chr17:7,277,313...7,281,859
G
CTLA4
cytotoxic T-lymphocyte associated protein 4
treatment
ISO
RGD
PMID:10436391
RGD:11344920
NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498
G
F2
coagulation factor II, thrombin
ISO
protein:increased expression:nasal mucus
RGD
PMID:21711961
RGD:5147783
NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
G
FCGR3A
Fc gamma receptor IIIa
susceptibility
ISO
DNA:polymorphism:exon:p.F158V(rs396991)(human)
RGD
PMID:18199088
RGD:5508449
NCBI chr 1:137,027,943...137,036,738
G
GRIA1
glutamate ionotropic receptor AMPA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr 5:148,879,996...149,206,914
Ensembl chr 5:154,879,080...155,204,660
G
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr 4:149,566,563...149,712,135
Ensembl chr 4:161,380,933...161,524,376
G
HRH1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23333628
NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757
G
IFNG
interferon gamma
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Asthma
RGD CTD
PMID:12787306 PMID:18510219 PMID:29871060
RGD:10755770 RGD:7829803
NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
G
IL10
interleukin 10
treatment
ISO
RGD
PMID:23253209 PMID:23883806
RGD:7364793 RGD:7364818
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
G
IL13
interleukin 13
susceptibility no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)
OMIM CTD RGD
PMID:12928861
RGD:8549516
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
G
IL13RA2
interleukin 13 receptor subunit alpha 2
ISO
protein:increased expression:serum
RGD
PMID:21462799
RGD:8549521
NCBI chr X:104,092,993...104,146,062
Ensembl chr X:114,597,077...114,635,253
G
IL17A
interleukin 17A
susceptibility
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human) DNA:snp:promoter:c.-444A>G (human)
RGD
PMID:21535180 PMID:22507625
RGD:5147409 RGD:9068429
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
G
IL18
interleukin 18
no_association severity
ISO
DNA:SNP:promoter:-140C>G (rs360721) (human) DNA:SNP:promoter:-137G>C (rs187238) (human)
RGD
PMID:22840759
RGD:8655914
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
G
IL1B
interleukin 1 beta
ISO
protein:increased expression:nasal mucus
RGD
PMID:7750009
RGD:7401199
NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424
G
IL2
interleukin 2
ISO
RGD
PMID:12592663
RGD:8662963
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
G
IL4
interleukin 4
treatment
ISO
RGD
PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662
RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
G
IL5
interleukin 5
treatment
ISO
RGD
PMID:23934070 PMID:24620662
RGD:11354976 RGD:11522769
NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
G
ITGB2
integrin subunit beta 2
treatment
ISO
RGD
PMID:12046991
RGD:9698435
NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963
G
MUC1
mucin 1, cell surface associated
severity
ISO
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:31425778
RGD:127345100
NCBI chr 1:130,533,508...130,537,866
Ensembl chr 1:134,141,969...134,145,850
G
MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:22972875
RGD:7364746
NCBI chr11:1,191,223...1,234,373
G
NOD2
nucleotide binding oligomerization domain containing 2
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:23858718
RGD:8547523
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
G
OCLN
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342
G
PON1
paraoxonase 1
severity
ISO
protein:decreased activity:plasma (human)
RGD
PMID:23406590
RGD:8547583
NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493
G
PRKG1
protein kinase cGMP-dependent 1
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:24012634
RGD:7775060
NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16979129
NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
G
SCGB1A1
secretoglobin family 1A member 1
ISO
mRNA:decreased expression:nasal mucosa, lung
RGD
PMID:17882576
RGD:5144135
NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873
G
SCGB3A2
secretoglobin family 3A member 2
susceptibility
ISO
DNA:SNP: :rs7726552 (human)
RGD
PMID:21410962
RGD:5144225
NCBI chr 5:143,319,941...143,323,625
Ensembl chr 5:149,329,201...149,333,003
G
SERPINE1
serpin family E member 1
ISO
mRNA:increased expression:nasal mucosa (mouse)
RGD
PMID:21339035
RGD:8547809
NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
G
TACR1
tachykinin receptor 1
ISO
mRNA:increased expression:nasal mucosa
RGD
PMID:12768696
RGD:5147835
NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
G
TGFB1
transforming growth factor beta 1
treatment
ISO
RGD
PMID:31368266
RGD:14995445
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
G
TLR2
toll like receptor 2
severity
ISO
mRNA:decreased expression:nasal mucosa: DNA:polymorphism:cds:p.R753Q(human) protein:increased expression:neutrophil:
RGD
PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057
RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993
NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331
G
TLR4
toll like receptor 4
susceptibility no_association treatment severity
ISO
protein:increased expression:nasal lavage,leukocyte, bone marrow: DNA:SNP: :rs1927911(human) protein:decreased expression:nasal mucosa: DNA:polymorphism: :4216G>C(human) DNA:polymorphism:cds:p.D299G(human)
RGD
PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 PMID:23639307 More...
RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
G
CYP2C19
cytochrome P450 family 2 subfamily C member 19
treatment
ISO
associated with Eosinophilic Esophagitis; DNA:polymorphisms::
RGD
PMID:26416193
RGD:11352743
NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065
G
IL3
interleukin 3
susceptibility
ISO
DNA:SNP: :rs40401(human)
RGD
PMID:23953855
RGD:13506915
NCBI chr 5:127,483,843...127,486,388
Ensembl chr 5:133,647,667...133,650,213
G
ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
protein:decreased expression:serum
RGD
PMID:19725899
RGD:5686851
NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
G
ALB
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19389874
NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418
G
ALOX5AP
arachidonate 5-lipoxygenase activating protein
ISO
protein:increased expression:nasal turbinate
RGD
PMID:19364335
RGD:5147461
NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607
G
CAT
catalase
ISO
protein:decreased expression:plasma
RGD
PMID:20493834
RGD:5130771
NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
G
CCL2
C-C motif chemokine ligand 2
ISO
protein:increased expression:nasal turbinate, mucosa (human)
RGD
PMID:9865755
RGD:8548839
NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384
G
CCR2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:Nasal Mucosa
RGD
PMID:17982926
RGD:4145109
NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312
G
CCR5
C-C motif chemokine receptor 5
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:17982926
RGD:4145109
NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379
G
CD40
CD40 molecule
ISO
RGD
PMID:20226305
RGD:5132269
NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994
G
CD86
CD86 molecule
ISO
protein:increased expression:nasal mucosa, dendritic cell (human)
RGD
PMID:17088138
RGD:4892343
NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339
G
CHIA
chitinase acidic
ISO
mRNA, protein:increased expression:turbinate, mucosa (human)
RGD
PMID:20422678
RGD:5037226
NCBI chr 1:113,935,888...113,965,541
Ensembl chr 1:126,381,724...126,391,909
G
EGR1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)
RGD
PMID:19833116
RGD:5131984
NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260
G
F2RL1
F2R like trypsin receptor 1
ISO
RGD
PMID:17727088
RGD:4892590
G
GSTP1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:polymorphism:exon:p.I105V (rs1695) (human)
RGD
PMID:17181111
RGD:4142523
NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472
G
HMOX1
heme oxygenase 1
ISO
mRNA, protein:increased expression: nasal mucosa
RGD
PMID:16540907
RGD:4145406
NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063
G
ICAM1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx (human) protein:increased expression:lung, endothelium (mouse)
RGD
PMID:19047814 PMID:19968652
RGD:4145464 RGD:4145520
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
G
IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053
G
IL13
interleukin 13
ISO
mRNA, protein:increased expression:nasal mucosa
RGD
PMID:8520776
RGD:4782826
NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
G
IL17A
interleukin 17A
severity
ISO
protein:increased expression:serum
RGD
PMID:19226302
RGD:4889151
NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074
G
IL18
interleukin 18
susceptibility
ISO
DNA:SNP:promoter:c. -607A>C (rs1946518) (human)
RGD
PMID:16406079
RGD:4889924
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
G
IL1A
interleukin 1 alpha
ISO
DNA:polymorphism:exon:c.4845G>T (human)
RGD
PMID:14533660
RGD:4142859
NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801
G
IL1R1
interleukin 1 receptor type 1
ISO
RGD
PMID:18637763
RGD:5037238
Ensembl chr2A:103,193,131...103,230,005
G
IL2
interleukin 2
ISO
protein:decreased expression:serum:
RGD
PMID:17608155
RGD:8662959
NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984
G
IL4
interleukin 4
treatment
ISO
protein:increased expression:serum
RGD
PMID:9237816 PMID:15329007 PMID:21171297
RGD:5128559 RGD:7829804 RGD:7829817
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
G
IL5
interleukin 5
ISO
protein: increased levels: sputum
RGD
PMID:22186238
RGD:5687140
NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675
G
MMP2
matrix metallopeptidase 2
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279
G
MMP9
matrix metallopeptidase 9
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
G
NOS2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:14587983
RGD:4892078
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
G
NOS3
nitric oxide synthase 3
ISO
DNA:snp:promoter:g.-786T>C (human)
RGD
PMID:18086269
RGD:4892054
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
G
NR3C1
nuclear receptor subfamily 3 group C member 1
ISO
protein:altered expression:nasal mucosa
RGD
PMID:20185258
RGD:4892593
NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269
G
PPARG
peroxisome proliferator activated receptor gamma
ISO
mRNA, protein:increased expression:nasal mucosa (human)
RGD
PMID:17116814
RGD:8552811
NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
G
TBXA2R
thromboxane A2 receptor
treatment
ISO
RGD
PMID:15247523
RGD:11059532
NCBI chr19:2,621,606...2,632,800
Ensembl chr19:3,570,290...3,581,924
G
ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:16677242
RGD:5147463
NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016
G
APOA4
apolipoprotein A4
resistance
ISO
protein:increased expression:blood serum (human)
RGD
PMID:20810159
RGD:5685642
NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
G
BDNF
brain derived neurotrophic factor
severity
ISO
protein:increased expression:blood, nasal cavity epithelium
RGD
PMID:18266897
RGD:5144117
NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239
G
CCL5
C-C motif chemokine ligand 5
ISO
protein:increased expression:inferior turbinate, epithelium (human)
RGD
PMID:20459697
RGD:4891379
NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
G
CMA1
chymase 1
ISO
protein:increased expression:nasal mucosa, mast cell (human)
RGD
PMID:11549546
RGD:5128839
NCBI chr14:5,277,269...5,280,335
Ensembl chr14:23,400,345...23,403,548
G
FGA
fibrinogen alpha chain
ISO
RGD
PMID:21887273
RGD:5688767
NCBI chr 4:146,949,680...146,957,291
G
GSTO1
glutathione S-transferase omega 1
ISO
protein:decreased expression;T lymphocyte:
RGD
PMID:21410266
RGD:5491008
NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733
G
ICAM1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx, secretion (human)
RGD
PMID:20128420
RGD:4145459
NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
G
IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053
G
IL10
interleukin 10
treatment
ISO
RGD
PMID:19505388
RGD:7365025
NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
G
IL18
interleukin 18
susceptibility no_association
ISO
DNA:SNPs:promoters, exon:multiple DNA:SNPs:promoters:multiple
RGD
PMID:12532106
RGD:8655871
NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
G
IL4
interleukin 4
ISO
protein:increased expression:serum mRNA:increased expression:nose:
RGD
PMID:7551298 PMID:9237816
RGD:7829817 RGD:8662960
NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581
G
KDR
kinase insert domain receptor
ISO
protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148
RGD:8551771
NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
G
LOC100972994
HLA class II histocompatibility antigen, DQ beta 1 chain
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*05 (human) DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human)
RGD
PMID:9641569 PMID:22032123
RGD:7421561 RGD:7421576
NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
G
MC1R
melanocortin 1 receptor
no_association
ISO
RGD
PMID:20357480
RGD:5687317
NCBI chr16:70,676,447...70,697,636
G
MMP9
matrix metallopeptidase 9
ISO
DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human)
RGD
PMID:22237587
RGD:8547819
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
G
NOD1
nucleotide binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human)
RGD
PMID:16918516
RGD:5131519
NCBI chr 7:31,060,245...31,109,012
Ensembl chr 7:31,182,275...31,208,742
G
NOD2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human)
RGD
PMID:16008671
RGD:5131477
NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283
G
SCGB1A1
secretoglobin family 1A member 1
ISO
mRNA, protein:decreased expression:nasal lavage fluid
RGD
PMID:15836756
RGD:5144234
NCBI chr11:57,774,560...57,780,334
Ensembl chr11:61,133,649...61,137,873
G
TLR3
toll like receptor 3
ISO
protein:decreased expression:bone marrow, blood, eosinophil (human)
RGD
PMID:19752565
RGD:5129130
NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728
G
TLR4
toll like receptor 4
susceptibility
ISO
DNA:polymorphisms:cds:p.D299G, T399I (human)
RGD
PMID:18517079
RGD:4144192
NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
G
VEGFA
vascular endothelial growth factor A
ISO
mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid:
RGD
PMID:12633568
RGD:7483595
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all