RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)
associated with Retinal vein occlusion;protein:increased expression:vitreous: associated with central retinal vein occlusion;protein:increased expression:aqueous humor of eyeball (human)
associated with Branch Retinal Vein Occlusion;protein:decreased expression:vitreous humor (human) associated with Diabetes Mellitus, Experimental; human protein in a rat model
associated with retinal vein occlusion;protein:increased expression:vitreous humor associated with central retinal vein occlusion;protein:increased expression:aqueous humor of eyeball (human) CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus;protein:increased expression:aqueous humor
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