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Accession:DOID:4441 term browser browse the term
Definition:A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
Synonyms:exact_synonym: Disgerminoma;   disgerminomas;   dysgerminomas
 primary_id: MESH:D004407
 alt_id: RDO:0005405
 xref: NCI:C2996
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dysgerminoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amhr2 anti-Mullerian hormone receptor type 2 JBrowse link 7 144,052,202 144,060,678 RGD:2315651
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:8554872
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:2289660
G Inha inhibin subunit alpha JBrowse link 9 82,700,482 82,703,383 RGD:2290380
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:2292181
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:2292443
G Set SET nuclear proto-oncogene JBrowse link 19 58,420,635 58,422,153 RGD:8554872
G St14 suppression of tumorigenicity 14 JBrowse link 8 32,240,113 32,280,813 RGD:2315091

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15609
    disease of cellular proliferation 5822
      Neoplasms by Histologic Type 3638
        cell type cancer 3054
          germ cell cancer 94
            dysgerminoma 8
              dysgerminoma of ovary + 0
Path 2
Term Annotations click to browse term
  disease 15609
    disease of anatomical entity 14966
      Urogenital Diseases 4002
        Female Urogenital Diseases and Pregnancy Complications 1778
          Female Urogenital Diseases 1485
            female reproductive system disease 1481
              Adnexal Diseases 657
                ovarian disease 651
                  Ovarian Neoplasms 384
                    ovarian cancer 228
                      dysgerminoma 8
                        dysgerminoma of ovary + 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.