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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Lynch syndrome
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Accession:DOID:3883 term browser browse the term
Definition:A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers. (DO)
Synonyms:exact_synonym: APC-mutation negative familial colorectal cancer;   Colorectal Cancer, Non-Polyposis;   Familial Nonpolyposis Colon Cancer;   HNPCC - hereditary nonpolyposis colon cancer;   hereditary defective mismatch repair syndrome;   hereditary nonpolyposis colon cancer;   hereditary nonpolyposis colorectal cancer;   hereditary nonpolyposis colorectal carcinoma;   hereditary nonpolyposis colorectal neoplasm;   hereditary nonpolyposis colorectal neoplasms
 primary_id: MESH:D003123
 xref: GARD:9905;   NCI:C120083;   NCI:C8494;   OMIM:PS120435;   ORDO:144
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Lynch syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar PMID:16472587 PMID:17453009 PMID:18602922 PMID:18809606 PMID:20186688 More... NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769
JBrowse link
G Apc APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:7661930 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:28255344 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 ISO ClinVar Annotator: match by term: APC-mutation negative familial colorectal cancer ClinVar PMID:28306719 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Eif2b2 eukaryotic translation initiation factor 2B subunit beta ISO ClinVar Annotator: match by term: Lynch syndrome ClinVar PMID:25741868 NCBI chr 6:104,866,926...104,873,351
Ensembl chr 6:104,866,753...104,873,353
JBrowse link
G Epcam epithelial cell adhesion molecule ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar Annotator: match by term: Lynch syndrome
ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancer
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:9536098 PMID:11830542 PMID:11857745 PMID:12373605 PMID:12938096 More... NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Epm2aip1 EPM2A interacting protein 1 ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar Annotator: match by term: Lynch syndrome
ClinVar PMID:12373605 PMID:12658575 PMID:14635101 PMID:14729822 PMID:15942939 More... NCBI chr 8:111,233,871...111,241,219
Ensembl chr 8:111,233,826...111,241,871
JBrowse link
G Fbxo11 F-box protein 11 ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar PMID:18269114 PMID:24323032 PMID:24362816 PMID:28135145 PMID:28492532 NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662
JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO DNA:deletion, haplotype: : (human) RGD PMID:9834266 RGD:12792228 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO DNA:deletion, haplotype:: (human) RGD PMID:9834266 RGD:12792228 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Kcnk12 potassium two pore domain channel subfamily K member 12 ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms ClinVar PMID:18269114 PMID:24323032 PMID:24362816 PMID:28135145 PMID:28492532 NCBI chr 6:6,740,147...6,790,664
Ensembl chr 6:6,739,991...6,790,661
JBrowse link
G Lrrfip2 LRR binding FLII interacting protein 2 ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer ClinVar NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255
JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar Annotator: match by term: Lynch syndrome
ClinVar Annotator: match by term: Familial nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancer
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lynch syndrome I
ClinVar Annotator: match by synonym: Lynch Syndrome
ClinVar
CTD
PMID:1061282 PMID:1749856 PMID:1756143 PMID:2022152 PMID:2362047 More... NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mlh3 mutL homolog 3 ISO DNA:point mutations:exon:Q24E, N499S, E624Q, E1451K
ClinVar Annotator: match by term: Lynch syndrome
ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancer
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Colorectal cancer, non-polyposis
ClinVar
CTD
PMID:11586295 PMID:12702580 PMID:18521850 PMID:19156873 PMID:25637381 More... RGD:1600415 NCBI chr 6:104,881,483...104,917,686
Ensembl chr 6:104,881,483...104,917,728
JBrowse link
G Msh2 mutS homolog 2 onset ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar Annotator: match by term: Lynch syndrome
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Familial nonpolyposis colon cancer
DNA:missense mutation:exon:p.M688R (c.2063T>G) (human)
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:1061282 PMID:1586275 PMID:1710317 PMID:2695166 PMID:3616036 More... RGD:11063948, RGD:126790559 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 ISO ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Lynch syndrome I
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal carcinoma
ClinVar Annotator: match by term: Familial nonpolyposis colon cancer
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer
ClinVar
CTD
PMID:1548301 PMID:1753181 PMID:2059188 PMID:2563738 PMID:2633163 More... NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 ISO ClinVar Annotator: match by term: APC-mutation negative familial colorectal cancer ClinVar PMID:33094510 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nudc nuclear distribution C, dynein complex regulator ISO ClinVar Annotator: match by term: APC-mutation negative familial colorectal cancer ClinVar PMID:33094510 NCBI chr 5:145,758,006...145,771,390
Ensembl chr 5:145,758,002...145,771,425
JBrowse link
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 ISO ClinVar Annotator: match by term: Lynch syndrome ClinVar NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal carcinoma
ClinVar Annotator: match by term: Lynch syndrome
ClinVar PMID:25741868 PMID:8072530 RGD:1599137 NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms
ClinVar Annotator: match by term: Lynch syndrome
ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancer
ClinVar Annotator: match by term: Familial nonpolyposis colon cancer
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lynch syndrome I
ClinVar Annotator: match by synonym: Hereditary nonpolyposis colon cancer
ClinVar
CTD
PMID:2402700 PMID:2440087 PMID:7628019 PMID:7629132 PMID:7632227 More... RGD:1599142, RGD:1599137 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Rnasel ribonuclease L onset ISO RGD PMID:16054567 RGD:2292000 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
JBrowse link
G Smad2 SMAD family member 2 ISO RGD PMID:10819637 RGD:1599900 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:10819637 RGD:1599900 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:10819637 RGD:1599900 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Stpg4 sperm-tail PG-rich repeat containing 4 ISO ClinVar Annotator: match by term: Lynch syndrome ClinVar PMID:30374176 NCBI chr 6:7,108,827...7,158,519
Ensembl chr 6:7,108,869...7,151,390
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:17613544 RGD:2306282 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lynch syndrome
CTD
ClinVar
PMID:9590282 PMID:25741868 PMID:28492532 PMID:28659821 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Trank1 tetratricopeptide repeat and ankyrin repeat containing 1 ISO ClinVar Annotator: match by term: Lynch syndrome ClinVar NCBI chr 8:111,275,973...111,355,491
Ensembl chr 8:111,276,354...111,355,092
JBrowse link
hereditary nonpolyposis colorectal cancer type 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Lynch syndrome II
ClinVar Annotator: match by term: COLON CANCER, FAMILIAL NONPOLYPOSIS, TYPE 2
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by OMIM:609310
OMIM
ClinVar
CTD
PMID:1756143 PMID:2022152 PMID:5713769 PMID:7557107 PMID:7584997 More... NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
hereditary nonpolyposis colorectal cancer type 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pms2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 4
ClinVar Annotator: match by OMIM:614337
OMIM
ClinVar
PMID:2402700 PMID:2440087 PMID:7628019 PMID:7629132 PMID:7632227 More... NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 4 ClinVar PMID:7795591 PMID:12541220 PMID:14722923 PMID:15884040 PMID:16343894 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
hereditary nonpolyposis colorectal cancer type 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo11 F-box protein 11 ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 5 ClinVar PMID:19250818 PMID:24689082 PMID:26467025 NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662
JBrowse link
G Msh6 mutS homolog 6 ISO
IMP
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 5
ClinVar Annotator: match by OMIM:614350
OMIM
ClinVar
PMID:1548301 PMID:2059188 PMID:2563738 PMID:2633163 PMID:7604266 More... RGD:2292505 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Msh6m1Hubr mutS homolog 6; ENU induced mutant 1, Hubr IMP RGD PMID:18417481 RGD:2292505
hereditary nonpolyposis colorectal cancer type 6 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 6
ClinVar Annotator: match by term: Colon cancer, hereditary nonpolyposis, type 6
OMIM
ClinVar
PMID:9590282 PMID:9927040 PMID:11212236 PMID:15235604 PMID:15731757 More... NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
hereditary nonpolyposis colorectal cancer type 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 ISO ClinVar Annotator: match by term: MLH3-Related Lynch Syndrome
ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 7
ClinVar PMID:12702580 PMID:17656264 PMID:22290698 PMID:28492532 NCBI chr 6:104,560,556...104,617,712
Ensembl chr 6:104,564,986...104,617,628
JBrowse link
G Eif2b2 eukaryotic translation initiation factor 2B subunit beta ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 7 ClinVar NCBI chr 6:104,866,926...104,873,351
Ensembl chr 6:104,866,753...104,873,353
JBrowse link
G Mlh3 mutL homolog 3 ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 7
ClinVar Annotator: match by term: MLH3-Related Lynch Syndrome
ClinVar Annotator: match by OMIM:614385
OMIM
ClinVar
PMID:9536098 PMID:11586295 PMID:12702580 PMID:12800209 PMID:16885347 More... NCBI chr 6:104,881,483...104,917,686
Ensembl chr 6:104,881,483...104,917,728
JBrowse link
hereditary nonpolyposis colorectal cancer type 8 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epcam epithelial cell adhesion molecule ISO ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal cancer type 8
ClinVar Annotator: match by OMIM:613244
OMIM
ClinVar
PMID:16951683 PMID:19098912 PMID:25741868 PMID:28492532 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
Lynch syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epcam epithelial cell adhesion molecule ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lynch syndrome I
CTD
ClinVar
PMID:19098912 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Kcnk12 potassium two pore domain channel subfamily K member 12 ISO ClinVar Annotator: match by term: Lynch syndrome I ClinVar NCBI chr 6:6,740,147...6,790,664
Ensembl chr 6:6,739,991...6,790,661
JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Lynch syndrome I
ClinVar Annotator: match by term: Lynch syndrome II
ClinVar Annotator: match by term: Colorectal cancer, hereditary, nonpolyposis, type 1
ClinVar Annotator: match by term: Lynch syndrome 1
ClinVar PMID:661956 PMID:1756143 PMID:2022152 PMID:5713769 PMID:7557107 More... NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Msh2 mutS homolog 2 ISO ClinVar Annotator: match by term: Colorectal cancer, hereditary, nonpolyposis, type 1
ClinVar Annotator: match by term: Lynch syndrome I
ClinVar Annotator: match by term: Lynch syndrome 1
ClinVar Annotator: match by term: Lynch syndrome II
ClinVar Annotator: match by term: COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:2695166 PMID:3616036 PMID:6096739 PMID:7585065 PMID:7616541 More... NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 ISO ClinVar Annotator: match by term: Lynch syndrome I
ClinVar Annotator: match by term: Lynch syndrome 1
ClinVar Annotator: match by term: Lynch syndrome II
ClinVar PMID:1548301 PMID:8838326 PMID:9354786 PMID:9510473 PMID:10348829 More... NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lynch syndrome I
CTD
ClinVar
PMID:25741868 NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Lynch syndrome I ClinVar PMID:7632227 PMID:7661930 PMID:7704024 PMID:8072530 PMID:9419979 More... NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Rad51d RAD51 paralog D ISO ClinVar Annotator: match by term: Lynch syndrome I ClinVar PMID:21822267 PMID:25741868 PMID:26261251 PMID:26467025 PMID:28166811 More... NCBI chr10:67,805,720...67,824,452 JBrowse link
Muir-Torre syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fhit fragile histidine triad diadenosine triphosphatase ISS OMIM:158320 MouseDO NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Cutaneous sebaceous neoplasms and keratoacanthomas multiple with gastrointestinal and other carcinomas
ClinVar Annotator: match by term: Muir-Torré syndrome
OMIM
ClinVar
PMID:4063166 PMID:7705822 PMID:8198129 PMID:8751876 PMID:9311737 More... NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Msh2 mutS homolog 2 ISO ClinVar Annotator: match by term: Cutaneous sebaceous neoplasms and keratoacanthomas multiple with gastrointestinal and other carcinomas
ClinVar Annotator: match by term: Muir-Torré syndrome
OMIM
ClinVar
PMID:7585065 PMID:7713503 PMID:8566964 PMID:8592341 PMID:9002677 More... NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17205
    disease of cellular proliferation 7034
      Hereditary Neoplastic Syndromes 912
        Lynch syndrome 35
          Hereditary Nonpolyposis Colorectal Cancer Type 3 0
          Lynch syndrome 1 8
          hereditary nonpolyposis colorectal cancer type 2 + 3
          hereditary nonpolyposis colorectal cancer type 4 2
          hereditary nonpolyposis colorectal cancer type 5 4
          hereditary nonpolyposis colorectal cancer type 6 1
          hereditary nonpolyposis colorectal cancer type 7 3
          hereditary nonpolyposis colorectal cancer type 8 1
Path 2
Term Annotations click to browse term
  disease 17205
    disease of anatomical entity 16551
      gastrointestinal system disease 6061
        Gastrointestinal Diseases 4144
          Gastrointestinal Neoplasms 3307
            Intestinal Neoplasms 1528
              Colorectal Neoplasms 1506
                Lynch syndrome 35
                  Hereditary Nonpolyposis Colorectal Cancer Type 3 0
                  Lynch syndrome 1 8
                  hereditary nonpolyposis colorectal cancer type 2 + 3
                  hereditary nonpolyposis colorectal cancer type 4 2
                  hereditary nonpolyposis colorectal cancer type 5 4
                  hereditary nonpolyposis colorectal cancer type 6 1
                  hereditary nonpolyposis colorectal cancer type 7 3
                  hereditary nonpolyposis colorectal cancer type 8 1
paths to the root