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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:olfactory neuroblastoma
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Accession:DOID:369 term browser browse the term
Definition:A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Synonyms:exact_synonym: Aesthesioneuroblastoma;   Esthesioneuroblastoma;   Esthesioneuroblastomas;   Olfactory Esthesioneuroblastomas;   Olfactory Neuroblastomas;   aesthesioneuroblastomas;   asthesioneuroblastoma;   esthesioneuroepithelioma;   olfactory esthesioneuroblastoma;   paranasal sinus nasal cavity esthesioneuroblastoma;   paranasal sinus olfactory neuroblastoma
 primary_id: MESH:D018304
 xref: EFO:1000407;   GARD:2197;   NCI:C3789;   NCI:C6016
For additional species annotation, visit the Alliance of Genome Resources.


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olfactory neuroblastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha severity ISO protein:increased expression:neuroblastoma (human) RGD PMID:18431543 RGD:8694471 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18212
      nervous system disease 14060
        peripheral nervous system disease 4107
          neuropathy 3892
            cranial nerve disease 684
              olfactory nerve disease 1
                olfactory neuroblastoma 1
                  nasal cavity olfactory neuroblastoma 0
Path 2
Term Annotations click to browse term
  disease 21128
    disease of cellular proliferation 7667
      cancer 5483
        organ system cancer 5237
          nervous system cancer 959
            central nervous system cancer 766
              brain cancer 750
                supratentorial cancer 475
                  cerebrum cancer 422
                    malignant astrocytoma 418
                      astroblastoma 256
                        Primitive Neuroectodermal Tumors 165
                          Primitive Peripheral Neuroectodermal Tumors 95
                            Neuroblastic Tumor 94
                              neuroblastoma 94
                                olfactory neuroblastoma 1
                                  nasal cavity olfactory neuroblastoma 0
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