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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:olfactory neuroblastoma
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Accession:DOID:369 term browser browse the term
Definition:A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Synonyms:exact_synonym: Aesthesioneuroblastoma;   Esthesioneuroblastoma;   Esthesioneuroblastomas;   Olfactory Esthesioneuroblastomas;   Olfactory Neuroblastomas;   aesthesioneuroblastomas;   asthesioneuroblastoma;   esthesioneuroepithelioma;   olfactory esthesioneuroblastoma;   paranasal sinus nasal cavity esthesioneuroblastoma;   paranasal sinus olfactory neuroblastoma
 primary_id: MESH:D018304
 xref: EFO:1000407;   GARD:2197;   NCI:C3789;   NCI:C6016
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olfactory neuroblastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha severity ISO protein:increased expression:neuroblastoma (human) RGD PMID:18431543 RGD:8694471 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      nervous system disease 12088
        peripheral nervous system disease 3827
          neuropathy 3646
            cranial nerve disease 637
              olfactory nerve disease 1
                olfactory neuroblastoma 1
                  nasal cavity olfactory neuroblastoma 0
Path 2
Term Annotations click to browse term
  disease 16063
    disease of cellular proliferation 6683
      cancer 4843
        organ system cancer 4626
          nervous system cancer 849
            central nervous system cancer 696
              brain cancer 682
                supratentorial cancer 425
                  cerebrum cancer 396
                    malignant astrocytoma 392
                      astroblastoma 243
                        Primitive Neuroectodermal Tumors 158
                          Primitive Peripheral Neuroectodermal Tumors 90
                            Neuroblastic Tumor 89
                              neuroblastoma 89
                                olfactory neuroblastoma 1
                                  nasal cavity olfactory neuroblastoma 0
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