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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:intermittent claudication
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Accession:DOID:3669 term browser browse the term
Definition:A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Synonyms:exact_synonym: Charcot's syndrome;   Claudication, Intermittent;   intermittent vascular claudication
 primary_id: MESH:D007383
 alt_id: RDO:0005897
 xref: EFO:0003876;   ICD10CM:I73.9
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
intermittent claudication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death IEP RGD PMID:23658678 RGD:9586024 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 IEP RGD PMID:23658678 RGD:9586024 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:23658678 RGD:9586024 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 IEP RGD PMID:23658678 RGD:9586024 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Casp3 caspase 3 IDA RGD PMID:23658678 RGD:9586024 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E treatment IMP RGD PMID:21771896 RGD:10395378 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
JBrowse link
G Epas1 endothelial PAS domain protein 1 treatment IDA RGD PMID:21771896 RGD:10395378 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Mdm2 MDM2 proto-oncogene treatment IEP RGD PMID:23658678 RGD:9586024 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Sirt2 sirtuin 2 IEP associated with Spinal Stenosis;protein:decreased expression:dorsal horn of spinal cord, ventral horn of spinal cord RGD PMID:23658678 RGD:9586024 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18154
    Pathological Conditions, Signs and Symptoms 11299
      Signs and Symptoms 7246
        intermittent claudication 9
Path 2
Term Annotations click to browse term
  disease 18154
    disease of anatomical entity 17529
      cardiovascular system disease 4847
        vascular disease 3620
          artery disease 2527
            arteriosclerosis 679
              intermittent claudication 9
paths to the root