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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:intermittent claudication
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Accession:DOID:3669 term browser browse the term
Definition:A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Synonyms:exact_synonym: Charcot's syndrome;   intermittent vascular claudication
 primary_id: MESH:D007383
 xref: EFO:0003876;   ICD10CM:I73.9
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
intermittent claudication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death ISO RGD PMID:23658678 RGD:9586024 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO RGD PMID:23658678 RGD:9586024 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein ISO RGD PMID:23658678 RGD:9586024 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 ISO RGD PMID:23658678 RGD:9586024 NCBI chr 7:16,042,307...16,052,259
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Casp3 caspase 3 ISO RGD PMID:23658678 RGD:9586024 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Eif3e eukaryotic translation initiation factor 3, subunit E treatment ISO RGD PMID:21771896 RGD:10395378 NCBI chr15:43,113,436...43,146,132
Ensembl chr15:43,113,454...43,146,115
JBrowse link
G Epas1 endothelial PAS domain protein 1 treatment ISO RGD PMID:21771896 RGD:10395378 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 treatment ISO RGD PMID:23658678 RGD:9586024 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Sirt2 sirtuin 2 ISO associated with Spinal Stenosis;protein:decreased expression:dorsal horn of spinal cord, ventral horn of spinal cord RGD PMID:23658678 RGD:9586024 NCBI chr 7:28,466,177...28,488,090
Ensembl chr 7:28,466,160...28,488,086
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15352
    Pathological Conditions, Signs and Symptoms 10541
      Signs and Symptoms 6805
        intermittent claudication 9
Path 2
Term Annotations click to browse term
  disease 15352
    disease of anatomical entity 14993
      cardiovascular system disease 4038
        vascular disease 2900
          artery disease 1843
            arteriosclerosis 643
              intermittent claudication 9
paths to the root