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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:intermittent claudication
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Accession:DOID:3669 term browser browse the term
Definition:A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Synonyms:exact_synonym: Charcot's syndrome;   intermittent vascular claudication
 primary_id: MESH:D007383
 xref: EFO:0003876;   ICD10CM:I73.9
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
intermittent claudication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death ISO RGD PMID:23658678 RGD:9586024 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAK1 BCL2 antagonist/killer 1 ISO RGD PMID:23658678 RGD:9586024 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:23658678 RGD:9586024 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 ISO RGD PMID:23658678 RGD:9586024 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G CASP3 caspase 3 ISO RGD PMID:23658678 RGD:9586024 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G EIF3E eukaryotic translation initiation factor 3 subunit E treatment ISO RGD PMID:21771896 RGD:10395378 NCBI chr 8:108,201,216...108,248,717
Ensembl chr 8:108,162,787...108,443,496
JBrowse link
G EPAS1 endothelial PAS domain protein 1 treatment ISO RGD PMID:21771896 RGD:10395378 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G MDM2 MDM2 proto-oncogene treatment ISO RGD PMID:23658678 RGD:9586024 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G SIRT2 sirtuin 2 ISO associated with Spinal Stenosis;protein:decreased expression:dorsal horn of spinal cord, ventral horn of spinal cord RGD PMID:23658678 RGD:9586024 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 22315
    Pathological Conditions, Signs and Symptoms 13370
      Signs and Symptoms 8663
        intermittent claudication 9
Path 2
Term Annotations click to browse term
  disease 22315
    disease of anatomical entity 20855
      cardiovascular system disease 4579
        vascular disease 3192
          artery disease 2058
            arteriosclerosis 681
              intermittent claudication 9
paths to the root