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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:intermittent claudication
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Accession:DOID:3669 term browser browse the term
Definition:A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Synonyms:exact_synonym: Charcot's syndrome;   intermittent vascular claudication
 primary_id: MESH:D007383
 xref: EFO:0003876;   ICD10CM:I73.9
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intermittent claudication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2 associated agonist of cell death ISO RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245
JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997
JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
JBrowse link
G Bbc3 BCL2 binding component 3 ISO RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955574:1,167,790...1,174,966
Ensembl chrNW_004955574:1,167,242...1,174,966
JBrowse link
G Casp3 caspase 3 ISO RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Epas1 endothelial PAS domain protein 1 treatment ISO RGD PMID:21771896 RGD:10395378 NCBI chrNW_004955441:13,244,626...13,328,220
Ensembl chrNW_004955441:13,244,626...13,328,369
JBrowse link
G Mdm2 MDM2 proto-oncogene treatment ISO RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955458:15,264,028...15,287,290
Ensembl chrNW_004955458:15,263,739...15,286,808
JBrowse link
G Sirt2 sirtuin 2 ISO associated with Spinal Stenosis;protein:decreased expression:dorsal horn of spinal cord, ventral horn of spinal cord RGD PMID:23658678 RGD:9586024 NCBI chrNW_004955468:626,365...644,441
Ensembl chrNW_004955468:626,365...644,441
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13526
    Pathological Conditions, Signs and Symptoms 9390
      Signs and Symptoms 6119
        intermittent claudication 8
Path 2
Term Annotations click to browse term
  disease 13526
    disease of anatomical entity 13249
      cardiovascular system disease 3624
        vascular disease 2556
          artery disease 1669
            arteriosclerosis 580
              intermittent claudication 8
paths to the root