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ONTOLOGY REPORT - ANNOTATIONS
Term:lactic acidosis
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Accession:DOID:3650 term browser browse the term
Definition:Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
Synonyms:narrow_synonym: SEIZURES AND LACTIC ACIDOSIS
 primary_id: MESH:D000140
 alt_id: RDO:0001764
 xref: ICD10CM:E87.2;   NCI:C98969
For additional species annotation, visit the Alliance of Genome Resources.

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lactic acidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:11554173
G Mt-atp6 mitochondrially encoded ATP synthase 6 JBrowse link MT 7,919 8,599 RGD:8554872
G Mt-co3 mitochondrially encoded cytochrome c oxidase III JBrowse link MT 8,599 9,382 RGD:8554872
G Mt-nd6 mitochondrially encoded NADH dehydrogenase 6 JBrowse link MT 13,543 14,061 RGD:13592920
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:11554173
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11554173
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 7 76,750,045 76,780,817 RGD:11554173
combined oxidative phosphorylation deficiency 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mrps16 mitochondrial ribosomal protein S16 JBrowse link 15 4,351,292 4,353,694 RGD:7240710
RGD:8554872
combined oxidative phosphorylation deficiency 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tsfm Ts translation elongation factor, mitochondrial JBrowse link 7 70,311,948 70,319,389 RGD:7240710
RGD:8554872
Congenital Infantile Lactic Acidosis due to LAD Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:7240710
RGD:8554872
GRACILE syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone JBrowse link 9 81,868,158 81,872,201 RGD:7240710
RGD:8554872
HYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lars2 leucyl-tRNA synthetase 2, mitochondrial JBrowse link 8 132,441,277 132,537,176 RGD:8554872
RGD:7240710
Hyperglycinemia, Lactic Acidosis, and Seizures term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lias lipoic acid synthetase JBrowse link 14 44,507,217 44,524,287 RGD:7240710
RGD:8554872
G Rpl9 ribosomal protein L9 JBrowse link 14 44,524,419 44,527,613 RGD:8554872
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:8554872
mitochondrial DNA depletion syndrome 9 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha JBrowse link 4 101,181,315 101,210,692 RGD:7240710
RGD:8554872
Mitochondrial Myopathy with Lactic Acidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pnpla8 patatin-like phospholipase domain containing 8 JBrowse link 6 64,224,870 64,288,465 RGD:8554872
RGD:7240710
mitochondrial pyruvate carrier deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpc1 mitochondrial pyruvate carrier 1 JBrowse link 1 53,026,608 53,038,229 RGD:7240710
RGD:8554872
Myopathy with Lactic Acidosis, Hereditary term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Iscu iron-sulfur cluster assembly enzyme JBrowse link 12 48,621,454 48,627,297 RGD:7240710
RGD:8554872
Pyruvate Dehydrogenase E1 Alpha Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:8554872
G Pdhx pyruvate dehydrogenase complex, component X JBrowse link 3 92,910,300 92,933,725 RGD:8554872
Pyruvate Dehydrogenase E2 Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:7240710
RGD:8554872
G Pih1d2 PIH1 domain containing 2 JBrowse link 8 55,050,284 55,060,289 RGD:8554872
Pyruvate Dehydrogenase E3-Binding Protein Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdhx pyruvate dehydrogenase complex, component X JBrowse link 3 92,910,300 92,933,725 RGD:8554872
RGD:7240710
Pyruvate Dehydrogenase Phosphatase Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 JBrowse link 5 25,577,593 25,584,325 RGD:7240710
RGD:8554872
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15553
    Nutritional and Metabolic Diseases 4392
      disease of metabolism 4392
        acquired metabolic disease 2710
          metabolic acidosis 31
            lactic acidosis 23
              Congenital Infantile Lactic Acidosis + 2
              GRACILE syndrome 1
              HYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA 1
              Hyperglycinemia, Lactic Acidosis, and Seizures 3
              Lactic Acidosis, Chronic Adult Form 0
              Maple Syrup Urine Disease, E3 Deficient, with Lactic Acidosis 0
              Mitochondrial Myopathy with Lactic Acidosis 1
              Myopathy with Lactic Acidosis, Hereditary 1
              Pyruvate Dehydrogenase E1 Alpha Deficiency 2
              Pyruvate Dehydrogenase E2 Deficiency 2
              Pyruvate Dehydrogenase E3-Binding Protein Deficiency 1
              Pyruvate Dehydrogenase Phosphatase Deficiency 1
              Tricarboxylic Acid Cycle, Defect of 0
              combined oxidative phosphorylation deficiency 2 1
              combined oxidative phosphorylation deficiency 3 1
              mitochondrial DNA depletion syndrome 9 1
              mitochondrial pyruvate carrier deficiency 1
Path 2
Term Annotations click to browse term
  disease 15553
    Nutritional and Metabolic Diseases 4392
      disease of metabolism 4392
        Acid-Base Imbalance 72
          Acidoses 60
            metabolic acidosis 31
              lactic acidosis 23
                Congenital Infantile Lactic Acidosis + 2
                GRACILE syndrome 1
                HYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA 1
                Hyperglycinemia, Lactic Acidosis, and Seizures 3
                Lactic Acidosis, Chronic Adult Form 0
                Maple Syrup Urine Disease, E3 Deficient, with Lactic Acidosis 0
                Mitochondrial Myopathy with Lactic Acidosis 1
                Myopathy with Lactic Acidosis, Hereditary 1
                Pyruvate Dehydrogenase E1 Alpha Deficiency 2
                Pyruvate Dehydrogenase E2 Deficiency 2
                Pyruvate Dehydrogenase E3-Binding Protein Deficiency 1
                Pyruvate Dehydrogenase Phosphatase Deficiency 1
                Tricarboxylic Acid Cycle, Defect of 0
                combined oxidative phosphorylation deficiency 2 1
                combined oxidative phosphorylation deficiency 3 1
                mitochondrial DNA depletion syndrome 9 1
                mitochondrial pyruvate carrier deficiency 1
paths to the root

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