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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pancreatic ductal carcinoma
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Accession:DOID:3587 term browser browse the term
Definition:A pancreatic carcinoma located_in the pancreatic duct. (DO)
Synonyms:exact_synonym: Duct Cell Carcinoma of the Pancreas;   Pancreas Duct-Cell Carcinoma;   Pancreas Duct-Cell Carcinomas;   Pancreatic Ductal Carcinomas;   ductal carcinoma of the pancreas;   malignant neoplasm of duct of Wirsung;   pancreatic duct cancer;   pancreatic duct cell carcinoma
 primary_id: MESH:D021441
 xref: ICD10CM:C25.3;   ICD9CM:157.3
For additional species annotation, visit the Alliance of Genome Resources.


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pancreatic ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO mRNA, protein:increased expression:pancreas RGD PMID:17481528 RGD:2325211 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO protein:decreased expression:pancreas RGD PMID:19212105 RGD:2325210 NCBI chr  X:11,798,839...11,839,591
Ensembl chr  X:11,798,839...11,900,594 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 disease_progression ISO mRNA:increased expression:pancreas RGD PMID:17979891 RGD:2325243 NCBI chr28:40,853,665...40,865,604
Ensembl chr28:40,855,509...40,863,747 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 disease_progression ISO protein:altered localization:cytoplasm RGD PMID:14997207 RGD:2325249 NCBI chr16:26,413,345...26,551,293
Ensembl chr16:26,414,583...26,551,122 		JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member ISO mRNA:increased expression:pancreas RGD PMID:19609859 RGD:2325659 NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238 		JBrowse link
G ALB albumin disease_progression ISO RGD PMID:19011933 RGD:2325677 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G ANXA2 annexin A2 disease_progression ISO mRNA, protein:increased expression, altered localization:pancreas, plasma membrane RGD PMID:16450333 PMID:19260470 RGD:2317307 RGD:2325731 NCBI chr30:25,176,845...25,210,244
Ensembl chr30:25,115,842...25,218,281 		JBrowse link
G ANXA5 annexin A5 ISO protein:increased expression:pancreas RGD PMID:19488907 RGD:2317538 NCBI chr19:18,419,936...18,450,088
Ensembl chr19:18,407,587...18,570,378 		JBrowse link
G APOC1 apolipoprotein C1 ISO RGD PMID:15876873 RGD:2325793 NCBI chr 1:110,520,177...110,522,563
Ensembl chr 1:110,520,198...110,631,412 		JBrowse link
G ARG2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23424623 NCBI chr 8:41,588,051...41,619,406
Ensembl chr 8:41,588,150...41,619,402 		JBrowse link
G B9D2 B9 domain containing 2 disease_progression ISO RGD PMID:16101174 RGD:2325019 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger ISO protein:increased expression:pancreas
protein:increased expression:exocrine pancreas: 		RGD PMID:19585519 RGD:9491843 NCBI chr 2:10,818,232...10,828,473
Ensembl chr 2:10,818,232...10,833,613 		JBrowse link
G C1H19orf33 chromosome 1 C19orf33 homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:35142956 NCBI chr 1:114,689,909...114,693,980 JBrowse link
G CALR calreticulin ISO protein:increased expression:pancreatic duct RGD PMID:15289361 RGD:2326165 NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245 		JBrowse link
G CBX7 chromobox 7 disease_progression ISO protein:decreased expression:pancreas RGD PMID:20185297 RGD:9587360 NCBI chr10:25,876,022...25,896,284
Ensembl chr10:25,876,016...25,893,501 		JBrowse link
G CCKAR cholecystokinin A receptor ISO mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas		 RGD PMID:9239407 PMID:12851875 RGD:4110816 RGD:4110818 NCBI chr 3:84,010,700...84,019,066
Ensembl chr 3:84,010,205...84,021,293 		JBrowse link
G CCKBR cholecystokinin B receptor ISO protein:decreased expression:pancreas RGD PMID:12851875 RGD:4110816 NCBI chr21:29,602,066...29,606,343
Ensembl chr21:29,604,150...29,605,725 		JBrowse link
G CCND1 cyclin D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:17420962 RGD:13462063 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005 		JBrowse link
G CD40 CD40 molecule treatment ISO protein:increased expression:dendritic cell RGD PMID:20976171 PMID:21436454 PMID:23983255 RGD:11522743 RGD:5490301 RGD:5490524 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301 		JBrowse link
G CDK6 cyclin dependent kinase 6 treatment ISO human cells in a mouse model RGD PMID:24389175 RGD:13782187 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:17671118 RGD:8662851 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24986516 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G CLDN4 claudin 4 ISO RGD PMID:15693851 RGD:2317592 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr32:631,084...636,997
Ensembl chr32:631,478...632,868
Ensembl chr32:631,478...632,868 		JBrowse link
G DNMT1 DNA methyltransferase 1 disease_progression ISO protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19424621 PMID:29844410 RGD:9588974 NCBI chr20:50,872,213...50,928,352
Ensembl chr20:50,879,527...50,928,029 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta disease_progression ISO RGD PMID:22919364 RGD:9589121 NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900 		JBrowse link
G DTX1 deltex E3 ubiquitin ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr26:10,469,850...10,502,682 JBrowse link
G DTX4 deltex E3 ubiquitin ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr18:37,535,957...37,570,937
Ensembl chr18:37,538,342...37,591,589 		JBrowse link
G EGF epidermal growth factor disease_progression ISO protein:increased expression: : RGD PMID:18505086 RGD:2317644 NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295 		JBrowse link
G FASLG Fas ligand ISO protein:increased expression:pancreas, liver RGD PMID:10547193 PMID:15375495 RGD:2317741 RGD:2317747 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G FGF2 fibroblast growth factor 2 disease_progression ISO RGD PMID:12717266 PMID:18704599 RGD:2317756 RGD:2317758 NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:12109856 RGD:2317790 NCBI chr 6:12,360,849...12,370,906
Ensembl chr 6:12,354,599...12,370,808 		JBrowse link
G GPNMB glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:36,919,184...36,947,023
Ensembl chr14:36,919,296...36,946,643 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 resistance ISO DNA:methylation: :
mRNA, protein:increased expression:pancreas		 RGD PMID:12488200 PMID:16537562 PMID:17265526 RGD:2317806 RGD:2317809 RGD:2317811 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182 		JBrowse link
G HDAC1 histone deacetylase 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 2:68,901,339...68,936,473
Ensembl chr 2:68,901,651...68,936,186 		JBrowse link
G HEATR1 HEAT repeat containing 1 treatment ISO RGD PMID:26676747 RGD:10761108 NCBI chr 4:3,501,191...3,547,212
Ensembl chr 4:3,501,571...3,547,100 		JBrowse link
G HES1 hes family bHLH transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:64,630,656...64,646,546 JBrowse link
G HSP70 heat shock protein 70 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:20098680 RGD:2317639 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO protein:increased expression:pancreas RGD PMID:14506643 PMID:14627343 RGD:2317649 RGD:2317652 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387 		JBrowse link
G IL4 interleukin 4 ISO RGD PMID:17942922 RGD:2317264 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G IL4R interleukin 4 receptor ISO protein:increased expression:pancreas RGD PMID:17942922 RGD:2317264 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G INS insulin ISO Glucagon/insulin RGD PMID:19571666 RGD:2317248 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199 		JBrowse link
G JAG2 jagged canonical Notch ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 8:72,535,539...72,553,531
Ensembl chr 8:72,535,107...72,550,322 		JBrowse link
G KDM2B lysine demethylase 2B severity ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:23321669 RGD:9588253 NCBI chr26:7,625,857...7,746,049
Ensembl chr26:7,598,931...7,745,113 		JBrowse link
G KITLG KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr15:29,591,068...29,671,985
Ensembl chr15:29,591,170...29,671,974 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25347530 PMID:30654191 NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369 		JBrowse link
G KRT7 keratin 7 disease_progression ISO RGD PMID:19260470 RGD:2317307 NCBI chr27:2,812,709...2,827,451 JBrowse link
G L1CAM L1 cell adhesion molecule severity ISO protein:increased expression:pancreas (human) RGD PMID:20162456 RGD:6483447 NCBI chr  X:121,708,695...121,722,819
Ensembl chr  X:121,708,894...121,733,365 		JBrowse link
G LOC611363 mesothelin disease_progression ISO protein:increased secretion:serum
CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR		 RGD
CTD		 PMID:12874021 PMID:14576474 PMID:19818733 PMID:21775916 PMID:25347530 RGD:2326055 RGD:2326065 NCBI chr 6:39,827,985...39,834,945 JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 treatment ISO human cells in mouse model RGD PMID:20179210 RGD:14348973 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MCM7 minichromosome maintenance complex component 7 ISO mRNA, protein:increased expression:pancreatic duct RGD PMID:15548371 RGD:2317697 NCBI chr 6:9,492,654...9,499,846
Ensembl chr 6:9,492,573...9,499,855 		JBrowse link
G MDM2 MDM2 proto-oncogene severity
onset		 ISO protein:increased expression:pancreas (human)
DNA:snp:promoter, intron:IVS1+309T>G (human)		 RGD PMID:15810085 PMID:19752772 RGD:2317414 RGD:2317416 NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596 		JBrowse link
G MEN1 menin 1 ISO protein:decreased expression:pancreas RGD PMID:19170121 RGD:2317294 NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:pancreatic duct (human) RGD PMID:7866999 RGD:2317530 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase susceptibility ISO protein:increased activity, increased expression:ductal adenocarcinoma (human)
DNA:missense mutation:cds:p.L84F rs12917 (human)		 RGD PMID:9393761 PMID:16844323 RGD:2317648 RGD:2317664 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380 		JBrowse link
G MIR142 microRNA mir-142 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr 9:32,977,393...32,977,455
Ensembl chr 9:32,977,382...32,977,468 		JBrowse link
G MMP2 matrix metallopeptidase 2 severity ISO protein:increased expression:pancreas RGD PMID:17377415 RGD:2325746 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:blood
protein:increased expression:pancreas, serum		 RGD PMID:18706098 PMID:20332475 RGD:2325830 RGD:2325844 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G MUC1 mucin 1, cell surface associated disease_progression ISO protein:increased expression, altered localization:pancreas RGD PMID:14681945 PMID:18713982 PMID:19109152 RGD:2317983 RGD:2324616 RGD:2324633 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690 		JBrowse link
G MUC4 mucin 4, cell surface associated disease_progression ISO mRNA:increased expression:pancreas
protein:increased expression:pancreas		 RGD PMID:12657964 PMID:16049287 RGD:2324942 RGD:2324946 NCBI chr33:29,061,372...29,084,938
Ensembl chr33:29,063,096...29,111,802 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming disease_progression ISO mRNA:increased expression:pancreas RGD PMID:7657125 PMID:10227724 RGD:2324907 RGD:2324986 NCBI chr18:45,471,232...45,498,961 JBrowse link
G MUC5B mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:pancreas RGD PMID:7657125 RGD:2324986 NCBI chr18:45,517,479...45,545,765
Ensembl chr18:45,517,474...45,545,184 		JBrowse link
G NDRG1 N-myc downstream regulated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16778198 NCBI chr13:29,689,294...29,745,964
Ensembl chr13:29,650,444...29,746,382 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21489257 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO protein:increased expression:pancreas (human) RGD PMID:17492507 RGD:5132867 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:12660813 RGD:2325254 NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588 		JBrowse link
G NOTCH1 notch receptor 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19028876 PMID:19208345 PMID:20484026 RGD:2325323 RGD:2325324 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G NOTCH3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr20:46,946,654...46,978,821
Ensembl chr20:46,937,485...46,978,219 		JBrowse link
G NOTCH4 notch receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr12:1,585,249...1,608,721
Ensembl chr12:1,587,918...1,607,760 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 disease_progression ISO protein:increased expression:pancreas RGD PMID:10209957 PMID:11295066 RGD:2325660 RGD:2325663 NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024 		JBrowse link
G OSM oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr26:23,421,787...23,439,332
Ensembl chr26:23,421,787...23,426,036 		JBrowse link
G PALLD palladin, cytoskeletal associated protein ISO protein:increased expression, alternative form:pancreas, fibroblast RGD PMID:17404500 RGD:2325781 NCBI chr25:19,147,310...19,568,712
Ensembl chr25:19,146,898...19,553,679 		JBrowse link
G PAX6 paired box 6 ISO protein:increased expression:pancreatic duct (human) RGD PMID:17849422 RGD:8552381
G PMS1 PMS1 homolog 1, mismatch repair system component ISO protein:increased expression:pancreatic duct RGD PMID:15856462 RGD:2324870 NCBI chr37:502,752...609,640
Ensembl chr37:502,747...790,904 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma disease_progression ISO RGD PMID:19396032 RGD:2317461 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18670639 RGD:2317185 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G RNF2 ring finger protein 2 ISO protein:increased expression:pancreas RGD PMID:19585519 RGD:9491843 NCBI chr 7:18,240,672...18,283,091
Ensembl chr 7:18,236,115...18,281,387 		JBrowse link
G RXRA retinoid X receptor alpha severity ISO RGD PMID:19396032 RGD:2317461 NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119 		JBrowse link
G SERPINA1 serpin family A member 1 ISO mRNA, protein:increased expression:pancreas RGD PMID:12488200 RGD:2317811 NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 ISO protein:increased expression:pancreatic duct RGD PMID:19252908 RGD:2324975 NCBI chr34:35,368,583...35,398,197
Ensembl chr34:35,370,192...35,400,409 		JBrowse link
G SMAD4 SMAD family member 4 disease_progression ISO RGD PMID:15173084 RGD:21066334 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405 		JBrowse link
G SMO smoothened, frizzled class receptor ISO RGD PMID:16826192 RGD:2324981 NCBI chr14:7,518,871...7,527,703
Ensembl chr14:7,518,856...7,528,033 		JBrowse link
G STK11 serine/threonine kinase 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26887594 NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 disease_progression ISO mRNA:increased expresssion:pancreas RGD PMID:10547197 PMID:17114585 RGD:2317498 RGD:2317500 NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636 		JBrowse link
G THBS1 thrombospondin 1 disease_progression ISO DNA:hypermethylation:promoter (human) RGD PMID:12429967 PMID:19065635 RGD:2325022 RGD:2325025 NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915 		JBrowse link
G TMPRSS3 transmembrane serine protease 3 ISO RGD PMID:14695172 RGD:2325152 NCBI chr31:36,706,229...36,730,444
Ensembl chr31:36,707,723...36,730,520 		JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G TSC2 TSC complex subunit 2 severity ISO RGD PMID:16213898 RGD:11568674 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO DNA:hypermethylation:promoter (human) RGD PMID:19065635 RGD:2325022 NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323 		JBrowse link
G YEATS2 YEATS domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr34:16,654,672...16,777,493
Ensembl chr34:16,654,493...16,777,506 		JBrowse link
G ZZZ3 zinc finger ZZ-type containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34686948 NCBI chr 6:69,180,465...69,278,740
Ensembl chr 6:69,180,349...69,277,596 		JBrowse link
pancreatic adenosquamous carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB2 transforming growth factor beta 2 ameliorates ISO human cells in a mouse model RGD PMID:21366804 RGD:155630611 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
pancreatic ductal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member ISO protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 ISO protein:increased expression:pancreas RGD PMID:19077459 RGD:2325696 NCBI chr 2:79,334,179...79,343,880
Ensembl chr 2:79,334,205...79,343,007 		JBrowse link
G B9D2 B9 domain containing 2 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CALR calreticulin ameliorates ISO human cells in mouse model
human cells in a mouse model		 RGD PMID:29072694 PMID:33028359 RGD:150520160 RGD:150521706 NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245 		JBrowse link
G CCND1 cyclin D1 severity ISO protein:increased expression:pancreas (human)
DNA:snp:exon:c.870G>A (human)		 RGD PMID:22939953 PMID:25470788 RGD:13462050 RGD:13462062 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005 		JBrowse link
G CD59 CD59 molecule disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr18:33,977,433...33,999,145
Ensembl chr18:33,977,480...33,998,329 		JBrowse link
G CDK4 cyclin dependent kinase 4 severity ISO protein:increased expression:pancreas, islet of Langerhans (human) RGD PMID:29735403 RGD:13781899 NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789 		JBrowse link
G E2F1 E2F transcription factor 1 severity ISO protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)		 RGD PMID:12650514 PMID:17233815 PMID:27573434 RGD:13838735 RGD:13838738 RGD:13838739 NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656 		JBrowse link
G FOXM1 forkhead box M1 disease_progression ISO RGD PMID:24859161 RGD:156430321 NCBI chr27:41,894,605...41,905,656
Ensembl chr27:41,894,672...41,905,663 		JBrowse link
G FUBP1 far upstream element binding protein 1 ISO mRNA:increased expression:pancreatic duct (human) RGD PMID:32481602 RGD:151361197 NCBI chr 6:68,923,215...68,963,766 JBrowse link
G GLIPR2 GLI pathogenesis related 2 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr11:52,622,460...52,634,602
Ensembl chr11:52,615,039...52,681,270 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 treatment ISO human cells in a mouse model RGD PMID:23535601 RGD:13504844 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta susceptibility ISO RGD PMID:22264792 RGD:13838741 NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075 		JBrowse link
G JAK1 Janus kinase 1 ISO mRNA:decreased expression:pancreatic ductal cell (human) RGD PMID:28677798 RGD:13838745 NCBI chr 5:45,251,653...45,408,571
Ensembl chr 5:45,251,653...45,408,571 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 disease_progression
severity		 ISO protein:increased phosphorylation:pancreas (mouse) RGD PMID:23237571 PMID:28837246 RGD:14348974 RGD:14348975 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MIR155 microRNA mir-155 disease_progression ISO RGD PMID:28198398 RGD:25314300 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833 		JBrowse link
G MIR494 microRNA mir-494 ameliorates
disease_progression		 ISO RGD PMID:24859161 RGD:156430321 NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465 		JBrowse link
G PGF placental growth factor severity ISO associated with obesity RGD PMID:26861455 RGD:14349030 NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:20876794 RGD:14390130 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 severity ISO human cells in a mouse model RGD PMID:15591514 RGD:14390084 NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558 		JBrowse link
G PLD1 phospholipase D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:27713167 RGD:14392801 NCBI chr34:35,917,759...36,080,383
Ensembl chr34:35,921,058...36,121,631 		JBrowse link
G PTPRB protein tyrosine phosphatase receptor type B disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr10:12,267,891...12,384,522
Ensembl chr10:12,241,716...12,384,435 		JBrowse link
G PTPRM protein tyrosine phosphatase receptor type M disease_progression ISO protein:decreased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 7:74,005,682...74,597,498
Ensembl chr 7:73,815,186...74,609,116 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)		 RGD PMID:21684285 PMID:23334332 RGD:14392806 RGD:14392816 NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216 		JBrowse link
G RALA RAS like proto-oncogene A ISO mRNA:increased expression:pancreas (human) RGD PMID:29113235 RGD:14394418 NCBI chr18:10,022,490...10,047,583
Ensembl chr18:10,024,311...10,039,183 		JBrowse link
G S100A8 S100 calcium binding protein A8 disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 7:43,540,667...43,541,604
Ensembl chr 7:43,501,989...43,541,604 		JBrowse link
G SMAD2 SMAD family member 2 severity ISO RGD PMID:26908446 RGD:14394493 NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983 		JBrowse link
G TGFB2 transforming growth factor beta 2 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
G TGFB3 transforming growth factor beta 3 ameliorates ISO protein:decreased expression:pancreas (human) RGD PMID:8253361 RGD:155630628 NCBI chr 8:48,920,874...48,946,037
Ensembl chr 8:48,923,423...48,945,816 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ameliorates ISO human cell line in a mouse model RGD PMID:17297450 RGD:155630637 NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594 		JBrowse link
G VEGFD vascular endothelial growth factor D ISO protein:increased expression:blood serum (human) RGD PMID:21410412 RGD:155630646 NCBI chr  X:11,590,097...11,627,199
Ensembl chr  X:11,590,089...11,626,486 		JBrowse link
G VNN1 vanin 1 disease_progression ISO protein:increased expression:blood (human) RGD PMID:32663515 RGD:151660329 NCBI chr 1:25,678,039...25,704,579
Ensembl chr 1:25,678,042...25,696,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15755
    disease of cellular proliferation 7490
      Neoplasms by Histologic Type 5152
        Glandular and Epithelial Neoplasms 3675
          carcinoma 3174
            pancreatic carcinoma 172
              pancreatic ductal carcinoma 128
                pancreatic ductal adenocarcinoma + 33
Path 2
Term Annotations click to browse term
  disease 15755
    disease of cellular proliferation 7490
      cancer 5508
        organ system cancer 5269
          endocrine gland cancer 2524
            pancreatic cancer 397
              malignant exocrine pancreas neoplasm 173
                pancreatic carcinoma 172
                  pancreatic ductal carcinoma 128
                    pancreatic ductal adenocarcinoma + 33
paths to the root