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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:meningioma
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Accession:DOID:3565 term browser browse the term
Definition:A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid cap cells of the arachnoid villi in the meninges. (DO)
Synonyms:exact_synonym: Meningiomatosis;   meningiomas;   meningiomatoses;   meningothelial cell tumor;   multiple meningioma;   multiple meningiomas;   neoplasm of the meninges;   primary meningeal tumor
 primary_id: MESH:D008579
 xref: GARD:7015;   ICD10CM:D32.9;   NCI:C3230;   NCI:C6971;   ORDO:2495
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
meningioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23334667 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase EXP CTD Direct Evidence: marker/mechanism CTD PMID:16140629 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G BAP1 BRCA1 associated protein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25231345 NCBI chr 3:52,401,004...52,410,030
Ensembl chr 3:52,401,008...52,410,008
JBrowse link
G CST3 cystatin C EXP CTD Direct Evidence: marker/mechanism CTD PMID:19747051 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CSTB cystatin B EXP CTD Direct Evidence: marker/mechanism CTD PMID:19747051 NCBI chr21:43,773,950...43,776,308
Ensembl chr21:43,772,511...43,776,330
Ensembl chr21:43,772,511...43,776,330
Ensembl chr21:43,772,511...43,776,330
JBrowse link
G CTSL cathepsin L EXP CTD Direct Evidence: marker/mechanism CTD PMID:19747051 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,726,109...87,731,469
Ensembl chr 9:87,726,109...87,731,469
JBrowse link
G DNMT1 DNA methyltransferase 1 IAGP ClinVar Annotator: match by term: Meningioma ClinVar NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G EPB41L3 erythrocyte membrane protein band 4.1 like 3 IEP RGD PMID:10888600 RGD:1300356 NCBI chr18:5,392,386...5,630,663
Ensembl chr18:5,392,381...5,630,700
JBrowse link
G GSTM3 glutathione S-transferase mu 3 IAGP DNA: deletion: intron 6 RGD PMID:16598069 RGD:5688743 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G HES1 hes family bHLH transcription factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
JBrowse link
G HGF hepatocyte growth factor disease_progression IEP protein:increased expression:brain: RGD PMID:12115353 RGD:8548633 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G MLLT10 MLLT10 histone lysine methyltransferase DOT1L cofactor EXP CTD Direct Evidence: marker/mechanism CTD PMID:21804547 NCBI chr10:21,524,616...21,743,630
Ensembl chr10:21,524,646...21,743,630
JBrowse link
G MN1 MN1 proto-oncogene, transcriptional regulator TAS
IAGP
DNA:translocation RGD PMID:16398473, PMID:7731706 RGD:1624321, RGD:1600423 NCBI chr22:27,748,277...27,801,756
Ensembl chr22:27,748,277...27,801,756
JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase susceptibility IAGP DNA:SNP: :66A>G, (rs1801394) (human) RGD PMID:18483342 RGD:5508186 NCBI chr 5:7,851,186...7,901,124
Ensembl chr 5:7,851,186...7,906,025
JBrowse link
G NF2 neurofibromin 2 TAS
IAGP
EXP
ClinVar Annotator: match by term: Meningioma
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:7868131 PMID:8162072 PMID:8379998 PMID:8882871 PMID:9718334 PMID:9884492 PMID:18033041 PMID:22711605 PMID:23334667 PMID:25741868 PMID:26073919 PMID:28492532, PMID:16398473 RGD:1624321 NCBI chr22:29,603,556...29,698,600
Ensembl chr22:29,603,556...29,698,598
JBrowse link
G PDGFB platelet derived growth factor subunit B IAGP ClinVar Annotator: match by term: Meningioma ClinVar PMID:2212004 PMID:3133569 PMID:3969118 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PGR progesterone receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:8008172 PMID:19731987 PMID:19747051 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PTEN phosphatase and tensin homolog EXP
IAGP
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Meningioma
CTD
ClinVar
PMID:12085208 PMID:23442912 PMID:25741868 PMID:27535533 PMID:28492532 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G SMO smoothened, frizzled class receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:23334667 NCBI chr 7:129,188,633...129,213,548
Ensembl chr 7:129,188,633...129,213,545
JBrowse link
cavernous sinus meningioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHFR dihydrofolate reductase IAGP ClinVar Annotator: match by term: Cavernous Sinus Meningioma ClinVar NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G KMT2D lysine methyltransferase 2D IAGP ClinVar Annotator: match by term: Cavernous Sinus Meningioma ClinVar NCBI chr12:49,018,975...49,060,884
Ensembl chr12:49,018,978...49,060,794
Ensembl chr12:49,018,978...49,060,794
JBrowse link
G MSH3 mutS homolog 3 IAGP ClinVar Annotator: match by term: Cavernous Sinus Meningioma ClinVar NCBI chr 5:80,654,652...80,876,815
Ensembl chr 5:80,654,652...80,876,815
JBrowse link
familial meningioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MN1 MN1 proto-oncogene, transcriptional regulator susceptibility IAGP
EXP
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Meningioma, familial
OMIM
CTD
ClinVar
PMID:25741868 NCBI chr22:27,748,277...27,801,756
Ensembl chr22:27,748,277...27,801,756
JBrowse link
G NF2 neurofibromin 2 susceptibility IAGP
EXP
ClinVar Annotator: match by term: Meningioma, familial
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:20553997 PMID:25741868 PMID:28492532 NCBI chr22:29,603,556...29,698,600
Ensembl chr22:29,603,556...29,698,598
JBrowse link
G PDGFB platelet derived growth factor subunit B susceptibility IAGP
EXP
ClinVar Annotator: match by term: Meningioma, familial
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:25741868 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PTEN phosphatase and tensin homolog susceptibility IAGP
EXP
ClinVar Annotator: match by term: Meningioma, familial
ClinVar Annotator: match by term: Meningioma, familial, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:9399897 PMID:9425889 PMID:9467011 PMID:10232405 PMID:10353779 PMID:10400993 PMID:10468583 PMID:10555148 PMID:10749983 PMID:10848731 PMID:11685670 PMID:11939587 PMID:14518070 PMID:14566704 PMID:16014636 PMID:16773562 PMID:17392703 PMID:17526801 PMID:17898811 PMID:17942903 PMID:20600018 PMID:21194675 PMID:21659347 PMID:21828076 PMID:21956414 PMID:22381246 PMID:23442912 PMID:23470840 PMID:23475934 PMID:23695273 PMID:24033266 PMID:24052722 PMID:24375884 PMID:24778394 PMID:25022750 PMID:25132236 PMID:25157968 PMID:25326635 PMID:25525159 PMID:25669429 PMID:25741868 PMID:25756585 PMID:25875300 PMID:26468640 PMID:27477328 PMID:27531073 PMID:27959697 PMID:28492532 PMID:28526761 PMID:28677221 PMID:30287823 PMID:30311380 PMID:32238909 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 susceptibility IAGP
EXP
ClinVar Annotator: match by term: Meningioma, familial
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:9536098 PMID:17576681 PMID:22426308 PMID:23377182 PMID:25169753 PMID:25741868 PMID:28166811 PMID:28492532 NCBI chr17:40,624,962...40,647,818
Ensembl chr17:40,624,962...40,648,654
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling susceptibility IAGP
EXP
ClinVar Annotator: match by term: Meningioma, familial
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:22958902 PMID:25741868 NCBI chr10:102,502,801...102,633,535
Ensembl chr10:102,503,987...102,633,535
Ensembl chr10:102,503,987...102,633,535
JBrowse link
meninges sarcoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 ISO RGD PMID:27528400 RGD:12738450 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19902
    disease of cellular proliferation 7951
      Neoplasms by Histologic Type 4889
        Nerve Tissue Neoplasms 819
          meningioma 25
            Gasserian ganglion meningioma 0
            Hunter-Macdonald Syndrome 0
            Radiation Induced Meningioma 0
            angiomatous meningioma 0
            benign meningioma 0
            bilateral meningioma of optic nerve 0
            brain meningioma + 0
            childhood meningioma + 0
            clear cell meningioma + 0
            ethmoid sinus ectopic meningioma 0
            familial meningioma + 6
            fibrous meningioma 0
            foramen magnum meningioma + 0
            internal auditory canal meningioma 0
            intracranial meningioma 0
            intraorbital meningioma 0
            lung meningioma 0
            lymphoplasmacyte-rich meningioma 0
            malignant leptomeningeal tumor + 0
            meninges hemangiopericytoma 0
            meninges sarcoma + 1
            meningothelial meningioma 0
            microcystic meningioma 0
            parapharyngeal meningioma 0
            periocular meningioma 0
            petrous apex meningioma 0
            pineal region meningioma 0
            pituitary stalk meningioma 0
            posterior cranial fossa meningioma + 0
            psammomatous meningioma 0
            rhabdoid meningioma + 0
            secretory meningioma 0
            skin meningioma 0
            skull base meningioma + 3
            spinal canal and spinal cord meningioma + 0
            spinal meningioma 0
            suprasellar meningioma 0
            supratentorial meningioma 0
            transitional meningioma 0
Path 2
Term Annotations click to browse term
  disease 19902
    disease of cellular proliferation 7951
      cancer 5317
        organ system cancer 5147
          nervous system cancer 1186
            central nervous system cancer 846
              meningioma 25
                Gasserian ganglion meningioma 0
                Hunter-Macdonald Syndrome 0
                Radiation Induced Meningioma 0
                angiomatous meningioma 0
                benign meningioma 0
                bilateral meningioma of optic nerve 0
                brain meningioma + 0
                childhood meningioma + 0
                clear cell meningioma + 0
                ethmoid sinus ectopic meningioma 0
                familial meningioma + 6
                fibrous meningioma 0
                foramen magnum meningioma + 0
                internal auditory canal meningioma 0
                intracranial meningioma 0
                intraorbital meningioma 0
                lung meningioma 0
                lymphoplasmacyte-rich meningioma 0
                malignant leptomeningeal tumor + 0
                meninges hemangiopericytoma 0
                meninges sarcoma + 1
                meningothelial meningioma 0
                microcystic meningioma 0
                parapharyngeal meningioma 0
                periocular meningioma 0
                petrous apex meningioma 0
                pineal region meningioma 0
                pituitary stalk meningioma 0
                posterior cranial fossa meningioma + 0
                psammomatous meningioma 0
                rhabdoid meningioma + 0
                secretory meningioma 0
                skin meningioma 0
                skull base meningioma + 3
                spinal canal and spinal cord meningioma + 0
                spinal meningioma 0
                suprasellar meningioma 0
                supratentorial meningioma 0
                transitional meningioma 0
paths to the root