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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:middle cerebral artery infarction
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Accession:DOID:3525 term browser browse the term
Definition:NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Synonyms:exact_synonym: Left Middle Cerebral Artery Infarction;   MCA Infarction;   MCAO;   Middle Cerebral Artery Circulation Infarction;   Middle Cerebral Artery Embolic Infarction;   Middle Cerebral Artery Embolus;   Middle Cerebral Artery Occlusion;   Middle Cerebral Artery Stroke;   Middle Cerebral Artery Syndrome;   Middle Cerebral Artery Thrombosis;   Middle Cerebral Artery Thrombotic Infarction;   cerebral infarction, middle cerebral artery;   right middle cerebral artery infarction
 broad_synonym: THROMBOTIC STROKE
 primary_id: MESH:D020244
For additional species annotation, visit the Alliance of Genome Resources.


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middle cerebral artery infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment ISO RGD PMID:23149556 PMID:24602692 RGD:12790979 RGD:12791996 NCBI chrNW_004936528:1,608,782...1,682,873 JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO mRNA, protein:increased expression:brain RGD PMID:24090950 RGD:9685436 NCBI chrNW_004936470:4,964,526...5,011,808 JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chrNW_004936567:1,430,128...1,508,626 JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
CTD
RGD
PMID:24211797 PMID:25446913 RGD:8696008 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Agt angiotensinogen ISO protein:increased expression:brain, serum RGD PMID:24090950 RGD:9685436 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Aifm1 apoptosis inducing factor mitochondria associated 1 ISO protein:altered localization: : RGD PMID:15181376 RGD:10047403 NCBI chrNW_004936479:1,441,508...1,477,133 JBrowse link
G Ak1 adenylate kinase 1 ISO protein:decreased expression:cerebral cortex (rat) RGD PMID:16468349 RGD:5508760 NCBI chrNW_004936487:15,507,663...15,517,401 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19309543 NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chrNW_004936490:5,156...127,666 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:24012531 RGD:13703113 NCBI chrNW_004936492:14,818,561...14,902,231 JBrowse link
G Apoe apolipoprotein E ISO RGD PMID:19623195 RGD:6903926 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G App amyloid beta precursor protein treatment ISO RGD PMID:28963051 RGD:13782054 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Aqp4 aquaporin 4 treatment ISO RGD PMID:20815926 RGD:8695955 NCBI chrNW_004936550:5,931,201...5,943,999 JBrowse link
G Arc activity regulated cytoskeleton associated protein ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936470:9,185,145...9,188,260 JBrowse link
G Atf3 activating transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936557:909,302...922,619 JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO RGD PMID:21891976 PMID:22200499 RGD:10053665 RGD:10053704 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:23143152 RGD:10054501 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcan brevican ISO RGD PMID:15869933 RGD:9590118 NCBI chrNW_004936580:5,816,196...5,828,531 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:23143152 RGD:10054501 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO RGD PMID:20417695 RGD:4891138 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G Becn1 beclin 1 treatment ISO RGD PMID:22108007 RGD:11561900 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO protein:increased expression:brain RGD PMID:17379825 RGD:9685412 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:15902200 PMID:21029239 RGD:2314138 RGD:9068917 NCBI chrNW_004936757:499,485...523,494 JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
CTD
RGD
PMID:22103620 PMID:23199288 RGD:7175514 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha ISO RGD PMID:14688616 RGD:1358416 NCBI chrNW_004936504:4,636,863...4,700,887 JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:21891976 PMID:23143152 PMID:26868427 RGD:10053704 RGD:10054501 RGD:13782346 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp6 caspase 6 ISO RGD PMID:26868427 RGD:13782346 NCBI chrNW_004936563:912,502...920,025 JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:26868427 RGD:13782346 NCBI chrNW_004936474:3,178,097...3,196,130 JBrowse link
G Cd36 CD36 molecule treatment ISO RGD PMID:25216018 RGD:11041113 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Cd86 CD86 molecule ISO protein:increased expression:brain subventricular zone, microglial cell (rat) RGD PMID:19053043 RGD:2313025 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Cdk5 cyclin dependent kinase 5 ISO RGD PMID:24920629 RGD:13782375 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G Cldn5 claudin 5 treatment ISO RGD PMID:24842554 RGD:13204729 NCBI chrNW_004936619:3,455,508...3,457,053 JBrowse link
G Crh corticotropin releasing hormone ISO protein:decreased expression:median eminence of hypothalamus (rat) RGD PMID:21741032 RGD:5490538 NCBI chrNW_004936496:7,759,656...7,761,555 JBrowse link
G Crp C-reactive protein ISO RGD PMID:15545914 RGD:9585995 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Crtc1 CREB regulated transcription coactivator 1 treatment ISO RGD PMID:20417695 RGD:4891138 NCBI chrNW_004936596:2,551,621...2,625,327 JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO mRNA, protein:increased expression:brain: RGD PMID:15530654 PMID:19298757 RGD:11039420 RGD:11039425 NCBI chrNW_004936490:15,142,526...15,146,375 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:10825390 RGD:632989 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO mRNA:increased expression:cerebral cortex RGD PMID:10825390 RGD:632989 NCBI chrNW_004936762:66,636...69,694 JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:11726790 RGD:9588643 NCBI chrNW_004936659:520,181...565,496 JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO RGD PMID:23516428 RGD:9589049 NCBI chrNW_004936493:6,963,406...7,013,256 JBrowse link
G Dynll1 dynein light chain LC8-type 1 ISO RGD PMID:9522364 RGD:13208524 NCBI chrNW_004936668:451,846...484,841 JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17197033 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Egr2 early growth response 2 ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936753:1,958,250...1,962,640 JBrowse link
G Egr4 early growth response 4 ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936491:17,068,797...17,071,608 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha treatment ISO RGD PMID:19763736 PMID:23669639 RGD:10395346 RGD:10755569 NCBI chrNW_004936495:10,746,687...10,769,304 JBrowse link
G Eng endoglin ISO RGD PMID:24876084 RGD:11041171 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Epcam epithelial cell adhesion molecule ISO RGD PMID:15950761 RGD:11038820 NCBI chrNW_004936508:5,019,513...5,032,610 JBrowse link
G Epn1 epsin 1 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chrNW_004936981:194,176...213,021 JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20547143 PMID:20833153 RGD:10400898 RGD:10401066 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor ISO RGD PMID:9974119 RGD:10401103 NCBI chrNW_004936728:706,499...843,447 JBrowse link
G F11 coagulation factor XI ISO RGD PMID:16533887 RGD:11041786 NCBI chrNW_004936554:3,205,539...3,223,228 JBrowse link
G F12 coagulation factor XII treatment ISO RGD PMID:16533887 RGD:11041786 NCBI chrNW_004936597:1,687,511...1,694,782 JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29651748 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:18950622 PMID:23378241 RGD:11341807 RGD:11344885 NCBI chrNW_004936599:633,501...639,412 JBrowse link
G Fgf21 fibroblast growth factor 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936664:2,826,823...2,828,330 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936488:4,384,710...4,388,118 JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936515:1,982,415...1,997,740 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:25882840 RGD:13792686 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide treatment ISO RGD PMID:19352052 RGD:9850083 NCBI chrNW_004936602:3,037,862...3,044,863 JBrowse link
G Ghsr growth hormone secretagogue receptor ISO RGD PMID:19352052 RGD:9850083 NCBI chrNW_004936593:268,736...273,623 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 treatment ISO RGD PMID:26674869 RGD:11068571 NCBI chrNW_004936669:814,330...838,881 JBrowse link
G Grn granulin precursor treatment ISO RGD PMID:23972823 RGD:10401661 NCBI chrNW_004936541:793,548...800,271 JBrowse link
G Grpel1 GrpE like 1, mitochondrial ISO mRNA:increased expression:cerebral cortex RGD PMID:12505684 RGD:632868 NCBI chrNW_004936477:18,883,556...18,891,108 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO RGD PMID:28440874 RGD:13792734 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Hamp hepcidin antimicrobial peptide ISO mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum RGD PMID:21957487 RGD:11041635 NCBI chrNW_004936570:1,009,344...1,010,654 JBrowse link
G Has2 hyaluronan synthase 2 ISO mRNA:increased expression:brain RGD PMID:11283406 RGD:9588631 NCBI chrNW_004936470:25,418,069...25,443,332 JBrowse link
G Hdac4 histone deacetylase 4 treatment ISO mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936745:1,730,743...1,942,071 JBrowse link
G Hdac5 histone deacetylase 5 treatment ISO mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936541:561,721...598,915 JBrowse link
G Hdac9 histone deacetylase 9 ISO mRNA:increased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936546:4,398,003...5,247,649 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:21029239 RGD:9068917 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936472:25,236,728...25,246,585 JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:20888632 PMID:23870531 PMID:24252362 RGD:10755587 RGD:10755588 RGD:10755755 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO rat gene in mouse model RGD PMID:17473852 PMID:21709150 RGD:5688754 RGD:6218961 NCBI chrNW_004936647:2,087,650...2,133,343 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Htra2 HtrA serine peptidase 2 ISO protein:increased expression:brain, cytosol (mouse)
protein:increased expression:brain, cytosol (rat)
RGD PMID:15306124 PMID:16978742 RGD:2314385 RGD:5688372 NCBI chrNW_004936556:741,718...746,016 JBrowse link
G Hvcn1 hydrogen voltage gated channel 1 ISO RGD PMID:31250553 RGD:14985213 NCBI chrNW_004936558:3,581,409...3,609,714 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Igf1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:16286924 RGD:10045955 NCBI chrNW_004936785:358,128...406,751 JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936886:617,531...620,661 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il1b interleukin 1 beta treatment ISO protein:increased expression:cerebral cortex (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:23028794 PMID:24916922 PMID:25257527 PMID:29498696 RGD:10450594 RGD:13792833 RGD:7204480 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human gene in a rat model RGD PMID:7790404 RGD:8551708 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il22 interleukin 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936545:6,227,118...6,231,745 JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
G Il5 interleukin 5 ISO RGD PMID:23028794 RGD:7204480 NCBI chrNW_004936647:2,647,982...2,651,477 JBrowse link
G Il6r interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Il6st interleukin 6 signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
G Ina internexin neuronal intermediate filament protein alpha ISO protein:decreased expression:brain RGD PMID:29967576 RGD:27226878 NCBI chrNW_004936600:2,747,649...2,760,517 JBrowse link
G Irf4 interferon regulatory factor 4 ISO RGD PMID:25652434 RGD:11530061 NCBI chrNW_004936633:1,565,293...1,580,859 JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936659:1,890,786...1,892,619 JBrowse link
G LOC101968921 angiotensin-converting enzyme treatment ISO RGD PMID:24471927 RGD:11039026 NCBI chrNW_004936541:4,157,847...4,178,156 JBrowse link
G LOC101973029 cytochrome P450 2E1 ISO RGD PMID:23002367 RGD:14700877 NCBI chrNW_004936486:19,691,822...19,702,684 JBrowse link
G LOC101976500 haptoglobin ISO RGD PMID:22103620 RGD:7175514 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mag myelin associated glycoprotein treatment ISO RGD PMID:15678116 RGD:9685232 NCBI chrNW_004936570:989,743...1,004,820 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:27152455 RGD:13800881 NCBI chrNW_004936619:1,889,841...1,932,646 JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:27152455 RGD:13800881 NCBI chrNW_004936501:12,342,670...12,390,650 JBrowse link
G Mapt microtubule associated protein tau treatment ISO RGD PMID:25903928 PMID:28886009 RGD:13800886 RGD:13800913 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19309543 PMID:24842554 RGD:13204729 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Mt3 metallothionein 3 ISO protein:decreased expression:brain RGD PMID:8869568 RGD:9685807 NCBI chrNW_004936475:8,864,512...8,866,516 JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:21185267 PMID:23777415 PMID:24583056 RGD:10040971 RGD:10040974 RGD:10041016 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 ISO RGD PMID:21386696 RGD:13801046 NCBI chrNW_004936475:17,083,175...17,105,098 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase treatment ISO RGD PMID:28495827 RGD:13781880 NCBI chrNW_004936479:17,682,070...17,716,713 JBrowse link
G Nefl neurofilament light ISO protein:increased expression:brain RGD PMID:29967576 RGD:27226878 NCBI chrNW_004936757:1,642,122...1,646,499 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 treatment ISO RGD PMID:23880501 PMID:24466583 RGD:10412696 RGD:10412714 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
G Nfkbia NFKB inhibitor alpha treatment ISO RGD PMID:21122797 RGD:10413868 NCBI chrNW_004936494:9,537,793...9,541,187 JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:10408807 NCBI chrNW_004936627:635,784...641,290 JBrowse link
G Ngfr nerve growth factor receptor treatment ISO RGD PMID:22678884 RGD:10413900 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 treatment ISO RGD PMID:24842554 RGD:13204729 NCBI chrNW_004936475:3,708,069...3,742,845 JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA:increased expression:brain (mouse)
protein:increased expression:brain (rat)
RGD PMID:21959178 PMID:22020035 RGD:5508751 RGD:5509037 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment ISO protein:increased expression:brain RGD PMID:21120604 PMID:25069640 RGD:11035212 RGD:5133239 NCBI chrNW_004936475:19,771,384...19,785,034 JBrowse link
G Nrg1 neuregulin 1 treatment ISO RGD PMID:20691195 RGD:10449015 NCBI chrNW_004936766:1,104,841...1,306,368 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase treatment ISO associated with Hypertension RGD PMID:17920569 RGD:8657395 NCBI chrNW_004936602:3,411,106...3,418,826 JBrowse link
G Park7 Parkinsonism associated deglycase treatment ISO RGD PMID:17882163 RGD:13463450 NCBI chrNW_004936623:2,422,780...2,436,817 JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 treatment ISO RGD PMID:21311064 PMID:23143152 PMID:23801245 PMID:25882840 RGD:10054501 RGD:11073732 RGD:13792686 RGD:5683909 NCBI chrNW_004936526:3,102,468...3,147,601 JBrowse link
G Pawr pro-apoptotic WT1 regulator treatment ISO protein:increased expression:brain: RGD PMID:11323519 PMID:16403464 PMID:19352052 RGD:9835380 RGD:9835381 RGD:9850083 NCBI chrNW_004936698:650,225...746,593 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment ISO RGD PMID:16917016 RGD:11084934 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment ISO RGD PMID:16917016 RGD:11084934 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic RGD
CTD
PMID:12297567 PMID:14512838 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 RGD:1580876 NCBI chrNW_004936785:476,200...503,371 JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:11677890 PMID:15181847 PMID:17702958 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Pld1 phospholipase D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936593:844,634...1,049,478 JBrowse link
G Prkcg protein kinase C gamma ISO RGD PMID:14688616 RGD:1358416 NCBI chrNW_004936994:87,525...105,125 JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:24159062 RGD:11100027 NCBI chrNW_004936469:43,841,989...43,850,322 JBrowse link
G Ptprz1 protein tyrosine phosphatase receptor type Z1 ISO mRNA:increased expression:cerebral cortex RGD PMID:15869933 RGD:9590118 NCBI chrNW_004936605:3,195,893...3,368,102 JBrowse link
G Reln reelin severity ISO RGD PMID:16438965 RGD:13207538 NCBI chrNW_004936479:19,628,488...20,088,278 JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a treatment ISO RGD PMID:21840379 PMID:23275173 RGD:9850121 RGD:9850122 NCBI chrNW_004936483:9,753,112...9,792,817 JBrowse link
G Rpl28 ribosomal protein L28 ISO RGD PMID:16805800 RGD:6480229 NCBI chrNW_004936886:633,303...635,888 JBrowse link
G S100a5 S100 calcium binding protein A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936580:3,349,655...3,353,601 JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:14512838 RGD:1580876 NCBI chrNW_004936543:1,032,543...1,040,956 JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO RGD PMID:22714093 RGD:8655545 NCBI chrNW_004936538:7,885,816...7,898,308 JBrowse link
G Serpinh1 serpin family H member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936498:4,341,944...4,351,432 JBrowse link
G Shh sonic hedgehog signaling molecule treatment ISO RGD PMID:22324418 RGD:12879461 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link
G Sirt1 sirtuin 1 treatment ISO RGD PMID:23600725 RGD:9585664 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Slc12a2 solute carrier family 12 member 2 treatment ISO protein:increased expression:brain: RGD PMID:12535773 PMID:27798271 RGD:14398833 RGD:1580583 NCBI chrNW_004936504:1,378,812...1,465,463 JBrowse link
G Slc2a1 solute carrier family 2 member 1 treatment ISO RGD PMID:9419067 RGD:12879855 NCBI chrNW_004936474:24,205,878...24,236,611 JBrowse link
G Slc9a1 solute carrier family 9 member A1 treatment ISO RGD PMID:31250553 RGD:14985213 NCBI chrNW_004936474:11,460,266...11,517,420 JBrowse link
G Slpi secretory leukocyte peptidase inhibitor treatment ISO RGD PMID:14500739 RGD:9999390 NCBI chrNW_004936514:7,618,382...7,620,790 JBrowse link
G Smo smoothened, frizzled class receptor treatment ISO RGD PMID:23499832 PMID:23696546 RGD:12832759 RGD:12879404 NCBI chrNW_004936579:5,893,064...5,917,021 JBrowse link
G Smox spermine oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30576531 NCBI chrNW_004936485:14,566,570...14,603,323 JBrowse link
G Snap91 synaptosome associated protein 91 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chrNW_004936510:7,222,200...7,345,138 JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (rat) RGD PMID:22001340 PMID:22133807 RGD:8657021 RGD:8657023 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Sphk2 sphingosine kinase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:23043544 NCBI chrNW_004936664:2,668,708...2,676,608 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO RGD PMID:31409163 RGD:14995477 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Th tyrosine hydroxylase ISO protein:decreased expression:substantia nigra pars compacta, neuron (rat) RGD PMID:21366664 RGD:5128609 NCBI chrNW_004936794:478,651...486,887 JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:15647744 PMID:24916922 PMID:29498696 RGD:10450594 RGD:13792833 RGD:13825261 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936469:26,129,339...26,145,464 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:15647744 RGD:13825261 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Upp1 uridine phosphorylase 1 ISO mRNA, protein:increased expression:brain (rat) RGD PMID:18457515 RGD:2317094 NCBI chrNW_004936478:22,508,602...22,531,604 JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11962
    disease of anatomical entity 11526
      cardiovascular system disease 3188
        vascular disease 2291
          artery disease 1544
            cerebral arterial disease 184
              middle cerebral artery infarction 152
Path 2
Term Annotations click to browse term
  disease 11962
    disease of anatomical entity 11526
      nervous system disease 9457
        central nervous system disease 8005
          brain disease 7410
            cerebrovascular disease 750
              brain ischemia 491
                brain infarction 220
                  cerebral infarction 200
                    middle cerebral artery infarction 152
paths to the root