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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:breast carcinoma
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Accession:DOID:3459 term browser browse the term
Definition:A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. (DO)
Synonyms:exact_synonym: Mammary carcinoma;   breast carcinomas;   carcinoma of breast;   human mammary carcinoma;   human mammary carcinomas
 narrow_synonym: MULTIFOCAL BREAST CARCINOMA
 primary_id: RDO:9001794
 xref: NCI:C124249;   NCI:C4872
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
breast carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 ISO mRNA:increased expression:breast (human) RGD PMID:23556449 RGD:11041882 NCBI chrNW_004936535:3,956,490...3,985,002 JBrowse link
G Afdn afadin, adherens junction formation factor disease_progression ISO RGD PMID:16819513 RGD:13838725 NCBI chrNW_004936489:16,878,423...16,971,229 JBrowse link
G Amacr alpha-methylacyl-CoA racemase severity ISO RGD PMID:15941950 RGD:2315635 NCBI chrNW_004936518:7,072,436...7,088,927 JBrowse link
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:8940262 PMID:9288102 PMID:9585599 PMID:9724771 PMID:9731522 More... NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 disease_progression ISO protein:altered localization:cytoplasm RGD PMID:11748448 RGD:2315667 NCBI chrNW_004936877:666,545...669,351 JBrowse link
G Atm ATM serine/threonine kinase disease_progression ISO protein:decreased expression:lymph node
ClinVar Annotator: match by term: Breast carcinoma
ClinVar Annotator: match by term: Multifocal breast carcinoma
RGD
ClinVar
PMID:8755918 PMID:9463314 PMID:9887333 PMID:10330348 PMID:10748873 More... RGD:1643351 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Atp7b ATPase copper transporting beta severity ISO mRNA,protein:increased expression:breast RGD PMID:11802810 RGD:2292670 NCBI chrNW_004936565:4,694,294...4,763,661 JBrowse link
G Bard1 BRCA1 associated RING domain 1 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:20077502 PMID:21344236 PMID:25741868 PMID:28492532 PMID:28724667 NCBI chrNW_004936586:2,200,211...2,272,781 JBrowse link
G Bcl2l1 BCL2 like 1 ISO RGD PMID:16886624 RGD:1643480 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Bcl2l10 BCL2 like 10 treatment ISO RGD PMID:22207111 RGD:14392810 NCBI chrNW_004936471:13,943,600...13,946,085 JBrowse link
G Bin1 bridging integrator 1 ISO RGD PMID:10652430 RGD:1580043 NCBI chrNW_004936469:44,128,308...44,185,739 JBrowse link
G Brca1 BRCA1 DNA repair associated disease_progression ISO protein:altered localization:cytoplasm
ClinVar Annotator: match by term: Breast carcinoma
RGD
ClinVar
PMID:2144777 PMID:7795652 PMID:7837387 PMID:7894493 PMID:7939630 More... RGD:2293150 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Brca2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:8589730 PMID:8673089 PMID:8706004 PMID:9042907 PMID:9150155 More... NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Brip1 BRCA1 interacting helicase 1 ISO mRNA:increased expression:breast (human)
ClinVar Annotator: match by term: Breast carcinoma
RGD
ClinVar
PMID:12872252 PMID:16116423 PMID:17033622 PMID:18345034 PMID:18628483 More... RGD:11251773 NCBI chrNW_004936490:3,001,445...3,139,538 JBrowse link
G Ca9 carbonic anhydrase 9 disease_progression ISO RGD PMID:17245699 RGD:2293195 NCBI chrNW_004936524:3,672,393...3,678,630 JBrowse link
G Cadm1 cell adhesion molecule 1 severity ISO DNA:hypermethylation RGD PMID:17260099 RGD:2289088 NCBI chrNW_004936542:569,739...883,738 JBrowse link
G Casp3 caspase 3 disease_progression ISO protein:increased expression:breast RGD PMID:12107344 RGD:2293309 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Cav1 caveolin 1 ISO protein:increased expression:breast
DNA:missense mutation: :p.P132L (human)
RGD PMID:11289096 PMID:17915016 RGD:2289101 RGD:8661775 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Cbx7 chromobox 7 severity ISO protein:decreased expression:breast (human) RGD PMID:21779448 RGD:11352698 NCBI chrNW_004936492:2,411,171...2,428,484 JBrowse link
G Cd46 CD46 molecule disease_progression ISO protein:increased expression:very strong diffuse staining on carcinomas
protein:increased expression:tumor:significant association with tumor grade (p < 0.05), type (p < 0.001) and incidence of recurrence (p < 0.05)
RGD PMID:7532466 PMID:15378282 RGD:2293547 RGD:2293551 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) disease_progression ISO RGD PMID:12898600 RGD:2326192 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G Cd82 CD82 molecule ISO protein:decreased expression:breast RGD PMID:15958618 RGD:2289398
G Cd9 CD9 molecule disease_progression ISO RGD PMID:16132579 RGD:2326200 NCBI chrNW_004936709:1,497,504...1,530,114 JBrowse link
G Cdc25a cell division cycle 25A disease_progression ISO RGD PMID:19555767 RGD:2734052 NCBI chrNW_004936596:1,657,411...1,680,109 JBrowse link
G Cdc25b cell division cycle 25B disease_progression ISO RGD PMID:15550849 RGD:4105449 NCBI chrNW_004936485:14,897,050...14,914,034 JBrowse link
G Cdh1 cadherin 1 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:25741868 PMID:28492532 PMID:29805042 NCBI chrNW_004936475:18,990,529...19,065,954 JBrowse link
G Cdh13 cadherin 13 ISO DNA:hypermethylation:promoter RGD PMID:11389090 RGD:2293545 NCBI chrNW_004936641:3,925,185...4,223,421 JBrowse link
G Cdk4 cyclin dependent kinase 4 ISO DNA:amplification RGD PMID:9916925 RGD:2293583 NCBI chrNW_004936646:1,886,262...1,889,260 JBrowse link
G Chek2 checkpoint kinase 2 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:9536098 PMID:10617473 PMID:11053450 PMID:11479205 PMID:11719428 More... NCBI chrNW_004936657:2,805,947...2,848,180 JBrowse link
G CUNH11orf65 chromosome unknown C11orf65 homolog ISO ClinVar Annotator: match by term: Multifocal breast carcinoma
ClinVar Annotator: match by term: Breast carcinoma
ClinVar NCBI chrNW_004936551:305,617...343,369 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 susceptibility ISO DNA:polymorphism (human) RGD PMID:15978329 RGD:2317609 NCBI chrNW_004936617:4,224,131...4,239,080 JBrowse link
G Dcn decorin ISO RGD PMID:18688028 RGD:2311418 NCBI chrNW_004936507:7,887,259...7,923,055 JBrowse link
G Egfr epidermal growth factor receptor disease_progression ISO DNA:amplification:cds, 3' utr (human) RGD PMID:18413808 PMID:18522728 RGD:2293728 RGD:2293732 NCBI chrNW_004936678:365,005...560,546 JBrowse link
G Eno2 enolase 2 ISO RGD PMID:16608642 RGD:2293740 NCBI chrNW_004936709:904,647...913,445 JBrowse link
G Ep300 E1A binding protein p300 ISO protein:increased expression:breast RGD PMID:12725419 RGD:2289908 NCBI chrNW_004936492:696,982...778,132 JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:8797827 PMID:9579555 PMID:20221251 PMID:21228398 PMID:21612988 More... NCBI chrNW_004936501:2,301,072...2,329,346 JBrowse link
G Esr1 estrogen receptor 1 severity
disease_progression
ISO mRNA, protein:increased expression:breast
protein:increased serine phosphorylation
RGD PMID:15355923 PMID:18234277 RGD:2290017 RGD:8552986 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Fas Fas cell surface death receptor ISO protein:decreased expression:breast RGD PMID:15792116 RGD:2290130 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Fzd1 frizzled class receptor 1 ISO protein:increased expression:tumor RGD PMID:15492823 RGD:2298699 NCBI chrNW_004936621:2,899,183...2,903,427 JBrowse link
G Fzd2 frizzled class receptor 2 ISO protein:increased expression:breast RGD PMID:15492823 RGD:2298699 NCBI chrNW_004936541:965,135...967,018 JBrowse link
G Hdac1 histone deacetylase 1 ISO RGD PMID:16172792 RGD:2306216 NCBI chrNW_004936474:15,320,635...15,351,418 JBrowse link
G Igf2r insulin like growth factor 2 receptor ISO protein:increased expression:serum,urine: RGD PMID:29940770 RGD:14985218 NCBI chrNW_004936489:11,447,043...11,523,695 JBrowse link
G Kdm6b lysine demethylase 6B ISO mRNA:increased expression:breast (human) RGD PMID:23152497 RGD:9587818 NCBI chrNW_004936595:1,077,318...1,099,082 JBrowse link
G Kdr kinase insert domain receptor severity
no_association
ISO protein:increased expression:tumor:correlated with nuclear grade of invasive carcinomas (p=0.003)
protein::tumor:no correlation with survival, metastasis or relapse in univariate analysis
RGD PMID:12378509 PMID:15753992 RGD:2291950 RGD:2291952 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Klk6 kallikrein related peptidase 6 ISO RGD PMID:18992199 RGD:2314863 NCBI chrNW_004936889:621,645...628,454 JBrowse link
G LOC101969640 C-reactive protein severity ISO RGD PMID:14648971 RGD:9585643 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 ISO protein:decreased expression:breast (human) RGD PMID:17546051 RGD:9589053 NCBI chrNW_004936837:363,870...379,406 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:21970370 PMID:25741868 PMID:28166811 PMID:28259294 PMID:28492532 More... NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:15713769 PMID:16083711 PMID:17510385 PMID:20533529 PMID:21404117 More... NCBI chrNW_004936473:26,556,636...26,600,830 JBrowse link
G Mlh3 mutL homolog 3 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:25741868 NCBI chrNW_004936488:4,164,322...4,195,408 JBrowse link
G Mmp14 matrix metallopeptidase 14 disease_progression ISO RGD PMID:9158005 RGD:2314951 NCBI chrNW_004936722:1,447,189...1,457,632 JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO protein:decreased expression:tumor (human)
ClinVar Annotator: match by term: Breast carcinoma
DNA:polymorphisms:intron, exon:multiple (human)
RGD
ClinVar
PMID:14511253 PMID:19383352 PMID:23080121 PMID:23912341 PMID:28492532 RGD:2300250 RGD:2317721 NCBI chrNW_004936674:466,495...528,072 JBrowse link
G Msh2 mutS homolog 2 severity
disease_progression
ISO ClinVar Annotator: match by term: Breast carcinoma
protein:decreased expression:breast
RGD
ClinVar
PMID:6096739 PMID:8062247 PMID:8872463 PMID:8895729 PMID:9036882 More... RGD:2293505 RGD:2293507 RGD:2293524 NCBI chrNW_004936508:4,943,987...5,013,356 JBrowse link
G Msh6 mutS homolog 6 ISO protein:decreased expression:breast
ClinVar Annotator: match by term: Breast carcinoma
RGD
ClinVar
PMID:8838326 PMID:10537275 PMID:10699937 PMID:11470537 PMID:12019211 More... RGD:2293505 RGD:2293507 NCBI chrNW_004936508:4,708,661...4,728,671 JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO mRNA, protein:decreased expression:breast carcinoma (human) RGD PMID:19794912 RGD:2317017 NCBI chrNW_004936614:242,710...387,541 JBrowse link
G Mutyh mutY DNA glycosylase ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:11818965 PMID:12606733 PMID:15931596 PMID:15987719 PMID:16134147 More... NCBI chrNW_004936474:26,484,316...26,492,652 JBrowse link
G Nbn nibrin ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:9590180 PMID:9620777 PMID:10398434 PMID:10852373 PMID:11093281 More... NCBI chrNW_004936544:3,773,828...3,812,673 JBrowse link
G Ncoa1 nuclear receptor coactivator 1 severity ISO RGD PMID:17902051 RGD:2293529 NCBI chrNW_004936493:7,368,393...7,605,754 JBrowse link
G Ncoa3 nuclear receptor coactivator 3 severity ISO protein:increased expression:breast (human) RGD PMID:12725419 RGD:2289908 NCBI chrNW_004936514:5,900,135...5,967,862 JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:17200668 PMID:18302019 PMID:18987736 PMID:19763884 PMID:20091115 More... NCBI chrNW_004936501:8,246,927...8,273,258 JBrowse link
G Parl presenilin associated rhomboid like severity ISO mRNA:increased expression:breast (human) RGD PMID:24185965 RGD:12902629 NCBI chrNW_004936578:5,945,765...5,992,972 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha disease_progression ISO protein:increased expression:breast RGD PMID:16741576 RGD:2292178 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta disease_progression ISO protein:increased expression:breast RGD PMID:16741576 RGD:2292178 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Plcg1 phospholipase C gamma 1 ISO protein:increased expression:breast RGD PMID:1683701 RGD:2299875 NCBI chrNW_004936561:598,372...631,575 JBrowse link
G Plk1 polo like kinase 1 severity ISO protein:increased expression:breast RGD PMID:15785925 RGD:2299942 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Plk3 polo like kinase 3 disease_progression ISO protein:increased expression:breast RGD PMID:15785925 RGD:2299942 NCBI chrNW_004936474:26,026,878...26,032,098 JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar NCBI chrNW_004936750:439,396...468,747 JBrowse link
G Prc1 protein regulator of cytokinesis 1 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar NCBI chrNW_004936483:16,034,577...16,061,856 JBrowse link
G Prss8 serine protease 8 ISO RGD PMID:11774283 RGD:2292485 NCBI chrNW_004936501:13,487,863...13,491,837 JBrowse link
G Psmb9 proteasome 20S subunit beta 9 ISO protein:altered expression:tumor (rat) RGD PMID:21889127 RGD:9854639 NCBI chrNW_004936476:25,894,313...25,899,132 JBrowse link
G Ptch1 patched 1 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936626:4,241,993...4,301,919 JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link
G Rad50 RAD50 double strand break repair protein ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:16385572 PMID:19409520 PMID:25741868 PMID:26023681 PMID:28492532 NCBI chrNW_004936647:2,546,100...2,637,524 JBrowse link
G Rad51c RAD51 paralog C ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:20400964 PMID:21990120 PMID:22538716 PMID:22725699 PMID:23117857 More... NCBI chrNW_004936490:4,440,638...4,473,301 JBrowse link
G Rad51d RAD51 paralog D ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:21822267 PMID:25741868 PMID:26720727 PMID:26720728 PMID:28492532 More... NCBI chrNW_004936538:119,409...132,830 JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:17007568 RGD:2298868 NCBI chrNW_004936529:1,000,050...1,045,655 JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 ISO protein:increased expression:tumor (human) RGD PMID:21556566 RGD:5133696 NCBI chrNW_004936532:6,348,041...6,390,144 JBrowse link
G Smad2 SMAD family member 2 disease_progression ISO RGD PMID:11809701 RGD:2300007 NCBI chrNW_004936497:14,723,199...14,812,160 JBrowse link
G Snw1 SNW domain containing 1 severity ISO protein:increased expression:breast (human) RGD PMID:24150787 RGD:11035252 NCBI chrNW_004936488:6,494,556...6,531,297 JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 ISO mRNA:increased expression:breast RGD PMID:15212687 RGD:2302558 NCBI chrNW_004936634:758,231...798,809 JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 ISO mRNA:increased expression:breast RGD PMID:15212687 RGD:2302558 NCBI chrNW_004936493:1,663,999...1,708,530 JBrowse link
G Stat1 signal transducer and activator of transcription 1 disease_progression ISO protein:increased activity:breast RGD PMID:12374673 RGD:2291894 NCBI chrNW_004936506:7,196,860...7,235,854 JBrowse link
G Stk11 serine/threonine kinase 11 ISO protein:decreased expression:breast
ClinVar Annotator: match by term: Breast carcinoma
RGD
ClinVar
PMID:16287113 PMID:16785781 PMID:17676035 PMID:24033266 PMID:25186627 More... RGD:2291945 NCBI chrNW_004936588:579,816...601,033 JBrowse link
G Tert telomerase reverse transcriptase ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:15814878 PMID:17460043 PMID:18753630 PMID:18931339 PMID:19147845 More... NCBI chrNW_004936815:468,987...492,666 JBrowse link
G Tfrc transferrin receptor ISO RGD PMID:11497259 RGD:2292020 NCBI chrNW_004936784:696,738...728,385 JBrowse link
G Thoc5 THO complex 5 ISO DNA:missense mutations:cds:c.1139C>A, c.1495G>A (human) RGD PMID:16959974 RGD:2317225 NCBI chrNW_004936657:3,465,707...3,503,966 JBrowse link
G Thrb thyroid hormone receptor beta ISO DNA:loss of heterozygosity (human) RGD PMID:2573734 RGD:2315100 NCBI chrNW_004936473:15,766,214...15,986,389 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 disease_progression ISO associated with Tumor Virus Infections;DNA:hypermethylation:promoter
protein:decreased expression:breast
RGD PMID:17032447 PMID:18205041 RGD:2290409 RGD:2290413 NCBI chrNW_004936492:6,996,627...7,046,137 JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:1565143 PMID:1683921 PMID:7887414 PMID:8118819 PMID:9242456 More... NCBI chrNW_004936595:919,807...935,367 JBrowse link
G Tsg101 tumor susceptibility 101 susceptibility ISO DNA:deletions RGD PMID:9019400 RGD:1600429 NCBI chrNW_004936590:61,352...62,037 JBrowse link
G Vegfc vascular endothelial growth factor C ISO RGD PMID:19382240 RGD:2315477 NCBI chrNW_004936516:7,217,543...7,332,531 JBrowse link
G Wnt2 Wnt family member 2 disease_progression ISO DNA:amplification:breast RGD PMID:7903963 RGD:2291879 NCBI chrNW_004936589:1,825,209...1,866,898 JBrowse link
G Zfhx3 zinc finger homeobox 3 disease_progression ISO RGD PMID:15671546 RGD:2315696 NCBI chrNW_004936475:21,005,242...21,235,992 JBrowse link
bilateral breast cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO ClinVar Annotator: match by term: Bilateral Breast Carcinoma ClinVar PMID:19781682 PMID:25741868 PMID:26689913 PMID:26787654 PMID:28492532 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Brca1 BRCA1 DNA repair associated ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar PMID:9150151 PMID:11376024 PMID:16683254 PMID:19491284 PMID:20104584 More... NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Brca2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Mc1r melanocortin 1 receptor ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar PMID:16809487 PMID:16982779 PMID:24335900 PMID:24982914 PMID:25741868 More... NCBI chrNW_004936641:193,885...198,730 JBrowse link
G Msh6 mutS homolog 6 ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar PMID:23047549 PMID:23621914 PMID:25741868 PMID:26467025 PMID:26689913 More... NCBI chrNW_004936508:4,708,661...4,728,671 JBrowse link
G Palb2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar PMID:20852946 PMID:22692731 PMID:24448499 PMID:24556926 PMID:25186627 More... NCBI chrNW_004936501:8,246,927...8,273,258 JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar PMID:17102082 PMID:19351833 PMID:20208144 PMID:21520333 PMID:23175444 More... NCBI chrNW_004936474:3,993,224...4,021,359 JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO ClinVar Annotator: match by term: bilateral breast cancer ClinVar PMID:28492532 NCBI chrNW_004936659:1,152,846...1,246,718 JBrowse link
breast adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Breast adenocarcinoma, somatic ClinVar PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More... NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Brca1 BRCA1 DNA repair associated treatment ISO RGD PMID:8589721 RGD:126925966 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Cat catalase ISO RGD PMID:25050522 RGD:9226881 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Ccne1 cyclin E1 ISO DNA:amplification RGD PMID:18089785 RGD:2289225 NCBI chrNW_004936570:5,536,817...5,547,880 JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 no_association ISO DNA:mutation:exons:no mutations found in mutation hotspots in exons 7, 10 or 15 RGD PMID:11466624 RGD:2289868 NCBI chrNW_004936477:21,591,772...21,606,289 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Breast adenocarcinoma, somatic ClinVar PMID:2278970 PMID:2547513 PMID:3122217 PMID:3627975 PMID:12460918 More... NCBI chrNW_004936548:2,078,568...2,113,877 JBrowse link
G Ksr1 kinase suppressor of ras 1 severity ISO RGD PMID:24909178 RGD:127229932 NCBI chrNW_004936538:3,945,411...4,006,300 JBrowse link
G LOC101970101 cytochrome P450 1B1 ISO mRNA:increased expression:mammary epithelium (rat) RGD PMID:11097088 RGD:7829735 NCBI chrNW_004936663:345,021...355,188 JBrowse link
G Muc1 mucin 1, cell surface associated ISO mRNA,protein:increased expression:breast RGD PMID:7678777 RGD:2324855 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Mxi1 MAX interactor 1, dimerization protein ISO RGD PMID:10849326 RGD:1298988 NCBI chrNW_004936486:1,103,908...1,173,982 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO ClinVar Annotator: match by term: Breast adenocarcinoma, somatic ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chrNW_004936566:3,924,013...3,951,052 JBrowse link
G Rb1cc1 RB1 inducible coiled-coil 1 ISO ClinVar Annotator: match by term: Breast adenocarcinoma ClinVar PMID:12068296 NCBI chrNW_004936590:260,685...335,143 JBrowse link
G Slc22a18 solute carrier family 22 member 18 ISO ClinVar Annotator: match by term: Breast adenocarcinoma ClinVar PMID:9520460 NCBI chrNW_004936794:1,042,103...1,061,347 JBrowse link
G Tnf tumor necrosis factor ISO human protein in a rat model RGD PMID:12536235 RGD:14995452 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Breast adenocarcinoma, somatic ClinVar PMID:1673792 PMID:1686725 PMID:7881428 PMID:8364550 PMID:10713666 More... NCBI chrNW_004936595:919,807...935,367 JBrowse link
breast carcinoma in situ term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf2r insulin like growth factor 2 receptor ISO DNA:loss of heterozygosity RGD PMID:8649861 RGD:2311631 NCBI chrNW_004936489:11,447,043...11,523,695 JBrowse link
breast ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936548:4,983,461...5,110,693 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Amfr autocrine motility factor receptor ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936475:8,692,969...8,727,252 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO RGD PMID:11605729 RGD:1579979 NCBI chrNW_004936475:23,994,130...24,032,829 JBrowse link
G Brca1 BRCA1 DNA repair associated ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:9063749 PMID:10196379 PMID:11400546 PMID:14555511 PMID:15235020 More... NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Brca2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:11062481 PMID:11927503 PMID:14555511 PMID:15235023 PMID:17767707 More... NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Bsg basigin (Ok blood group) ISO mRNA:increased expression:breast RGD PMID:9154157 RGD:2289059 NCBI chrNW_004936588:181,688...189,795 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936606:2,168,104...2,867,560 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:26467025 PMID:27148582 PMID:28492532 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G Ccdc180 coiled-coil domain containing 180 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936524:6,168,334...6,230,934 JBrowse link
G Ccdc71l coiled-coil domain containing 71 like ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004939850:3,101...4,265 JBrowse link
G Cd44 CD44 molecule (Indian blood group) disease_progression ISO mRNA, protein:splice variant, increased expression:breast RGD PMID:16425351 RGD:2289356 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936636:646,309...699,768 JBrowse link
G Coro6 coronin 6 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936538:5,724,336...5,732,487 JBrowse link
G Cpamd8 C3 and PZP like alpha-2-macroglobulin domain containing 8 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936596:3,756,446...3,819,840 JBrowse link
G Cpxm2 carboxypeptidase X, M14 family member 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936486:12,250,128...12,335,578 JBrowse link
G Creb3 cAMP responsive element binding protein 3 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936524:3,727,104...3,730,962 JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 severity ISO protein:increased expression:breast RGD PMID:12054692 RGD:2298489 NCBI chrNW_004936470:35,449,920...35,473,635 JBrowse link
G Fubp1 far upstream element binding protein 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936571:4,729,135...4,760,943 JBrowse link
G Htra2 HtrA serine peptidase 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936556:741,718...746,016 JBrowse link
G Kndc1 kinase non-catalytic C-lobe domain containing 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936486:19,287,468...19,341,127 JBrowse link
G LOC101966782 keratin-associated protein 10-12 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936778:1,582,160...1,583,314 JBrowse link
G LOC101974254 X-linked inhibitor of apoptosis severity ISO RGD PMID:17350670 RGD:2315853 NCBI chrNW_004936479:6,677,533...6,724,800 JBrowse link
G Lrat lecithin retinol acyltransferase ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936576:1,491,480...1,498,568 JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936528:6,217,130...6,349,891 JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
G Nts neurotensin ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936507:3,318,982...3,329,248 JBrowse link
G Phf24 PHD finger protein 24 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936524:3,020,421...3,031,720 JBrowse link
G Plk4 polo like kinase 4 ISO protein:increased expression:breast RGD PMID:26439168 RGD:11075990 NCBI chrNW_004936642:2,837,041...2,855,369 JBrowse link
G Pml PML nuclear body scaffold ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936471:33,135,186...33,173,218 JBrowse link
G Rad54l RAD54 like ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:10362365 NCBI chrNW_004936474:27,276,570...27,316,427 JBrowse link
G Rnf212 ring finger protein 212 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936477:22,122,854...22,173,324 JBrowse link
G Rp1 RP1 axonemal microtubule associated ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936496:1,524,123...1,583,114 JBrowse link
G Rrp1 ribosomal RNA processing 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936500:475,213...488,475 JBrowse link
G Slitrk6 SLIT and NTRK like family member 6 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936866:412,719...419,381 JBrowse link
G Spen spen family transcriptional repressor ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936474:3,473,892...3,535,307 JBrowse link
G Syt6 synaptotagmin 6 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936690:2,435,573...2,497,332 JBrowse link
G Tp73 tumor protein p73 ISO mRNA:decreased expression:breast RGD PMID:17011986 RGD:2290492 NCBI chrNW_004936737:171,894...211,464 JBrowse link
G Tspan8 tetraspanin 8 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936568:285,130...304,479 JBrowse link
G Tspear thrombospondin type laminin G domain and EAR repeats ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936778:1,576,580...1,660,344 JBrowse link
G Yeats2 YEATS domain containing 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936578:6,004,427...6,075,414 JBrowse link
G Zdbf2 zinc finger DBF-type containing 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936631:2,649,792...2,686,430 JBrowse link
G Znf420 zinc finger protein 420 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936801:338,743...403,206 JBrowse link
G Znf473 zinc finger protein 473 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chrNW_004936889:39,812...56,052 JBrowse link
breast lobular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8389152 NCBI chrNW_004936479:13,252,678...13,255,570 JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8557030 PMID:17660459 NCBI chrNW_004936475:18,990,529...19,065,954 JBrowse link
G Myh9 myosin heavy chain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28650484 NCBI chrNW_004936492:4,384,215...4,466,229 JBrowse link
G Ppp1r12b protein phosphatase 1 regulatory subunit 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28650484 NCBI chrNW_004936567:1,992,487...2,208,611 JBrowse link
G Tp53bp2 tumor protein p53 binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28650484 NCBI chrNW_004936526:936,981...1,000,070 JBrowse link
ductal carcinoma in situ term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang angiogenin ISO protein:increased expression:breast RGD PMID:15776477 RGD:2325702 NCBI chrNW_004936880:39,372...40,070 JBrowse link
G Anxa1 annexin A1 ISO protein:decreased expression:mammary gland RGD PMID:22323911 RGD:7421537 NCBI chrNW_004936503:9,124,314...9,142,372 JBrowse link
G Ar androgen receptor ISO RGD PMID:17543076 RGD:1643341 NCBI chrNW_004936635:485,903...647,820 JBrowse link
G Areg amphiregulin ISO protein:increased expression:breast RGD PMID:8543395 RGD:2292664 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Bcl2 BCL2 apoptosis regulator disease_progression ISO RGD PMID:12628841 RGD:2289659 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Birc5 baculoviral IAP repeat containing 5 disease_progression ISO protein:increased expression:breast RGD PMID:16421596 RGD:2293106 NCBI chrNW_004936594:2,812,165...2,820,618 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:14648660 RGD:7483575 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G Brca1 BRCA1 DNA repair associated treatment ISO RGD PMID:25861310 RGD:127284854 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Brca2 BRCA2 DNA repair associated onset
treatment
ISO DNA:missense mutation: :5972C>T RGD PMID:16280055 PMID:25861310 RGD:127284854 RGD:2289048 NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Ca9 carbonic anhydrase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chrNW_004936524:3,672,393...3,678,630 JBrowse link
G Casp6 caspase 6 ISO protein:increased expression:breast RGD PMID:10574243 RGD:2301339 NCBI chrNW_004936563:912,502...920,025 JBrowse link
G Ccnd1 cyclin D1 ISO protein:decreased expression:breast RGD PMID:14612904 RGD:2289132
G Ccnd2 cyclin D2 ISO DNA:hypermethylation:promoter, breast RGD PMID:14601057 RGD:2289156 NCBI chrNW_004936606:4,474,801...4,496,158 JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A disease_progression ISO protein:increased expression:breast RGD PMID:12628841 RGD:2289659 NCBI chrNW_004936476:22,717,308...22,725,127 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO protein:increased expression:breast RGD PMID:15788662 PMID:17119686 RGD:2289931 RGD:2289981 NCBI chrNW_004936490:14,887,062...14,910,038 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:9470844 RGD:2289952 NCBI chrNW_004936646:497,783...515,247 JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:15788662 RGD:2289981 NCBI chrNW_004936586:4,065,767...5,100,690 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO associated with Carcinoma, Ductal, Breast RGD PMID:15841074 RGD:2289965 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:breast RGD PMID:17254320 RGD:2293756 NCBI chrNW_004936599:3,642,504...3,649,294 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism
protein:altered localization:nucleus
CTD
RGD
PMID:16080559 PMID:20526721 RGD:2306227 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hoxb13 homeobox B13 ISO DNA:hypermethylation RGD PMID:19250546 RGD:2314726 NCBI chrNW_004936490:12,688,572...12,690,908 JBrowse link
G Ldhb lactate dehydrogenase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:23437403 NCBI chrNW_004936548:5,224,905...5,244,708 JBrowse link
G LOC101977033 thymidine phosphorylase ISO RGD PMID:9306962 RGD:2293726 NCBI chrNW_004936629:315,609...320,356 JBrowse link
G LOC106145452 kallikrein-10 disease_progression ISO mRNA:decreased expression:breast RGD PMID:12788170 RGD:2314849 NCBI chrNW_004936889:663,114...666,067 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:breast RGD PMID:17642161 RGD:2290392 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:breast RGD PMID:14744773 RGD:2290436 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:17440163 RGD:2299156 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 ISO RGD PMID:22886747 RGD:7775026 NCBI chrNW_004936784:1,351,034...1,391,992 JBrowse link
G Pgr progesterone receptor disease_progression ISO RGD PMID:12628841 RGD:2289659 NCBI chrNW_004936551:6,498,553...6,573,212 JBrowse link
G Prkca protein kinase C alpha ISO protein:decreased expression:breast RGD PMID:15454252 RGD:2292458 NCBI chrNW_004936541:6,231,604...6,488,201 JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:breast RGD PMID:16353170 RGD:2300083 NCBI chrNW_004936487:16,959,263...16,968,909 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 disease_progression ISO mRNA, protein:decreased expression:breast RGD PMID:18199541 PMID:18237383 RGD:2300199 RGD:2300203 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO protein:increased expression:breast RGD PMID:15564794 RGD:2292561 NCBI chrNW_004936470:10,379,855...10,578,531 JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO mRNA, protein:decreased expression:breast RGD PMID:15312366 RGD:2299890 NCBI chrNW_004936565:1,596,227...1,746,706 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO DNA:amplification RGD PMID:17375183 RGD:2298754 NCBI chrNW_004936599:3,800,142...3,810,583 JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chrNW_004936474:24,205,878...24,236,611 JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chrNW_004936507:10,013,982...10,015,480 JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chrNW_004936594:2,932,297...2,935,358 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase severity ISO protein:increased activity:breast RGD PMID:17060931 RGD:2315078 NCBI chrNW_004936561:3,826,802...3,844,406 JBrowse link
G St14 ST14 transmembrane serine protease matriptase ISO protein:increased expression:breast RGD PMID:17163404 RGD:2315089 NCBI chrNW_004936572:2,137,820...2,182,674 JBrowse link
G Tert telomerase reverse transcriptase ISO mRNA:decreased expression:breast RGD PMID:15010825 RGD:2291992 NCBI chrNW_004936815:468,987...492,666 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO protein:increased expression:breast RGD PMID:14744773 RGD:2290436 NCBI chrNW_004936594:3,232,433...3,244,241 JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 ISO protein:increased expression:breast RGD PMID:14744773 RGD:2290436 NCBI chrNW_004936602:1,488,993...1,496,108 JBrowse link
G Top2a DNA topoisomerase II alpha severity ISO protein:increased expression:breast RGD PMID:11070118 RGD:2315133 NCBI chrNW_004936490:15,441,463...15,465,692 JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:breast
ClinVar Annotator: match by term: Ductal carcinoma in situ
RGD
ClinVar
PMID:1565143 PMID:1683921 PMID:7887414 PMID:9242456 PMID:9569050 More... RGD:2289931 NCBI chrNW_004936595:919,807...935,367 JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:breast RGD PMID:19623180 RGD:2315458 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
Ehrlich tumor carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule treatment ISO RGD PMID:19269163 RGD:11352683 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:19269163 RGD:11352683 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
invasive ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 disease_progression ISO RGD PMID:19879256 RGD:2315549 NCBI chrNW_004936763:1,225,355...1,308,257 JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO protein:increased expression:breast RGD PMID:22366088 RGD:8695990 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO DNA:missense mutation:p.E17K (human) RGD PMID:18392055 RGD:13209138 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Anxa1 annexin A1 treatment ISO RGD PMID:18776816 PMID:19171478 RGD:7421535 RGD:7421560 NCBI chrNW_004936503:9,124,314...9,142,372 JBrowse link
G Anxa2 annexin A2 treatment ISO RGD PMID:19171478 RGD:7421560 NCBI chrNW_004936471:21,274,112...21,329,286 JBrowse link
G Ar androgen receptor severity ISO RGD PMID:16075292 RGD:1643344 NCBI chrNW_004936635:485,903...647,820 JBrowse link
G Areg amphiregulin ISO RGD PMID:11523048 RGD:2292660 NCBI chrNW_004936598:1,276,599...1,283,612 JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 ISO protein:increased expression:breast (human) RGD PMID:21136934 RGD:11049179 NCBI chrNW_004936569:758,358...786,995 JBrowse link
G Atf4 activating transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14604972 NCBI chrNW_004936492:2,114,478...2,115,969 JBrowse link
G Aurka aurora kinase A ISO protein:altered expression RGD PMID:14693746 RGD:1643348 NCBI chrNW_004936875:295,238...310,457 JBrowse link
G Bag1 BAG cochaperone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19066611 NCBI chrNW_004936524:1,793,001...1,804,145 JBrowse link
G Brca1 BRCA1 DNA repair associated ISO ClinVar Annotator: match by term: Infiltrating duct carcinoma of breast ClinVar PMID:7493024 PMID:11179017 PMID:11956590 PMID:12698193 PMID:12955716 More... NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Brca2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Infiltrating duct carcinoma of breast
ClinVar Annotator: match by term: Invasive Ductal Carcinoma, Not Otherwise Specified
ClinVar PMID:14973102 PMID:15145354 PMID:17899372 PMID:18627636 PMID:18779604 More... NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Brms1 BRMS1 transcriptional repressor and anoikis regulator disease_progression ISO mRNA, protein:decreased expression:brain metastases:10-fold lower expression in metastases vs primary tumors RGD PMID:15592684 RGD:2289400 NCBI chrNW_004936599:3,259,868...3,267,172 JBrowse link
G Cav1 caveolin 1 no_association ISO DNA:missense mutation: :p.P132L (human) RGD PMID:21909981 RGD:8661779 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:breast, ductal carcinoma (human) RGD PMID:18790652 RGD:4891911 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Ccnd3 cyclin D3 severity ISO protein:increased expression:breast RGD PMID:11329139 RGD:2316016 NCBI chrNW_004936476:17,799,754...17,886,835 JBrowse link
G Cd44 CD44 molecule (Indian blood group) disease_progression ISO protein:increased expression:breast RGD PMID:17059779 RGD:2289352 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8557030 PMID:17660459 NCBI chrNW_004936475:18,990,529...19,065,954 JBrowse link
G Cldn4 claudin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19142967 NCBI chrNW_004936543:2,984,797...2,986,563 JBrowse link
G Clu clusterin ISO RGD PMID:10934144 RGD:8699513 NCBI chrNW_004936675:499,745...513,515 JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein disease_progression ISO protein:increased expression:breast RGD PMID:23686806 RGD:7488897 NCBI chrNW_004936619:2,447,686...2,479,589 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO DNA:mutation:CDS:multiple nonsynonymous mutations RGD PMID:14871824 RGD:2306813 NCBI chrNW_004936833:551,989...843,064 JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 ISO mRNA, protein:increased expression:breast RGD PMID:11742495 RGD:2289858 NCBI chrNW_004936470:35,449,920...35,473,635 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28235801 NCBI chrNW_004936490:14,887,062...14,910,038 JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:14532106 RGD:9588325 NCBI chrNW_004936527:5,024,077...5,069,152 JBrowse link
G Fgd1 FYVE, RhoGEF and PH domain containing 1 ISO protein:increased expression:breast (human) RGD PMID:19141649 RGD:11554027 NCBI chrNW_004936751:1,355,606...1,397,282 JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO DNA:loss of heterozygosity,hypermethylation:breast:LOH in 8/40 tumors (20%), hypermethylation in 22/46 tumors (48%), significant positive association found (p=0.04) RGD PMID:12231533 RGD:2289894 NCBI chrNW_004936473:397,140...1,424,805 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:altered localization:nucleus RGD PMID:16080559 RGD:2306227 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hoxb7 homeobox B7 ISO mRNA:increased expression:breast epithelium (human) RGD PMID:17018609 RGD:10402178 NCBI chrNW_004936490:12,777,005...12,780,515 JBrowse link
G Hsd17b1 hydroxysteroid 17-beta dehydrogenase 1 severity ISO protein:decreased expression:ductal breast carcinoma (human) RGD PMID:10682658 RGD:4890946 NCBI chrNW_004936490:17,312,390...17,314,423 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:breast RGD PMID:22135852 RGD:8549515 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:breast RGD PMID:21263407 RGD:8655888 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Inha inhibin subunit alpha ISO protein:decreased expression:tumor:significantly lower in invasive, infiltrating and metastatic tumors than in ductal carcinoma in situ tumors RGD PMID:15583806 RGD:2290390 NCBI chrNW_004936569:1,949,747...1,954,179 JBrowse link
G Kiss1 KiSS-1 metastasis suppressor disease_progression ISO mRNA, protein:decreased expression:brain metastases:10-fold lower expression in metastases vs primary tumors RGD PMID:15592684 RGD:2289400 NCBI chrNW_004936567:584,443...595,045 JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase severity ISO protein:decreased expression:tumor:loss of expression associated with lymph node metastasis (p<0.0001) and reduced disease-free survival (p=0.0041) RGD PMID:16721362 RGD:2292426 NCBI chrNW_004936482:17,162,854...17,238,319 JBrowse link
G LOC101960169 junction plakoglobin disease_progression ISO protein:decreased expression:tumor:associated with higher Robinson grade (p=0.016) and lymph node metastases (p=0.012) RGD PMID:16610682 RGD:2291882 NCBI chrNW_004936490:16,671,176...16,694,552 JBrowse link
G LOC101964702 adhesion G protein-coupled receptor B1 disease_progression ISO RGD PMID:25376607 RGD:13831358 NCBI chrNW_004936470:9,247,749...9,313,230 JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 disease_progression ISO mRNA, protein:decreased expression:brain metastases:10-fold lower expression in metastases vs primary tumors RGD PMID:15592684 RGD:2289400 NCBI chrNW_004936595:4,762,327...4,828,433 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase severity ISO protein:increased expression:tumor (human) RGD PMID:10590366 RGD:2317607 NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
G Mmp13 matrix metallopeptidase 13 disease_progression ISO mRNA, protein:increased expression:tumor:associated with microinvasion during the transition from ductal carcinoma in situ to invasive carcinoma, also expressed in all invasive ductal carcinomas tested RGD PMID:11585740 RGD:2293606 NCBI chrNW_004936551:5,040,084...5,050,384 JBrowse link
G Ncoa4 nuclear receptor coactivator 4 ISO protein:decreased expression:breast RGD PMID:11561770 RGD:2293536 NCBI chrNW_004936728:376,915...402,539 JBrowse link
G Nefl neurofilament light chain ISO DNA:loss of heterozygosity RGD PMID:8814452 RGD:2298999 NCBI chrNW_004936757:1,642,122...1,646,499 JBrowse link
G Pcna proliferating cell nuclear antigen severity ISO RGD PMID:8102204 RGD:2315014 NCBI chrNW_004936485:13,766,221...13,771,215 JBrowse link
G Prkci protein kinase C iota disease_progression ISO protein:increased expression, altered localization:breast, cytoplasm RGD PMID:18538170 RGD:2314932 NCBI chrNW_004936593:2,170,539...2,236,904 JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11751431 NCBI chrNW_004936659:3,014,633...3,018,617 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21153458 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Rad50 RAD50 double strand break repair protein ISO protein:decreased expression:tumor:reduced in 28% vs adjacent or independent normal breast tissue RGD PMID:14511253 RGD:2300250 NCBI chrNW_004936647:2,546,100...2,637,524 JBrowse link
G Runx3 RUNX family transcription factor 3 disease_progression ISO DNA:promoter:hypermethylation protein:mislocalization RGD PMID:18256927 RGD:2302557 NCBI chrNW_004936474:9,751,946...9,802,910 JBrowse link
G Serpinb5 serpin family B member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19944674 NCBI chrNW_004936497:2,067,796...2,089,965 JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28235801 NCBI chrNW_004936594:119,808...136,620 JBrowse link
G Smad4 SMAD family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20565773 NCBI chrNW_004936497:12,242,869...12,278,012 JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chrNW_004936507:10,013,982...10,015,480 JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chrNW_004936594:2,932,297...2,935,358 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23964924 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 disease_progression ISO RGD PMID:17054309 RGD:2291958 NCBI chrNW_004936512:7,427,926...7,448,700 JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 ISO DNA:mutation:CDS:multiple nonsynonymous mutations RGD PMID:14871824 RGD:2306813 NCBI chrNW_004936470:41,222,782...41,345,755 JBrowse link
G Vegfc vascular endothelial growth factor C disease_progression ISO RGD PMID:19885590 RGD:2315471 NCBI chrNW_004936516:7,217,543...7,332,531 JBrowse link
G Wif1 WNT inhibitory factor 1 ISO protein:decreased expression:breast RGD PMID:14517837 RGD:727214 NCBI chrNW_004936545:3,263,646...3,334,163 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:polymorphism: :p.R399Q RGD PMID:18752184 RGD:2302569 NCBI chrNW_004936706:752,571...783,746 JBrowse link
invasive lobular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Invasive Lobular Breast Carcinoma ClinVar PMID:14973102 PMID:25741868 PMID:27257965 PMID:27907908 PMID:28222693 More... NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
G Ccnd1 cyclin D1 ISO DNA:amplification:cds (human)
protein:increased expression:breast
RGD PMID:12203362 PMID:12448002 RGD:11353788 RGD:2289133
G Ccnd2 cyclin D2 ISO DNA:hypermethylation:promoter, breast RGD PMID:14601057 RGD:2289156 NCBI chrNW_004936606:4,474,801...4,496,158 JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO mRNA, protein:splice variants, altered localization:breast RGD PMID:11245336 RGD:2289362 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cdh1 cadherin 1 ISO DNA:nonsense mutation: :517insA (human) RGD PMID:17660459 PMID:18213475 RGD:2289450 RGD:2289492 NCBI chrNW_004936475:18,990,529...19,065,954 JBrowse link
G Ctnna1 catenin alpha 1 ISO protein:decreased expression:breast RGD PMID:12047765 RGD:2289795 NCBI chrNW_004936531:7,865,907...8,036,020 JBrowse link
G Ctnnb1 catenin beta 1 ISO protein:decreased expression:breast RGD PMID:17721269 RGD:2289814 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 severity ISO RGD PMID:16761510 RGD:2289935 NCBI chrNW_004936490:14,887,062...14,910,038 JBrowse link
G Faslg Fas ligand ISO protein:increased expression:breast RGD PMID:10640988 RGD:2290134 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
mammary Paget's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO DNA:amplification RGD PMID:16932067 RGD:2289933 NCBI chrNW_004936490:14,887,062...14,910,038 JBrowse link
sporadic breast cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 no_association ISO DNA:hypermethylation:promoter
DNA:repeat:promoter
RGD PMID:17904846 PMID:17932744 RGD:2290043 RGD:8552977 NCBI chrNW_004936489:4,616,839...4,887,179 JBrowse link
G Mlh1 mutL homolog 1 ISO DNA, protein:hypermethylation, decreased expression:promoter, breast RGD PMID:12173039 RGD:2293522 NCBI chrNW_004936473:26,556,636...26,600,830 JBrowse link
G Mthfr methylenetetrahydrofolate reductase no_association ISO DNA:missense mutations:cds:g.677C>T, g.1298A>T (human) RGD PMID:28330681 RGD:38501055 NCBI chrNW_004936474:623,438...637,849 JBrowse link
G Phb prohibitin ISO DNA:loss of heterozygosity, mutations: :multiple RGD PMID:1540973 RGD:2292408 NCBI chrNW_004936490:12,127,065...12,138,870 JBrowse link
G Pten phosphatase and tensin homolog ISO DNA:hypermethylation:promoter: (human) RGD PMID:15287024 RGD:12859037 NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13006
    disease of cellular proliferation 6271
      Neoplasms by Site 5947
        Breast Neoplasms 1105
          breast cancer 597
            breast carcinoma 246
              Ehrlich tumor carcinoma 2
              bilateral breast cancer + 8
              breast adenocarcinoma + 16
              breast adenoid cystic carcinoma 0
              breast carcinoma in situ + 48
              breast ductal carcinoma + 101
              breast large cell neuroendocrine carcinoma 0
              breast lobular carcinoma + 13
              breast metaplastic carcinoma + 0
              breast myoepithelial carcinoma 0
              breast papillary carcinoma 0
              breast scirrhous carcinoma 0
              cribriform carcinoma 0
              female breast carcinoma 0
              lipid-rich carcinoma + 0
              luminal breast carcinoma A 0
              luminal breast carcinoma B 0
              nipple carcinoma + 0
              sebaceous breast carcinoma 0
              sporadic breast cancer 5
Path 2
Term Annotations click to browse term
  disease 13006
    disease of anatomical entity 12684
      nervous system disease 10538
        sensory system disease 4958
          skin disease 2606
            breast disease 1111
              Breast Neoplasms 1105
                breast cancer 597
                  breast carcinoma 246
                    Ehrlich tumor carcinoma 2
                    bilateral breast cancer + 8
                    breast adenocarcinoma + 16
                    breast adenoid cystic carcinoma 0
                    breast carcinoma in situ + 48
                    breast ductal carcinoma + 101
                    breast large cell neuroendocrine carcinoma 0
                    breast lobular carcinoma + 13
                    breast metaplastic carcinoma + 0
                    breast myoepithelial carcinoma 0
                    breast papillary carcinoma 0
                    breast scirrhous carcinoma 0
                    cribriform carcinoma 0
                    female breast carcinoma 0
                    lipid-rich carcinoma + 0
                    luminal breast carcinoma A 0
                    luminal breast carcinoma B 0
                    nipple carcinoma + 0
                    sebaceous breast carcinoma 0
                    sporadic breast cancer 5
paths to the root